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A6NKD2

- TSPY2_HUMAN

UniProt

A6NKD2 - TSPY2_HUMAN

Protein

Testis-specific Y-encoded protein 2

Gene

TSPY2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Unknown. May be involved in sperm differentiation and proliferation By similarity.By similarity

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. gonadal mesoderm development Source: UniProtKB-KW
    3. nucleosome assembly Source: InterPro
    4. spermatogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Gonadal differentiation, Spermatogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Testis-specific Y-encoded protein 2
    Alternative name(s):
    Testis-specific Y-encoded protein Q1
    Gene namesi
    Name:TSPY2
    Synonyms:TSPYQ1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome Y

    Organism-specific databases

    HGNCiHGNC:23924. TSPY2.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134958857.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 308308Testis-specific Y-encoded protein 2PRO_0000333197Add
    BLAST

    Proteomic databases

    PaxDbiA6NKD2.
    PRIDEiA6NKD2.

    Expressioni

    Gene expression databases

    BgeeiA6NKD2.
    CleanExiHS_TSPY2.
    GenevestigatoriA6NKD2.

    Organism-specific databases

    HPAiHPA049384.

    Interactioni

    Protein-protein interaction databases

    BioGridi122212. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NKD2.
    SMRiA6NKD2. Positions 106-288.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG277815.
    HOGENOMiHOG000253937.
    HOVERGENiHBG014779.
    InParanoidiA6NKD2.
    OMAiFVERRNE.
    OrthoDBiEOG7FBRJB.
    PhylomeDBiA6NKD2.
    TreeFamiTF313386.

    Family and domain databases

    InterProiIPR002164. NAP_family.
    [Graphical view]
    PANTHERiPTHR11875. PTHR11875. 1 hit.
    PfamiPF00956. NAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6NKD2-1 [UniParc]FASTAAdd to Basket

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    MRPEGSLTYR VPERLRQGSC GVGRAAQALV CASAKEGTAF RMEAVQEGAA    50
    GVESEQAALG EEAVLLLDDI MAEVEVVAEE EGLVERREEA QRAQQAVPGP 100
    GPMTPESALE ELLAVQVELE PVNAQARKAF SRQREKMERR RKPHLDRRGA 150
    VIQSVPGFWA NVIANHPQMS ALITDEDEDM LSYMVSLEVE EEKHRVHLCK 200
    IMLFFRSNPY FQNKVITKEY LVNITEYRAS HSTPIEWYPD YEVEAYRRRH 250
    HNSSLNFFNW FSDHNFAGSN KIAEILCKDL WRNPLQYYKR MKPPEEGTET 300
    SGDSQLLS 308
    Length:308
    Mass (Da):35,100
    Last modified:January 15, 2008 - v1
    Checksum:i244AF6DEC39277FE
    GO

    Polymorphismi

    Maps to a tandemly repeated region on chromosome Yp11; additionally at least one copy is reported originating from Yq. The gene is thought to be present with an inter-individual variation in copy number and between 20 and 60 copies per Y chromosome are expected. PubMed:12815422 reports 35 tandemly repeated gene copies on Yp11 originating from one individual.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC006335 Genomic DNA. No translation available.
    CCDSiCCDS35465.1.
    RefSeqiNP_072095.2. NM_022573.2.
    UniGeneiHs.556121.
    Hs.646249.

    Genome annotation databases

    EnsembliENST00000320701; ENSP00000314077; ENSG00000168757.
    GeneIDi64591.
    KEGGihsa:64591.
    UCSCiuc004fqr.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC006335 Genomic DNA. No translation available.
    CCDSi CCDS35465.1.
    RefSeqi NP_072095.2. NM_022573.2.
    UniGenei Hs.556121.
    Hs.646249.

    3D structure databases

    ProteinModelPortali A6NKD2.
    SMRi A6NKD2. Positions 106-288.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122212. 2 interactions.

    Proteomic databases

    PaxDbi A6NKD2.
    PRIDEi A6NKD2.

    Protocols and materials databases

    DNASUi 64591.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000320701 ; ENSP00000314077 ; ENSG00000168757 .
    GeneIDi 64591.
    KEGGi hsa:64591.
    UCSCi uc004fqr.1. human.

    Organism-specific databases

    CTDi 64591.
    GeneCardsi GC0YP006114.
    HGNCi HGNC:23924. TSPY2.
    HPAi HPA049384.
    neXtProti NX_A6NKD2.
    PharmGKBi PA134958857.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG277815.
    HOGENOMi HOG000253937.
    HOVERGENi HBG014779.
    InParanoidi A6NKD2.
    OMAi FVERRNE.
    OrthoDBi EOG7FBRJB.
    PhylomeDBi A6NKD2.
    TreeFami TF313386.

    Miscellaneous databases

    GenomeRNAii 64591.
    NextBioi 66538.
    PROi A6NKD2.

    Gene expression databases

    Bgeei A6NKD2.
    CleanExi HS_TSPY2.
    Genevestigatori A6NKD2.

    Family and domain databases

    InterProi IPR002164. NAP_family.
    [Graphical view ]
    PANTHERi PTHR11875. PTHR11875. 1 hit.
    Pfami PF00956. NAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiTSPY2_HUMAN
    AccessioniPrimary (citable) accession number: A6NKD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome Y
      Human chromosome Y: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3