A6NKD9 (CC85C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Coiled-coil domain-containing protein 85C

Gene names

Name:

CCDC85C

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	419 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play an important role in cortical development, especially in the maintenance of radial glia By similarity.
Subcellular location	Cell junction › tight junction By similarity. Note: Localizes to the apical junction of radial glia in the wall of lateral ventricles of the developing brain By similarity. Colocalizes with TJP1 on the meshwork-like structure of adherens junctions on the lateral ventricles wall By similarity.
Sequence similarities	Belongs to the CCDC85 family.

Ontologies

Keywords
Cellular component	Cell junction Tight junction
Domain	Coiled coil
Molecular function	Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cerebral cortex development Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	apical junction complex Inferred from sequence or structural similarity. Source: UniProtKB tight junction Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 419	419	Coiled-coil domain-containing protein 85C		PRO_0000345410
Regions
	Coiled coil	22 – 88	67	Potential
	Coiled coil	118 – 159	42	Potential
	Compositional bias	162 – 215	54	Gly-rich
Amino acid modifications
	Modified residue	246	1	Phosphoserine Ref.2

Sequences

	Sequence		Length	Mass (Da)
	A6NKD9 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 01A8F447CE951007	FASTA	419	45,210
	10 20 30 40 50 60 MAKPAATAAA ASEELSQVPD EELLRWSKEE LARRLRRAEG EKVGLMLEHG GLMRDVNRRL 70 80 90 100 110 120 QQHLLEIRGL KDVNQRLQDD NQELRELCCF LDDDRQKGRK LAREWQRFGR HAAGAVWHEV 130 140 150 160 170 180 ARSQQKLREL EARQEALLRE NLELKELVLL LDEERAALAA TGAASGGGGG GGGAGSRSSI 190 200 210 220 230 240 DSQASLSGPL SGGAPGAGAR DVGDGSSTSS AGSGGSPDHH HHVPPPLLPP GPHKAPDGKA 250 260 270 280 290 300 GATRRSLDDL SAPPHHRSIP NGLHDPSSTY IRQLESKVRL LEGDKLLAQQ AGSGEFRTLR 310 320 330 340 350 360 KGFSPYHSES QLASLPPSYQ DSLQNGPACP APELPSPPSA GYSPAGQKPE AVVHAMKVLE 370 380 390 400 410 VHENLDRQLQ DSCEEDLSEK EKAIVREMCN VVWRKLGDAA SSKPSIRQHL SGNQFKGPL

References

[1]

"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL110504 Genomic DNA. No translation available. AL160313 Genomic DNA. No translation available.
IPI	IPI00657798.
RefSeq	NP_001138467.1. NM_001144995.1.
UniGene	Hs.709288.
3D structure databases
ProteinModelPortal	A6NKD9.
ModBase	Search...
Protein-protein interaction databases
IntAct	A6NKD9. 2 interactions.
STRING	9606.ENSP00000369592.
PTM databases
PhosphoSite	A6NKD9.
Proteomic databases
PaxDb	A6NKD9.
PRIDE	A6NKD9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000380243; ENSP00000369592; ENSG00000205476.
GeneID	317762.
KEGG	hsa:317762.
UCSC	uc010avr.3. human.
Organism-specific databases
CTD	317762.
GeneCards	GC14M099978.
H-InvDB	HIX0011960. HIX0059368.
HGNC	HGNC:35459. CCDC85C.
neXtProt	NX_A6NKD9.
PharmGKB	PA164717760.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG315844.
HOGENOM	HOG000294096.
HOVERGEN	HBG060368.
InParanoid	A6NKD9.
OMA	VMWKEVG.
OrthoDB	EOG4J3WH9.
Gene expression databases
ArrayExpress	A6NKD9.
Bgee	A6NKD9.
Genevestigator	A6NKD9.
Family and domain databases
InterPro	IPR019359. DUF2216_coiled-coil. [Graphical view]
Pfam	PF10226. DUF2216. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	317762.
NextBio	96417.

Entry information

Entry name

CC85C_HUMAN

Accession

Primary (citable) accession number: A6NKD9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	July 24, 2007
Last modified:	April 3, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.