A6NL99 (AQP73_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative aquaporin-7-like protein 3

Gene names

Name:

AQP7P3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	342 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Domain	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro/Ala-Ala/Ser (NPA).
Sequence similarities	Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]
Caution	Could be the product of a pseudogene.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 342	342	Putative aquaporin-7-like protein 3		PRO_0000332129
Regions
	Topological domain	1 – 36	36	Cytoplasmic Potential
	Transmembrane	37 – 57	21	Helical; Potential
	Topological domain	58 – 63	6	Extracellular Potential
	Transmembrane	64 – 84	21	Helical; Potential
	Topological domain	85 – 113	29	Cytoplasmic Potential
	Transmembrane	114 – 134	21	Helical; Potential
	Topological domain	135 – 137	3	Extracellular Potential
	Transmembrane	138 – 158	21	Helical; Potential
	Topological domain	159 – 170	12	Cytoplasmic Potential
	Transmembrane	171 – 191	21	Helical; Potential
	Topological domain	192 – 195	4	Extracellular Potential
	Transmembrane	196 – 216	21	Helical; Potential
	Topological domain	217 – 230	14	Cytoplasmic Potential
	Transmembrane	231 – 247	17	Helical; Potential
	Topological domain	248 – 252	5	Extracellular Potential
	Transmembrane	253 – 276	24	Helical; Potential
	Topological domain	277 – 342	66	Cytoplasmic Potential
	Motif	94 – 96	3	NPA 1
	Motif	226 – 228	3	NPA 2

Sequences

	Sequence		Length	Mass (Da)
	A6NL99 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: 6BDD4CB18DEB6FD0	FASTA	342	37,357
	10 20 30 40 50 60 MVQASGHRRS TRGSKMVSWS VIAKIQEICE RKMAREFLAE FMSTYVMMVF GLGSVAHMLL 70 80 90 100 110 120 NKTFGSYLGV NLGFGFGVTM GVHMAGRTSG AHMNAAVSLT NCALGRVPWR KFPVYVLGQF 130 140 150 160 170 180 LGSFLAAATI YSLFYTAILH FSGGELMVTG PVATVGIFAT YLPDHMTLWR GFLNEEWLTG 190 200 210 220 230 240 MLQLCLFAIV DQENNPALPG THALVIGILV VIIRVYHGMN TGYAINPSRD LPPRIFTFIA 250 260 270 280 290 300 GWGKLVFSDG ENLWWVPVVA PLLGASLGGI IYLVFIGSTI PREPLKLEDS VAYEDHGITV 310 320 330 340 LPKMGSHEPM ISPLTLISVS PANRSSVHPA PPLHESMALE HF

References

[1]

"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC129778 Genomic DNA. No translation available. AL136317 Genomic DNA. No translation available.
IPI	IPI00878464.
UniGene	Hs.203087.
3D structure databases
ProteinModelPortal	A6NL99.
ModBase	Search...
Proteomic databases
PaxDb	A6NL99.
PRIDE	A6NL99.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC09P042858.
HGNC	HGNC:31976. AQP7P3.
neXtProt	NX_A6NL99.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0580.
HOVERGEN	HBG106057.
InParanoid	A6NL99.
Gene expression databases
Genevestigator	A6NL99.
Family and domain databases
Gene3D	1.20.1080.10. 1 hit.
InterPro	IPR023271. Aquaporin-like. IPR015686. Aquaporin_7. IPR000425. MIP. [Graphical view]
PANTHER	PTHR19139. PTHR19139. 1 hit. PTHR19139:SF16. PTHR19139:SF16. 1 hit.
Pfam	PF00230. MIP. 1 hit. [Graphical view]
PRINTS	PR00783. MINTRINSICP.
SUPFAM	SSF81338. MIP. 1 hit.
TIGRFAMs	TIGR00861. MIP. 1 hit.
PROSITE	PS00221. MIP. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AQP73_HUMAN

Accession

Primary (citable) accession number: A6NL99

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	January 15, 2008
Last modified:	May 1, 2013
This is version 47 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.