Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

RanBP2-like and GRIP domain-containing protein 3

Gene

RGPD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
RanBP2-like and GRIP domain-containing protein 3
Gene namesi
Name:RGPD3
Synonyms:RGP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:32416. RGPD3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671072.

Polymorphism and mutation databases

BioMutaiRGPD3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17581758RanBP2-like and GRIP domain-containing protein 3PRO_0000340666Add
BLAST

Proteomic databases

EPDiA6NKT7.
MaxQBiA6NKT7.
PaxDbiA6NKT7.
PRIDEiA6NKT7.

PTM databases

iPTMnetiA6NKT7.
PhosphoSiteiA6NKT7.

Expressioni

Gene expression databases

BgeeiENSG00000153165.
CleanExiHS_RGPD3.
ExpressionAtlasiA6NKT7. baseline and differential.
GenevisibleiA6NKT7. HS.

Organism-specific databases

HPAiHPA049497.
HPA051675.

Interactioni

Protein-protein interaction databases

BioGridi575821. 12 interactions.
IntActiA6NKT7. 6 interactions.
STRINGi9606.ENSP00000386588.

Structurei

3D structure databases

ProteinModelPortaliA6NKT7.
SMRiA6NKT7. Positions 4-145, 1052-1179, 1664-1701.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati60 – 9334TPR 1Add
BLAST
Repeati584 – 61734TPR 2Add
BLAST
Domaini1037 – 1173137RanBD1 1PROSITE-ProRule annotationAdd
BLAST
Domaini1334 – 1470137RanBD1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1703 – 175351GRIPPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili176 – 22954Sequence analysisAdd
BLAST
Coiled coili805 – 83733Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1262 – 12676Poly-Ser

Sequence similaritiesi

Contains 1 GRIP domain.PROSITE-ProRule annotation
Contains 2 RanBD1 domains.PROSITE-ProRule annotation
Contains 2 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0864. Eukaryota.
COG5171. LUCA.
GeneTreeiENSGT00840000129823.
HOGENOMiHOG000089994.
HOVERGENiHBG108404.
InParanoidiA6NKT7.
KOiK12172.
PhylomeDBiA6NKT7.
TreeFamiTF314797.

Family and domain databases

Gene3Di1.10.220.60. 1 hit.
1.25.40.10. 2 hits.
2.30.29.30. 2 hits.
InterProiIPR032023. GCC2_Rab_bind.
IPR000237. GRIP_dom.
IPR011993. PH_dom-like.
IPR000156. Ran_bind_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF01465. GRIP. 1 hit.
PF16704. Rab_bind. 1 hit.
PF00638. Ran_BP1. 2 hits.
[Graphical view]
SMARTiSM00755. Grip. 1 hit.
SM00160. RanBD. 2 hits.
SM00028. TPR. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50913. GRIP. 1 hit.
PS50196. RANBD1. 2 hits.
PS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NKT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCSKAYGER YVASVQGSAP SPRKKSTRGF YFAKLYYEAK EYDLAKKYIC
60 70 80 90 100
TYINVREMDP RAHRFLGLLY ELEENTEKAV ECYRRSVELN PTQKDLVLKI
110 120 130 140 150
AELLCKNDVT DGRAEYWVER AAKLFPGSPA IYKLKEQLLD CEGEDGWNKL
160 170 180 190 200
FDLIQSELYV RPDDVHVNIR LVELYRSTKR LKDAVARCHE AERNIALRSS
210 220 230 240 250
LEWNSCVVQT LKEYLESLQC LESDKSDWRA TNTDLLLAYA NLMLLTLSTR
260 270 280 290 300
DVQESRELLE SFDSALQSAK SSLGGNDELS ATFLEMKGHF YMHAGSLLLK
310 320 330 340 350
MGQHGNNVQW RALSELAALC YLIAFQVPRP KIKLIKGEAG QNLLEMMACD
360 370 380 390 400
RLSQSGHMLL NLSRGKQDFL KVVVETFANK SGQSALYDAL FSSQSPKDTS
410 420 430 440 450
FLGSDDIGNI DVQEPELEDL ARYDVGAIRA HNGSLQHLTW LGLQWNSLPA
460 470 480 490 500
LPGIRKWLKQ LFHHLPQETS RLETNAPESI CILDLEVFLL GVVYTSHLQL
510 520 530 540 550
KEKCNSHHSS YQPLCLPLPV CKQLCTERQK SWWDAVCTLI HRKAVPGNSA
560 570 580 590 600
KLRLLVQHEI NTLRAQEKHG LQPALLVHWA KCLQKMGSGL NSFYDQREYI
610 620 630 640 650
GRSVHYWKKV LPLLKIIKKK NSIPEPIDPL FKHFHSVDIQ ASEIVEYEED
660 670 680 690 700
AHVTFAILDA VNGNIEDAMT AFESIKSVVS YWNLALIFHR KAEDIANDAL
710 720 730 740 750
SPEEQEECKN YLRKTRGYLI KILDDSDSNL SVVKKLPVPL ESVKEMLKSV
760 770 780 790 800
MQELENYSEG GPLYKNGSLR NADSEIKHST PSPTKYSLSP SKSYKYSPKT
810 820 830 840 850
PPRWAEDQNS LLKMIRQEVK AIKEEMQELK LNSSKSASHH RWPTENYGPD
860 870 880 890 900
SVPDGYQGSQ TFHGAPLTVA TTGPSVYYSQ SPAYNSQYLL RPAANVTPTK
910 920 930 940 950
GSSNTEFKST KEGFSIPVSA DGFKFGISEP GNQEKKSEKP LENDTGLQAQ
960 970 980 990 1000
DISGRKKGRG VIFGQTSSTF TFADVAKSTS GEGFQFGKKD LNFKGFSGAG
1010 1020 1030 1040 1050
EKLFSSQYGK MANKANTSGD FEKDDDAYKT EDSDDIHFEP VVQMPEKVEL
1060 1070 1080 1090 1100
VTGEEGEKVL YSQGVKLFRF DAEVSQWKER GLGNLKILKN EVNGKVRMLM
1110 1120 1130 1140 1150
QREQVLKVCA NHWITTTMNL KPLSGSDRAW MWSASDFSDG DAKLERLAAK
1160 1170 1180 1190 1200
FKTPELAEEF KQKFEECQRL LLDIPLQTPH KLVDTGRAAK LIQRAEEMKS
1210 1220 1230 1240 1250
GLKDFKTFLT NDQTKVAEEE NKGSGTGAAG ASDTTIKPNA ENTGPTLEWD
1260 1270 1280 1290 1300
NYDLREDALD DSVSSSSVHA SPLASSPVRK NLFHFDESTT GSNFSFKSAL
1310 1320 1330 1340 1350
SLSKSPAKLN QSGTSVGTDE ESDVTQEEER DGQYFEPVVP LPDLVEVSSG
1360 1370 1380 1390 1400
EENEQVVFSH RAEFYRYDKD VGQWKERGIG DIKILQNYDN KHVRILMRRD
1410 1420 1430 1440 1450
QVLKLCANHR ITPDMSLQNM KGTERVWVWT ACDFADGERK VEHLAVRFKL
1460 1470 1480 1490 1500
QDVADSFKKI FDEAKTAQEK DSLITPHVSR SSTPRESPCG KIAVAVLEET
1510 1520 1530 1540 1550
TRERTDVIQG DDVADAASEV EVSSTSETTT KAVVSPPKFV FGSESVKRIF
1560 1570 1580 1590 1600
SSEKSKPFAF GNSSATGSLF GFSFNAPLKS NNSETSSVAQ SGSESKVEPK
1610 1620 1630 1640 1650
KCELSKNSDI EQSSDSKVKN LSASFPTEES SINYTFKTPE KEPPLWYAEF
1660 1670 1680 1690 1700
TKEELVQKLS STTKSADHLN GLLREIEATN AVLMEQIKLL KSEIRRLERN
1710 1720 1730 1740 1750
QEQEVSAANV EHLKNVLLQF IFLKPGSERE RLLPVINTML QLSLEEKGKL

AAVAQGEE
Length:1,758
Mass (Da):197,487
Last modified:March 8, 2011 - v2
Checksum:i76CCC1934CCD6E48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097527 Genomic DNA. No translation available.
AC114755 Genomic DNA. No translation available.
CCDSiCCDS46379.1.
RefSeqiNP_001137485.1. NM_001144013.1.
UniGeneiHs.726367.

Genome annotation databases

EnsembliENST00000409886; ENSP00000386588; ENSG00000153165.
GeneIDi653489.
KEGGihsa:653489.
UCSCiuc010ywi.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097527 Genomic DNA. No translation available.
AC114755 Genomic DNA. No translation available.
CCDSiCCDS46379.1.
RefSeqiNP_001137485.1. NM_001144013.1.
UniGeneiHs.726367.

3D structure databases

ProteinModelPortaliA6NKT7.
SMRiA6NKT7. Positions 4-145, 1052-1179, 1664-1701.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi575821. 12 interactions.
IntActiA6NKT7. 6 interactions.
STRINGi9606.ENSP00000386588.

PTM databases

iPTMnetiA6NKT7.
PhosphoSiteiA6NKT7.

Polymorphism and mutation databases

BioMutaiRGPD3.

Proteomic databases

EPDiA6NKT7.
MaxQBiA6NKT7.
PaxDbiA6NKT7.
PRIDEiA6NKT7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409886; ENSP00000386588; ENSG00000153165.
GeneIDi653489.
KEGGihsa:653489.
UCSCiuc010ywi.2. human.

Organism-specific databases

CTDi653489.
GeneCardsiRGPD3.
H-InvDBHIX0030036.
HGNCiHGNC:32416. RGPD3.
HPAiHPA049497.
HPA051675.
MIMi612706. gene.
neXtProtiNX_A6NKT7.
PharmGKBiPA142671072.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0864. Eukaryota.
COG5171. LUCA.
GeneTreeiENSGT00840000129823.
HOGENOMiHOG000089994.
HOVERGENiHBG108404.
InParanoidiA6NKT7.
KOiK12172.
PhylomeDBiA6NKT7.
TreeFamiTF314797.

Miscellaneous databases

GenomeRNAii653489.
PROiA6NKT7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153165.
CleanExiHS_RGPD3.
ExpressionAtlasiA6NKT7. baseline and differential.
GenevisibleiA6NKT7. HS.

Family and domain databases

Gene3Di1.10.220.60. 1 hit.
1.25.40.10. 2 hits.
2.30.29.30. 2 hits.
InterProiIPR032023. GCC2_Rab_bind.
IPR000237. GRIP_dom.
IPR011993. PH_dom-like.
IPR000156. Ran_bind_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF01465. GRIP. 1 hit.
PF16704. Rab_bind. 1 hit.
PF00638. Ran_BP1. 2 hits.
[Graphical view]
SMARTiSM00755. Grip. 1 hit.
SM00160. RanBD. 2 hits.
SM00028. TPR. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50913. GRIP. 1 hit.
PS50196. RANBD1. 2 hits.
PS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRGPD3_HUMAN
AccessioniPrimary (citable) accession number: A6NKT7
Secondary accession number(s): B8ZZM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 8, 2011
Last modified: September 7, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.