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Protein

RNA polymerase II transcription factor SIII subunit A3-like-2

Gene

TCEB3CL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A3 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:G66-33100-MONOMER.
ReactomeiR-HSA-112382. Formation of RNA Pol II elongation complex.
R-HSA-112387. Elongation arrest and recovery.
R-HSA-167152. Formation of HIV elongation complex in the absence of HIV Tat.
R-HSA-167200. Formation of HIV-1 elongation complex containing HIV-1 Tat.
R-HSA-167238. Pausing and recovery of Tat-mediated HIV elongation.
R-HSA-167243. Tat-mediated HIV elongation arrest and recovery.
R-HSA-167246. Tat-mediated elongation of the HIV-1 transcript.
R-HSA-167287. HIV elongation arrest and recovery.
R-HSA-167290. Pausing and recovery of HIV elongation.
R-HSA-674695. RNA Polymerase II Pre-transcription Events.
R-HSA-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-HSA-75955. RNA Polymerase II Transcription Elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor SIII subunit A3-like-2
Alternative name(s):
Elongin-A3-like-2
Short name:
EloA3-like-2
Transcription elongation factor B polypeptide 3C-like-2
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:33511. TCEB3CL2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000274744.

Polymorphism and mutation databases

BioMutaiTCEB3CL2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003434291 – 546RNA polymerase II transcription factor SIII subunit A3-like-2Add BLAST546

Proteomic databases

PaxDbiA6NLF2.
PRIDEiA6NLF2.

PTM databases

iPTMnetiA6NLF2.
PhosphoSitePlusiA6NLF2.

Expressioni

Gene expression databases

BgeeiENSG00000266996.
GenevisibleiA6NLF2. HS.

Organism-specific databases

HPAiHPA048971.
HPA049178.
HPA050086.

Interactioni

Subunit structurei

Heterotrimer of an A (A1, A2 or A3), B and C subunit.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000468046.

Structurei

3D structure databases

ProteinModelPortaliA6NLF2.
SMRiA6NLF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 80TFIIS N-terminalPROSITE-ProRule annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni308 – 467Activation domainBy similarityAdd BLAST160
Regioni336 – 345Interaction with elongin BCBy similarity10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi119 – 193Pro-richAdd BLAST75

Domaini

The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].

Sequence similaritiesi

Contains 1 TFIIS N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2821. Eukaryota.
ENOG4110PG3. LUCA.
GeneTreeiENSGT00390000002428.
HOVERGENiHBG051467.
InParanoidiA6NLF2.
OMAiHFETIEN.
OrthoDBiEOG091G0D2G.
PhylomeDBiA6NLF2.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
InterProiIPR010684. RNA_pol_II_trans_fac_SIII_A.
IPR003617. TFIIS/CRSP70_N_sub.
IPR017923. TFIIS_N.
[Graphical view]
PfamiPF06881. Elongin_A. 1 hit.
PF08711. Med26. 1 hit.
[Graphical view]
SMARTiSM00509. TFS2N. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
PROSITEiPS51319. TFIIS_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NLF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGSTTLRA VGKLQVRLAT KTEPKKLEKY LQKLSALPMT ADILAETGIR
60 70 80 90 100
KTVKRLRKHQ HVGDFARDLA ARWKKLVLVD RNTGPDPQDP EESASRQRFG
110 120 130 140 150
EALQEREKAW GFPENATAPR SPSHSPEHRR TARRTPPGQQ RPHPRSPSRE
160 170 180 190 200
PRAERKRPRM APADSGPHRD PPTRTAPLPM PEGPEPAVPG EQPGRGHAHA
210 220 230 240 250
AQGGPLLGQG CQGQPQGEAV GSHSKGHKSS RGASAQKSPP VQESQSERLQ
260 270 280 290 300
AAVADSAGPK TVPSHVFSEL WDPSEAWMQA NYDLLSAFEA MTSQANPEAL
310 320 330 340 350
SAPTLQEEAA FPGRRVNAKM PVYSGSRPAC QLQVPTLRQQ CLRVPRNNPD
360 370 380 390 400
ALGDVEGVPY SALEPVLEGW TPDQPYRTEK DNAALARETD ELWRIHCLQD
410 420 430 440 450
FKEEKPQEHE SWRELYLRLR DAREQRLRVV TTKIRSAREN KPSGRQTKMI
460 470 480 490 500
CFNSVAKTPY DASRRQEKSA GAADPGNGEM EPAPKPAGSS QAPSGLGDGD
510 520 530 540
GGSVSGGGSS NRHAAPADKT RKQAAKKVAP LMAKAIRDYK GRFSRR
Length:546
Mass (Da):59,772
Last modified:July 24, 2007 - v1
Checksum:i00CB437E866753B3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_044378375P → L.Corresponds to variant rs2261291dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090373 Genomic DNA. No translation available.
CCDSiCCDS59316.1.
RefSeqiNP_001229836.1. NM_001242907.1.
UniGeneiHs.729823.

Genome annotation databases

EnsembliENST00000620881; ENSP00000483981; ENSG00000274744.
GeneIDi100506888.
KEGGihsa:100506888.
UCSCiuc021ujk.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090373 Genomic DNA. No translation available.
CCDSiCCDS59316.1.
RefSeqiNP_001229836.1. NM_001242907.1.
UniGeneiHs.729823.

3D structure databases

ProteinModelPortaliA6NLF2.
SMRiA6NLF2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000468046.

PTM databases

iPTMnetiA6NLF2.
PhosphoSitePlusiA6NLF2.

Polymorphism and mutation databases

BioMutaiTCEB3CL2.

Proteomic databases

PaxDbiA6NLF2.
PRIDEiA6NLF2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000620881; ENSP00000483981; ENSG00000274744.
GeneIDi100506888.
KEGGihsa:100506888.
UCSCiuc021ujk.2. human.

Organism-specific databases

CTDi100506888.
GeneCardsiTCEB3CL2.
HGNCiHGNC:33511. TCEB3CL2.
HPAiHPA048971.
HPA049178.
HPA050086.
neXtProtiNX_A6NLF2.
OpenTargetsiENSG00000274744.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2821. Eukaryota.
ENOG4110PG3. LUCA.
GeneTreeiENSGT00390000002428.
HOVERGENiHBG051467.
InParanoidiA6NLF2.
OMAiHFETIEN.
OrthoDBiEOG091G0D2G.
PhylomeDBiA6NLF2.

Enzyme and pathway databases

BioCyciZFISH:G66-33100-MONOMER.
ReactomeiR-HSA-112382. Formation of RNA Pol II elongation complex.
R-HSA-112387. Elongation arrest and recovery.
R-HSA-167152. Formation of HIV elongation complex in the absence of HIV Tat.
R-HSA-167200. Formation of HIV-1 elongation complex containing HIV-1 Tat.
R-HSA-167238. Pausing and recovery of Tat-mediated HIV elongation.
R-HSA-167243. Tat-mediated HIV elongation arrest and recovery.
R-HSA-167246. Tat-mediated elongation of the HIV-1 transcript.
R-HSA-167287. HIV elongation arrest and recovery.
R-HSA-167290. Pausing and recovery of HIV elongation.
R-HSA-674695. RNA Polymerase II Pre-transcription Events.
R-HSA-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-HSA-75955. RNA Polymerase II Transcription Elongation.

Miscellaneous databases

PROiA6NLF2.

Gene expression databases

BgeeiENSG00000266996.
GenevisibleiA6NLF2. HS.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
InterProiIPR010684. RNA_pol_II_trans_fac_SIII_A.
IPR003617. TFIIS/CRSP70_N_sub.
IPR017923. TFIIS_N.
[Graphical view]
PfamiPF06881. Elongin_A. 1 hit.
PF08711. Med26. 1 hit.
[Graphical view]
SMARTiSM00509. TFS2N. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
PROSITEiPS51319. TFIIS_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEA3L2_HUMAN
AccessioniPrimary (citable) accession number: A6NLF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 24, 2007
Last modified: November 30, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.