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Protein

Putative aquaporin-7-like protein 3

Gene

AQP7P3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Putative aquaporin-7-like protein 3
Gene namesi
Name:AQP7P3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:31976. AQP7P3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei37 – 5721HelicalSequence AnalysisAdd
BLAST
Topological domaini58 – 636ExtracellularSequence Analysis
Transmembranei64 – 8421HelicalSequence AnalysisAdd
BLAST
Topological domaini85 – 11329CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence AnalysisAdd
BLAST
Topological domaini135 – 1373ExtracellularSequence Analysis
Transmembranei138 – 15821HelicalSequence AnalysisAdd
BLAST
Topological domaini159 – 17012CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence AnalysisAdd
BLAST
Topological domaini192 – 1954ExtracellularSequence Analysis
Transmembranei196 – 21621HelicalSequence AnalysisAdd
BLAST
Topological domaini217 – 23014CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei231 – 24717HelicalSequence AnalysisAdd
BLAST
Topological domaini248 – 2525ExtracellularSequence Analysis
Transmembranei253 – 27624HelicalSequence AnalysisAdd
BLAST
Topological domaini277 – 34266CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Putative aquaporin-7-like protein 3PRO_0000332129Add
BLAST

Proteomic databases

PaxDbiA6NL99.
PRIDEiA6NL99.

Expressioni

Organism-specific databases

HPAiHPA044049.
HPA048106.

Structurei

3D structure databases

ProteinModelPortaliA6NL99.
SMRiA6NL99. Positions 35-265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi94 – 963NPA 1
Motifi226 – 2283NPA 2

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro/Ala-Ala/Ser (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0580.
HOVERGENiHBG106057.
InParanoidiA6NL99.
PhylomeDBiA6NL99.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR015686. Aquaporin_7.
IPR000425. MIP.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PTHR19139:SF16. PTHR19139:SF16. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NL99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQASGHRRS TRGSKMVSWS VIAKIQEICE RKMAREFLAE FMSTYVMMVF
60 70 80 90 100
GLGSVAHMLL NKTFGSYLGV NLGFGFGVTM GVHMAGRTSG AHMNAAVSLT
110 120 130 140 150
NCALGRVPWR KFPVYVLGQF LGSFLAAATI YSLFYTAILH FSGGELMVTG
160 170 180 190 200
PVATVGIFAT YLPDHMTLWR GFLNEEWLTG MLQLCLFAIV DQENNPALPG
210 220 230 240 250
THALVIGILV VIIRVYHGMN TGYAINPSRD LPPRIFTFIA GWGKLVFSDG
260 270 280 290 300
ENLWWVPVVA PLLGASLGGI IYLVFIGSTI PREPLKLEDS VAYEDHGITV
310 320 330 340
LPKMGSHEPM ISPLTLISVS PANRSSVHPA PPLHESMALE HF
Length:342
Mass (Da):37,357
Last modified:January 15, 2008 - v2
Checksum:i6BDD4CB18DEB6FD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129778 Genomic DNA. No translation available.
AL136317 Genomic DNA. No translation available.
UniGeneiHs.743215.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129778 Genomic DNA. No translation available.
AL136317 Genomic DNA. No translation available.
UniGeneiHs.743215.

3D structure databases

ProteinModelPortaliA6NL99.
SMRiA6NL99. Positions 35-265.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiA6NL99.
PRIDEiA6NL99.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiGC09P042858.
HGNCiHGNC:31976. AQP7P3.
HPAiHPA044049.
HPA048106.
neXtProtiNX_A6NL99.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0580.
HOVERGENiHBG106057.
InParanoidiA6NL99.
PhylomeDBiA6NL99.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR015686. Aquaporin_7.
IPR000425. MIP.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PTHR19139:SF16. PTHR19139:SF16. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiAQP73_HUMAN
AccessioniPrimary (citable) accession number: A6NL99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 15, 2008
Last modified: July 22, 2015
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.