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Protein

Putative high affinity immunoglobulin gamma Fc receptor IC

Gene

FCGR1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

May bind to the Fc region of immunoglobulins gamma. May function in the humoral immune response (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity

Keywords - Ligandi

IgG-binding protein

Names & Taxonomyi

Protein namesi
Recommended name:
Putative high affinity immunoglobulin gamma Fc receptor IC
Short name:
IgG Fc receptor IC
Alternative name(s):
Fc-gamma RIC
Short name:
FcRIC
Short name:
hFcgammaRIC
Gene namesi
Name:FCGR1C
Synonyms:IGFRC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:3615. FCGR1C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini16 – 198183ExtracellularSequence analysisAdd
BLAST
Transmembranei199 – 21921HelicalSequence analysisAdd
BLAST
Topological domaini220 – 28061CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence analysisAdd
BLAST
Chaini16 – 280265Putative high affinity immunoglobulin gamma Fc receptor ICPRO_0000331463Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 85PROSITE-ProRule annotation
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence analysis
Disulfide bondi124 ↔ 168PROSITE-ProRule annotation
Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence analysis
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NKC4.
PRIDEiA6NKC4.

PTM databases

iPTMnetiA6NKC4.
PhosphoSiteiA6NKC4.

Expressioni

Gene expression databases

BgeeiENSG00000265531.
CleanExiHS_FCGR1C.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000358391.

Structurei

3D structure databases

ProteinModelPortaliA6NKC4.
SMRiA6NKC4. Positions 21-195.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 10180Ig-like C2-type 1Add
BLAST
Domaini105 – 18278Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVK2. Eukaryota.
ENOG410YF57. LUCA.
HOVERGENiHBG051602.
InParanoidiA6NKC4.
PhylomeDBiA6NKC4.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6NKC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWFLTTLLLW VPVDGQVDTT KAVITLQPPW VSVFQEETVT LHCEVLHLPG
60 70 80 90 100
SSSTQWFLNG TATQTSTPSY RITSASVNDS GEYRCQRGLS GRSDPIQLEI
110 120 130 140 150
HRGWPLLQVS SRVFTEGEPL ALRCHAWKDK LVYNVLYYRN GKAFKFFHWN
160 170 180 190 200
SNLTILKTNI SHNGTYHCSG KGKHHYTSAG ISQYTVKGLQ LPTPVWFHVL
210 220 230 240 250
FYLAVGIMFL VNTVLWVTIR KELKRKKKWN LEISLDSGHE KKVISSLQED
260 270 280
RHLEEELKCQ EQKEEQLQEG VHRKEPQGAT
Length:280
Mass (Da):32,164
Last modified:January 15, 2008 - v2
Checksum:iF6A52C654C664ADF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti105 – 1051P → L.
Corresponds to variant rs619322 [ dbSNP | Ensembl ].
VAR_042882
Natural varianti115 – 1151T → M.
Corresponds to variant rs619366 [ dbSNP | Ensembl ].
VAR_042883
Natural varianti171 – 1711K → M.
Corresponds to variant rs658149 [ dbSNP | Ensembl ].
VAR_042884
Natural varianti175 – 1751H → R.
Corresponds to variant rs658160 [ dbSNP | Ensembl ].
VAR_042885

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109948 Genomic DNA. No translation available.
UniGeneiHs.635062.
Hs.77424.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109948 Genomic DNA. No translation available.
UniGeneiHs.635062.
Hs.77424.

3D structure databases

ProteinModelPortaliA6NKC4.
SMRiA6NKC4. Positions 21-195.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000358391.

PTM databases

iPTMnetiA6NKC4.
PhosphoSiteiA6NKC4.

Proteomic databases

PaxDbiA6NKC4.
PRIDEiA6NKC4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiFCGR1C.
HGNCiHGNC:3615. FCGR1C.
MIMi601503. gene.
neXtProtiNX_A6NKC4.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVK2. Eukaryota.
ENOG410YF57. LUCA.
HOVERGENiHBG051602.
InParanoidiA6NKC4.
PhylomeDBiA6NKC4.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSG00000265531.
CleanExiHS_FCGR1C.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFCGRC_HUMAN
AccessioniPrimary (citable) accession number: A6NKC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 15, 2008
Last modified: September 7, 2016
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.