Reviewed, UniProtKB/Swiss-Prot A6NKD2 (TSPY2_HUMAN)

Names and origin

Protein names

Recommended name:
    Testis-specific Y-encoded protein 2
Alternative name(s):
    Testis-specific Y-encoded protein Q1

Gene names

Name:	TSPY2
Synonyms:	TSPYQ1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Unknown. May be involved in sperm differentiation and proliferation By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Polymorphism	Maps to a tandemly repeated region on chromosome Yp11; additionally at least one copy is reported originating from Yq. The gene is thought to be present with an inter-individual variation in copy number and between 20 and 60 copies per Y chromosome are expected. Ref.1 reports 35 tandemly repeated gene copies on Yp11 originating from one individual.
Sequence similarities	Belongs to the nucleosome assembly protein (NAP) family.

Ontologies

Keywords
Biological process	Differentiation Gonadal differentiation Spermatogenesis
Cellular component	Cytoplasm Nucleus
Molecular function	Developmental protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW gonadal mesoderm development Inferred from electronic annotation. Source: UniProtKB-KW nucleosome assembly Inferred from electronic annotation. Source: InterPro spermatogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 308	308	Testis-specific Y-encoded protein 2		PRO_0000333197

Sequences

	Sequence		Length	Mass (Da)
	A6NKD2-1 [UniParc]. Last modified January 15, 2008. Version 1. Checksum: 244AF6DEC39277FE	FASTA	308	35,100
	10 20 30 40 50 60 MRPEGSLTYR VPERLRQGSC GVGRAAQALV CASAKEGTAF RMEAVQEGAA GVESEQAALG 70 80 90 100 110 120 EEAVLLLDDI MAEVEVVAEE EGLVERREEA QRAQQAVPGP GPMTPESALE ELLAVQVELE 130 140 150 160 170 180 PVNAQARKAF SRQREKMERR RKPHLDRRGA VIQSVPGFWA NVIANHPQMS ALITDEDEDM 190 200 210 220 230 240 LSYMVSLEVE EEKHRVHLCK IMLFFRSNPY FQNKVITKEY LVNITEYRAS HSTPIEWYPD 250 260 270 280 290 300 YEVEAYRRRH HNSSLNFFNW FSDHNFAGSN KIAEILCKDL WRNPLQYYKR MKPPEEGTET SGDSQLLS

References

[1]

"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes." Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. , Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H., Wilson R.K., Rozen S., Page D.C. Nature 423:825-837(2003) [PubMed: 12815422] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC006335 Genomic DNA. No translation available.
IPI	IPI00479931.
RefSeq	NP_072095.2.
UniGene	Hs.592352 Hs.646249
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6NKD2.
Proteomic databases
PRIDE	A6NKD2.
Genome annotation databases
Ensembl	ENST00000320701; ENSP00000314077; ENSG00000168757; Homo sapiens. [Genome view]
GeneID	64591.
KEGG	hsa:64591.
UCSC	uc004fqr.1. human.
Organism-specific databases
CTD	64591.
GeneCards	GC0YP006174.
HGNC	HGNC:23924. TSPY2.
GenAtlas	Search...
Phylogenomic databases
OMA	FVERRNE
OrthoDB	EOG9SJ82Q
Gene expression databases
Bgee	A6NKD2.
CleanEx	HS_TSPY2.
Genevestigator	A6NKD2.
Family and domain databases
InterPro	IPR002164. NAP_family. [Graphical view]
PANTHER	PTHR11875. NAP_family. 1 hit.
Pfam	PF00956. NAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	66538.

Entry information

Entry name

TSPY2_HUMAN

Accession

Primary (citable) accession number: A6NKD2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	January 15, 2008
Last modified:	November 24, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.