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Protein

Putative solute carrier family 22 member 31

Gene

SLC22A31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Organic anion transporter that mediates the uptake of ions.Curated

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi2.A.1.19.23. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Putative solute carrier family 22 member 31
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:27091. SLC22A31.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23CytoplasmicSequence analysisAdd BLAST23
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Topological domaini45 – 128ExtracellularSequence analysisAdd BLAST84
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Topological domaini150 – 157CytoplasmicSequence analysis8
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 182ExtracellularSequence analysis4
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 218CytoplasmicSequence analysisAdd BLAST15
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 246ExtracellularSequence analysis7
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Topological domaini268 – 341CytoplasmicSequence analysisAdd BLAST74
Transmembranei342 – 359HelicalSequence analysisAdd BLAST18
Topological domaini360 – 368ExtracellularSequence analysis9
Transmembranei369 – 389HelicalSequence analysisAdd BLAST21
Topological domaini390 – 397CytoplasmicSequence analysis8
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Topological domaini419 – 422ExtracellularSequence analysis4
Transmembranei423 – 443HelicalSequence analysisAdd BLAST21
Topological domaini444 – 450CytoplasmicSequence analysis7
Transmembranei451 – 471HelicalSequence analysisAdd BLAST21
Topological domaini472 – 485ExtracellularSequence analysisAdd BLAST14
Transmembranei486 – 506HelicalSequence analysisAdd BLAST21
Topological domaini507 – 558CytoplasmicSequence analysisAdd BLAST52

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003330311 – 558Putative solute carrier family 22 member 31Add BLAST558

Proteomic databases

PRIDEiA6NKX4.

PTM databases

iPTMnetiA6NKX4.
PhosphoSitePlusiA6NKX4.

Expressioni

Gene expression databases

BgeeiENSG00000259803.

Organism-specific databases

HPAiCAB002669.

Structurei

3D structure databases

ProteinModelPortaliA6NKX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000015298.
HOVERGENiHBG108438.
InParanoidiA6NKX4.
PhylomeDBiA6NKX4.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NKX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQEARVLRA AGGFGRARRL LASASWVPCI VLGLVLSSEE LLTAQPAPHC
60 70 80 90 100
RPDPTLLPPA LRALRGPALL DAAIPRLGPT RAPAEALGVL SPSYLAPLTR
110 120 130 140 150
APRPSSWASC SGAAAGPTWN LVCGDGWKVP LEQVSHLLGW LLGCVILGAG
160 170 180 190 200
CDRFGRRAVF VASLVLTTGL GASEALAASF PTLLVLRLLH GGTLAGALLA
210 220 230 240 250
LYLARLELCD PPHRLAFSMG AGLFSVVGTL LLPGLAALVQ DWRLLQGLGA
260 270 280 290 300
LMSGLLLLFW GFPALFPESP CWLLATGQVA RARKILWRFA EASGVGPGDS
310 320 330 340 350
SLEENSLATA TELTMLSARS PQPRYHSPLG LLRTRVTWRN GLILGFSSLV
360 370 380 390 400
GGGIRASFRR SLAPQVPTFY LPYFLEAGLE AAALVFLLLT ADCCGRRPVL
410 420 430 440 450
LLGTMVTGLA SLLLLAGAQY LPGWTVLFLS VLGLLASRAV SALSSLFAAE
460 470 480 490 500
VFPTVIRGAG LGLVLGAGFL GQAAGPLDTL HGRQGFFLQQ VVFASLAVLA
510 520 530 540 550
LLCVLLLPES RSRGLPQSLQ DADRLRRSPL LRGRPRQDHL PLLPPSNSYW

AGHTPEQH
Length:558
Mass (Da):58,987
Last modified:May 20, 2008 - v3
Checksum:i9E2CA5A533824EF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009113 Genomic DNA. No translation available.
UniGeneiHs.447544.
Hs.743726.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009113 Genomic DNA. No translation available.
UniGeneiHs.447544.
Hs.743726.

3D structure databases

ProteinModelPortaliA6NKX4.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi2.A.1.19.23. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiA6NKX4.
PhosphoSitePlusiA6NKX4.

Proteomic databases

PRIDEiA6NKX4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiSLC22A31.
HGNCiHGNC:27091. SLC22A31.
HPAiCAB002669.
neXtProtiNX_A6NKX4.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000015298.
HOVERGENiHBG108438.
InParanoidiA6NKX4.
PhylomeDBiA6NKX4.

Miscellaneous databases

PROiA6NKX4.

Gene expression databases

BgeeiENSG00000259803.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS22AV_HUMAN
AccessioniPrimary (citable) accession number: A6NKX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 30, 2016
This is version 73 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.