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A6NL99

- AQP73_HUMAN

UniProt

A6NL99 - AQP73_HUMAN

Protein

Putative aquaporin-7-like protein 3

Gene

AQP7P3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. transporter activity Source: InterPro

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative aquaporin-7-like protein 3
    Gene namesi
    Name:AQP7P3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:31976. AQP7P3.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 342342Putative aquaporin-7-like protein 3PRO_0000332129Add
    BLAST

    Proteomic databases

    PaxDbiA6NL99.
    PRIDEiA6NL99.

    Expressioni

    Gene expression databases

    GenevestigatoriA6NL99.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NL99.
    SMRiA6NL99. Positions 35-265.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3636CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini58 – 636ExtracellularSequence Analysis
    Topological domaini85 – 11329CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini135 – 1373ExtracellularSequence Analysis
    Topological domaini159 – 17012CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini192 – 1954ExtracellularSequence Analysis
    Topological domaini217 – 23014CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini248 – 2525ExtracellularSequence Analysis
    Topological domaini277 – 34266CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei37 – 5721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei64 – 8421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei114 – 13421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei171 – 19121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei196 – 21621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei231 – 24717HelicalSequence AnalysisAdd
    BLAST
    Transmembranei253 – 27624HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi94 – 963NPA 1
    Motifi226 – 2283NPA 2

    Domaini

    Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro/Ala-Ala/Ser (NPA).

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0580.
    HOVERGENiHBG106057.
    InParanoidiA6NL99.
    PhylomeDBiA6NL99.

    Family and domain databases

    Gene3Di1.20.1080.10. 1 hit.
    InterProiIPR023271. Aquaporin-like.
    IPR015686. Aquaporin_7.
    IPR000425. MIP.
    [Graphical view]
    PANTHERiPTHR19139. PTHR19139. 1 hit.
    PTHR19139:SF16. PTHR19139:SF16. 1 hit.
    PfamiPF00230. MIP. 1 hit.
    [Graphical view]
    PRINTSiPR00783. MINTRINSICP.
    SUPFAMiSSF81338. SSF81338. 1 hit.
    TIGRFAMsiTIGR00861. MIP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6NL99-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVQASGHRRS TRGSKMVSWS VIAKIQEICE RKMAREFLAE FMSTYVMMVF    50
    GLGSVAHMLL NKTFGSYLGV NLGFGFGVTM GVHMAGRTSG AHMNAAVSLT 100
    NCALGRVPWR KFPVYVLGQF LGSFLAAATI YSLFYTAILH FSGGELMVTG 150
    PVATVGIFAT YLPDHMTLWR GFLNEEWLTG MLQLCLFAIV DQENNPALPG 200
    THALVIGILV VIIRVYHGMN TGYAINPSRD LPPRIFTFIA GWGKLVFSDG 250
    ENLWWVPVVA PLLGASLGGI IYLVFIGSTI PREPLKLEDS VAYEDHGITV 300
    LPKMGSHEPM ISPLTLISVS PANRSSVHPA PPLHESMALE HF 342
    Length:342
    Mass (Da):37,357
    Last modified:January 15, 2008 - v2
    Checksum:i6BDD4CB18DEB6FD0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC129778 Genomic DNA. No translation available.
    AL136317 Genomic DNA. No translation available.
    UniGeneiHs.743215.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC129778 Genomic DNA. No translation available.
    AL136317 Genomic DNA. No translation available.
    UniGenei Hs.743215.

    3D structure databases

    ProteinModelPortali A6NL99.
    SMRi A6NL99. Positions 35-265.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi A6NL99.
    PRIDEi A6NL99.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC09P042858.
    HGNCi HGNC:31976. AQP7P3.
    neXtProti NX_A6NL99.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0580.
    HOVERGENi HBG106057.
    InParanoidi A6NL99.
    PhylomeDBi A6NL99.

    Gene expression databases

    Genevestigatori A6NL99.

    Family and domain databases

    Gene3Di 1.20.1080.10. 1 hit.
    InterProi IPR023271. Aquaporin-like.
    IPR015686. Aquaporin_7.
    IPR000425. MIP.
    [Graphical view ]
    PANTHERi PTHR19139. PTHR19139. 1 hit.
    PTHR19139:SF16. PTHR19139:SF16. 1 hit.
    Pfami PF00230. MIP. 1 hit.
    [Graphical view ]
    PRINTSi PR00783. MINTRINSICP.
    SUPFAMi SSF81338. SSF81338. 1 hit.
    TIGRFAMsi TIGR00861. MIP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiAQP73_HUMAN
    AccessioniPrimary (citable) accession number: A6NL99
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 57 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3