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A6NL99

- AQP73_HUMAN

UniProt

A6NL99 - AQP73_HUMAN

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Protein
Putative aquaporin-7-like protein 3
Gene
AQP7P3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Protein uncertaini

Functioni

GO - Molecular functioni

  1. transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Putative aquaporin-7-like protein 3
Gene namesi
Name:AQP7P3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:31976. AQP7P3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei37 – 5721Helical; Reviewed prediction
Add
BLAST
Topological domaini58 – 636Extracellular Reviewed prediction
Transmembranei64 – 8421Helical; Reviewed prediction
Add
BLAST
Topological domaini85 – 11329Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei114 – 13421Helical; Reviewed prediction
Add
BLAST
Topological domaini135 – 1373Extracellular Reviewed prediction
Transmembranei138 – 15821Helical; Reviewed prediction
Add
BLAST
Topological domaini159 – 17012Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei171 – 19121Helical; Reviewed prediction
Add
BLAST
Topological domaini192 – 1954Extracellular Reviewed prediction
Transmembranei196 – 21621Helical; Reviewed prediction
Add
BLAST
Topological domaini217 – 23014Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei231 – 24717Helical; Reviewed prediction
Add
BLAST
Topological domaini248 – 2525Extracellular Reviewed prediction
Transmembranei253 – 27624Helical; Reviewed prediction
Add
BLAST
Topological domaini277 – 34266Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Putative aquaporin-7-like protein 3
PRO_0000332129Add
BLAST

Proteomic databases

PaxDbiA6NL99.
PRIDEiA6NL99.

Expressioni

Gene expression databases

GenevestigatoriA6NL99.

Structurei

3D structure databases

ProteinModelPortaliA6NL99.
SMRiA6NL99. Positions 35-265.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi94 – 963NPA 1
Motifi226 – 2283NPA 2

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro/Ala-Ala/Ser (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0580.
HOVERGENiHBG106057.
InParanoidiA6NL99.
PhylomeDBiA6NL99.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR015686. Aquaporin_7.
IPR000425. MIP.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PTHR19139:SF16. PTHR19139:SF16. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NL99-1 [UniParc]FASTAAdd to Basket

« Hide

MVQASGHRRS TRGSKMVSWS VIAKIQEICE RKMAREFLAE FMSTYVMMVF    50
GLGSVAHMLL NKTFGSYLGV NLGFGFGVTM GVHMAGRTSG AHMNAAVSLT 100
NCALGRVPWR KFPVYVLGQF LGSFLAAATI YSLFYTAILH FSGGELMVTG 150
PVATVGIFAT YLPDHMTLWR GFLNEEWLTG MLQLCLFAIV DQENNPALPG 200
THALVIGILV VIIRVYHGMN TGYAINPSRD LPPRIFTFIA GWGKLVFSDG 250
ENLWWVPVVA PLLGASLGGI IYLVFIGSTI PREPLKLEDS VAYEDHGITV 300
LPKMGSHEPM ISPLTLISVS PANRSSVHPA PPLHESMALE HF 342
Length:342
Mass (Da):37,357
Last modified:January 15, 2008 - v2
Checksum:i6BDD4CB18DEB6FD0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC129778 Genomic DNA. No translation available.
AL136317 Genomic DNA. No translation available.
UniGeneiHs.743215.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC129778 Genomic DNA. No translation available.
AL136317 Genomic DNA. No translation available.
UniGenei Hs.743215.

3D structure databases

ProteinModelPortali A6NL99.
SMRi A6NL99. Positions 35-265.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi A6NL99.
PRIDEi A6NL99.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

GeneCardsi GC09P042858.
HGNCi HGNC:31976. AQP7P3.
neXtProti NX_A6NL99.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0580.
HOVERGENi HBG106057.
InParanoidi A6NL99.
PhylomeDBi A6NL99.

Gene expression databases

Genevestigatori A6NL99.

Family and domain databases

Gene3Di 1.20.1080.10. 1 hit.
InterProi IPR023271. Aquaporin-like.
IPR015686. Aquaporin_7.
IPR000425. MIP.
[Graphical view ]
PANTHERi PTHR19139. PTHR19139. 1 hit.
PTHR19139:SF16. PTHR19139:SF16. 1 hit.
Pfami PF00230. MIP. 1 hit.
[Graphical view ]
PRINTSi PR00783. MINTRINSICP.
SUPFAMi SSF81338. SSF81338. 1 hit.
TIGRFAMsi TIGR00861. MIP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiAQP73_HUMAN
AccessioniPrimary (citable) accession number: A6NL99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 15, 2008
Last modified: September 3, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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