ID   OR5H1_HUMAN             Reviewed;         313 AA.
AC   A6NKK0;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   27-MAR-2024, entry version 121.
DE   RecName: Full=Olfactory receptor 5H1;
DE   AltName: Full=HTPCRX14;
GN   Name=OR5H1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 126-239, AND VARIANTS LEU-153 AND ILE-181.
RC   TISSUE=Testis;
RX   PubMed=1370859; DOI=10.1038/355453a0;
RA   Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A.,
RA   Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A.,
RA   Vassart G.;
RT   "Expression of members of the putative olfactory receptor gene family in
RT   mammalian germ cells.";
RL   Nature 355:453-455(1992).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- INTERACTION:
CC       A6NKK0; Q70IA6: MOB2; NbExp=3; IntAct=EBI-23725364, EBI-2558739;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5H1";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC117460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; X64988; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS33797.1; -.
DR   RefSeq; NP_001005338.1; NM_001005338.1.
DR   AlphaFoldDB; A6NKK0; -.
DR   SMR; A6NKK0; -.
DR   BioGRID; 117686; 40.
DR   IntAct; A6NKK0; 1.
DR   STRING; 9606.ENSP00000492953; -.
DR   GlyCosmos; A6NKK0; 1 site, No reported glycans.
DR   GlyGen; A6NKK0; 1 site.
DR   iPTMnet; A6NKK0; -.
DR   PhosphoSitePlus; A6NKK0; -.
DR   BioMuta; OR5H1; -.
DR   MassIVE; A6NKK0; -.
DR   PaxDb; 9606-ENSP00000346575; -.
DR   PeptideAtlas; A6NKK0; -.
DR   Antibodypedia; 32126; 63 antibodies from 16 providers.
DR   DNASU; 26341; -.
DR   Ensembl; ENST00000641874.1; ENSP00000492953.1; ENSG00000231192.3.
DR   GeneID; 26341; -.
DR   KEGG; hsa:26341; -.
DR   MANE-Select; ENST00000641874.1; ENSP00000492953.1; NM_001005338.2; NP_001005338.1.
DR   UCSC; uc011bgt.2; human.
DR   AGR; HGNC:8346; -.
DR   CTD; 26341; -.
DR   GeneCards; OR5H1; -.
DR   HGNC; HGNC:8346; OR5H1.
DR   HPA; ENSG00000231192; Not detected.
DR   neXtProt; NX_A6NKK0; -.
DR   PharmGKB; PA32532; -.
DR   VEuPathDB; HostDB:ENSG00000231192; -.
DR   eggNOG; ENOG502T9JQ; Eukaryota.
DR   GeneTree; ENSGT01090000260017; -.
DR   HOGENOM; CLU_012526_8_1_1; -.
DR   InParanoid; A6NKK0; -.
DR   OMA; TYRLCTW; -.
DR   OrthoDB; 5401587at2759; -.
DR   PhylomeDB; A6NKK0; -.
DR   TreeFam; TF352737; -.
DR   PathwayCommons; A6NKK0; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 26341; 13 hits in 631 CRISPR screens.
DR   GenomeRNAi; 26341; -.
DR   Pharos; A6NKK0; Tdark.
DR   PRO; PR:A6NKK0; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; A6NKK0; Protein.
DR   Bgee; ENSG00000231192; Expressed in right uterine tube and 1 other cell type or tissue.
DR   ExpressionAtlas; A6NKK0; differential.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26452; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26452:SF747; OLFACTORY RECEPTOR 5H1; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; A6NKK0; HS.
PE   1: Evidence at protein level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..313
FT                   /note="Olfactory receptor 5H1"
FT                   /id="PRO_0000310867"
FT   TOPO_DOM        1..28
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..49
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..56
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..98
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        120..143
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        165..195
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        217..240
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        262..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..313
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..179
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         148
FT                   /note="S -> T (in dbSNP:rs5009896)"
FT                   /id="VAR_037089"
FT   VARIANT         153
FT                   /note="I -> L (in dbSNP:rs9845327)"
FT                   /evidence="ECO:0000269|PubMed:1370859"
FT                   /id="VAR_037091"
FT   VARIANT         181
FT                   /note="T -> I (in dbSNP:rs9826076)"
FT                   /evidence="ECO:0000269|PubMed:1370859"
FT                   /id="VAR_037092"
FT   VARIANT         230
FT                   /note="S -> T (in dbSNP:rs9849637)"
FT                   /id="VAR_037093"
FT   CONFLICT        228
FT                   /note="K -> R (in Ref. 2; X64988)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   313 AA;  35387 MW;  ABF576A58DF9BFF0 CRC64;
     MEEENATLLT EFVLTGFLYQ PQWKIPLFLA FLVIYLITIM GNLGLIAVIW KDPHLHIPMY
     LLLGNLAFVD AWISSTVTPK MLNNFLAKSK MISLSECKIQ FFSFAISVTT ECFLLATMAY
     DRYVAICKPL LYPAIMTNGL CIRLLILSYV GGILHALIHE GFLFRLTFCN SNIVHHIYCD
     TIPLSKISCT DSSINFLMVF IFSGSIQVFS IVTILVSYTF VLFAILKKKS DKGVRKAFST
     CGAHLFSVSL YYGPLLFIYV GPASPQADDQ DMVEPLFYTV IIPLLNPIIY SLRNKQVTVS
     FTKMLKKHVK VSY
//