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Protein

Olfactory receptor 5H1

Gene

OR5H1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-32352-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5H1
Alternative name(s):
HTPCRX14
Gene namesi
Name:OR5H1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:8346. OR5H1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 49Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini50 – 56CytoplasmicSequence analysis7
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 119Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini120 – 143CytoplasmicSequence analysisAdd BLAST24
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 195ExtracellularSequence analysisAdd BLAST31
Transmembranei196 – 216Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini217 – 240CytoplasmicSequence analysisAdd BLAST24
Transmembranei241 – 261Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini262 – 271ExtracellularSequence analysis10
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 313CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000231192.
PharmGKBiPA32532.

Polymorphism and mutation databases

BioMutaiOR5H1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003108671 – 313Olfactory receptor 5H1Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NKK0.
PRIDEiA6NKK0.

PTM databases

iPTMnetiA6NKK0.
PhosphoSitePlusiA6NKK0.

Expressioni

Gene expression databases

CleanExiHS_OR5H1.
GenevisibleiA6NKK0. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000346575.

Structurei

3D structure databases

ProteinModelPortaliA6NKK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J97S. Eukaryota.
ENOG4111537. LUCA.
GeneTreeiENSGT00550000074564.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6NKK0.
KOiK04257.
OMAiIAVIWKV.
OrthoDBiEOG091G0C7C.
PhylomeDBiA6NKK0.
TreeFamiTF352737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NKK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEENATLLT EFVLTGFLYQ PQWKIPLFLA FLVIYLITIM GNLGLIAVIW
60 70 80 90 100
KDPHLHIPMY LLLGNLAFVD AWISSTVTPK MLNNFLAKSK MISLSECKIQ
110 120 130 140 150
FFSFAISVTT ECFLLATMAY DRYVAICKPL LYPAIMTNGL CIRLLILSYV
160 170 180 190 200
GGILHALIHE GFLFRLTFCN SNIVHHIYCD TIPLSKISCT DSSINFLMVF
210 220 230 240 250
IFSGSIQVFS IVTILVSYTF VLFAILKKKS DKGVRKAFST CGAHLFSVSL
260 270 280 290 300
YYGPLLFIYV GPASPQADDQ DMVEPLFYTV IIPLLNPIIY SLRNKQVTVS
310
FTKMLKKHVK VSY
Length:313
Mass (Da):35,387
Last modified:July 24, 2007 - v1
Checksum:iABF576A58DF9BFF0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti228K → R in X64988 (PubMed:1370859).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037089148S → T.Corresponds to variant rs5009896dbSNPEnsembl.1
Natural variantiVAR_037090150V → I.Corresponds to variant rs5009895dbSNPEnsembl.1
Natural variantiVAR_037091153I → L.1 PublicationCorresponds to variant rs9845327dbSNPEnsembl.1
Natural variantiVAR_037092181T → I.1 PublicationCorresponds to variant rs9826076dbSNPEnsembl.1
Natural variantiVAR_037093230S → T.Corresponds to variant rs9849637dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117460 Genomic DNA. No translation available.
X64988 mRNA. No translation available.
CCDSiCCDS33797.1.
RefSeqiNP_001005338.1. NM_001005338.1.
UniGeneiHs.537383.

Genome annotation databases

EnsembliENST00000354565; ENSP00000346575; ENSG00000231192.
GeneIDi26341.
KEGGihsa:26341.
UCSCiuc011bgt.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117460 Genomic DNA. No translation available.
X64988 mRNA. No translation available.
CCDSiCCDS33797.1.
RefSeqiNP_001005338.1. NM_001005338.1.
UniGeneiHs.537383.

3D structure databases

ProteinModelPortaliA6NKK0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000346575.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiA6NKK0.
PhosphoSitePlusiA6NKK0.

Polymorphism and mutation databases

BioMutaiOR5H1.

Proteomic databases

PaxDbiA6NKK0.
PRIDEiA6NKK0.

Protocols and materials databases

DNASUi26341.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354565; ENSP00000346575; ENSG00000231192.
GeneIDi26341.
KEGGihsa:26341.
UCSCiuc011bgt.2. human.

Organism-specific databases

CTDi26341.
GeneCardsiOR5H1.
H-InvDBHIX0200568.
HGNCiHGNC:8346. OR5H1.
neXtProtiNX_A6NKK0.
OpenTargetsiENSG00000231192.
PharmGKBiPA32532.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J97S. Eukaryota.
ENOG4111537. LUCA.
GeneTreeiENSGT00550000074564.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6NKK0.
KOiK04257.
OMAiIAVIWKV.
OrthoDBiEOG091G0C7C.
PhylomeDBiA6NKK0.
TreeFamiTF352737.

Enzyme and pathway databases

BioCyciZFISH:G66-32352-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii26341.
PROiA6NKK0.

Gene expression databases

CleanExiHS_OR5H1.
GenevisibleiA6NKK0. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR5H1_HUMAN
AccessioniPrimary (citable) accession number: A6NKK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.