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Protein

Testis-specific Y-encoded protein 2

Gene

TSPY2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Unknown. May be involved in sperm differentiation and proliferation (By similarity).By similarity

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. gonadal mesoderm development Source: UniProtKB-KW
  3. nucleosome assembly Source: InterPro
  4. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Gonadal differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific Y-encoded protein 2
Alternative name(s):
Testis-specific Y-encoded protein Q1
Gene namesi
Name:TSPY2
Synonyms:TSPYQ1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome Y

Organism-specific databases

HGNCiHGNC:23924. TSPY2.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134958857.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Testis-specific Y-encoded protein 2PRO_0000333197Add
BLAST

Proteomic databases

PaxDbiA6NKD2.
PRIDEiA6NKD2.

Expressioni

Gene expression databases

BgeeiA6NKD2.
CleanExiHS_TSPY2.
ExpressionAtlasiA6NKD2. baseline.
GenevestigatoriA6NKD2.

Organism-specific databases

HPAiHPA049384.

Interactioni

Protein-protein interaction databases

BioGridi122212. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliA6NKD2.
SMRiA6NKD2. Positions 106-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG277815.
GeneTreeiENSGT00530000062882.
HOGENOMiHOG000253937.
HOVERGENiHBG014779.
InParanoidiA6NKD2.
OMAiFVERRNE.
OrthoDBiEOG7FBRJB.
PhylomeDBiA6NKD2.
TreeFamiTF313386.

Family and domain databases

InterProiIPR002164. NAP_family.
[Graphical view]
PANTHERiPTHR11875. PTHR11875. 1 hit.
PfamiPF00956. NAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NKD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPEGSLTYR VPERLRQGSC GVGRAAQALV CASAKEGTAF RMEAVQEGAA
60 70 80 90 100
GVESEQAALG EEAVLLLDDI MAEVEVVAEE EGLVERREEA QRAQQAVPGP
110 120 130 140 150
GPMTPESALE ELLAVQVELE PVNAQARKAF SRQREKMERR RKPHLDRRGA
160 170 180 190 200
VIQSVPGFWA NVIANHPQMS ALITDEDEDM LSYMVSLEVE EEKHRVHLCK
210 220 230 240 250
IMLFFRSNPY FQNKVITKEY LVNITEYRAS HSTPIEWYPD YEVEAYRRRH
260 270 280 290 300
HNSSLNFFNW FSDHNFAGSN KIAEILCKDL WRNPLQYYKR MKPPEEGTET

SGDSQLLS
Length:308
Mass (Da):35,100
Last modified:January 15, 2008 - v1
Checksum:i244AF6DEC39277FE
GO

Polymorphismi

Maps to a tandemly repeated region on chromosome Yp11; additionally at least one copy is reported originating from Yq. The gene is thought to be present with an inter-individual variation in copy number and between 20 and 60 copies per Y chromosome are expected. PubMed:12815422 reports 35 tandemly repeated gene copies on Yp11 originating from one individual.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006335 Genomic DNA. No translation available.
CCDSiCCDS35465.1.
RefSeqiNP_072095.2. NM_022573.2.
UniGeneiHs.556121.
Hs.646249.

Genome annotation databases

EnsembliENST00000320701; ENSP00000314077; ENSG00000168757.
ENST00000623051; ENSP00000485537; ENSG00000279308.
GeneIDi64591.
KEGGihsa:64591.
UCSCiuc004fqr.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006335 Genomic DNA. No translation available.
CCDSiCCDS35465.1.
RefSeqiNP_072095.2. NM_022573.2.
UniGeneiHs.556121.
Hs.646249.

3D structure databases

ProteinModelPortaliA6NKD2.
SMRiA6NKD2. Positions 106-288.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122212. 2 interactions.

Proteomic databases

PaxDbiA6NKD2.
PRIDEiA6NKD2.

Protocols and materials databases

DNASUi64591.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320701; ENSP00000314077; ENSG00000168757.
ENST00000623051; ENSP00000485537; ENSG00000279308.
GeneIDi64591.
KEGGihsa:64591.
UCSCiuc004fqr.1. human.

Organism-specific databases

CTDi64591.
GeneCardsiGC0YP006114.
HGNCiHGNC:23924. TSPY2.
HPAiHPA049384.
neXtProtiNX_A6NKD2.
PharmGKBiPA134958857.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG277815.
GeneTreeiENSGT00530000062882.
HOGENOMiHOG000253937.
HOVERGENiHBG014779.
InParanoidiA6NKD2.
OMAiFVERRNE.
OrthoDBiEOG7FBRJB.
PhylomeDBiA6NKD2.
TreeFamiTF313386.

Miscellaneous databases

GenomeRNAii64591.
NextBioi66538.
PROiA6NKD2.

Gene expression databases

BgeeiA6NKD2.
CleanExiHS_TSPY2.
ExpressionAtlasiA6NKD2. baseline.
GenevestigatoriA6NKD2.

Family and domain databases

InterProiIPR002164. NAP_family.
[Graphical view]
PANTHERiPTHR11875. PTHR11875. 1 hit.
PfamiPF00956. NAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTSPY2_HUMAN
AccessioniPrimary (citable) accession number: A6NKD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 15, 2008
Last modified: January 7, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.