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A6NKD2

- TSPY2_HUMAN

UniProt

A6NKD2 - TSPY2_HUMAN

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Protein

Testis-specific Y-encoded protein 2

Gene

TSPY2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Unknown. May be involved in sperm differentiation and proliferation By similarity.By similarity

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. gonadal mesoderm development Source: UniProtKB-KW
  3. nucleosome assembly Source: InterPro
  4. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Gonadal differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific Y-encoded protein 2
Alternative name(s):
Testis-specific Y-encoded protein Q1
Gene namesi
Name:TSPY2
Synonyms:TSPYQ1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome Y

Organism-specific databases

HGNCiHGNC:23924. TSPY2.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134958857.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Testis-specific Y-encoded protein 2PRO_0000333197Add
BLAST

Proteomic databases

PaxDbiA6NKD2.
PRIDEiA6NKD2.

Expressioni

Gene expression databases

BgeeiA6NKD2.
CleanExiHS_TSPY2.
ExpressionAtlasiA6NKD2. baseline.
GenevestigatoriA6NKD2.

Organism-specific databases

HPAiHPA049384.

Interactioni

Protein-protein interaction databases

BioGridi122212. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliA6NKD2.
SMRiA6NKD2. Positions 106-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG277815.
GeneTreeiENSGT00530000062882.
HOGENOMiHOG000253937.
HOVERGENiHBG014779.
InParanoidiA6NKD2.
OMAiFVERRNE.
OrthoDBiEOG7FBRJB.
PhylomeDBiA6NKD2.
TreeFamiTF313386.

Family and domain databases

InterProiIPR002164. NAP_family.
[Graphical view]
PANTHERiPTHR11875. PTHR11875. 1 hit.
PfamiPF00956. NAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NKD2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRPEGSLTYR VPERLRQGSC GVGRAAQALV CASAKEGTAF RMEAVQEGAA
60 70 80 90 100
GVESEQAALG EEAVLLLDDI MAEVEVVAEE EGLVERREEA QRAQQAVPGP
110 120 130 140 150
GPMTPESALE ELLAVQVELE PVNAQARKAF SRQREKMERR RKPHLDRRGA
160 170 180 190 200
VIQSVPGFWA NVIANHPQMS ALITDEDEDM LSYMVSLEVE EEKHRVHLCK
210 220 230 240 250
IMLFFRSNPY FQNKVITKEY LVNITEYRAS HSTPIEWYPD YEVEAYRRRH
260 270 280 290 300
HNSSLNFFNW FSDHNFAGSN KIAEILCKDL WRNPLQYYKR MKPPEEGTET

SGDSQLLS
Length:308
Mass (Da):35,100
Last modified:January 15, 2008 - v1
Checksum:i244AF6DEC39277FE
GO

Polymorphismi

Maps to a tandemly repeated region on chromosome Yp11; additionally at least one copy is reported originating from Yq. The gene is thought to be present with an inter-individual variation in copy number and between 20 and 60 copies per Y chromosome are expected. PubMed:12815422 reports 35 tandemly repeated gene copies on Yp11 originating from one individual.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006335 Genomic DNA. No translation available.
CCDSiCCDS35465.1.
RefSeqiNP_072095.2. NM_022573.2.
UniGeneiHs.556121.
Hs.646249.

Genome annotation databases

EnsembliENST00000320701; ENSP00000314077; ENSG00000168757.
GeneIDi64591.
KEGGihsa:64591.
UCSCiuc004fqr.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006335 Genomic DNA. No translation available.
CCDSi CCDS35465.1.
RefSeqi NP_072095.2. NM_022573.2.
UniGenei Hs.556121.
Hs.646249.

3D structure databases

ProteinModelPortali A6NKD2.
SMRi A6NKD2. Positions 106-288.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122212. 2 interactions.

Proteomic databases

PaxDbi A6NKD2.
PRIDEi A6NKD2.

Protocols and materials databases

DNASUi 64591.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000320701 ; ENSP00000314077 ; ENSG00000168757 .
GeneIDi 64591.
KEGGi hsa:64591.
UCSCi uc004fqr.1. human.

Organism-specific databases

CTDi 64591.
GeneCardsi GC0YP006114.
HGNCi HGNC:23924. TSPY2.
HPAi HPA049384.
neXtProti NX_A6NKD2.
PharmGKBi PA134958857.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG277815.
GeneTreei ENSGT00530000062882.
HOGENOMi HOG000253937.
HOVERGENi HBG014779.
InParanoidi A6NKD2.
OMAi FVERRNE.
OrthoDBi EOG7FBRJB.
PhylomeDBi A6NKD2.
TreeFami TF313386.

Miscellaneous databases

GenomeRNAii 64591.
NextBioi 66538.
PROi A6NKD2.

Gene expression databases

Bgeei A6NKD2.
CleanExi HS_TSPY2.
ExpressionAtlasi A6NKD2. baseline.
Genevestigatori A6NKD2.

Family and domain databases

InterProi IPR002164. NAP_family.
[Graphical view ]
PANTHERi PTHR11875. PTHR11875. 1 hit.
Pfami PF00956. NAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTSPY2_HUMAN
AccessioniPrimary (citable) accession number: A6NKD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 15, 2008
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3