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A6NKQ9

- CGB1_HUMAN

UniProt

A6NKQ9 - CGB1_HUMAN

Protein

Choriogonadotropin subunit beta variant 1

Gene

CGB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 3 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Keywords - Molecular functioni

    Hormone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Choriogonadotropin subunit beta variant 1
    Gene namesi
    Name:CGB1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:16721. CGB1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26435.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 5050Sequence AnalysisAdd
    BLAST
    Chaini51 – 187137Choriogonadotropin subunit beta variant 1PRO_0000342548Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi59 ↔ 107By similarity
    Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi73 ↔ 122By similarity
    Disulfide bondi76 ↔ 160By similarity
    Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi84 ↔ 138By similarity
    Disulfide bondi88 ↔ 140By similarity
    Disulfide bondi143 ↔ 150By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiA6NKQ9.
    PRIDEiA6NKQ9.

    Expressioni

    Tissue specificityi

    Expressed in placenta, testis and pituitary.2 Publications

    Gene expression databases

    CleanExiHS_CGB1.
    GenevestigatoriA6NKQ9.

    Organism-specific databases

    HPAiHPA038925.
    HPA038934.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000301407.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NKQ9.
    SMRiA6NKQ9. Positions 52-161.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG284462.
    HOVERGENiHBG006698.
    InParanoidiA6NKQ9.
    KOiK10045.
    OMAiTWASRET.
    OrthoDBiEOG7JQBQF.
    TreeFamiTF332940.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR006208. Glyco_hormone_CN.
    IPR001545. Gonadotropin_bsu.
    IPR018245. Gonadotropin_bsu_CS.
    [Graphical view]
    PANTHERiPTHR11515. PTHR11515. 1 hit.
    PfamiPF00007. Cys_knot. 1 hit.
    [Graphical view]
    SMARTiSM00068. GHB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
    PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A6NKQ9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSTFPVLAED IPLRERHVKG RVDPHFRAPK MEMFQRLLLL LLLSMGGTWA    50
    SKEPLRPRCR PINATLAVEK EGCPVCITVN TTICAGYCPT MTRVLQGVLP 100
    ALPQVVCNYR DVRFESIRLP GCPRGVNPVV SYAVALSCQC ALCRRSTTDC 150
    GGPKDHPLTC DDPRFQDSSS SKAPPPSLPS PSRLPGP 187
    Length:187
    Mass (Da):20,468
    Last modified:July 1, 2008 - v3
    Checksum:i1EB79D84CFA36ACA
    GO
    Isoform 2 (identifier: A6NKQ9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-32: Missing.
         33-35: MFQ → MSK

    Show »
    Length:155
    Mass (Da):16,666
    Checksum:i76F77A3681140D48
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti185 – 1851P → S.
    Corresponds to variant rs35371968 [ dbSNP | Ensembl ].
    VAR_055838

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3232Missing in isoform 2. 1 PublicationVSP_034490Add
    BLAST
    Alternative sequencei33 – 353MFQ → MSK in isoform 2. 1 PublicationVSP_034491

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC008687 Genomic DNA. No translation available.
    CH471177 Genomic DNA. Translation: EAW52436.1.
    BC126460 mRNA. Translation: AAI26461.1.
    CCDSiCCDS12751.2. [A6NKQ9-2]
    RefSeqiNP_203695.2. NM_033377.1. [A6NKQ9-2]
    UniGeneiHs.659014.

    Genome annotation databases

    EnsembliENST00000301407; ENSP00000301407; ENSG00000267631. [A6NKQ9-2]
    GeneIDi114335.
    KEGGihsa:114335.
    UCSCiuc002plx.3. human. [A6NKQ9-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC008687 Genomic DNA. No translation available.
    CH471177 Genomic DNA. Translation: EAW52436.1 .
    BC126460 mRNA. Translation: AAI26461.1 .
    CCDSi CCDS12751.2. [A6NKQ9-2 ]
    RefSeqi NP_203695.2. NM_033377.1. [A6NKQ9-2 ]
    UniGenei Hs.659014.

    3D structure databases

    ProteinModelPortali A6NKQ9.
    SMRi A6NKQ9. Positions 52-161.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000301407.

    Proteomic databases

    PaxDbi A6NKQ9.
    PRIDEi A6NKQ9.

    Protocols and materials databases

    DNASUi 114335.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000301407 ; ENSP00000301407 ; ENSG00000267631 . [A6NKQ9-2 ]
    GeneIDi 114335.
    KEGGi hsa:114335.
    UCSCi uc002plx.3. human. [A6NKQ9-2 ]

    Organism-specific databases

    CTDi 114335.
    GeneCardsi GC19M049538.
    HGNCi HGNC:16721. CGB1.
    HPAi HPA038925.
    HPA038934.
    MIMi 608823. gene.
    neXtProti NX_A6NKQ9.
    PharmGKBi PA26435.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG284462.
    HOVERGENi HBG006698.
    InParanoidi A6NKQ9.
    KOi K10045.
    OMAi TWASRET.
    OrthoDBi EOG7JQBQF.
    TreeFami TF332940.

    Miscellaneous databases

    GeneWikii CGB1.
    GenomeRNAii 114335.
    NextBioi 79069.
    PROi A6NKQ9.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_CGB1.
    Genevestigatori A6NKQ9.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR006208. Glyco_hormone_CN.
    IPR001545. Gonadotropin_bsu.
    IPR018245. Gonadotropin_bsu_CS.
    [Graphical view ]
    PANTHERi PTHR11515. PTHR11515. 1 hit.
    Pfami PF00007. Cys_knot. 1 hit.
    [Graphical view ]
    SMARTi SM00068. GHB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00261. GLYCO_HORMONE_BETA_1. 1 hit.
    PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues."
      Rull K., Hallast P., Uuskula L., Jackson J., Punab M., Salumets A., Campbell R.K., Laan M.
      Mol. Hum. Reprod. 14:23-31(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-183 (ISOFORM 2).
    5. "Expression of beta-subunit of HCG genes during normal and failed pregnancy."
      Rull K., Laan M.
      Hum. Reprod. 20:3360-3368(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCGB1_HUMAN
    AccessioniPrimary (citable) accession number: A6NKQ9
    Secondary accession number(s): A4FVC8, A8MUK6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 71 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3