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Protein

Coiled-coil domain-containing protein 85C

Gene

CCDC85C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in cortical development, especially in the maintenance of radial glia.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 85C
Gene namesi
Name:CCDC85C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:35459. CCDC85C.

Subcellular locationi

  • Cell junctiontight junction By similarity

  • Note: Localizes to the apical junction of radial glia in the wall of lateral ventricles of the developing brain. Colocalizes with TJP1 on the meshwork-like structure of adherens junctions on the lateral ventricles wall.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Tight junction

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164717760.

Polymorphism and mutation databases

BioMutaiCCDC85C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 419418Coiled-coil domain-containing protein 85CPRO_0000345410Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei178 – 1781Phosphoserine1 Publication
Modified residuei246 – 2461Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiA6NKD9.
PaxDbiA6NKD9.
PRIDEiA6NKD9.

PTM databases

PhosphoSiteiA6NKD9.

Expressioni

Gene expression databases

BgeeiA6NKD9.
ExpressionAtlasiA6NKD9. baseline and differential.
GenevisibleiA6NKD9. HS.

Organism-specific databases

HPAiHPA058346.

Interactioni

Protein-protein interaction databases

BioGridi130463. 17 interactions.
IntActiA6NKD9. 9 interactions.
STRINGi9606.ENSP00000369592.

Structurei

3D structure databases

ProteinModelPortaliA6NKD9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili22 – 8867Sequence AnalysisAdd
BLAST
Coiled coili118 – 15942Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi162 – 21554Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the CCDC85 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG315844.
GeneTreeiENSGT00390000003531.
HOGENOMiHOG000294096.
HOVERGENiHBG060368.
InParanoidiA6NKD9.
OMAiLMLEHGG.
OrthoDBiEOG7V49ZJ.
PhylomeDBiA6NKD9.
TreeFamiTF320243.

Family and domain databases

InterProiIPR019359. DUF2216_coiled-coil.
[Graphical view]
PfamiPF10226. DUF2216. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6NKD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKPAATAAA ASEELSQVPD EELLRWSKEE LARRLRRAEG EKVGLMLEHG
60 70 80 90 100
GLMRDVNRRL QQHLLEIRGL KDVNQRLQDD NQELRELCCF LDDDRQKGRK
110 120 130 140 150
LAREWQRFGR HAAGAVWHEV ARSQQKLREL EARQEALLRE NLELKELVLL
160 170 180 190 200
LDEERAALAA TGAASGGGGG GGGAGSRSSI DSQASLSGPL SGGAPGAGAR
210 220 230 240 250
DVGDGSSTSS AGSGGSPDHH HHVPPPLLPP GPHKAPDGKA GATRRSLDDL
260 270 280 290 300
SAPPHHRSIP NGLHDPSSTY IRQLESKVRL LEGDKLLAQQ AGSGEFRTLR
310 320 330 340 350
KGFSPYHSES QLASLPPSYQ DSLQNGPACP APELPSPPSA GYSPAGQKPE
360 370 380 390 400
AVVHAMKVLE VHENLDRQLQ DSCEEDLSEK EKAIVREMCN VVWRKLGDAA
410
SSKPSIRQHL SGNQFKGPL
Length:419
Mass (Da):45,210
Last modified:July 24, 2007 - v1
Checksum:i01A8F447CE951007
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL110504 Genomic DNA. No translation available.
AL160313 Genomic DNA. No translation available.
CCDSiCCDS45161.1.
RefSeqiNP_001138467.1. NM_001144995.1.
UniGeneiHs.709288.

Genome annotation databases

EnsembliENST00000380243; ENSP00000369592; ENSG00000205476.
GeneIDi317762.
KEGGihsa:317762.
UCSCiuc010avr.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL110504 Genomic DNA. No translation available.
AL160313 Genomic DNA. No translation available.
CCDSiCCDS45161.1.
RefSeqiNP_001138467.1. NM_001144995.1.
UniGeneiHs.709288.

3D structure databases

ProteinModelPortaliA6NKD9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130463. 17 interactions.
IntActiA6NKD9. 9 interactions.
STRINGi9606.ENSP00000369592.

PTM databases

PhosphoSiteiA6NKD9.

Polymorphism and mutation databases

BioMutaiCCDC85C.

Proteomic databases

MaxQBiA6NKD9.
PaxDbiA6NKD9.
PRIDEiA6NKD9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380243; ENSP00000369592; ENSG00000205476.
GeneIDi317762.
KEGGihsa:317762.
UCSCiuc010avr.3. human.

Organism-specific databases

CTDi317762.
GeneCardsiGC14M099978.
H-InvDBHIX0011960.
HIX0059368.
HGNCiHGNC:35459. CCDC85C.
HPAiHPA058346.
neXtProtiNX_A6NKD9.
PharmGKBiPA164717760.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG315844.
GeneTreeiENSGT00390000003531.
HOGENOMiHOG000294096.
HOVERGENiHBG060368.
InParanoidiA6NKD9.
OMAiLMLEHGG.
OrthoDBiEOG7V49ZJ.
PhylomeDBiA6NKD9.
TreeFamiTF320243.

Miscellaneous databases

GenomeRNAii317762.
NextBioi96417.
PROiA6NKD9.

Gene expression databases

BgeeiA6NKD9.
ExpressionAtlasiA6NKD9. baseline and differential.
GenevisibleiA6NKD9. HS.

Family and domain databases

InterProiIPR019359. DUF2216_coiled-coil.
[Graphical view]
PfamiPF10226. DUF2216. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178 AND SER-246, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCC85C_HUMAN
AccessioniPrimary (citable) accession number: A6NKD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 24, 2007
Last modified: June 24, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.