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A6NKQ9

- CGB1_HUMAN

UniProt

A6NKQ9 - CGB1_HUMAN

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Protein
Choriogonadotropin subunit beta variant 1
Gene
CGB1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Choriogonadotropin subunit beta variant 1
Gene namesi
Name:CGB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:16721. CGB1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26435.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 5050 Reviewed prediction
Add
BLAST
Chaini51 – 187137Choriogonadotropin subunit beta variant 1
PRO_0000342548Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi59 ↔ 107 By similarity
Glycosylationi63 – 631N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi73 ↔ 122 By similarity
Disulfide bondi76 ↔ 160 By similarity
Glycosylationi80 – 801N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi84 ↔ 138 By similarity
Disulfide bondi88 ↔ 140 By similarity
Disulfide bondi143 ↔ 150 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NKQ9.
PRIDEiA6NKQ9.

Expressioni

Tissue specificityi

Expressed in placenta, testis and pituitary.2 Publications

Gene expression databases

CleanExiHS_CGB1.
GenevestigatoriA6NKQ9.

Organism-specific databases

HPAiHPA038925.
HPA038934.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000301407.

Structurei

3D structure databases

ProteinModelPortaliA6NKQ9.
SMRiA6NKQ9. Positions 52-161.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG284462.
HOVERGENiHBG006698.
InParanoidiA6NKQ9.
KOiK10045.
OMAiTWASRET.
OrthoDBiEOG7JQBQF.
TreeFamiTF332940.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A6NKQ9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSTFPVLAED IPLRERHVKG RVDPHFRAPK MEMFQRLLLL LLLSMGGTWA    50
SKEPLRPRCR PINATLAVEK EGCPVCITVN TTICAGYCPT MTRVLQGVLP 100
ALPQVVCNYR DVRFESIRLP GCPRGVNPVV SYAVALSCQC ALCRRSTTDC 150
GGPKDHPLTC DDPRFQDSSS SKAPPPSLPS PSRLPGP 187
Length:187
Mass (Da):20,468
Last modified:July 1, 2008 - v3
Checksum:i1EB79D84CFA36ACA
GO
Isoform 2 (identifier: A6NKQ9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.
     33-35: MFQ → MSK

Show »
Length:155
Mass (Da):16,666
Checksum:i76F77A3681140D48
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti185 – 1851P → S.
Corresponds to variant rs35371968 [ dbSNP | Ensembl ].
VAR_055838

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3232Missing in isoform 2.
VSP_034490Add
BLAST
Alternative sequencei33 – 353MFQ → MSK in isoform 2.
VSP_034491

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC008687 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52436.1.
BC126460 mRNA. Translation: AAI26461.1.
CCDSiCCDS12751.2. [A6NKQ9-2]
RefSeqiNP_203695.2. NM_033377.1. [A6NKQ9-2]
UniGeneiHs.659014.

Genome annotation databases

EnsembliENST00000301407; ENSP00000301407; ENSG00000267631. [A6NKQ9-2]
GeneIDi114335.
KEGGihsa:114335.
UCSCiuc002plx.3. human. [A6NKQ9-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC008687 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52436.1 .
BC126460 mRNA. Translation: AAI26461.1 .
CCDSi CCDS12751.2. [A6NKQ9-2 ]
RefSeqi NP_203695.2. NM_033377.1. [A6NKQ9-2 ]
UniGenei Hs.659014.

3D structure databases

ProteinModelPortali A6NKQ9.
SMRi A6NKQ9. Positions 52-161.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000301407.

Proteomic databases

PaxDbi A6NKQ9.
PRIDEi A6NKQ9.

Protocols and materials databases

DNASUi 114335.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000301407 ; ENSP00000301407 ; ENSG00000267631 . [A6NKQ9-2 ]
GeneIDi 114335.
KEGGi hsa:114335.
UCSCi uc002plx.3. human. [A6NKQ9-2 ]

Organism-specific databases

CTDi 114335.
GeneCardsi GC19M049538.
HGNCi HGNC:16721. CGB1.
HPAi HPA038925.
HPA038934.
MIMi 608823. gene.
neXtProti NX_A6NKQ9.
PharmGKBi PA26435.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG284462.
HOVERGENi HBG006698.
InParanoidi A6NKQ9.
KOi K10045.
OMAi TWASRET.
OrthoDBi EOG7JQBQF.
TreeFami TF332940.

Miscellaneous databases

GeneWikii CGB1.
GenomeRNAii 114335.
NextBioi 79069.
PROi A6NKQ9.
SOURCEi Search...

Gene expression databases

CleanExi HS_CGB1.
Genevestigatori A6NKQ9.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view ]
PANTHERi PTHR11515. PTHR11515. 1 hit.
Pfami PF00007. Cys_knot. 1 hit.
[Graphical view ]
SMARTi SM00068. GHB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues."
    Rull K., Hallast P., Uuskula L., Jackson J., Punab M., Salumets A., Campbell R.K., Laan M.
    Mol. Hum. Reprod. 14:23-31(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-183 (ISOFORM 2).
  5. "Expression of beta-subunit of HCG genes during normal and failed pregnancy."
    Rull K., Laan M.
    Hum. Reprod. 20:3360-3368(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiCGB1_HUMAN
AccessioniPrimary (citable) accession number: A6NKQ9
Secondary accession number(s): A4FVC8, A8MUK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: July 9, 2014
This is version 70 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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