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Protein

Putative short-chain dehydrogenase/reductase family 42E member 2

Gene

SDR42E2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei176Proton acceptorBy similarity1
Binding sitei180NADBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Putative short-chain dehydrogenase/reductase family 42E member 2 (EC:1.1.1.-)
Gene namesi
Name:SDR42E2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:35414. SDR42E2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183921.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003347001 – 422Putative short-chain dehydrogenase/reductase family 42E member 2Add BLAST422

Proteomic databases

PaxDbiA6NKP2.
PRIDEiA6NKP2.

PTM databases

iPTMnetiA6NKP2.
PhosphoSitePlusiA6NKP2.

Expressioni

Gene expression databases

BgeeiENSG00000183921.

Organism-specific databases

HPAiHPA061278.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000330812.

Structurei

3D structure databases

ProteinModelPortaliA6NKP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-beta-HSD family.Curated

Phylogenomic databases

eggNOGiKOG1430. Eukaryota.
COG0451. LUCA.
GeneTreeiENSGT00550000074557.
HOGENOMiHOG000168007.
InParanoidiA6NKP2.
OMAiPLEKHMD.
OrthoDBiEOG091G0BI4.
PhylomeDBiA6NKP2.
TreeFamiTF313574.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002225. 3Beta_OHSteriod_DH/Estase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01073. 3Beta_HSD. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 2 hits.

Sequencei

Sequence statusi: Complete.

A6NKP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSNPPRSSL EACKAAGQAP QQKTQAKPTK AARQKVLVTG GGGYLGFSLG
60 70 80 90 100
SHLAKSGTSV ILLDRRRPQW ELSPETKFIQ ADVRDEEALY RAFEGVDCVF
110 120 130 140 150
HVASYGMSGA EKLQKEQIES INVGGTKLVI DVCVRRRVPR LIYTSTVNVA
160 170 180 190 200
FGGKPIEQGD EDSVPYFPLD EHVDHYSRTK AIADQLTLMA NGMPLPGGGT
210 220 230 240 250
LRTCVLRPPG IYGPEEQRHL PRVAGHIKKR LFMFRFGDHK ARMNWVHVHN
260 270 280 290 300
LVQAHVLAAE ALTTAKGYVA SGQAYYINDG ESVNLFEWMA PLFEKLGYSQ
310 320 330 340 350
PWIQVPTSWV YLTAAVMERL HLALRPICSL PPLLTRSEVR SVAVTHTFQI
360 370 380 390 400
AKARAQLGYA PDKFRFADAV ELYVQSTTRR PRGSTARTLL RLLLRLLLFL
410 420
GLLALALHFL GLQPLHAAVE RL
Length:422
Mass (Da):46,869
Last modified:July 22, 2008 - v3
Checksum:i24AC990529434BDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009019 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000602312; ENSP00000473474; ENSG00000183921.
UCSCiuc059ryf.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009019 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliA6NKP2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000330812.

PTM databases

iPTMnetiA6NKP2.
PhosphoSitePlusiA6NKP2.

Proteomic databases

PaxDbiA6NKP2.
PRIDEiA6NKP2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000602312; ENSP00000473474; ENSG00000183921.
UCSCiuc059ryf.1. human.

Organism-specific databases

GeneCardsiSDR42E2.
HGNCiHGNC:35414. SDR42E2.
HPAiHPA061278.
neXtProtiNX_A6NKP2.
OpenTargetsiENSG00000183921.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1430. Eukaryota.
COG0451. LUCA.
GeneTreeiENSGT00550000074557.
HOGENOMiHOG000168007.
InParanoidiA6NKP2.
OMAiPLEKHMD.
OrthoDBiEOG091G0BI4.
PhylomeDBiA6NKP2.
TreeFamiTF313574.

Miscellaneous databases

PROiA6NKP2.

Gene expression databases

BgeeiENSG00000183921.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002225. 3Beta_OHSteriod_DH/Estase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01073. 3Beta_HSD. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiD42E2_HUMAN
AccessioniPrimary (citable) accession number: A6NKP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 22, 2008
Last modified: November 30, 2016
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.