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A6NKK0

- OR5H1_HUMAN

UniProt

A6NKK0 - OR5H1_HUMAN

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Protein
Olfactory receptor 5H1
Gene
OR5H1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 5H1
    Alternative name(s):
    HTPCRX14
    Gene namesi
    Name:OR5H1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:8346. OR5H1.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2828Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei29 – 4921Helical; Name=1; Reviewed prediction
    Add
    BLAST
    Topological domaini50 – 567Cytoplasmic Reviewed prediction
    Transmembranei57 – 7721Helical; Name=2; Reviewed prediction
    Add
    BLAST
    Topological domaini78 – 9821Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei99 – 11921Helical; Name=3; Reviewed prediction
    Add
    BLAST
    Topological domaini120 – 14324Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei144 – 16421Helical; Name=4; Reviewed prediction
    Add
    BLAST
    Topological domaini165 – 19531Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei196 – 21621Helical; Name=5; Reviewed prediction
    Add
    BLAST
    Topological domaini217 – 24024Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei241 – 26121Helical; Name=6; Reviewed prediction
    Add
    BLAST
    Topological domaini262 – 27110Extracellular Reviewed prediction
    Transmembranei272 – 29221Helical; Name=7; Reviewed prediction
    Add
    BLAST
    Topological domaini293 – 31321Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32532.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 313313Olfactory receptor 5H1
    PRO_0000310867Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi97 ↔ 179 By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiA6NKK0.
    PRIDEiA6NKK0.

    Expressioni

    Gene expression databases

    CleanExiHS_OR5H1.
    GenevestigatoriA6NKK0.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NKK0.
    SMRiA6NKK0. Positions 109-140, 275-306.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40374.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiA6NKK0.
    KOiK04257.
    OMAiSFTKMLK.
    OrthoDBiEOG7NKKKV.
    PhylomeDBiA6NKK0.
    TreeFamiTF352737.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6NKK0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEENATLLT EFVLTGFLYQ PQWKIPLFLA FLVIYLITIM GNLGLIAVIW    50
    KDPHLHIPMY LLLGNLAFVD AWISSTVTPK MLNNFLAKSK MISLSECKIQ 100
    FFSFAISVTT ECFLLATMAY DRYVAICKPL LYPAIMTNGL CIRLLILSYV 150
    GGILHALIHE GFLFRLTFCN SNIVHHIYCD TIPLSKISCT DSSINFLMVF 200
    IFSGSIQVFS IVTILVSYTF VLFAILKKKS DKGVRKAFST CGAHLFSVSL 250
    YYGPLLFIYV GPASPQADDQ DMVEPLFYTV IIPLLNPIIY SLRNKQVTVS 300
    FTKMLKKHVK VSY 313
    Length:313
    Mass (Da):35,387
    Last modified:July 24, 2007 - v1
    Checksum:iABF576A58DF9BFF0
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti148 – 1481S → T.
    Corresponds to variant rs5009896 [ dbSNP | Ensembl ].
    VAR_037089
    Natural varianti150 – 1501V → I.
    Corresponds to variant rs5009895 [ dbSNP | Ensembl ].
    VAR_037090
    Natural varianti153 – 1531I → L.1 Publication
    Corresponds to variant rs9845327 [ dbSNP | Ensembl ].
    VAR_037091
    Natural varianti181 – 1811T → I.1 Publication
    Corresponds to variant rs9826076 [ dbSNP | Ensembl ].
    VAR_037092
    Natural varianti230 – 2301S → T.
    Corresponds to variant rs9849637 [ dbSNP | Ensembl ].
    VAR_037093

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti228 – 2281K → R in X64988. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC117460 Genomic DNA. No translation available.
    X64988 mRNA. No translation available.
    CCDSiCCDS33797.1.
    RefSeqiNP_001005338.1. NM_001005338.1.
    UniGeneiHs.537383.

    Genome annotation databases

    EnsembliENST00000354565; ENSP00000346575; ENSG00000231192.
    GeneIDi26341.
    KEGGihsa:26341.
    UCSCiuc011bgt.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC117460 Genomic DNA. No translation available.
    X64988 mRNA. No translation available.
    CCDSi CCDS33797.1.
    RefSeqi NP_001005338.1. NM_001005338.1.
    UniGenei Hs.537383.

    3D structure databases

    ProteinModelPortali A6NKK0.
    SMRi A6NKK0. Positions 109-140, 275-306.
    ModBasei Search...

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PaxDbi A6NKK0.
    PRIDEi A6NKK0.

    Protocols and materials databases

    DNASUi 26341.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000354565 ; ENSP00000346575 ; ENSG00000231192 .
    GeneIDi 26341.
    KEGGi hsa:26341.
    UCSCi uc011bgt.2. human.

    Organism-specific databases

    CTDi 26341.
    GeneCardsi GC03P097851.
    H-InvDB HIX0200568.
    HGNCi HGNC:8346. OR5H1.
    neXtProti NX_A6NKK0.
    PharmGKBi PA32532.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40374.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi A6NKK0.
    KOi K04257.
    OMAi SFTKMLK.
    OrthoDBi EOG7NKKKV.
    PhylomeDBi A6NKK0.
    TreeFami TF352737.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GenomeRNAii 26341.
    NextBioi 48681.
    PROi A6NKK0.

    Gene expression databases

    CleanExi HS_OR5H1.
    Genevestigatori A6NKK0.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Expression of members of the putative olfactory receptor gene family in mammalian germ cells."
      Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G.
      Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-239, VARIANTS LEU-153 AND ILE-181.
      Tissue: Testis.

    Entry informationi

    Entry nameiOR5H1_HUMAN
    AccessioniPrimary (citable) accession number: A6NKK0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: July 24, 2007
    Last modified: September 3, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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