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A6NKC9

- SH2D7_HUMAN

UniProt

A6NKC9 - SH2D7_HUMAN

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Protein

SH2 domain-containing protein 7

Gene
SH2D7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Enzyme and pathway databases

SignaLinkiA6NKC9.

Names & Taxonomyi

Protein namesi
Recommended name:
SH2 domain-containing protein 7
Gene namesi
Name:SH2D7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:34549. SH2D7.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164725681.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 451451SH2 domain-containing protein 7PRO_0000341254Add
BLAST

Proteomic databases

PaxDbiA6NKC9.
PRIDEiA6NKC9.

PTM databases

PhosphoSiteiA6NKC9.

Expressioni

Gene expression databases

ArrayExpressiA6NKC9.
BgeeiA6NKC9.
GenevestigatoriA6NKC9.

Organism-specific databases

HPAiHPA051320.

Structurei

3D structure databases

ProteinModelPortaliA6NKC9.
SMRiA6NKC9. Positions 13-142.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 14292SH2Add
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG82159.
HOGENOMiHOG000089978.
HOVERGENiHBG108485.
InParanoidiA6NKC9.
OMAiLPPWFHG.
PhylomeDBiA6NKC9.
TreeFamiTF337522.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NKC9-1 [UniParc]FASTAAdd to Basket

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MEDSLKQLSL GRDPEGAGDS QALAELQELA LKWFMETQAP FILQNGALPP    50
WFHGFITRKQ TEQLLRDKAL GSFLIRLSDR ATGYILSYRG SDRCRHFVIN 100
QLRNRRYIIS GDTQSHSTLA ELVHHYQEAQ LEPFKEMLTA ACPRPEDNDL 150
YDAITRGLHQ TIVDPENPPA TAFLTVVPDK AASPRSSPKP QVSFLHAQKS 200
LDVSPRNLSQ EESMEAPIRV SPLPEKSSSL LEESFGGPSD IIYADLRRMN 250
QARLGLGTEG SGRHGPVPAG SQAYSPGREA QRRLSDGEQN RPDGLGPVLS 300
GVSPDQGPTE SPTSWGCSDA MGSLGATWRQ EFPKLSQEAQ PCSQGSSADI 350
YEFIGTEGLL QEARDTPDQE GSTYEQIPAC WGGPARAPHP GASPTYSPWV 400
HGYKRISGTP ELSEPGNTYE QIPATKSKET GRTHKPDKLR RLFFTYRKHK 450
F 451
Length:451
Mass (Da):49,807
Last modified:June 10, 2008 - v2
Checksum:iA931C0905B132AEA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti137 – 1371M → T.
Corresponds to variant rs2289524 [ dbSNP | Ensembl ].
VAR_060127
Natural varianti206 – 2061R → W.
Corresponds to variant rs12593575 [ dbSNP | Ensembl ].
VAR_060128

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC090260 Genomic DNA. No translation available.
CCDSiCCDS45315.1.
RefSeqiNP_001094874.1. NM_001101404.1.
UniGeneiHs.569511.

Genome annotation databases

EnsembliENST00000328828; ENSP00000327846; ENSG00000183476.
GeneIDi646892.
KEGGihsa:646892.
UCSCiuc010blb.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC090260 Genomic DNA. No translation available.
CCDSi CCDS45315.1.
RefSeqi NP_001094874.1. NM_001101404.1.
UniGenei Hs.569511.

3D structure databases

ProteinModelPortali A6NKC9.
SMRi A6NKC9. Positions 13-142.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei A6NKC9.

Proteomic databases

PaxDbi A6NKC9.
PRIDEi A6NKC9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000328828 ; ENSP00000327846 ; ENSG00000183476 .
GeneIDi 646892.
KEGGi hsa:646892.
UCSCi uc010blb.1. human.

Organism-specific databases

CTDi 646892.
GeneCardsi GC15P078370.
HGNCi HGNC:34549. SH2D7.
HPAi HPA051320.
neXtProti NX_A6NKC9.
PharmGKBi PA164725681.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG82159.
HOGENOMi HOG000089978.
HOVERGENi HBG108485.
InParanoidi A6NKC9.
OMAi LPPWFHG.
PhylomeDBi A6NKC9.
TreeFami TF337522.

Enzyme and pathway databases

SignaLinki A6NKC9.

Miscellaneous databases

GenomeRNAii 646892.
NextBioi 119499.
PROi A6NKC9.

Gene expression databases

ArrayExpressi A6NKC9.
Bgeei A6NKC9.
Genevestigatori A6NKC9.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR000980. SH2.
[Graphical view ]
Pfami PF00017. SH2. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
SMARTi SM00252. SH2. 1 hit.
[Graphical view ]
SUPFAMi SSF55550. SSF55550. 1 hit.
PROSITEi PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSH2D7_HUMAN
AccessioniPrimary (citable) accession number: A6NKC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: July 9, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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