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A6NKD9

- CC85C_HUMAN

UniProt

A6NKD9 - CC85C_HUMAN

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Protein

Coiled-coil domain-containing protein 85C

Gene

CCDC85C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May play an important role in cortical development, especially in the maintenance of radial glia.By similarity

GO - Biological processi

  1. cerebral cortex development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 85C
Gene namesi
Name:CCDC85C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:35459. CCDC85C.

Subcellular locationi

Cell junctiontight junction By similarity
Note: Localizes to the apical junction of radial glia in the wall of lateral ventricles of the developing brain. Colocalizes with TJP1 on the meshwork-like structure of adherens junctions on the lateral ventricles wall.By similarity

GO - Cellular componenti

  1. apical junction complex Source: UniProtKB
  2. tight junction Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Tight junction

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164717760.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 419418Coiled-coil domain-containing protein 85CPRO_0000345410Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei246 – 2461Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiA6NKD9.
PaxDbiA6NKD9.
PRIDEiA6NKD9.

PTM databases

PhosphoSiteiA6NKD9.

Expressioni

Gene expression databases

BgeeiA6NKD9.
ExpressionAtlasiA6NKD9. baseline and differential.
GenevestigatoriA6NKD9.

Organism-specific databases

HPAiHPA058346.

Interactioni

Protein-protein interaction databases

BioGridi130463. 13 interactions.
IntActiA6NKD9. 9 interactions.
STRINGi9606.ENSP00000369592.

Structurei

3D structure databases

ProteinModelPortaliA6NKD9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili22 – 8867Sequence AnalysisAdd
BLAST
Coiled coili118 – 15942Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi162 – 21554Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the CCDC85 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG315844.
GeneTreeiENSGT00390000003531.
HOGENOMiHOG000294096.
HOVERGENiHBG060368.
InParanoidiA6NKD9.
OMAiLMLEHGG.
OrthoDBiEOG7V49ZJ.
PhylomeDBiA6NKD9.
TreeFamiTF320243.

Family and domain databases

InterProiIPR019359. DUF2216_coiled-coil.
[Graphical view]
PfamiPF10226. DUF2216. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6NKD9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKPAATAAA ASEELSQVPD EELLRWSKEE LARRLRRAEG EKVGLMLEHG
60 70 80 90 100
GLMRDVNRRL QQHLLEIRGL KDVNQRLQDD NQELRELCCF LDDDRQKGRK
110 120 130 140 150
LAREWQRFGR HAAGAVWHEV ARSQQKLREL EARQEALLRE NLELKELVLL
160 170 180 190 200
LDEERAALAA TGAASGGGGG GGGAGSRSSI DSQASLSGPL SGGAPGAGAR
210 220 230 240 250
DVGDGSSTSS AGSGGSPDHH HHVPPPLLPP GPHKAPDGKA GATRRSLDDL
260 270 280 290 300
SAPPHHRSIP NGLHDPSSTY IRQLESKVRL LEGDKLLAQQ AGSGEFRTLR
310 320 330 340 350
KGFSPYHSES QLASLPPSYQ DSLQNGPACP APELPSPPSA GYSPAGQKPE
360 370 380 390 400
AVVHAMKVLE VHENLDRQLQ DSCEEDLSEK EKAIVREMCN VVWRKLGDAA
410
SSKPSIRQHL SGNQFKGPL
Length:419
Mass (Da):45,210
Last modified:July 24, 2007 - v1
Checksum:i01A8F447CE951007
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL110504 Genomic DNA. No translation available.
AL160313 Genomic DNA. No translation available.
CCDSiCCDS45161.1.
RefSeqiNP_001138467.1. NM_001144995.1.
UniGeneiHs.709288.

Genome annotation databases

EnsembliENST00000380243; ENSP00000369592; ENSG00000205476.
GeneIDi317762.
KEGGihsa:317762.
UCSCiuc010avr.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL110504 Genomic DNA. No translation available.
AL160313 Genomic DNA. No translation available.
CCDSi CCDS45161.1.
RefSeqi NP_001138467.1. NM_001144995.1.
UniGenei Hs.709288.

3D structure databases

ProteinModelPortali A6NKD9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 130463. 13 interactions.
IntActi A6NKD9. 9 interactions.
STRINGi 9606.ENSP00000369592.

PTM databases

PhosphoSitei A6NKD9.

Proteomic databases

MaxQBi A6NKD9.
PaxDbi A6NKD9.
PRIDEi A6NKD9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000380243 ; ENSP00000369592 ; ENSG00000205476 .
GeneIDi 317762.
KEGGi hsa:317762.
UCSCi uc010avr.3. human.

Organism-specific databases

CTDi 317762.
GeneCardsi GC14M099978.
H-InvDB HIX0011960.
HIX0059368.
HGNCi HGNC:35459. CCDC85C.
HPAi HPA058346.
neXtProti NX_A6NKD9.
PharmGKBi PA164717760.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG315844.
GeneTreei ENSGT00390000003531.
HOGENOMi HOG000294096.
HOVERGENi HBG060368.
InParanoidi A6NKD9.
OMAi LMLEHGG.
OrthoDBi EOG7V49ZJ.
PhylomeDBi A6NKD9.
TreeFami TF320243.

Miscellaneous databases

GenomeRNAii 317762.
NextBioi 96417.
PROi A6NKD9.

Gene expression databases

Bgeei A6NKD9.
ExpressionAtlasi A6NKD9. baseline and differential.
Genevestigatori A6NKD9.

Family and domain databases

InterProi IPR019359. DUF2216_coiled-coil.
[Graphical view ]
Pfami PF10226. DUF2216. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCC85C_HUMAN
AccessioniPrimary (citable) accession number: A6NKD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3