A6NKC9 (SH2D7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SH2 domain-containing protein 7

Gene names

Name:

SH2D7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	451 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 SH2 domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	SH2 domain
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 451	451	SH2 domain-containing protein 7		PRO_0000341254
Regions
	Domain	51 – 142	92	SH2
Natural variations
	Natural variant	137	1	M → T. Corresponds to variant rs2289524 [ dbSNP | Ensembl ].		VAR_060127
	Natural variant	206	1	R → W. Corresponds to variant rs12593575 [ dbSNP | Ensembl ].		VAR_060128

Sequences

	Sequence		Length	Mass (Da)
	A6NKC9 [UniParc]. Last modified June 10, 2008. Version 2. Checksum: A931C0905B132AEA	FASTA	451	49,807
	10 20 30 40 50 60 MEDSLKQLSL GRDPEGAGDS QALAELQELA LKWFMETQAP FILQNGALPP WFHGFITRKQ 70 80 90 100 110 120 TEQLLRDKAL GSFLIRLSDR ATGYILSYRG SDRCRHFVIN QLRNRRYIIS GDTQSHSTLA 130 140 150 160 170 180 ELVHHYQEAQ LEPFKEMLTA ACPRPEDNDL YDAITRGLHQ TIVDPENPPA TAFLTVVPDK 190 200 210 220 230 240 AASPRSSPKP QVSFLHAQKS LDVSPRNLSQ EESMEAPIRV SPLPEKSSSL LEESFGGPSD 250 260 270 280 290 300 IIYADLRRMN QARLGLGTEG SGRHGPVPAG SQAYSPGREA QRRLSDGEQN RPDGLGPVLS 310 320 330 340 350 360 GVSPDQGPTE SPTSWGCSDA MGSLGATWRQ EFPKLSQEAQ PCSQGSSADI YEFIGTEGLL 370 380 390 400 410 420 QEARDTPDQE GSTYEQIPAC WGGPARAPHP GASPTYSPWV HGYKRISGTP ELSEPGNTYE 430 440 450 QIPATKSKET GRTHKPDKLR RLFFTYRKHK F

References

[1]

"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC090260 Genomic DNA. No translation available.
IPI	IPI00079683.
RefSeq	NP_001094874.1. NM_001101404.1.
UniGene	Hs.569511.
3D structure databases
ProteinModelPortal	A6NKC9.
ModBase	Search...
PTM databases
PhosphoSite	A6NKC9.
Proteomic databases
PaxDb	A6NKC9.
PRIDE	A6NKC9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000328828; ENSP00000327846; ENSG00000183476.
GeneID	646892.
KEGG	hsa:646892.
UCSC	uc010blb.1. human.
Organism-specific databases
CTD	646892.
GeneCards	GC15P078370.
HGNC	HGNC:34549. SH2D7.
HPA	HPA051320.
neXtProt	NX_A6NKC9.
PharmGKB	PA164725681.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG82159.
HOGENOM	HOG000089978.
HOVERGEN	HBG108485.
InParanoid	A6NKC9.
OMA	PEDNDLY.
Gene expression databases
ArrayExpress	A6NKC9.
Bgee	A6NKC9.
Genevestigator	A6NKC9.
Family and domain databases
Gene3D	3.30.505.10. 1 hit.
InterPro	IPR000980. SH2. [Graphical view]
Pfam	PF00017. SH2. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN.
SMART	SM00252. SH2. 1 hit. [Graphical view]
PROSITE	PS50001. SH2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	646892.
NextBio	119499.

Entry information

Entry name

SH2D7_HUMAN

Accession

Primary (citable) accession number: A6NKC9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	May 1, 2013
This is version 48 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.