A6NKQ9 (CGB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Choriogonadotropin subunit beta variant 1

Gene names

Name:

CGB1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	187 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted.
Tissue specificity	Expressed in placenta, testis and pituitary. Ref.1 Ref.5
Sequence similarities	Belongs to the glycoprotein hormones subunit beta family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
Molecular function	Hormone
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A6NKQ9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A6NKQ9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.
     33-35: MFQ → MSK

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 50	50	Potential
	Chain	51 – 187	137	Choriogonadotropin subunit beta variant 1		PRO_0000342548
Amino acid modifications
	Glycosylation	63	1	N-linked (GlcNAc...) Potential
	Glycosylation	80	1	N-linked (GlcNAc...) Potential
	Disulfide bond	59 ↔ 107		By similarity
	Disulfide bond	73 ↔ 122		By similarity
	Disulfide bond	76 ↔ 160		By similarity
	Disulfide bond	84 ↔ 138		By similarity
	Disulfide bond	88 ↔ 140		By similarity
	Disulfide bond	143 ↔ 150		By similarity
Natural variations
	Alternative sequence	1 – 32	32	Missing in isoform 2.		VSP_034490
	Alternative sequence	33 – 35	3	MFQ → MSK in isoform 2.		VSP_034491
	Natural variant	185	1	P → S. Corresponds to variant rs35371968 [ dbSNP | Ensembl ].		VAR_055838

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 1, 2008. Version 3. Checksum: 1EB79D84CFA36ACA	FASTA	187	20,468
	10 20 30 40 50 60 MSTFPVLAED IPLRERHVKG RVDPHFRAPK MEMFQRLLLL LLLSMGGTWA SKEPLRPRCR 70 80 90 100 110 120 PINATLAVEK EGCPVCITVN TTICAGYCPT MTRVLQGVLP ALPQVVCNYR DVRFESIRLP 130 140 150 160 170 180 GCPRGVNPVV SYAVALSCQC ALCRRSTTDC GGPKDHPLTC DDPRFQDSSS SKAPPPSLPS PSRLPGP
	Isoform 2 [UniParc]. Checksum: 76F77A3681140D48	FASTA	155	16,666
	10 20 30 40 50 60 MSKRLLLLLL LSMGGTWASK EPLRPRCRPI NATLAVEKEG CPVCITVNTT ICAGYCPTMT 70 80 90 100 110 120 RVLQGVLPAL PQVVCNYRDV RFESIRLPGC PRGVNPVVSY AVALSCQCAL CRRSTTDCGG 130 140 150 PKDHPLTCDD PRFQDSSSSK APPPSLPSPS RLPGP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues." Rull K., Hallast P., Uuskula L., Jackson J., Punab M., Salumets A., Campbell R.K., Laan M. Mol. Hum. Reprod. 14:23-31(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-183 (ISOFORM 2).
[5]	"Expression of beta-subunit of HCG genes during normal and failed pregnancy." Rull K., Laan M. Hum. Reprod. 20:3360-3368(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC008687 Genomic DNA. No translation available. CH471177 Genomic DNA. Translation: EAW52436.1. BC126460 mRNA. Translation: AAI26461.1.
IPI	IPI00844271. IPI00896513.
RefSeq	NP_203695.2. NM_033377.1.
UniGene	Hs.741782.
3D structure databases
ProteinModelPortal	A6NKQ9.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000301407.
Proteomic databases
PaxDb	A6NKQ9.
PRIDE	A6NKQ9.
Protocols and materials databases
DNASU	114335.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000301407; ENSP00000301407; ENSG00000267631.
GeneID	114335.
KEGG	hsa:114335.
UCSC	uc002plx.3. human.
Organism-specific databases
CTD	114335.
GeneCards	GC19M049538.
HGNC	HGNC:16721. CGB1.
HPA	HPA038925. HPA038934.
MIM	608823. gene.
neXtProt	NX_A6NKQ9.
PharmGKB	PA26435.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG284462.
HOVERGEN	HBG006698.
InParanoid	A6NKQ9.
KO	K10045.
OMA	TWASRET.
Gene expression databases
CleanEx	HS_CGB1.
Genevestigator	A6NKQ9.
Family and domain databases
InterPro	IPR006208. Cys_knot. IPR001545. Gonadotropin_bsu. IPR018245. Gonadotropin_bsu_CS. [Graphical view]
PANTHER	PTHR11515. PTHR11515. 1 hit.
Pfam	PF00007. Cys_knot. 1 hit. [Graphical view]
SMART	SM00068. GHB. 1 hit. [Graphical view]
PROSITE	PS00261. GLYCO_HORMONE_BETA_1. 1 hit. PS00689. GLYCO_HORMONE_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	114335.
NextBio	79069.
SOURCE	Search...

Entry information

Entry name

CGB1_HUMAN

Accession

Primary (citable) accession number: A6NKQ9
Secondary accession number(s): A4FVC8, A8MUK6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	July 1, 2008
Last modified:	May 1, 2013
This is version 57 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.