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Protein

Olfactory receptor 5B21

Gene

OR5B21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-33472-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5B21
Gene namesi
Name:OR5B21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:19616. OR5B21.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 95ExtracellularSequence analysisAdd BLAST19
Transmembranei96 – 116Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini117 – 137CytoplasmicSequence analysisAdd BLAST21
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 199ExtracellularSequence analysisAdd BLAST41
Transmembranei200 – 220Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini221 – 235CytoplasmicSequence analysisAdd BLAST15
Transmembranei236 – 256Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini257 – 270ExtracellularSequence analysisAdd BLAST14
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 309CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198283.
PharmGKBiPA134867164.

Polymorphism and mutation databases

BioMutaiOR5B21.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003104741 – 309Olfactory receptor 5B21Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 177PROSITE-ProRule annotation
Glycosylationi260N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NL26.
PRIDEiA6NL26.

PTM databases

iPTMnetiA6NL26.
PhosphoSitePlusiA6NL26.

Expressioni

Gene expression databases

CleanExiHS_OR5B21.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353537.

Structurei

3D structure databases

ProteinModelPortaliA6NL26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVUX. Eukaryota.
ENOG41117FD. LUCA.
GeneTreeiENSGT00760000118941.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6NL26.
KOiK04257.
OMAiGMMVIIH.
OrthoDBiEOG091G0AZH.
PhylomeDBiA6NL26.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NL26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENSTEVTEF ILLGLTDDPN LQIPLLLAFL FIYLITLLGN GGMMVIIHSD
60 70 80 90 100
SHLHTPMYFF LSNLSLVDLG YSSAVAPKTV AALRSGDKAI SYDGCAAQFF
110 120 130 140 150
FFVGFATVEC YLLASMAYDR HAAVCRPLHY TTTMTAGVCA LLATGSYVSG
160 170 180 190 200
FLNASIHAAG TFRLSFCGSN EINHFFCDIP PLLALSCSDT RISKLVVFVA
210 220 230 240 250
GFNVFFTLLV ILISYFFICI TIQRMHSAEG QKKVFSTCAS HLTALSIFYG
260 270 280 290 300
TIIFMYLQPN SSQSVDTDKI ASVFYTVVIP MLNPLIYSLR NKEVKSALWK

ILNKLYPQY
Length:309
Mass (Da):34,174
Last modified:July 24, 2007 - v1
Checksum:i5AAA162D09AC8BA1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062041272S → Y.Corresponds to variant rs58454093dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003557 Genomic DNA. No translation available.
CCDSiCCDS31552.1.
RefSeqiNP_001005218.1. NM_001005218.1.
UniGeneiHs.553647.

Genome annotation databases

EnsembliENST00000360374; ENSP00000353537; ENSG00000198283.
GeneIDi219968.
KEGGihsa:219968.
UCSCiuc010rki.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003557 Genomic DNA. No translation available.
CCDSiCCDS31552.1.
RefSeqiNP_001005218.1. NM_001005218.1.
UniGeneiHs.553647.

3D structure databases

ProteinModelPortaliA6NL26.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000353537.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiA6NL26.
PhosphoSitePlusiA6NL26.

Polymorphism and mutation databases

BioMutaiOR5B21.

Proteomic databases

PaxDbiA6NL26.
PRIDEiA6NL26.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360374; ENSP00000353537; ENSG00000198283.
GeneIDi219968.
KEGGihsa:219968.
UCSCiuc010rki.3. human.

Organism-specific databases

CTDi219968.
GeneCardsiOR5B21.
HGNCiHGNC:19616. OR5B21.
neXtProtiNX_A6NL26.
OpenTargetsiENSG00000198283.
PharmGKBiPA134867164.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVUX. Eukaryota.
ENOG41117FD. LUCA.
GeneTreeiENSGT00760000118941.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6NL26.
KOiK04257.
OMAiGMMVIIH.
OrthoDBiEOG091G0AZH.
PhylomeDBiA6NL26.
TreeFamiTF352753.

Enzyme and pathway databases

BioCyciZFISH:G66-33472-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii219968.
PROiA6NL26.

Gene expression databases

CleanExiHS_OR5B21.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR5BL_HUMAN
AccessioniPrimary (citable) accession number: A6NL26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.