Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A6NKD2 (TSPY2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Testis-specific Y-encoded protein 2
Alternative name(s):
Testis-specific Y-encoded protein Q1
Gene names
Name:TSPY2
Synonyms:TSPYQ1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Unknown. May be involved in sperm differentiation and proliferation By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Polymorphism

Maps to a tandemly repeated region on chromosome Yp11; additionally at least one copy is reported originating from Yq. The gene is thought to be present with an inter-individual variation in copy number and between 20 and 60 copies per Y chromosome are expected. Ref.1 reports 35 tandemly repeated gene copies on Yp11 originating from one individual.

Sequence similarities

Belongs to the nucleosome assembly protein (NAP) family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 308308Testis-specific Y-encoded protein 2
PRO_0000333197

Sequences

Sequence LengthMass (Da)Tools
A6NKD2 [UniParc].

Last modified January 15, 2008. Version 1.
Checksum: 244AF6DEC39277FE

FASTA30835,100
        10         20         30         40         50         60 
MRPEGSLTYR VPERLRQGSC GVGRAAQALV CASAKEGTAF RMEAVQEGAA GVESEQAALG 

        70         80         90        100        110        120 
EEAVLLLDDI MAEVEVVAEE EGLVERREEA QRAQQAVPGP GPMTPESALE ELLAVQVELE 

       130        140        150        160        170        180 
PVNAQARKAF SRQREKMERR RKPHLDRRGA VIQSVPGFWA NVIANHPQMS ALITDEDEDM 

       190        200        210        220        230        240 
LSYMVSLEVE EEKHRVHLCK IMLFFRSNPY FQNKVITKEY LVNITEYRAS HSTPIEWYPD 

       250        260        270        280        290        300 
YEVEAYRRRH HNSSLNFFNW FSDHNFAGSN KIAEILCKDL WRNPLQYYKR MKPPEEGTET 


SGDSQLLS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC006335 Genomic DNA. No translation available.
CCDSCCDS35465.1.
RefSeqNP_072095.2. NM_022573.2.
UniGeneHs.556121.
Hs.646249.

3D structure databases

ProteinModelPortalA6NKD2.
SMRA6NKD2. Positions 106-288.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122212. 2 interactions.

Proteomic databases

PaxDbA6NKD2.
PRIDEA6NKD2.

Protocols and materials databases

DNASU64591.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000320701; ENSP00000314077; ENSG00000168757.
GeneID64591.
KEGGhsa:64591.
UCSCuc004fqr.1. human.

Organism-specific databases

CTD64591.
GeneCardsGC0YP006114.
HGNCHGNC:23924. TSPY2.
HPAHPA049384.
neXtProtNX_A6NKD2.
PharmGKBPA134958857.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG277815.
HOGENOMHOG000253937.
HOVERGENHBG014779.
InParanoidA6NKD2.
OMAFVERRNE.
OrthoDBEOG7FBRJB.
PhylomeDBA6NKD2.
TreeFamTF313386.

Gene expression databases

BgeeA6NKD2.
CleanExHS_TSPY2.
GenevestigatorA6NKD2.

Family and domain databases

InterProIPR002164. NAP_family.
[Graphical view]
PANTHERPTHR11875. PTHR11875. 1 hit.
PfamPF00956. NAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi64591.
NextBio66538.
PROA6NKD2.

Entry information

Entry nameTSPY2_HUMAN
AccessionPrimary (citable) accession number: A6NKD2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 15, 2008
Last modified: July 9, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome Y

Human chromosome Y: entries, gene names and cross-references to MIM