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A6NKD9 (CC85C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coiled-coil domain-containing protein 85C
Gene names
Name:CCDC85C
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play an important role in cortical development, especially in the maintenance of radial glia By similarity.

Subcellular location

Cell junctiontight junction By similarity. Note: Localizes to the apical junction of radial glia in the wall of lateral ventricles of the developing brain By similarity. Colocalizes with TJP1 on the meshwork-like structure of adherens junctions on the lateral ventricles wall By similarity.

Sequence similarities

Belongs to the CCDC85 family.

Ontologies

Keywords
   Cellular componentCell junction
Tight junction
   DomainCoiled coil
   Molecular functionDevelopmental protein
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcerebral cortex development

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentapical junction complex

Inferred from sequence or structural similarity. Source: UniProtKB

tight junction

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.4
Chain2 – 419418Coiled-coil domain-containing protein 85C
PRO_0000345410

Regions

Coiled coil22 – 8867 Potential
Coiled coil118 – 15942 Potential
Compositional bias162 – 21554Gly-rich

Amino acid modifications

Modified residue21N-acetylalanine Ref.4
Modified residue2461Phosphoserine Ref.3

Sequences

Sequence LengthMass (Da)Tools
A6NKD9 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 01A8F447CE951007

FASTA41945,210
        10         20         30         40         50         60 
MAKPAATAAA ASEELSQVPD EELLRWSKEE LARRLRRAEG EKVGLMLEHG GLMRDVNRRL 

        70         80         90        100        110        120 
QQHLLEIRGL KDVNQRLQDD NQELRELCCF LDDDRQKGRK LAREWQRFGR HAAGAVWHEV 

       130        140        150        160        170        180 
ARSQQKLREL EARQEALLRE NLELKELVLL LDEERAALAA TGAASGGGGG GGGAGSRSSI 

       190        200        210        220        230        240 
DSQASLSGPL SGGAPGAGAR DVGDGSSTSS AGSGGSPDHH HHVPPPLLPP GPHKAPDGKA 

       250        260        270        280        290        300 
GATRRSLDDL SAPPHHRSIP NGLHDPSSTY IRQLESKVRL LEGDKLLAQQ AGSGEFRTLR 

       310        320        330        340        350        360 
KGFSPYHSES QLASLPPSYQ DSLQNGPACP APELPSPPSA GYSPAGQKPE AVVHAMKVLE 

       370        380        390        400        410 
VHENLDRQLQ DSCEEDLSEK EKAIVREMCN VVWRKLGDAA SSKPSIRQHL SGNQFKGPL 

« Hide

References

[1]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[3]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[4]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL110504 Genomic DNA. No translation available.
AL160313 Genomic DNA. No translation available.
RefSeqNP_001138467.1. NM_001144995.1.
UniGeneHs.709288.

3D structure databases

ProteinModelPortalA6NKD9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid130463. 3 interactions.
IntActA6NKD9. 9 interactions.
STRING9606.ENSP00000369592.

PTM databases

PhosphoSiteA6NKD9.

Proteomic databases

PaxDbA6NKD9.
PRIDEA6NKD9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000380243; ENSP00000369592; ENSG00000205476.
GeneID317762.
KEGGhsa:317762.
UCSCuc010avr.3. human.

Organism-specific databases

CTD317762.
GeneCardsGC14M099978.
H-InvDBHIX0011960.
HIX0059368.
HGNCHGNC:35459. CCDC85C.
HPAHPA058346.
neXtProtNX_A6NKD9.
PharmGKBPA164717760.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG315844.
HOGENOMHOG000294096.
HOVERGENHBG060368.
InParanoidA6NKD9.
OMALMLEHGG.
OrthoDBEOG7V49ZJ.
PhylomeDBA6NKD9.
TreeFamTF320243.

Gene expression databases

ArrayExpressA6NKD9.
BgeeA6NKD9.
GenevestigatorA6NKD9.

Family and domain databases

InterProIPR019359. DUF2216_coiled-coil.
[Graphical view]
PfamPF10226. DUF2216. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi317762.
NextBio96417.
PROA6NKD9.

Entry information

Entry nameCC85C_HUMAN
AccessionPrimary (citable) accession number: A6NKD9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM