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A6NKK0 (OR5H1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 5H1
Alternative name(s):
HTPCRX14
Gene names
Name:OR5H1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Olfactory receptor 5H1
PRO_0000310867

Regions

Topological domain1 – 2828Extracellular Potential
Transmembrane29 – 4921Helical; Name=1; Potential
Topological domain50 – 567Cytoplasmic Potential
Transmembrane57 – 7721Helical; Name=2; Potential
Topological domain78 – 9821Extracellular Potential
Transmembrane99 – 11921Helical; Name=3; Potential
Topological domain120 – 14324Cytoplasmic Potential
Transmembrane144 – 16421Helical; Name=4; Potential
Topological domain165 – 19531Extracellular Potential
Transmembrane196 – 21621Helical; Name=5; Potential
Topological domain217 – 24024Cytoplasmic Potential
Transmembrane241 – 26121Helical; Name=6; Potential
Topological domain262 – 27110Extracellular Potential
Transmembrane272 – 29221Helical; Name=7; Potential
Topological domain293 – 31321Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 179 By similarity

Natural variations

Natural variant1481S → T.
Corresponds to variant rs5009896 [ dbSNP | Ensembl ].
VAR_037089
Natural variant1501V → I.
Corresponds to variant rs5009895 [ dbSNP | Ensembl ].
VAR_037090
Natural variant1531I → L. Ref.2
Corresponds to variant rs9845327 [ dbSNP | Ensembl ].
VAR_037091
Natural variant1811T → I. Ref.2
Corresponds to variant rs9826076 [ dbSNP | Ensembl ].
VAR_037092
Natural variant2301S → T.
Corresponds to variant rs9849637 [ dbSNP | Ensembl ].
VAR_037093

Experimental info

Sequence conflict2281K → R in X64988. Ref.2

Sequences

Sequence LengthMass (Da)Tools
A6NKK0 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: ABF576A58DF9BFF0

FASTA31335,387
        10         20         30         40         50         60 
MEEENATLLT EFVLTGFLYQ PQWKIPLFLA FLVIYLITIM GNLGLIAVIW KDPHLHIPMY 

        70         80         90        100        110        120 
LLLGNLAFVD AWISSTVTPK MLNNFLAKSK MISLSECKIQ FFSFAISVTT ECFLLATMAY 

       130        140        150        160        170        180 
DRYVAICKPL LYPAIMTNGL CIRLLILSYV GGILHALIHE GFLFRLTFCN SNIVHHIYCD 

       190        200        210        220        230        240 
TIPLSKISCT DSSINFLMVF IFSGSIQVFS IVTILVSYTF VLFAILKKKS DKGVRKAFST 

       250        260        270        280        290        300 
CGAHLFSVSL YYGPLLFIYV GPASPQADDQ DMVEPLFYTV IIPLLNPIIY SLRNKQVTVS 

       310 
FTKMLKKHVK VSY 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Expression of members of the putative olfactory receptor gene family in mammalian germ cells."
Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G.
Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-239, VARIANTS LEU-153 AND ILE-181.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC117460 Genomic DNA. No translation available.
X64988 mRNA. No translation available.
RefSeqNP_001005338.1. NM_001005338.1.
UniGeneHs.537383.

3D structure databases

ProteinModelPortalA6NKK0.
SMRA6NKK0. Positions 109-140, 275-306.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PaxDbA6NKK0.
PRIDEA6NKK0.

Protocols and materials databases

DNASU26341.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000354565; ENSP00000346575; ENSG00000231192.
GeneID26341.
KEGGhsa:26341.
UCSCuc011bgt.2. human.

Organism-specific databases

CTD26341.
GeneCardsGC03P097851.
H-InvDBHIX0200568.
HGNCHGNC:8346. OR5H1.
neXtProtNX_A6NKK0.
PharmGKBPA32532.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40374.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidA6NKK0.
KOK04257.
OMASFTKMLK.
OrthoDBEOG7NKKKV.
PhylomeDBA6NKK0.
TreeFamTF352737.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR5H1.
GenevestigatorA6NKK0.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi26341.
NextBio48681.
PROA6NKK0.

Entry information

Entry nameOR5H1_HUMAN
AccessionPrimary (citable) accession number: A6NKK0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries