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A6NKQ9 (CGB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Choriogonadotropin subunit beta variant 1
Gene names
Name:CGB1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length187 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted.

Tissue specificity

Expressed in placenta, testis and pituitary. Ref.1 Ref.5

Sequence similarities

Belongs to the glycoprotein hormones subunit beta family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
   Molecular functionHormone
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A6NKQ9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A6NKQ9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.
     33-35: MFQ → MSK

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 5050 Potential
Chain51 – 187137Choriogonadotropin subunit beta variant 1
PRO_0000342548

Amino acid modifications

Glycosylation631N-linked (GlcNAc...) Potential
Glycosylation801N-linked (GlcNAc...) Potential
Disulfide bond59 ↔ 107 By similarity
Disulfide bond73 ↔ 122 By similarity
Disulfide bond76 ↔ 160 By similarity
Disulfide bond84 ↔ 138 By similarity
Disulfide bond88 ↔ 140 By similarity
Disulfide bond143 ↔ 150 By similarity

Natural variations

Alternative sequence1 – 3232Missing in isoform 2.
VSP_034490
Alternative sequence33 – 353MFQ → MSK in isoform 2.
VSP_034491
Natural variant1851P → S.
Corresponds to variant rs35371968 [ dbSNP | Ensembl ].
VAR_055838

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 1, 2008. Version 3.
Checksum: 1EB79D84CFA36ACA

FASTA18720,468
        10         20         30         40         50         60 
MSTFPVLAED IPLRERHVKG RVDPHFRAPK MEMFQRLLLL LLLSMGGTWA SKEPLRPRCR 

        70         80         90        100        110        120 
PINATLAVEK EGCPVCITVN TTICAGYCPT MTRVLQGVLP ALPQVVCNYR DVRFESIRLP 

       130        140        150        160        170        180 
GCPRGVNPVV SYAVALSCQC ALCRRSTTDC GGPKDHPLTC DDPRFQDSSS SKAPPPSLPS 


PSRLPGP 

« Hide

Isoform 2 [UniParc].

Checksum: 76F77A3681140D48
Show »

FASTA15516,666

References

« Hide 'large scale' references
[1]"Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues."
Rull K., Hallast P., Uuskula L., Jackson J., Punab M., Salumets A., Campbell R.K., Laan M.
Mol. Hum. Reprod. 14:23-31(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-183 (ISOFORM 2).
[5]"Expression of beta-subunit of HCG genes during normal and failed pregnancy."
Rull K., Laan M.
Hum. Reprod. 20:3360-3368(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC008687 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52436.1.
BC126460 mRNA. Translation: AAI26461.1.
CCDSCCDS12751.2. [A6NKQ9-2]
RefSeqNP_203695.2. NM_033377.1. [A6NKQ9-2]
UniGeneHs.659014.

3D structure databases

ProteinModelPortalA6NKQ9.
SMRA6NKQ9. Positions 52-161.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000301407.

Proteomic databases

PaxDbA6NKQ9.
PRIDEA6NKQ9.

Protocols and materials databases

DNASU114335.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000301407; ENSP00000301407; ENSG00000267631. [A6NKQ9-2]
GeneID114335.
KEGGhsa:114335.
UCSCuc002plx.3. human. [A6NKQ9-2]

Organism-specific databases

CTD114335.
GeneCardsGC19M049538.
HGNCHGNC:16721. CGB1.
HPAHPA038925.
HPA038934.
MIM608823. gene.
neXtProtNX_A6NKQ9.
PharmGKBPA26435.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG284462.
HOVERGENHBG006698.
InParanoidA6NKQ9.
KOK10045.
OMATWASRET.
OrthoDBEOG7JQBQF.
TreeFamTF332940.

Gene expression databases

CleanExHS_CGB1.
GenevestigatorA6NKQ9.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERPTHR11515. PTHR11515. 1 hit.
PfamPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
PROSITEPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCGB1.
GenomeRNAi114335.
NextBio79069.
PROA6NKQ9.
SOURCESearch...

Entry information

Entry nameCGB1_HUMAN
AccessionPrimary (citable) accession number: A6NKQ9
Secondary accession number(s): A4FVC8, A8MUK6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: July 9, 2014
This is version 70 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM