A6NKF2 (ARI3C_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 43.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: AT-rich interactive domain-containing protein 3C Short name=ARID domain-containing protein 3C | ||
| Gene names |
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| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 412 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Subcellular location | Nucleus By similarity. |
| Sequence similarities | Contains 1 ARID domain. Contains 1 REKLES domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Coding sequence diversity | Polymorphism |
| Ligand | DNA-binding |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependentInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | DNA binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 412 | 412 | AT-rich interactive domain-containing protein 3C | PRO_0000333001 | |||||
Regions | |||||||||
| Domain | 113 – 205 | 93 | ARID | ||||||
| Domain | 304 – 389 | 86 | REKLES | ||||||
| Compositional bias | 51 – 75 | 25 | Glu-rich | ||||||
| Compositional bias | 240 – 412 | 173 | Pro-rich | ||||||
Natural variations | |||||||||
| Natural variant | 310 | 1 | R → Q. Corresponds to variant rs12337871 [ dbSNP | Ensembl ]. | VAR_043033 | |||||
| Natural variant | 335 | 1 | C → G. Corresponds to variant rs3808869 [ dbSNP | Ensembl ]. | VAR_043034 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. Dunham I.Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [2] | "REKLES is an ARID3-restricted multifunctional domain." Kim D., Probst L., Das C., Tucker P.W. J. Biol. Chem. 282:15768-15777(2007) [PubMed: 17400556] [Abstract] Cited for: IDENTIFICATION. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL450283 Genomic DNA. No translation available. |
| IPI | IPI00062225. |
| RefSeq | NP_001017363.1. NM_001017363.1. |
| UniGene | Hs.534549. |
3D structure databases | |
| ProteinModelPortal | A6NKF2. |
| SMR | A6NKF2. Positions 97-226. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A6NKF2. |
Proteomic databases | |
| PRIDE | A6NKF2. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000378909; ENSP00000368189; ENSG00000205143. |
| GeneID | 138715. |
| KEGG | hsa:138715. |
| UCSC | uc003zuy.1. human. |
Organism-specific databases | |
| CTD | 138715. |
| GeneCards | GC09M034575. |
| HGNC | HGNC:21209. ARID3C. |
| neXtProt | NX_A6NKF2. |
| PharmGKB | PA134928507. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG05484. |
| GeneTree | ENSGT00550000074575. |
| HOGENOM | HBG402789. |
| HOVERGEN | HBG050574. |
| InParanoid | A6NKF2. |
| OMA | FARRQPV. |
| OrthoDB | EOG415GF5. |
| PhylomeDB | A6NKF2. |
Gene expression databases | |
| CleanEx | HS_ARID3C. |
| Genevestigator | A6NKF2. |
Family and domain databases | |
| InterPro | IPR001606. ARID/BRIGHT_DNA-bd. IPR023334. REKLES_domain. [Graphical view] |
| Gene3D | G3DSA:1.10.150.60. ARID. 1 hit. |
| Pfam | PF01388. ARID. 1 hit. [Graphical view] |
| SMART | SM00501. BRIGHT. 1 hit. [Graphical view] |
| SUPFAM | SSF46774. ARID. 1 hit. |
| PROSITE | PS51011. ARID. 1 hit. PS51486. REKLES. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 83815. |
Entry information
| Entry name | ARI3C_HUMAN | ||||||||
| Accession | Primary (citable) accession number: A6NKF2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 9 Human chromosome 9: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

Clusters with