Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tetratricopeptide repeat protein 36

Gene

TTC36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 36
Short name:
TPR repeat protein 36
Alternative name(s):
HSP70-binding protein 21
Gene namesi
Name:TTC36
Synonyms:HBP21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:33708. TTC36.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162407225.

Polymorphism and mutation databases

BioMutaiTTC36.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Tetratricopeptide repeat protein 36PRO_0000332179Add
BLAST

Proteomic databases

PaxDbiA6NLP5.
PRIDEiA6NLP5.

PTM databases

PhosphoSiteiA6NLP5.

Expressioni

Gene expression databases

BgeeiA6NLP5.
CleanExiHS_TTC36.
ExpressionAtlasiA6NLP5. baseline and differential.
GenevisibleiA6NLP5. HS.

Organism-specific databases

HPAiHPA038731.

Interactioni

Protein-protein interaction databases

BioGridi126825. 1 interaction.
STRINGi9606.ENSP00000307640.

Structurei

3D structure databases

ProteinModelPortaliA6NLP5.
SMRiA6NLP5. Positions 49-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati51 – 8434TPR 1Add
BLAST
Repeati86 – 11833TPR 2Add
BLAST
Repeati123 – 15634TPR 3Add
BLAST

Sequence similaritiesi

Belongs to the TTC36 family.Curated
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG4555. Eukaryota.
ENOG4111VN1. LUCA.
GeneTreeiENSGT00390000007968.
HOGENOMiHOG000031109.
HOVERGENiHBG106742.
InParanoidiA6NLP5.
OMAiPNTPFGD.
OrthoDBiEOG7QG45H.
PhylomeDBiA6NLP5.
TreeFamiTF105820.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NLP5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTPNDQAVL QAIFNPDTPF GDIVGLDLGE EAEKEEREED EVFPQAQLEQ
60 70 80 90 100
SKALELQGVM AAEAGDLSTA LERFGQAICL LPERASAYNN RAQARRLQGD
110 120 130 140 150
VAGALEDLER AVELSGGRGR AARQSFVQRG LLARLQGRDD DARRDFERAA
160 170 180
RLGSPFARRQ LVLLNPYAAL CNRMLADMMG QLRRPRDSR
Length:189
Mass (Da):20,896
Last modified:July 24, 2007 - v1
Checksum:i2CB6547BADC98404
GO
Isoform 2 (identifier: A6NLP5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.

Note: No experimental confirmation available.
Show »
Length:130
Mass (Da):14,427
Checksum:i9C683E69D3429EE6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti78 – 781I → M.
Corresponds to variant rs7111428 [ dbSNP | Ensembl ].
VAR_042972

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5959Missing in isoform 2. 1 PublicationVSP_055760Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU489483 mRNA. Translation: ACA62794.1.
AP000941 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67387.1.
BC146916 mRNA. Translation: AAI46917.1.
BC146921 mRNA. Translation: AAI46922.1.
BC171906 mRNA. Translation: AAI71906.1.
BC171913 mRNA. Translation: AAI71913.1.
CCDSiCCDS31687.1. [A6NLP5-1]
RefSeqiNP_001073910.1. NM_001080441.1. [A6NLP5-1]
UniGeneiHs.653449.

Genome annotation databases

EnsembliENST00000302783; ENSP00000307640; ENSG00000172425. [A6NLP5-1]
GeneIDi143941.
KEGGihsa:143941.
UCSCiuc001ptg.2. human. [A6NLP5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU489483 mRNA. Translation: ACA62794.1.
AP000941 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67387.1.
BC146916 mRNA. Translation: AAI46917.1.
BC146921 mRNA. Translation: AAI46922.1.
BC171906 mRNA. Translation: AAI71906.1.
BC171913 mRNA. Translation: AAI71913.1.
CCDSiCCDS31687.1. [A6NLP5-1]
RefSeqiNP_001073910.1. NM_001080441.1. [A6NLP5-1]
UniGeneiHs.653449.

3D structure databases

ProteinModelPortaliA6NLP5.
SMRiA6NLP5. Positions 49-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126825. 1 interaction.
STRINGi9606.ENSP00000307640.

PTM databases

PhosphoSiteiA6NLP5.

Polymorphism and mutation databases

BioMutaiTTC36.

Proteomic databases

PaxDbiA6NLP5.
PRIDEiA6NLP5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302783; ENSP00000307640; ENSG00000172425. [A6NLP5-1]
GeneIDi143941.
KEGGihsa:143941.
UCSCiuc001ptg.2. human. [A6NLP5-1]

Organism-specific databases

CTDi143941.
GeneCardsiTTC36.
HGNCiHGNC:33708. TTC36.
HPAiHPA038731.
neXtProtiNX_A6NLP5.
PharmGKBiPA162407225.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4555. Eukaryota.
ENOG4111VN1. LUCA.
GeneTreeiENSGT00390000007968.
HOGENOMiHOG000031109.
HOVERGENiHBG106742.
InParanoidiA6NLP5.
OMAiPNTPFGD.
OrthoDBiEOG7QG45H.
PhylomeDBiA6NLP5.
TreeFamiTF105820.

Miscellaneous databases

GenomeRNAii143941.
PROiA6NLP5.

Gene expression databases

BgeeiA6NLP5.
CleanExiHS_TTC36.
ExpressionAtlasiA6NLP5. baseline and differential.
GenevisibleiA6NLP5. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of HSP70 binding protein 21 in human PVR and breast cancer."
    Liu Q.H., Gao J.Y., Li J.M.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiTTC36_HUMAN
AccessioniPrimary (citable) accession number: A6NLP5
Secondary accession number(s): B7ZW72, B9EJD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 24, 2007
Last modified: June 8, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.