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A6NKD9

- CC85C_HUMAN

UniProt

A6NKD9 - CC85C_HUMAN

Protein

Coiled-coil domain-containing protein 85C

Gene

CCDC85C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    May play an important role in cortical development, especially in the maintenance of radial glia.By similarity

    GO - Biological processi

    1. cerebral cortex development Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coiled-coil domain-containing protein 85C
    Gene namesi
    Name:CCDC85C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:35459. CCDC85C.

    Subcellular locationi

    Cell junctiontight junction By similarity
    Note: Localizes to the apical junction of radial glia in the wall of lateral ventricles of the developing brain. Colocalizes with TJP1 on the meshwork-like structure of adherens junctions on the lateral ventricles wall.By similarity

    GO - Cellular componenti

    1. apical junction complex Source: UniProtKB
    2. tight junction Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Tight junction

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164717760.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 419418Coiled-coil domain-containing protein 85CPRO_0000345410Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei246 – 2461Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiA6NKD9.
    PaxDbiA6NKD9.
    PRIDEiA6NKD9.

    PTM databases

    PhosphoSiteiA6NKD9.

    Expressioni

    Gene expression databases

    ArrayExpressiA6NKD9.
    BgeeiA6NKD9.
    GenevestigatoriA6NKD9.

    Organism-specific databases

    HPAiHPA058346.

    Interactioni

    Protein-protein interaction databases

    BioGridi130463. 3 interactions.
    IntActiA6NKD9. 9 interactions.
    STRINGi9606.ENSP00000369592.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NKD9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili22 – 8867Sequence AnalysisAdd
    BLAST
    Coiled coili118 – 15942Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi162 – 21554Gly-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CCDC85 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG315844.
    HOGENOMiHOG000294096.
    HOVERGENiHBG060368.
    InParanoidiA6NKD9.
    OMAiLMLEHGG.
    OrthoDBiEOG7V49ZJ.
    PhylomeDBiA6NKD9.
    TreeFamiTF320243.

    Family and domain databases

    InterProiIPR019359. DUF2216_coiled-coil.
    [Graphical view]
    PfamiPF10226. DUF2216. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A6NKD9-1 [UniParc]FASTAAdd to Basket

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    MAKPAATAAA ASEELSQVPD EELLRWSKEE LARRLRRAEG EKVGLMLEHG    50
    GLMRDVNRRL QQHLLEIRGL KDVNQRLQDD NQELRELCCF LDDDRQKGRK 100
    LAREWQRFGR HAAGAVWHEV ARSQQKLREL EARQEALLRE NLELKELVLL 150
    LDEERAALAA TGAASGGGGG GGGAGSRSSI DSQASLSGPL SGGAPGAGAR 200
    DVGDGSSTSS AGSGGSPDHH HHVPPPLLPP GPHKAPDGKA GATRRSLDDL 250
    SAPPHHRSIP NGLHDPSSTY IRQLESKVRL LEGDKLLAQQ AGSGEFRTLR 300
    KGFSPYHSES QLASLPPSYQ DSLQNGPACP APELPSPPSA GYSPAGQKPE 350
    AVVHAMKVLE VHENLDRQLQ DSCEEDLSEK EKAIVREMCN VVWRKLGDAA 400
    SSKPSIRQHL SGNQFKGPL 419
    Length:419
    Mass (Da):45,210
    Last modified:July 24, 2007 - v1
    Checksum:i01A8F447CE951007
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL110504 Genomic DNA. No translation available.
    AL160313 Genomic DNA. No translation available.
    CCDSiCCDS45161.1.
    RefSeqiNP_001138467.1. NM_001144995.1.
    UniGeneiHs.709288.

    Genome annotation databases

    EnsembliENST00000380243; ENSP00000369592; ENSG00000205476.
    GeneIDi317762.
    KEGGihsa:317762.
    UCSCiuc010avr.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL110504 Genomic DNA. No translation available.
    AL160313 Genomic DNA. No translation available.
    CCDSi CCDS45161.1.
    RefSeqi NP_001138467.1. NM_001144995.1.
    UniGenei Hs.709288.

    3D structure databases

    ProteinModelPortali A6NKD9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 130463. 3 interactions.
    IntActi A6NKD9. 9 interactions.
    STRINGi 9606.ENSP00000369592.

    PTM databases

    PhosphoSitei A6NKD9.

    Proteomic databases

    MaxQBi A6NKD9.
    PaxDbi A6NKD9.
    PRIDEi A6NKD9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380243 ; ENSP00000369592 ; ENSG00000205476 .
    GeneIDi 317762.
    KEGGi hsa:317762.
    UCSCi uc010avr.3. human.

    Organism-specific databases

    CTDi 317762.
    GeneCardsi GC14M099978.
    H-InvDB HIX0011960.
    HIX0059368.
    HGNCi HGNC:35459. CCDC85C.
    HPAi HPA058346.
    neXtProti NX_A6NKD9.
    PharmGKBi PA164717760.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG315844.
    HOGENOMi HOG000294096.
    HOVERGENi HBG060368.
    InParanoidi A6NKD9.
    OMAi LMLEHGG.
    OrthoDBi EOG7V49ZJ.
    PhylomeDBi A6NKD9.
    TreeFami TF320243.

    Miscellaneous databases

    GenomeRNAii 317762.
    NextBioi 96417.
    PROi A6NKD9.

    Gene expression databases

    ArrayExpressi A6NKD9.
    Bgeei A6NKD9.
    Genevestigatori A6NKD9.

    Family and domain databases

    InterProi IPR019359. DUF2216_coiled-coil.
    [Graphical view ]
    Pfami PF10226. DUF2216. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCC85C_HUMAN
    AccessioniPrimary (citable) accession number: A6NKD9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3