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A6NL99 (AQP73_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative aquaporin-7-like protein 3
Gene names
Name:AQP7P3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Domain

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro/Ala-Ala/Ser (NPA).

Sequence similarities

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]

Caution

Could be the product of a pseudogene.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   DomainRepeat
Transmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiontransporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 342342Putative aquaporin-7-like protein 3
PRO_0000332129

Regions

Topological domain1 – 3636Cytoplasmic Potential
Transmembrane37 – 5721Helical; Potential
Topological domain58 – 636Extracellular Potential
Transmembrane64 – 8421Helical; Potential
Topological domain85 – 11329Cytoplasmic Potential
Transmembrane114 – 13421Helical; Potential
Topological domain135 – 1373Extracellular Potential
Transmembrane138 – 15821Helical; Potential
Topological domain159 – 17012Cytoplasmic Potential
Transmembrane171 – 19121Helical; Potential
Topological domain192 – 1954Extracellular Potential
Transmembrane196 – 21621Helical; Potential
Topological domain217 – 23014Cytoplasmic Potential
Transmembrane231 – 24717Helical; Potential
Topological domain248 – 2525Extracellular Potential
Transmembrane253 – 27624Helical; Potential
Topological domain277 – 34266Cytoplasmic Potential
Motif94 – 963NPA 1
Motif226 – 2283NPA 2

Sequences

Sequence LengthMass (Da)Tools
A6NL99 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: 6BDD4CB18DEB6FD0

FASTA34237,357
        10         20         30         40         50         60 
MVQASGHRRS TRGSKMVSWS VIAKIQEICE RKMAREFLAE FMSTYVMMVF GLGSVAHMLL 

        70         80         90        100        110        120 
NKTFGSYLGV NLGFGFGVTM GVHMAGRTSG AHMNAAVSLT NCALGRVPWR KFPVYVLGQF 

       130        140        150        160        170        180 
LGSFLAAATI YSLFYTAILH FSGGELMVTG PVATVGIFAT YLPDHMTLWR GFLNEEWLTG 

       190        200        210        220        230        240 
MLQLCLFAIV DQENNPALPG THALVIGILV VIIRVYHGMN TGYAINPSRD LPPRIFTFIA 

       250        260        270        280        290        300 
GWGKLVFSDG ENLWWVPVVA PLLGASLGGI IYLVFIGSTI PREPLKLEDS VAYEDHGITV 

       310        320        330        340 
LPKMGSHEPM ISPLTLISVS PANRSSVHPA PPLHESMALE HF 

« Hide

References

[1]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC129778 Genomic DNA. No translation available.
AL136317 Genomic DNA. No translation available.
UniGeneHs.743215.

3D structure databases

ProteinModelPortalA6NL99.
SMRA6NL99. Positions 35-265.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbA6NL99.
PRIDEA6NL99.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC09P042858.
HGNCHGNC:31976. AQP7P3.
neXtProtNX_A6NL99.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0580.
HOVERGENHBG106057.
InParanoidA6NL99.
PhylomeDBA6NL99.

Gene expression databases

GenevestigatorA6NL99.

Family and domain databases

Gene3D1.20.1080.10. 1 hit.
InterProIPR023271. Aquaporin-like.
IPR015686. Aquaporin_7.
IPR000425. MIP.
[Graphical view]
PANTHERPTHR19139. PTHR19139. 1 hit.
PTHR19139:SF16. PTHR19139:SF16. 1 hit.
PfamPF00230. MIP. 1 hit.
[Graphical view]
PRINTSPR00783. MINTRINSICP.
SUPFAMSSF81338. SSF81338. 1 hit.
TIGRFAMsTIGR00861. MIP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAQP73_HUMAN
AccessionPrimary (citable) accession number: A6NL99
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 15, 2008
Last modified: April 16, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM