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Protein

Olfactory receptor 6C75

Gene

OR6C75

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6C75
Gene namesi
Name:OR6C75
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000187857.3
HGNCiHGNC:31304 OR6C75
neXtProtiNX_A6NL08

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 63CytoplasmicSequence analysisAdd BLAST19
Transmembranei64 – 84Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini85 – 95ExtracellularSequence analysisAdd BLAST11
Transmembranei96 – 116Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini117 – 140CytoplasmicSequence analysisAdd BLAST24
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 194ExtracellularSequence analysisAdd BLAST33
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 237CytoplasmicSequence analysisAdd BLAST22
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 269ExtracellularSequence analysisAdd BLAST11
Transmembranei270 – 290Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini291 – 312CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134873229

Polymorphism and mutation databases

BioMutaiOR6C75

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003094941 – 312Olfactory receptor 6C75Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 177PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NL08
PRIDEiA6NL08

PTM databases

iPTMnetiA6NL08
PhosphoSitePlusiA6NL08

Expressioni

Gene expression databases

CleanExiHS_OR6C75
ExpressionAtlasiA6NL08 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000368987

Structurei

3D structure databases

ProteinModelPortaliA6NL08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFJ6 Eukaryota
ENOG41120HT LUCA
GeneTreeiENSGT00900000140821
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiA6NL08
KOiK04257
OMAiIPSMSQR
OrthoDBiEOG091G0F9F
PhylomeDBiA6NL08
TreeFamiTF336833

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

A6NL08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNSTAVTDF ILLGLTSDPQ WQVVLFIFLL VTYMLSVTGN LIIITLTLSD
60 70 80 90 100
PHLQTPMYFF LRNFSFLEIS FTSVCIPRFL VTVVTGNRTI SYNGCVAQLF
110 120 130 140 150
FFIFLGVTEF YLLAAMSYDR CMAICKPLHY TIIMSTRVCT LLVFSSWLAG
160 170 180 190 200
FLIIFPPVML LLQLDFCASN VIDHFICDSS PMLQLSCTNT HFLELMAFFL
210 220 230 240 250
AVVTLMVTLT LVILSYTNII RTILKIPSMS QRKKAFSTCS SHMIVVSISY
260 270 280 290 300
SSCIFMYIKT SARERVTLSK GVAVLNTSVA PLLNPFIYTL RNKQVKQAFK
310
SMVQKMIFSL NK
Length:312
Mass (Da):35,372
Last modified:July 24, 2007 - v1
Checksum:i1A35D8585787F56B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036972141L → F. Corresponds to variant dbSNP:rs7976023Ensembl.1
Natural variantiVAR_036973235A → D. Corresponds to variant dbSNP:rs7976416Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125816 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96808.1
CCDSiCCDS31820.1
RefSeqiNP_001005497.1, NM_001005497.1
UniGeneiHs.554554

Genome annotation databases

EnsembliENST00000343399; ENSP00000368987; ENSG00000187857
ENST00000641576; ENSP00000493430; ENSG00000187857
GeneIDi390323
KEGGihsa:390323
UCSCiuc010spk.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO6C75_HUMAN
AccessioniPrimary (citable) accession number: A6NL08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: February 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome