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Protein

Choriogonadotropin subunit beta variant 1

Gene

CGB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. hormone activity Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Choriogonadotropin subunit beta variant 1
Gene namesi
Name:CGB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16721. CGB1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26435.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 5050Sequence AnalysisAdd
BLAST
Chaini51 – 187137Choriogonadotropin subunit beta variant 1PRO_0000342548Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi59 ↔ 107By similarity
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi73 ↔ 122By similarity
Disulfide bondi76 ↔ 160By similarity
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi84 ↔ 138By similarity
Disulfide bondi88 ↔ 140By similarity
Disulfide bondi143 ↔ 150By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NKQ9.
PRIDEiA6NKQ9.

Expressioni

Tissue specificityi

Expressed in placenta, testis and pituitary.2 Publications

Gene expression databases

CleanExiHS_CGB1.
GenevestigatoriA6NKQ9.

Organism-specific databases

HPAiHPA038925.
HPA038934.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000301407.

Structurei

3D structure databases

SMRiA6NKQ9. Positions 52-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG284462.
GeneTreeiENSGT00390000010115.
HOVERGENiHBG006698.
InParanoidiA6NKQ9.
KOiK10045.
OMAiTWASRET.
OrthoDBiEOG7JQBQF.
TreeFamiTF332940.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NKQ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTFPVLAED IPLRERHVKG RVDPHFRAPK MEMFQRLLLL LLLSMGGTWA
60 70 80 90 100
SKEPLRPRCR PINATLAVEK EGCPVCITVN TTICAGYCPT MTRVLQGVLP
110 120 130 140 150
ALPQVVCNYR DVRFESIRLP GCPRGVNPVV SYAVALSCQC ALCRRSTTDC
160 170 180
GGPKDHPLTC DDPRFQDSSS SKAPPPSLPS PSRLPGP
Length:187
Mass (Da):20,468
Last modified:July 1, 2008 - v3
Checksum:i1EB79D84CFA36ACA
GO
Isoform 2 (identifier: A6NKQ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.
     33-35: MFQ → MSK

Show »
Length:155
Mass (Da):16,666
Checksum:i76F77A3681140D48
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti185 – 1851P → S.
Corresponds to variant rs35371968 [ dbSNP | Ensembl ].
VAR_055838

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3232Missing in isoform 2. 1 PublicationVSP_034490Add
BLAST
Alternative sequencei33 – 353MFQ → MSK in isoform 2. 1 PublicationVSP_034491

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008687 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52436.1.
BC126460 mRNA. Translation: AAI26461.1.
CCDSiCCDS12751.2. [A6NKQ9-2]
RefSeqiNP_203695.2. NM_033377.1. [A6NKQ9-2]
UniGeneiHs.659014.

Genome annotation databases

EnsembliENST00000301407; ENSP00000301407; ENSG00000267631. [A6NKQ9-2]
GeneIDi114335.
KEGGihsa:114335.
UCSCiuc002plx.3. human. [A6NKQ9-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008687 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52436.1.
BC126460 mRNA. Translation: AAI26461.1.
CCDSiCCDS12751.2. [A6NKQ9-2]
RefSeqiNP_203695.2. NM_033377.1. [A6NKQ9-2]
UniGeneiHs.659014.

3D structure databases

SMRiA6NKQ9. Positions 52-161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000301407.

Proteomic databases

PaxDbiA6NKQ9.
PRIDEiA6NKQ9.

Protocols and materials databases

DNASUi114335.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301407; ENSP00000301407; ENSG00000267631. [A6NKQ9-2]
GeneIDi114335.
KEGGihsa:114335.
UCSCiuc002plx.3. human. [A6NKQ9-2]

Organism-specific databases

CTDi114335.
GeneCardsiGC19M049538.
HGNCiHGNC:16721. CGB1.
HPAiHPA038925.
HPA038934.
MIMi608823. gene.
neXtProtiNX_A6NKQ9.
PharmGKBiPA26435.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG284462.
GeneTreeiENSGT00390000010115.
HOVERGENiHBG006698.
InParanoidiA6NKQ9.
KOiK10045.
OMAiTWASRET.
OrthoDBiEOG7JQBQF.
TreeFamiTF332940.

Miscellaneous databases

GeneWikiiCGB1.
GenomeRNAii114335.
NextBioi79069.
PROiA6NKQ9.
SOURCEiSearch...

Gene expression databases

CleanExiHS_CGB1.
GenevestigatoriA6NKQ9.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues."
    Rull K., Hallast P., Uuskula L., Jackson J., Punab M., Salumets A., Campbell R.K., Laan M.
    Mol. Hum. Reprod. 14:23-31(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-183 (ISOFORM 2).
  5. "Expression of beta-subunit of HCG genes during normal and failed pregnancy."
    Rull K., Laan M.
    Hum. Reprod. 20:3360-3368(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiCGB1_HUMAN
AccessioniPrimary (citable) accession number: A6NKQ9
Secondary accession number(s): A4FVC8, A8MUK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: April 1, 2015
This is version 75 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.