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Protein

Olfactory receptor 5H1

Gene

OR5H1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5H1
Alternative name(s):
HTPCRX14
Gene namesi
Name:OR5H1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000231192.1
HGNCiHGNC:8346 OR5H1
neXtProtiNX_A6NKK0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 49Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini50 – 56CytoplasmicSequence analysis7
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 119Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini120 – 143CytoplasmicSequence analysisAdd BLAST24
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 195ExtracellularSequence analysisAdd BLAST31
Transmembranei196 – 216Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini217 – 240CytoplasmicSequence analysisAdd BLAST24
Transmembranei241 – 261Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini262 – 271ExtracellularSequence analysis10
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 313CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32532

Polymorphism and mutation databases

BioMutaiOR5H1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003108671 – 313Olfactory receptor 5H1Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NKK0
PRIDEiA6NKK0

PTM databases

iPTMnetiA6NKK0
PhosphoSitePlusiA6NKK0

Expressioni

Gene expression databases

CleanExiHS_OR5H1
ExpressionAtlasiA6NKK0 differential
GenevisibleiA6NKK0 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000346575

Structurei

3D structure databases

ProteinModelPortaliA6NKK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J97S Eukaryota
ENOG4111537 LUCA
GeneTreeiENSGT00550000074564
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiA6NKK0
KOiK04257
OMAiIAVIWKV
OrthoDBiEOG091G0C7C
PhylomeDBiA6NKK0
TreeFamiTF352737

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

A6NKK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEENATLLT EFVLTGFLYQ PQWKIPLFLA FLVIYLITIM GNLGLIAVIW
60 70 80 90 100
KDPHLHIPMY LLLGNLAFVD AWISSTVTPK MLNNFLAKSK MISLSECKIQ
110 120 130 140 150
FFSFAISVTT ECFLLATMAY DRYVAICKPL LYPAIMTNGL CIRLLILSYV
160 170 180 190 200
GGILHALIHE GFLFRLTFCN SNIVHHIYCD TIPLSKISCT DSSINFLMVF
210 220 230 240 250
IFSGSIQVFS IVTILVSYTF VLFAILKKKS DKGVRKAFST CGAHLFSVSL
260 270 280 290 300
YYGPLLFIYV GPASPQADDQ DMVEPLFYTV IIPLLNPIIY SLRNKQVTVS
310
FTKMLKKHVK VSY
Length:313
Mass (Da):35,387
Last modified:July 24, 2007 - v1
Checksum:iABF576A58DF9BFF0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti228K → R in X64988 (PubMed:1370859).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037089148S → T. Corresponds to variant dbSNP:rs5009896Ensembl.1
Natural variantiVAR_037091153I → L1 PublicationCorresponds to variant dbSNP:rs9845327Ensembl.1
Natural variantiVAR_037092181T → I1 PublicationCorresponds to variant dbSNP:rs9826076Ensembl.1
Natural variantiVAR_037093230S → T. Corresponds to variant dbSNP:rs9849637Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117460 Genomic DNA No translation available.
X64988 mRNA No translation available.
CCDSiCCDS33797.1
RefSeqiNP_001005338.1, NM_001005338.1
UniGeneiHs.537383

Genome annotation databases

EnsembliENST00000354565; ENSP00000346575; ENSG00000231192
ENST00000641874; ENSP00000492953; ENSG00000231192
GeneIDi26341
KEGGihsa:26341
UCSCiuc011bgt.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR5H1_HUMAN
AccessioniPrimary (citable) accession number: A6NKK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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