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Protein

Olfactory receptor 5H1

Gene

OR5H1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5H1
Alternative name(s):
HTPCRX14
Gene namesi
Name:OR5H1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:8346. OR5H1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828ExtracellularSequence AnalysisAdd
BLAST
Transmembranei29 – 4921Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 567CytoplasmicSequence Analysis
Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini78 – 9821ExtracellularSequence AnalysisAdd
BLAST
Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini120 – 14324CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei144 – 16421Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini165 – 19531ExtracellularSequence AnalysisAdd
BLAST
Transmembranei196 – 21621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini217 – 24024CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei241 – 26121Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini262 – 27110ExtracellularSequence Analysis
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 31321CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32532.

Polymorphism and mutation databases

BioMutaiOR5H1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Olfactory receptor 5H1PRO_0000310867Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NKK0.
PRIDEiA6NKK0.

Expressioni

Gene expression databases

CleanExiHS_OR5H1.
GenevisibleiA6NKK0. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000346575.

Structurei

3D structure databases

ProteinModelPortaliA6NKK0.
SMRiA6NKK0. Positions 27-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40374.
GeneTreeiENSGT00550000074564.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6NKK0.
KOiK04257.
OMAiSFTKMLK.
OrthoDBiEOG7NKKKV.
PhylomeDBiA6NKK0.
TreeFamiTF352737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NKK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEENATLLT EFVLTGFLYQ PQWKIPLFLA FLVIYLITIM GNLGLIAVIW
60 70 80 90 100
KDPHLHIPMY LLLGNLAFVD AWISSTVTPK MLNNFLAKSK MISLSECKIQ
110 120 130 140 150
FFSFAISVTT ECFLLATMAY DRYVAICKPL LYPAIMTNGL CIRLLILSYV
160 170 180 190 200
GGILHALIHE GFLFRLTFCN SNIVHHIYCD TIPLSKISCT DSSINFLMVF
210 220 230 240 250
IFSGSIQVFS IVTILVSYTF VLFAILKKKS DKGVRKAFST CGAHLFSVSL
260 270 280 290 300
YYGPLLFIYV GPASPQADDQ DMVEPLFYTV IIPLLNPIIY SLRNKQVTVS
310
FTKMLKKHVK VSY
Length:313
Mass (Da):35,387
Last modified:July 24, 2007 - v1
Checksum:iABF576A58DF9BFF0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti228 – 2281K → R in X64988 (PubMed:1370859).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti148 – 1481S → T.
Corresponds to variant rs5009896 [ dbSNP | Ensembl ].
VAR_037089
Natural varianti150 – 1501V → I.
Corresponds to variant rs5009895 [ dbSNP | Ensembl ].
VAR_037090
Natural varianti153 – 1531I → L.1 Publication
Corresponds to variant rs9845327 [ dbSNP | Ensembl ].
VAR_037091
Natural varianti181 – 1811T → I.1 Publication
Corresponds to variant rs9826076 [ dbSNP | Ensembl ].
VAR_037092
Natural varianti230 – 2301S → T.
Corresponds to variant rs9849637 [ dbSNP | Ensembl ].
VAR_037093

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117460 Genomic DNA. No translation available.
X64988 mRNA. No translation available.
CCDSiCCDS33797.1.
RefSeqiNP_001005338.1. NM_001005338.1.
UniGeneiHs.537383.

Genome annotation databases

EnsembliENST00000354565; ENSP00000346575; ENSG00000231192.
GeneIDi26341.
KEGGihsa:26341.
UCSCiuc011bgt.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117460 Genomic DNA. No translation available.
X64988 mRNA. No translation available.
CCDSiCCDS33797.1.
RefSeqiNP_001005338.1. NM_001005338.1.
UniGeneiHs.537383.

3D structure databases

ProteinModelPortaliA6NKK0.
SMRiA6NKK0. Positions 27-129.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000346575.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR5H1.

Proteomic databases

PaxDbiA6NKK0.
PRIDEiA6NKK0.

Protocols and materials databases

DNASUi26341.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354565; ENSP00000346575; ENSG00000231192.
GeneIDi26341.
KEGGihsa:26341.
UCSCiuc011bgt.2. human.

Organism-specific databases

CTDi26341.
GeneCardsiGC03P097851.
H-InvDBHIX0200568.
HGNCiHGNC:8346. OR5H1.
neXtProtiNX_A6NKK0.
PharmGKBiPA32532.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG40374.
GeneTreeiENSGT00550000074564.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6NKK0.
KOiK04257.
OMAiSFTKMLK.
OrthoDBiEOG7NKKKV.
PhylomeDBiA6NKK0.
TreeFamiTF352737.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii26341.
NextBioi48681.
PROiA6NKK0.

Gene expression databases

CleanExiHS_OR5H1.
GenevisibleiA6NKK0. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Expression of members of the putative olfactory receptor gene family in mammalian germ cells."
    Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G.
    Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-239, VARIANTS LEU-153 AND ILE-181.
    Tissue: Testis.

Entry informationi

Entry nameiOR5H1_HUMAN
AccessioniPrimary (citable) accession number: A6NKK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: June 24, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.