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Protein

Olfactory receptor 5B21

Gene

OR5B21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5B21
Gene namesi
Name:OR5B21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:19616. OR5B21.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence analysisAdd
BLAST
Transmembranei27 – 4721Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini48 – 558CytoplasmicSequence analysis
Transmembranei56 – 7621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini77 – 9519ExtracellularSequence analysisAdd
BLAST
Transmembranei96 – 11621Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini117 – 13721CytoplasmicSequence analysisAdd
BLAST
Transmembranei138 – 15821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini159 – 19941ExtracellularSequence analysisAdd
BLAST
Transmembranei200 – 22021Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini221 – 23515CytoplasmicSequence analysisAdd
BLAST
Transmembranei236 – 25621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini257 – 27014ExtracellularSequence analysisAdd
BLAST
Transmembranei271 – 29121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini292 – 30918CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134867164.

Polymorphism and mutation databases

BioMutaiOR5B21.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Olfactory receptor 5B21PRO_0000310474Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Disulfide bondi95 ↔ 177PROSITE-ProRule annotation
Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NL26.
PRIDEiA6NL26.

PTM databases

PhosphoSiteiA6NL26.

Expressioni

Gene expression databases

CleanExiHS_OR5B21.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353537.

Structurei

3D structure databases

ProteinModelPortaliA6NL26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVUX. Eukaryota.
ENOG41117FD. LUCA.
GeneTreeiENSGT00760000118941.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6NL26.
KOiK04257.
OMAiGMMVIIH.
OrthoDBiEOG71K63J.
PhylomeDBiA6NL26.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NL26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENSTEVTEF ILLGLTDDPN LQIPLLLAFL FIYLITLLGN GGMMVIIHSD
60 70 80 90 100
SHLHTPMYFF LSNLSLVDLG YSSAVAPKTV AALRSGDKAI SYDGCAAQFF
110 120 130 140 150
FFVGFATVEC YLLASMAYDR HAAVCRPLHY TTTMTAGVCA LLATGSYVSG
160 170 180 190 200
FLNASIHAAG TFRLSFCGSN EINHFFCDIP PLLALSCSDT RISKLVVFVA
210 220 230 240 250
GFNVFFTLLV ILISYFFICI TIQRMHSAEG QKKVFSTCAS HLTALSIFYG
260 270 280 290 300
TIIFMYLQPN SSQSVDTDKI ASVFYTVVIP MLNPLIYSLR NKEVKSALWK

ILNKLYPQY
Length:309
Mass (Da):34,174
Last modified:July 24, 2007 - v1
Checksum:i5AAA162D09AC8BA1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti272 – 2721S → Y.
Corresponds to variant rs58454093 [ dbSNP | Ensembl ].
VAR_062041

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003557 Genomic DNA. No translation available.
CCDSiCCDS31552.1.
RefSeqiNP_001005218.1. NM_001005218.1.
UniGeneiHs.553647.

Genome annotation databases

EnsembliENST00000360374; ENSP00000353537; ENSG00000198283.
GeneIDi219968.
KEGGihsa:219968.
UCSCiuc010rki.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003557 Genomic DNA. No translation available.
CCDSiCCDS31552.1.
RefSeqiNP_001005218.1. NM_001005218.1.
UniGeneiHs.553647.

3D structure databases

ProteinModelPortaliA6NL26.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000353537.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiA6NL26.

Polymorphism and mutation databases

BioMutaiOR5B21.

Proteomic databases

PaxDbiA6NL26.
PRIDEiA6NL26.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360374; ENSP00000353537; ENSG00000198283.
GeneIDi219968.
KEGGihsa:219968.
UCSCiuc010rki.3. human.

Organism-specific databases

CTDi219968.
GeneCardsiOR5B21.
HGNCiHGNC:19616. OR5B21.
neXtProtiNX_A6NL26.
PharmGKBiPA134867164.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVUX. Eukaryota.
ENOG41117FD. LUCA.
GeneTreeiENSGT00760000118941.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6NL26.
KOiK04257.
OMAiGMMVIIH.
OrthoDBiEOG71K63J.
PhylomeDBiA6NL26.
TreeFamiTF352753.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii219968.
NextBioi90898.
PROiA6NL26.

Gene expression databases

CleanExiHS_OR5B21.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiOR5BL_HUMAN
AccessioniPrimary (citable) accession number: A6NL26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: March 16, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.