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Protein

AT-rich interactive domain-containing protein 3C

Gene

ARID3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 3C
Short name:
ARID domain-containing protein 3C
Gene namesi
Name:ARID3C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:21209. ARID3C.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • membrane raft Source: MGI
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134928507.

Polymorphism and mutation databases

BioMutaiARID3C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 412412AT-rich interactive domain-containing protein 3CPRO_0000333001Add
BLAST

Proteomic databases

MaxQBiA6NKF2.
PaxDbiA6NKF2.
PRIDEiA6NKF2.

PTM databases

PhosphoSiteiA6NKF2.

Expressioni

Gene expression databases

BgeeiA6NKF2.
CleanExiHS_ARID3C.

Interactioni

Protein-protein interaction databases

BioGridi126518. 1 interaction.
STRINGi9606.ENSP00000368189.

Structurei

3D structure databases

ProteinModelPortaliA6NKF2.
SMRiA6NKF2. Positions 97-226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini113 – 20593ARIDPROSITE-ProRule annotationAdd
BLAST
Domaini304 – 38986REKLESPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi51 – 7525Glu-richAdd
BLAST
Compositional biasi240 – 412173Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 ARID domain.PROSITE-ProRule annotation
Contains 1 REKLES domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2744. Eukaryota.
ENOG410Y2AP. LUCA.
GeneTreeiENSGT00550000074575.
HOGENOMiHOG000236281.
HOVERGENiHBG050574.
InParanoidiA6NKF2.
OMAiGLHPHEW.
OrthoDBiEOG77DJ6W.
PhylomeDBiA6NKF2.
TreeFamiTF320364.

Family and domain databases

Gene3Di1.10.150.60. 1 hit.
InterProiIPR001606. ARID_dom.
IPR023334. REKLES_domain.
[Graphical view]
PfamiPF01388. ARID. 1 hit.
[Graphical view]
SMARTiSM00501. BRIGHT. 1 hit.
[Graphical view]
SUPFAMiSSF46774. SSF46774. 1 hit.
PROSITEiPS51011. ARID. 1 hit.
PS51486. REKLES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NKF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEALQKQQAA RLAQGVGPLA PACPLLPPQP PLPDHRTLQA PEGALGNVGA
60 70 80 90 100
EEEEDAEEDE EKREEAGAEE EAAEESRPGA QGPSSPSSQP PGLHPHEWTY
110 120 130 140 150
EEQFKQLYEL DADPKRKEFL DDLFSFMQKR GTPVNRVPIM AKQVLDLYAL
160 170 180 190 200
FRLVTAKGGL VEVINRKVWR EVTRGLSLPT TITSAAFTLR TQYMKYLYPY
210 220 230 240 250
ECETRALSSP GELQAAIDSN RREGRRQAYT ATPLFGLAGP PPRGAQDPAL
260 270 280 290 300
GPGPAPPATQ SSPGPAQGST SGLPAHACAQ LSPSPIKKEE SGIPNPCLAL
310 320 330 340 350
PVGLALGPTR EKLAPEEPPE KRAVLMGPMD PPRPCMPPSF LPRGKVPLRE
360 370 380 390 400
ERLDGPLNLA GSGISSINMA LEINGVVYTG VLFARRQPVP ASQGPTNPAP
410
PPSTGPPSSI LP
Length:412
Mass (Da):44,073
Last modified:July 24, 2007 - v1
Checksum:iA4F27053248A49A7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti310 – 3101R → Q.
Corresponds to variant rs12337871 [ dbSNP | Ensembl ].
VAR_043033
Natural varianti335 – 3351C → G.
Corresponds to variant rs3808869 [ dbSNP | Ensembl ].
VAR_043034

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL450283 Genomic DNA. No translation available.
CCDSiCCDS35006.1.
RefSeqiNP_001017363.1. NM_001017363.1.
UniGeneiHs.534549.

Genome annotation databases

EnsembliENST00000378909; ENSP00000368189; ENSG00000205143.
GeneIDi138715.
KEGGihsa:138715.
UCSCiuc011lon.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL450283 Genomic DNA. No translation available.
CCDSiCCDS35006.1.
RefSeqiNP_001017363.1. NM_001017363.1.
UniGeneiHs.534549.

3D structure databases

ProteinModelPortaliA6NKF2.
SMRiA6NKF2. Positions 97-226.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126518. 1 interaction.
STRINGi9606.ENSP00000368189.

PTM databases

PhosphoSiteiA6NKF2.

Polymorphism and mutation databases

BioMutaiARID3C.

Proteomic databases

MaxQBiA6NKF2.
PaxDbiA6NKF2.
PRIDEiA6NKF2.

Protocols and materials databases

DNASUi138715.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378909; ENSP00000368189; ENSG00000205143.
GeneIDi138715.
KEGGihsa:138715.
UCSCiuc011lon.3. human.

Organism-specific databases

CTDi138715.
GeneCardsiARID3C.
HGNCiHGNC:21209. ARID3C.
neXtProtiNX_A6NKF2.
PharmGKBiPA134928507.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2744. Eukaryota.
ENOG410Y2AP. LUCA.
GeneTreeiENSGT00550000074575.
HOGENOMiHOG000236281.
HOVERGENiHBG050574.
InParanoidiA6NKF2.
OMAiGLHPHEW.
OrthoDBiEOG77DJ6W.
PhylomeDBiA6NKF2.
TreeFamiTF320364.

Miscellaneous databases

GenomeRNAii138715.
NextBioi83815.
PROiA6NKF2.

Gene expression databases

BgeeiA6NKF2.
CleanExiHS_ARID3C.

Family and domain databases

Gene3Di1.10.150.60. 1 hit.
InterProiIPR001606. ARID_dom.
IPR023334. REKLES_domain.
[Graphical view]
PfamiPF01388. ARID. 1 hit.
[Graphical view]
SMARTiSM00501. BRIGHT. 1 hit.
[Graphical view]
SUPFAMiSSF46774. SSF46774. 1 hit.
PROSITEiPS51011. ARID. 1 hit.
PS51486. REKLES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "REKLES is an ARID3-restricted multifunctional domain."
    Kim D., Probst L., Das C., Tucker P.W.
    J. Biol. Chem. 282:15768-15777(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiARI3C_HUMAN
AccessioniPrimary (citable) accession number: A6NKF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 24, 2007
Last modified: March 16, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.