A6NKF2 (ARI3C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
AT-rich interactive domain-containing protein 3C
Short name=ARID domain-containing protein 3C

Gene names

Name:

ARID3C

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	412 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus By similarity.
Sequence similarities	Contains 1 ARID domain. Contains 1 REKLES domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 412	412	AT-rich interactive domain-containing protein 3C		PRO_0000333001
Regions
	Domain	113 – 205	93	ARID
	Domain	304 – 389	86	REKLES
	Compositional bias	51 – 75	25	Glu-rich
	Compositional bias	240 – 412	173	Pro-rich
Natural variations
	Natural variant	310	1	R → Q. Corresponds to variant rs12337871 [ dbSNP | Ensembl ].		VAR_043033
	Natural variant	335	1	C → G. Corresponds to variant rs3808869 [ dbSNP | Ensembl ].		VAR_043034

Sequences

	Sequence		Length	Mass (Da)
	A6NKF2 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: A4F27053248A49A7	FASTA	412	44,073
	10 20 30 40 50 60 MEALQKQQAA RLAQGVGPLA PACPLLPPQP PLPDHRTLQA PEGALGNVGA EEEEDAEEDE 70 80 90 100 110 120 EKREEAGAEE EAAEESRPGA QGPSSPSSQP PGLHPHEWTY EEQFKQLYEL DADPKRKEFL 130 140 150 160 170 180 DDLFSFMQKR GTPVNRVPIM AKQVLDLYAL FRLVTAKGGL VEVINRKVWR EVTRGLSLPT 190 200 210 220 230 240 TITSAAFTLR TQYMKYLYPY ECETRALSSP GELQAAIDSN RREGRRQAYT ATPLFGLAGP 250 260 270 280 290 300 PPRGAQDPAL GPGPAPPATQ SSPGPAQGST SGLPAHACAQ LSPSPIKKEE SGIPNPCLAL 310 320 330 340 350 360 PVGLALGPTR EKLAPEEPPE KRAVLMGPMD PPRPCMPPSF LPRGKVPLRE ERLDGPLNLA 370 380 390 400 410 GSGISSINMA LEINGVVYTG VLFARRQPVP ASQGPTNPAP PPSTGPPSSI LP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"REKLES is an ARID3-restricted multifunctional domain." Kim D., Probst L., Das C., Tucker P.W. J. Biol. Chem. 282:15768-15777(2007) [PubMed: 17400556] [Abstract] Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL450283 Genomic DNA. No translation available.
IPI	IPI00062225.
RefSeq	NP_001017363.1. NM_001017363.1.
UniGene	Hs.534549.
3D structure databases
ProteinModelPortal	A6NKF2.
SMR	A6NKF2. Positions 97-226.
ModBase	Search...
Protein-protein interaction databases
STRING	A6NKF2.
Proteomic databases
PRIDE	A6NKF2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000378909; ENSP00000368189; ENSG00000205143.
GeneID	138715.
KEGG	hsa:138715.
UCSC	uc003zuy.1. human.
Organism-specific databases
CTD	138715.
GeneCards	GC09M034575.
HGNC	HGNC:21209. ARID3C.
neXtProt	NX_A6NKF2.
PharmGKB	PA134928507.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG05484.
GeneTree	ENSGT00550000074575.
HOGENOM	HBG402789.
HOVERGEN	HBG050574.
InParanoid	A6NKF2.
OMA	FARRQPV.
OrthoDB	EOG415GF5.
PhylomeDB	A6NKF2.
Gene expression databases
CleanEx	HS_ARID3C.
Genevestigator	A6NKF2.
Family and domain databases
InterPro	IPR001606. ARID/BRIGHT_DNA-bd. IPR023334. REKLES_domain. [Graphical view]
Gene3D	G3DSA:1.10.150.60. ARID. 1 hit.
Pfam	PF01388. ARID. 1 hit. [Graphical view]
SMART	SM00501. BRIGHT. 1 hit. [Graphical view]
SUPFAM	SSF46774. ARID. 1 hit.
PROSITE	PS51011. ARID. 1 hit. PS51486. REKLES. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	83815.

Entry information

Entry name

ARI3C_HUMAN

Accession

Primary (citable) accession number: A6NKF2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.