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Protein

SAC3 domain-containing protein 1

Gene

SAC3D1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in centrosome duplication and mitotic progression.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
SAC3 domain-containing protein 1
Alternative name(s):
SAC3 homology domain-containing protein 1
Gene namesi
Name:SAC3D1
Synonyms:SHD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:30179. SAC3D1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404SAC3 domain-containing protein 1PRO_0000308204Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei402 – 4021PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA6NKF1.
MaxQBiA6NKF1.
PaxDbiA6NKF1.
PeptideAtlasiA6NKF1.
PRIDEiA6NKF1.
TopDownProteomicsiA6NKF1-2. [A6NKF1-2]

PTM databases

iPTMnetiA6NKF1.
PhosphoSiteiA6NKF1.

Expressioni

Gene expression databases

BgeeiA6NKF1.
CleanExiHS_SAC3D1.
ExpressionAtlasiA6NKF1. baseline and differential.
GenevisibleiA6NKF1. HS.

Organism-specific databases

HPAiHPA042677.

Interactioni

Subunit structurei

May be part of a SHFM1-containing complex.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000381824.

Structurei

3D structure databases

ProteinModelPortaliA6NKF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi8 – 118111Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the SAC3 family.Curated

Phylogenomic databases

eggNOGiKOG1860. Eukaryota.
COG5079. LUCA.
GeneTreeiENSGT00530000063781.
HOGENOMiHOG000168632.
HOVERGENiHBG108455.
InParanoidiA6NKF1.
OMAiQIFTHAY.
PhylomeDBiA6NKF1.

Family and domain databases

InterProiIPR005062. SAC3/GANP/THP3.
[Graphical view]
PfamiPF03399. SAC3_GANP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NKF1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGRRAQTGS APPRPAAPHP RPASRAFPQH CRPRDAERPP SPRSPLMPGC
60 70 80 90 100
ELPVGTCPDM CPAAERAQRE REHRLHRLEV VPGCRQDPPR ADPQRAVKEY
110 120 130 140 150
SRPAAGKPRP PPSQLRPPSV LLATVRYLAG EVAESADIAR AEVASFVADR
160 170 180 190 200
LRAVLLDLAL QGAGDAEAAV VLEAALATLL TVVARLGPDA ARGPADPVLL
210 220 230 240 250
QAQVQEGFGS LRRCYARGAG PHPRQPAFQG LFLLYNLGSV EALHEVLQLP
260 270 280 290 300
AALRACPPLR KALAVDAAFR EGNAARLFRL LQTLPYLPSC AVQCHVGHAR
310 320 330 340 350
REALARFARA FSTPKGQTLP LGFMVNLLAL DGLREARDLC QAHGLPLDGE
360 370 380 390 400
ERVVFLRGRY VEEGLPPAST CKVLVESKLR GRTLEEVVMA EEEDEGTDRP

GSPA
Length:404
Mass (Da):43,553
Last modified:March 24, 2009 - v2
Checksum:i9B3499AAA23F97B7
GO
Isoform 2 (identifier: A6NKF1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     239-404: SVEALHEVLQ...EGTDRPGSPA → ESGSWRLGRA...PARPSARPWR

Note: No experimental confirmation available.
Show »
Length:285
Mass (Da):30,913
Checksum:i6E23EC439A9A6628
GO

Sequence cautioni

The sequence AP003068 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti181 – 1811T → A in AAB50210 (PubMed:9110174).Curated
Sequence conflicti181 – 1811T → A in BC007448 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81T → P.2 Publications
Corresponds to variant rs10160811 [ dbSNP | Ensembl ].
VAR_036755
Natural varianti155 – 1551L → R.2 Publications
Corresponds to variant rs12271134 [ dbSNP | Ensembl ].
VAR_062213
Natural varianti186 – 1861L → P.
Corresponds to variant rs3741390 [ dbSNP | Ensembl ].
VAR_036756

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei239 – 404166SVEAL…PGSPA → ESGSWRLGRAWGQEPTMTVE ARWKPCMRFYSCLLPCAPAR PSARPWR in isoform 2. 1 PublicationVSP_036589Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79266 mRNA. Translation: AAB50210.1.
AP003068 Genomic DNA. No translation available.
BC007448 mRNA. No translation available.
UniGeneiHs.23642.

Genome annotation databases

EnsembliENST00000614106; ENSP00000482039; ENSG00000168061. [A6NKF1-1]
UCSCiuc058dcn.1. human. [A6NKF1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79266 mRNA. Translation: AAB50210.1.
AP003068 Genomic DNA. No translation available.
BC007448 mRNA. No translation available.
UniGeneiHs.23642.

3D structure databases

ProteinModelPortaliA6NKF1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000381824.

PTM databases

iPTMnetiA6NKF1.
PhosphoSiteiA6NKF1.

Proteomic databases

EPDiA6NKF1.
MaxQBiA6NKF1.
PaxDbiA6NKF1.
PeptideAtlasiA6NKF1.
PRIDEiA6NKF1.
TopDownProteomicsiA6NKF1-2. [A6NKF1-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000614106; ENSP00000482039; ENSG00000168061. [A6NKF1-1]
UCSCiuc058dcn.1. human. [A6NKF1-1]

Organism-specific databases

GeneCardsiSAC3D1.
HGNCiHGNC:30179. SAC3D1.
HPAiHPA042677.
neXtProtiNX_A6NKF1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1860. Eukaryota.
COG5079. LUCA.
GeneTreeiENSGT00530000063781.
HOGENOMiHOG000168632.
HOVERGENiHBG108455.
InParanoidiA6NKF1.
OMAiQIFTHAY.
PhylomeDBiA6NKF1.

Miscellaneous databases

PROiA6NKF1.

Gene expression databases

BgeeiA6NKF1.
CleanExiHS_SAC3D1.
ExpressionAtlasiA6NKF1. baseline and differential.
GenevisibleiA6NKF1. HS.

Family and domain databases

InterProiIPR005062. SAC3/GANP/THP3.
[Graphical view]
PfamiPF03399. SAC3_GANP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Large-scale concatenation cDNA sequencing."
    Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.
    Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS PRO-8 AND ARG-155.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS PRO-8 AND ARG-155.
    Tissue: Muscle.
  4. "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II."
    Baillat D., Hakimi M.-A., Naeaer A.M., Shilatifard A., Cooch N., Shiekhattar R.
    Cell 123:265-276(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN COMPLEX WITH SHFM1, IDENTIFICATION BY MASS SPECTROMETRY.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-402, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-402, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-402, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-402, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.

Entry informationi

Entry nameiSAC31_HUMAN
AccessioniPrimary (citable) accession number: A6NKF1
Secondary accession number(s): A8MX08, Q99773
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 24, 2009
Last modified: July 6, 2016
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-47 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.