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Protein

Transmembrane protein 200C

Gene

TMEM200C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-31396-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 200C
Alternative name(s):
Transmembrane protein TTMA
Two transmembrane domain-containing family member A
Gene namesi
Name:TMEM200C
Synonyms:TTMA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:37208. TMEM200C.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000206432.
PharmGKBiPA165429148.

Polymorphism and mutation databases

BioMutaiTMEM200C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003489441 – 621Transmembrane protein 200CAdd BLAST621

Proteomic databases

PaxDbiA6NKL6.
PRIDEiA6NKL6.

PTM databases

iPTMnetiA6NKL6.
PhosphoSitePlusiA6NKL6.

Expressioni

Gene expression databases

BgeeiENSG00000206432.
GenevisibleiA6NKL6. HS.

Organism-specific databases

HPAiHPA047253.
HPA050490.

Structurei

3D structure databases

ProteinModelPortaliA6NKL6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi215 – 347Ala-richAdd BLAST133
Compositional biasi476 – 517Pro-richAdd BLAST42

Sequence similaritiesi

Belongs to the TMEM200 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4823. Eukaryota.
ENOG41106JF. LUCA.
GeneTreeiENSGT00530000063698.
HOGENOMiHOG000208781.
InParanoidiA6NKL6.
OMAiCSPPESW.
OrthoDBiEOG091G05JS.
PhylomeDBiA6NKL6.
TreeFamiTF332635.

Family and domain databases

InterProiIPR018787. DUF2371_TMEM200.
[Graphical view]
PfamiPF10177. DUF2371. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NKL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIATGGLLRI SARKQDPLRP PSQIPKRKRK AKKRRKNDVV VVKGKLKLCS
60 70 80 90 100
ISGLIALCGI LVLLVGIAMA VVGYWPKATG TNREGGKQLP PAGSSHRVPT
110 120 130 140 150
TANSSSSGSK NRSRSHPRAP GGVNSSSAGA PRSTPPARAA SPSSSSTSVG
160 170 180 190 200
FFFRIFSGYL HSDKLKVFGP LIMGIGIFLF ICANAVLHEN RDKKTKIINL
210 220 230 240 250
RDLYSTVIDV HSLRAKDLAA AAAAAAAAAA SSSSSAPAAA PPGAIPLNGF
260 270 280 290 300
LSYVQSRGLE LKPGGCGGSG DAFGAAAMLA KGSWPPHPAA PSGGRPRGAA
310 320 330 340 350
SPPDLASSPR CPREPPSLAE AVYSVYRERS GVAGSRRAAA ATAAAAASSC
360 370 380 390 400
SSPAPCSPPE SWGRQSTASS FVDSSLSAFA LLPLQGGRDR GGDAEGASCS
410 420 430 440 450
WQRPPGERGS QEIPRGELDL SMTNLRGAEG SMRGARREPE EPEGAVAARA
460 470 480 490 500
ARGQGGRLPR TGRYAALRRR STSGLPDYRA PPSPEPPPSP GSADPDSSPL
510 520 530 540 550
AKAASPSPPL RLEGSPPTRR DSGSSQSDDP SSSNKGYTPL REAGTSTESV
560 570 580 590 600
LDAVAGQTRD SAVAAPVLGA EQSSPEGASQ EPPTAEQPQP VQRQFTNKEK
610 620
LIMISRSHAI GVEEELESTG I
Length:621
Mass (Da):63,928
Last modified:September 2, 2008 - v2
Checksum:i5192A3FA727CAFB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP005433 Genomic DNA. No translation available.
BK005124 mRNA. Translation: DAA05326.1.
CCDSiCCDS45825.1.
RefSeqiNP_001073678.1. NM_001080209.1.
XP_005258187.1. XM_005258130.4.
XP_011524031.1. XM_011525729.2.
UniGeneiHs.346566.

Genome annotation databases

EnsembliENST00000383490; ENSP00000372982; ENSG00000206432.
ENST00000581347; ENSP00000463375; ENSG00000206432.
GeneIDi645369.
KEGGihsa:645369.
UCSCiuc002kmx.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP005433 Genomic DNA. No translation available.
BK005124 mRNA. Translation: DAA05326.1.
CCDSiCCDS45825.1.
RefSeqiNP_001073678.1. NM_001080209.1.
XP_005258187.1. XM_005258130.4.
XP_011524031.1. XM_011525729.2.
UniGeneiHs.346566.

3D structure databases

ProteinModelPortaliA6NKL6.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiA6NKL6.
PhosphoSitePlusiA6NKL6.

Polymorphism and mutation databases

BioMutaiTMEM200C.

Proteomic databases

PaxDbiA6NKL6.
PRIDEiA6NKL6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383490; ENSP00000372982; ENSG00000206432.
ENST00000581347; ENSP00000463375; ENSG00000206432.
GeneIDi645369.
KEGGihsa:645369.
UCSCiuc002kmx.1. human.

Organism-specific databases

CTDi645369.
GeneCardsiTMEM200C.
HGNCiHGNC:37208. TMEM200C.
HPAiHPA047253.
HPA050490.
neXtProtiNX_A6NKL6.
OpenTargetsiENSG00000206432.
PharmGKBiPA165429148.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4823. Eukaryota.
ENOG41106JF. LUCA.
GeneTreeiENSGT00530000063698.
HOGENOMiHOG000208781.
InParanoidiA6NKL6.
OMAiCSPPESW.
OrthoDBiEOG091G05JS.
PhylomeDBiA6NKL6.
TreeFamiTF332635.

Enzyme and pathway databases

BioCyciZFISH:G66-31396-MONOMER.

Miscellaneous databases

GenomeRNAii645369.
PROiA6NKL6.

Gene expression databases

BgeeiENSG00000206432.
GenevisibleiA6NKL6. HS.

Family and domain databases

InterProiIPR018787. DUF2371_TMEM200.
[Graphical view]
PfamiPF10177. DUF2371. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT200C_HUMAN
AccessioniPrimary (citable) accession number: A6NKL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: November 2, 2016
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.