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A6NKC9 (SH2D7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SH2 domain-containing protein 7
Gene names
Name:SH2D7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length451 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Sequence similarities

Contains 1 SH2 domain.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainSH2 domain
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 451451SH2 domain-containing protein 7
PRO_0000341254

Regions

Domain51 – 14292SH2

Natural variations

Natural variant1371M → T.
Corresponds to variant rs2289524 [ dbSNP | Ensembl ].
VAR_060127
Natural variant2061R → W.
Corresponds to variant rs12593575 [ dbSNP | Ensembl ].
VAR_060128

Sequences

Sequence LengthMass (Da)Tools
A6NKC9 [UniParc].

Last modified June 10, 2008. Version 2.
Checksum: A931C0905B132AEA

FASTA45149,807
        10         20         30         40         50         60 
MEDSLKQLSL GRDPEGAGDS QALAELQELA LKWFMETQAP FILQNGALPP WFHGFITRKQ 

        70         80         90        100        110        120 
TEQLLRDKAL GSFLIRLSDR ATGYILSYRG SDRCRHFVIN QLRNRRYIIS GDTQSHSTLA 

       130        140        150        160        170        180 
ELVHHYQEAQ LEPFKEMLTA ACPRPEDNDL YDAITRGLHQ TIVDPENPPA TAFLTVVPDK 

       190        200        210        220        230        240 
AASPRSSPKP QVSFLHAQKS LDVSPRNLSQ EESMEAPIRV SPLPEKSSSL LEESFGGPSD 

       250        260        270        280        290        300 
IIYADLRRMN QARLGLGTEG SGRHGPVPAG SQAYSPGREA QRRLSDGEQN RPDGLGPVLS 

       310        320        330        340        350        360 
GVSPDQGPTE SPTSWGCSDA MGSLGATWRQ EFPKLSQEAQ PCSQGSSADI YEFIGTEGLL 

       370        380        390        400        410        420 
QEARDTPDQE GSTYEQIPAC WGGPARAPHP GASPTYSPWV HGYKRISGTP ELSEPGNTYE 

       430        440        450 
QIPATKSKET GRTHKPDKLR RLFFTYRKHK F 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC090260 Genomic DNA. No translation available.
RefSeqNP_001094874.1. NM_001101404.1.
UniGeneHs.569511.

3D structure databases

ProteinModelPortalA6NKC9.
SMRA6NKC9. Positions 13-142.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteA6NKC9.

Proteomic databases

PaxDbA6NKC9.
PRIDEA6NKC9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000328828; ENSP00000327846; ENSG00000183476.
GeneID646892.
KEGGhsa:646892.
UCSCuc010blb.1. human.

Organism-specific databases

CTD646892.
GeneCardsGC15P078370.
HGNCHGNC:34549. SH2D7.
HPAHPA051320.
neXtProtNX_A6NKC9.
PharmGKBPA164725681.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG82159.
HOGENOMHOG000089978.
HOVERGENHBG108485.
InParanoidA6NKC9.
OMALPPWFHG.
PhylomeDBA6NKC9.
TreeFamTF337522.

Enzyme and pathway databases

SignaLinkA6NKC9.

Gene expression databases

ArrayExpressA6NKC9.
BgeeA6NKC9.
GenevestigatorA6NKC9.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR000980. SH2.
[Graphical view]
PfamPF00017. SH2. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
SMARTSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMSSF55550. SSF55550. 1 hit.
PROSITEPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi646892.
NextBio119499.
PROA6NKC9.

Entry information

Entry nameSH2D7_HUMAN
AccessionPrimary (citable) accession number: A6NKC9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: April 16, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM