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Protein

Elongin-A3 member D

Gene

ELOA3D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).By similarity

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-112382. Formation of RNA Pol II elongation complex.
R-HSA-167152. Formation of HIV elongation complex in the absence of HIV Tat.
R-HSA-167200. Formation of HIV-1 elongation complex containing HIV-1 Tat.
R-HSA-167238. Pausing and recovery of Tat-mediated HIV elongation.
R-HSA-167243. Tat-mediated HIV elongation arrest and recovery.
R-HSA-167246. Tat-mediated elongation of the HIV-1 transcript.
R-HSA-167287. HIV elongation arrest and recovery.
R-HSA-167290. Pausing and recovery of HIV elongation.
R-HSA-674695. RNA Polymerase II Pre-transcription Events.
R-HSA-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-HSA-75955. RNA Polymerase II Transcription Elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongin-A3 member D
Short name:
EloA3D
Alternative name(s):
Elongin-A3-like-2
Short name:
EloA3-like-2
RNA polymerase II transcription factor SIII subunit A3-like-2
Transcription elongation factor B polypeptide 3C-like-2
Gene namesi
Name:ELOA3DImported
Synonyms:TCEB3CL2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000274744.1.
HGNCiHGNC:33511. ELOA3D.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000274744.

Polymorphism and mutation databases

BioMutaiTCEB3CL2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003434291 – 546Elongin-A3 member DAdd BLAST546

Proteomic databases

PaxDbiA6NLF2.
PRIDEiA6NLF2.

PTM databases

iPTMnetiA6NLF2.
PhosphoSitePlusiA6NLF2.

Expressioni

Gene expression databases

BgeeiENSG00000274744.
GenevisibleiA6NLF2. HS.

Organism-specific databases

HPAiHPA048971.
HPA049178.
HPA050086.

Interactioni

Subunit structurei

Heterotrimer of an A (ELOA3, ELOA2, ELOA3, ELOA3B, ELOA3C or ELOA3D), ELOB and ELOC subunit.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000468046.

Structurei

3D structure databases

ProteinModelPortaliA6NLF2.
SMRiA6NLF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 80TFIIS N-terminalPROSITE-ProRule annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni308 – 467Activation domainBy similarityAdd BLAST160
Regioni336 – 345BC-boxBy similarity10
Regioni336 – 345Interaction with elongin BCBy similarity10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi119 – 193Pro-richAdd BLAST75

Domaini

The BC-box, which mediates binding to the elongin BC complex, has the consensus sequence [APST]-L-x3-C-x3-[AILV].By similarity

Phylogenomic databases

eggNOGiKOG2821. Eukaryota.
ENOG4110PG3. LUCA.
GeneTreeiENSGT00390000002428.
HOVERGENiHBG051467.
InParanoidiA6NLF2.
OMAiIPHEDEN.
OrthoDBiEOG091G0D2G.
PhylomeDBiA6NLF2.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
InterProiView protein in InterPro
IPR010684. RNA_pol_II_trans_fac_SIII_A.
IPR003617. TFIIS/CRSP70_N_sub.
IPR035441. TFIIS/LEDGF_domain.
IPR017923. TFIIS_N.
PfamiView protein in Pfam
PF06881. Elongin_A. 1 hit.
PF08711. Med26. 1 hit.
SMARTiView protein in SMART
SM00509. TFS2N. 1 hit.
SUPFAMiSSF47676. SSF47676. 1 hit.
PROSITEiView protein in PROSITE
PS51319. TFIIS_N. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NLF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGSTTLRA VGKLQVRLAT KTEPKKLEKY LQKLSALPMT ADILAETGIR
60 70 80 90 100
KTVKRLRKHQ HVGDFARDLA ARWKKLVLVD RNTGPDPQDP EESASRQRFG
110 120 130 140 150
EALQEREKAW GFPENATAPR SPSHSPEHRR TARRTPPGQQ RPHPRSPSRE
160 170 180 190 200
PRAERKRPRM APADSGPHRD PPTRTAPLPM PEGPEPAVPG EQPGRGHAHA
210 220 230 240 250
AQGGPLLGQG CQGQPQGEAV GSHSKGHKSS RGASAQKSPP VQESQSERLQ
260 270 280 290 300
AAVADSAGPK TVPSHVFSEL WDPSEAWMQA NYDLLSAFEA MTSQANPEAL
310 320 330 340 350
SAPTLQEEAA FPGRRVNAKM PVYSGSRPAC QLQVPTLRQQ CLRVPRNNPD
360 370 380 390 400
ALGDVEGVPY SALEPVLEGW TPDQPYRTEK DNAALARETD ELWRIHCLQD
410 420 430 440 450
FKEEKPQEHE SWRELYLRLR DAREQRLRVV TTKIRSAREN KPSGRQTKMI
460 470 480 490 500
CFNSVAKTPY DASRRQEKSA GAADPGNGEM EPAPKPAGSS QAPSGLGDGD
510 520 530 540
GGSVSGGGSS NRHAAPADKT RKQAAKKVAP LMAKAIRDYK GRFSRR
Length:546
Mass (Da):59,772
Last modified:July 24, 2007 - v1
Checksum:i00CB437E866753B3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_044378375P → L. Corresponds to variant dbSNP:rs2261291Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090373 Genomic DNA. No translation available.
CCDSiCCDS59316.1.
RefSeqiNP_001229836.1. NM_001242907.1.
UniGeneiHs.729823.

Genome annotation databases

EnsembliENST00000620881; ENSP00000483981; ENSG00000274744.
GeneIDi100506888.
KEGGihsa:100506888.
UCSCiuc021ujk.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiELB3D_HUMAN
AccessioniPrimary (citable) accession number: A6NLF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 24, 2007
Last modified: October 25, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations