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Protein

Ubiquitin carboxyl-terminal hydrolase

Gene

UCHL1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseUniRule annotation
Biological processUbl conjugation pathwayUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolaseUniRule annotation (EC:3.4.19.12UniRule annotation)
Gene namesi
Name:UCHL1Imported
ORF Names:hCG_33087Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

PTM / Processingi

Proteomic databases

MaxQBiA6NLJ7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 19UCH_1InterPro annotationAdd BLAST17

Sequence similaritiesi

Belongs to the peptidase C12 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1415. Eukaryota.
ENOG4111HNA. LUCA.
HOGENOMiHOG000182400.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiView protein in InterPro
IPR001578. Peptidase_C12_UCH.
IPR036959. Peptidase_C12_UCH_sf.
IPR030297. UCHL1.
PANTHERiPTHR10589. PTHR10589. 1 hit.
PTHR10589:SF19. PTHR10589:SF19. 1 hit.
PfamiView protein in Pfam
PF01088. Peptidase_C12. 1 hit.
PRINTSiPR00707. UBCTHYDRLASE.
PROSITEiView protein in PROSITE
PS00140. UCH_1. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NLJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQTIGNSCG TIGLIHAVAN NQDKLGFEDG SVLKQFLSET EKMSPEDRAK
60 70 80 90 100
CFEKNEAIQA AHDAVAQEGQ CRVDDKVNFH FILFNNVDGH LYELDGRMPF
110 120 130 140
PVNHGASSED TLLKDAAKVC REFTEREQGE VRFSAVALCK AA
Length:142
Mass (Da):15,691
Last modified:July 13, 2010 - v1
Checksum:i2F624CA63604F771
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054579 mRNA. Translation: BAG51393.1.
CH471069 Genomic DNA. Translation: EAW92978.1.
CH471069 Genomic DNA. Translation: EAW92980.1.
UniGeneiHs.518731.

Similar proteinsi

Entry informationi

Entry nameiA6NLJ7_HUMAN
AccessioniPrimary (citable) accession number: A6NLJ7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 13, 2010
Last sequence update: July 13, 2010
Last modified: October 25, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.