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Protein

Testis-specific Y-encoded protein 2

Gene

TSPY2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Gonadal differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific Y-encoded protein 2
Alternative name(s):
Testis-specific Y-encoded protein Q1
Gene namesi
Name:TSPY2
Synonyms:TSPYQ1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome Y

Organism-specific databases

EuPathDBiHostDB:ENSG00000168757.12
HGNCiHGNC:23924 TSPY2
neXtProtiNX_A6NKD2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134958857

Polymorphism and mutation databases

BioMutaiTSPY2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003331971 – 308Testis-specific Y-encoded protein 2Add BLAST308

Proteomic databases

MaxQBiA6NKD2
PaxDbiA6NKD2
PRIDEiA6NKD2

PTM databases

iPTMnetiA6NKD2
PhosphoSitePlusiA6NKD2

Expressioni

Gene expression databases

BgeeiENSG00000168757
CleanExiHS_TSPY2
ExpressionAtlasiA6NKD2 baseline and differential
GenevisibleiA6NKD2 HS

Organism-specific databases

HPAiHPA049384

Interactioni

Protein-protein interaction databases

BioGridi1222122 interactors.
IntActiA6NKD2 1 interactor.
STRINGi9606.ENSP00000314077

Structurei

3D structure databases

ProteinModelPortaliA6NKD2
SMRiA6NKD2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1508 Eukaryota
ENOG410XQRX LUCA
GeneTreeiENSGT00530000062882
HOGENOMiHOG000253937
HOVERGENiHBG014779
InParanoidiA6NKD2
OMAiWEPREND
OrthoDBiEOG091G0FRU
PhylomeDBiA6NKD2
TreeFamiTF313386

Family and domain databases

InterProiView protein in InterPro
IPR037231 NAP-like_sf
IPR002164 NAP_family
PANTHERiPTHR11875 PTHR11875, 1 hit
PfamiView protein in Pfam
PF00956 NAP, 1 hit
SUPFAMiSSF143113 SSF143113, 1 hit

Sequencei

Sequence statusi: Complete.

A6NKD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPEGSLTYR VPERLRQGSC GVGRAAQALV CASAKEGTAF RMEAVQEGAA
60 70 80 90 100
GVESEQAALG EEAVLLLDDI MAEVEVVAEE EGLVERREEA QRAQQAVPGP
110 120 130 140 150
GPMTPESALE ELLAVQVELE PVNAQARKAF SRQREKMERR RKPHLDRRGA
160 170 180 190 200
VIQSVPGFWA NVIANHPQMS ALITDEDEDM LSYMVSLEVE EEKHRVHLCK
210 220 230 240 250
IMLFFRSNPY FQNKVITKEY LVNITEYRAS HSTPIEWYPD YEVEAYRRRH
260 270 280 290 300
HNSSLNFFNW FSDHNFAGSN KIAEILCKDL WRNPLQYYKR MKPPEEGTET

SGDSQLLS
Length:308
Mass (Da):35,100
Last modified:January 15, 2008 - v1
Checksum:i244AF6DEC39277FE
GO

Polymorphismi

Maps to a tandemly repeated region on chromosome Yp11; additionally at least one copy is reported originating from Yq. The gene is thought to be present with an inter-individual variation in copy number and between 20 and 60 copies per Y chromosome are expected. PubMed:12815422 reports 35 tandemly repeated gene copies on Yp11 originating from one individual.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006335 Genomic DNA No translation available.
CCDSiCCDS35465.1
RefSeqiNP_072095.2, NM_022573.2
UniGeneiHs.646249

Genome annotation databases

EnsembliENST00000320701; ENSP00000314077; ENSG00000168757
GeneIDi64591
KEGGihsa:64591
UCSCiuc004fqr.2 human

Similar proteinsi

Entry informationi

Entry nameiTSPY2_HUMAN
AccessioniPrimary (citable) accession number: A6NKD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 15, 2008
Last modified: April 25, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome