A6NKB5 (PCX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pecanex-like protein 2

Gene names

Name:	PCNXL2
Synonyms:	KIAA0435

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2137 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H). Ref.7 Ref.8
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Miscellaneous	PCNXL2 is characterized by high mutational frequencies and biallelic mutations in MSI-H colorectal tumors, and is thus likely to be a target gene in these tumors.
Sequence similarities	Belongs to the pecanex family.
Sequence caution	The sequence BAA23708.2 differs from that shown. Reason: Erroneous initiation. The sequence BAB84904.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A6NKB5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A6NKB5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-701: Missing.
     955-987: VFLYCFPAISLLGLFPQINTFCTYLLEQIDMLF → GKIMNSHKDFFTSEKKKDKIISAISSVIFLKSW
     988-2137: Missing.

Isoform 3 (identifier: A6NKB5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1348: Missing.
     1349-1359: RPVKFWEKNYN → MTFYPFVASSS
     2081-2137: HLSEPCEPPD...ASQQSVSDEQ → VRGWAGLTRT...PIPFSMGLPE

Note: No experimental confirmation available.

Isoform 5 (identifier: A6NKB5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-867: Missing.
     1280-1288: LGDLLHKLQ → VFLGYVRQK
     1289-2137: Missing.

Isoform 4 (identifier: A6NKB5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1462: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2137	2137	Pecanex-like protein 2		PRO_0000333965
Regions
	Transmembrane	34 – 54	21	Helical; Potential
	Transmembrane	57 – 77	21	Helical; Potential
	Transmembrane	844 – 864	21	Helical; Potential
	Transmembrane	868 – 888	21	Helical; Potential
	Transmembrane	901 – 921	21	Helical; Potential
	Transmembrane	952 – 972	21	Helical; Potential
	Transmembrane	983 – 1003	21	Helical; Potential
	Transmembrane	1029 – 1049	21	Helical; Potential
	Transmembrane	1099 – 1119	21	Helical; Potential
	Transmembrane	1124 – 1144	21	Helical; Potential
	Transmembrane	1193 – 1213	21	Helical; Potential
	Transmembrane	1237 – 1257	21	Helical; Potential
	Transmembrane	1265 – 1285	21	Helical; Potential
	Transmembrane	1302 – 1322	21	Helical; Potential
	Transmembrane	1324 – 1344	21	Helical; Potential
	Compositional bias	1937 – 2063	127	Ser-rich
Amino acid modifications
	Glycosylation	136	1	N-linked (GlcNAc...) Potential
	Glycosylation	449	1	N-linked (GlcNAc...) Potential
	Glycosylation	550	1	N-linked (GlcNAc...) Potential
	Glycosylation	572	1	N-linked (GlcNAc...) Potential
	Glycosylation	587	1	N-linked (GlcNAc...) Potential
	Glycosylation	598	1	N-linked (GlcNAc...) Potential
	Glycosylation	613	1	N-linked (GlcNAc...) Potential
	Glycosylation	1412	1	N-linked (GlcNAc...) Potential
	Glycosylation	1553	1	N-linked (GlcNAc...) Potential
	Glycosylation	1818	1	N-linked (GlcNAc...) Potential
	Glycosylation	2054	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 1462	1462	Missing in isoform 4.		VSP_033605
	Alternative sequence	1 – 1348	1348	Missing in isoform 3.		VSP_033606
	Alternative sequence	1 – 867	867	Missing in isoform 5.		VSP_035048
	Alternative sequence	1 – 701	701	Missing in isoform 2.		VSP_033607
	Alternative sequence	955 – 987	33	VFLYC…IDMLF → GKIMNSHKDFFTSEKKKDKI ISAISSVIFLKSW in isoform 2.		VSP_033608
	Alternative sequence	988 – 2137	1150	Missing in isoform 2.		VSP_033609
	Alternative sequence	1280 – 1288	9	LGDLLHKLQ → VFLGYVRQK in isoform 5.		VSP_035049
	Alternative sequence	1289 – 2137	849	Missing in isoform 5.		VSP_035050
	Alternative sequence	1349 – 1359	11	RPVKFWEKNYN → MTFYPFVASSS in isoform 3.		VSP_033610
	Alternative sequence	2081 – 2137	57	HLSEP…VSDEQ → VRGWAGLTRTGWDGGTGSWP ERGTCLAFPPFCLQNPIPFS MGLPE in isoform 3.		VSP_033611
	Natural variant	117	1	R → K. Corresponds to variant rs1033325 [ dbSNP | Ensembl ].		VAR_050479
	Natural variant	454	1	T → A. Corresponds to variant rs10910120 [ dbSNP | Ensembl ].		VAR_043341
	Natural variant	1901	1	S → N. Ref.1 Corresponds to variant rs56231757 [ dbSNP | Ensembl ].		VAR_061498
	Natural variant	1984	1	R → Q. Corresponds to variant rs41309639 [ dbSNP | Ensembl ].		VAR_061499

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 20, 2008. Version 3. Checksum: 064D91B62BF84E44	FASTA	2,137	237,277
	10 20 30 40 50 60 MVSQVLQLLR QGVWAALTGG WYHDPEQSKF TNSCHLYLWL FLLLLPLALH LAFPPNAIIV 70 80 90 100 110 120 FFYCSAVTIF FTIIKLVSYR LHLMFDKGEV IQQKPSRKEE KPNKDKEAKG EHITNHRNPS 130 140 150 160 170 180 NNRQIHNGKK EEASRNLSTP PLRCSSRGQS ITSHHSSGPL ELSAQETVED LKGVILLEDH 190 200 210 220 230 240 PIAPVSSTSP GIKVESLPAS QAHMLETTTK SVIPVKPVAT ETLINGKGKE RGGKGQPPLR 250 260 270 280 290 300 HRSEGGLVDK GPLKKLPHLS LSQYDLLETD VSFQPWGSEN SVLIPEPVSC PRGSIRERVQ 310 320 330 340 350 360 SKSPQDSLSS SCPQCDTIVA KPVEEPADTS CQVDTSCQGD LPLHQEVDSS DSEVAVTLID 370 380 390 400 410 420 TSQPGDPLSL HEPIKIVITM SSTPNSMTDL ESSLHLRVVG TEKTSVKSDA EPTNPGAAGS 430 440 450 460 470 480 PNAEQISIPV ITLDLPEGGG GGVPCPEGNG SERTPERLKT RVSTNQCSGY GSGEGGNAIK 490 500 510 520 530 540 DHSSSSREPW ESVSRLTPDT GSESKVGKEG QTNLDPSSCK SSHEKRHARV LSVDSGTDVF 550 560 570 580 590 600 LSKSSAEIVN DTEKTMPTSK SDLEAKEGQM PNESNFLEFV SLLESINTSK MTASSQLNGS 610 620 630 640 650 660 AEQNEESGLL RDNCSQEKKE EILENEKPSG HSSKQGKPDL QSQDHTSTGP ACTQPAKTTA 670 680 690 700 710 720 FFQGNRQRQI IYRVTSQQDS SVLQVISGPE TSVQEEISVD AMHVFIDEHG EIRSCYLKSG 730 740 750 760 770 780 NQKEGPLQPL PSNNDCLSQA REMQVSSSST TTSESQDPSS GDPAVSALQQ QLLLMVARRT 790 800 810 820 830 840 QSETPRHVSQ DLEASSCSST QGKFNREQFY KFIIFPGKWI KVWYDRLTLL ALLDRTEDIK 850 860 870 880 890 900 ENVLAILLIV LVSLLGFLTL SQGFCKDMWV LLFCLVMASC QYSLLKSVQP DPASPIHGHN 910 920 930 940 950 960 QIITYSRPIY FCVLCGLILL LDTGAKARHP PSYVVYGLKL FSPVFLQSAR DYLIVFLYCF 970 980 990 1000 1010 1020 PAISLLGLFP QINTFCTYLL EQIDMLFFGG SAVSGITSAV YSVARSVLAA ALLHAVCFSA 1030 1040 1050 1060 1070 1080 VKEPWSMQHI PALFSAFCGL LVALSYHLSR QSSDPSVLMS FIQCRLFPKF LHQNLAESAA 1090 1100 1110 1120 1130 1140 DPLPKKMKDS VTDVLKWDLI VCAVVAVLSF AVSASTVFLS LRPFLSIVLF ALAGAVGFVT 1150 1160 1170 1180 1190 1200 HYVLPQLRKH HPWMWISHPI LKNKEYHQRE VRDVAHLMWF ERLYVWLQCF EKYILYPALI 1210 1220 1230 1240 1250 1260 LNALTIDAFL ISNHRRLGTH WDIFLMIIAG MKLLRTSFCN PVYQFINLSF TVIFFHFDYK 1270 1280 1290 1300 1310 1320 DISESFLLDF FMVSILFSKL GDLLHKLQFV LTYVAPWQMA WGSSFHVFAQ LFAIPHSAML 1330 1340 1350 1360 1370 1380 FFQTIATSIF STPLSPFLGS VIFITSYVRP VKFWEKNYNT RRVDNSNTRL AVQIERDPGN 1390 1400 1410 1420 1430 1440 DDNNLNSIFY EHLTRTLQES LCGDLVLGRW GNYSSGDCFI LASDDLNAFV HLIEIGNGLV 1450 1460 1470 1480 1490 1500 TFQLRGLEFR GTYCQQREVE AIMEGDEEDR GCCCCKPGHL PHLLSCNAAF HLRWLTWEIT 1510 1520 1530 1540 1550 1560 QTQYILEGYS ILDNNAATML QVFDLRRILI RYYIKSIIYY MVTSPKLLSW IKNESLLKSL 1570 1580 1590 1600 1610 1620 QPFAKWHYIE RDLAMFNINI DDDYVPCLQG ITRASFCNVY LEWIQHCARK RQEPSTTLDS 1630 1640 1650 1660 1670 1680 DEDSPLVTLS FALCTLGRRA LGTAAHNMAI SLDSFLYGLH VLFKGDFRIT ARDEWVFADM 1690 1700 1710 1720 1730 1740 DLLHKVVAPA IRMSLKLHQD QFTCPDEYED PAVLYEAIQS FEKKVVICHE GDPAWRGAVL 1750 1760 1770 1780 1790 1800 SNKEELLTLR HVVDEGADEY KVIMLHRSFL SFKVIKVNKE CVRGLWAGQQ QELIFLRNRN 1810 1820 1830 1840 1850 1860 PERGSIQNNK QVLRNLINSS CDQPLGYPMY VSPLTTSYLG THRQLKNIWG GPITLDRIRT 1870 1880 1890 1900 1910 1920 WFWTKWVRMR KDCNARQHSG GNIEDVDGGG APTTGGNNAP SGGSQESSAE QPRKGGAQHG 1930 1940 1950 1960 1970 1980 VSSCEGTQRT GRRKGRSQSV QAHSALSQRP PMLSSSGPIL ESRQTFLQTS TSVHELAQRL 1990 2000 2010 2020 2030 2040 SGSRLSLHAS ATSLHSQPPP VTTTGHLSVR ERAEALIRSS LGSSTSSTLS FLFGKRSFSS 2050 2060 2070 2080 2090 2100 ALVISGLSAA EGGNTSDTQS SSSVNIVMGP SARAASQATR HLSEPCEPPD ATEQGQLHDR 2110 2120 2130 CLAEAVADTL GVVCRRASQE DMGLDDTASQ QSVSDEQ
	Isoform 2 [UniParc]. Checksum: 6C2E4681ED159F22	FASTA	286	32,206
	10 20 30 40 50 60 MHVFIDEHGE IRSCYLKSGN QKEGPLQPLP SNNDCLSQAR EMQVSSSSTT TSESQDPSSG 70 80 90 100 110 120 DPAVSALQQQ LLLMVARRTQ SETPRHVSQD LEASSCSSTQ GKFNREQFYK FIIFPGKWIK 130 140 150 160 170 180 VWYDRLTLLA LLDRTEDIKE NVLAILLIVL VSLLGFLTLS QGFCKDMWVL LFCLVMASCQ 190 200 210 220 230 240 YSLLKSVQPD PASPIHGHNQ IITYSRPIYF CVLCGLILLL DTGAKARHPP SYVVYGLKLF 250 260 270 280 SPVFLQSARD YLIGKIMNSH KDFFTSEKKK DKIISAISSV IFLKSW
	Isoform 3 [UniParc]. Checksum: 35E12F71B1BCE69E	FASTA	777	86,628
	10 20 30 40 50 60 MTFYPFVASS STRRVDNSNT RLAVQIERDP GNDDNNLNSI FYEHLTRTLQ ESLCGDLVLG 70 80 90 100 110 120 RWGNYSSGDC FILASDDLNA FVHLIEIGNG LVTFQLRGLE FRGTYCQQRE VEAIMEGDEE 130 140 150 160 170 180 DRGCCCCKPG HLPHLLSCNA AFHLRWLTWE ITQTQYILEG YSILDNNAAT MLQVFDLRRI 190 200 210 220 230 240 LIRYYIKSII YYMVTSPKLL SWIKNESLLK SLQPFAKWHY IERDLAMFNI NIDDDYVPCL 250 260 270 280 290 300 QGITRASFCN VYLEWIQHCA RKRQEPSTTL DSDEDSPLVT LSFALCTLGR RALGTAAHNM 310 320 330 340 350 360 AISLDSFLYG LHVLFKGDFR ITARDEWVFA DMDLLHKVVA PAIRMSLKLH QDQFTCPDEY 370 380 390 400 410 420 EDPAVLYEAI QSFEKKVVIC HEGDPAWRGA VLSNKEELLT LRHVVDEGAD EYKVIMLHRS 430 440 450 460 470 480 FLSFKVIKVN KECVRGLWAG QQQELIFLRN RNPERGSIQN NKQVLRNLIN SSCDQPLGYP 490 500 510 520 530 540 MYVSPLTTSY LGTHRQLKNI WGGPITLDRI RTWFWTKWVR MRKDCNARQH SGGNIEDVDG 550 560 570 580 590 600 GGAPTTGGNN APSGGSQESS AEQPRKGGAQ HGVSSCEGTQ RTGRRKGRSQ SVQAHSALSQ 610 620 630 640 650 660 RPPMLSSSGP ILESRQTFLQ TSTSVHELAQ RLSGSRLSLH ASATSLHSQP PPVTTTGHLS 670 680 690 700 710 720 VRERAEALIR SSLGSSTSST LSFLFGKRSF SSALVISGLS AAEGGNTSDT QSSSSVNIVM 730 740 750 760 770 GPSARAASQA TRVRGWAGLT RTGWDGGTGS WPERGTCLAF PPFCLQNPIP FSMGLPE
	Isoform 5 [UniParc]. Checksum: D6C30F9210A8A1C8	FASTA	421	48,009
	10 20 30 40 50 60 MWVLLFCLVM ASCQYSLLKS VQPDPASPIH GHNQIITYSR PIYFCVLCGL ILLLDTGAKA 70 80 90 100 110 120 RHPPSYVVYG LKLFSPVFLQ SARDYLIVFL YCFPAISLLG LFPQINTFCT YLLEQIDMLF 130 140 150 160 170 180 FGGSAVSGIT SAVYSVARSV LAAALLHAVC FSAVKEPWSM QHIPALFSAF CGLLVALSYH 190 200 210 220 230 240 LSRQSSDPSV LMSFIQCRLF PKFLHQNLAE SAADPLPKKM KDSVTDVLKW DLIVCAVVAV 250 260 270 280 290 300 LSFAVSASTV FLSLRPFLSI VLFALAGAVG FVTHYVLPQL RKHHPWMWIS HPILKNKEYH 310 320 330 340 350 360 QREVRDVAHL MWFERLYVWL QCFEKYILYP ALILNALTID AFLISNHRRL GTHWDIFLMI 370 380 390 400 410 420 IAGMKLLRTS FCNPVYQFIN LSFTVIFFHF DYKDISESFL LDFFMVSILF SKVFLGYVRQ K
	Isoform 4 [UniParc]. Checksum: 80B564005A8ED96E	FASTA	675	75,024
	10 20 30 40 50 60 MEGDEEDRGC CCCKPGHLPH LLSCNAAFHL RWLTWEITQT QYILEGYSIL DNNAATMLQV 70 80 90 100 110 120 FDLRRILIRY YIKSIIYYMV TSPKLLSWIK NESLLKSLQP FAKWHYIERD LAMFNINIDD 130 140 150 160 170 180 DYVPCLQGIT RASFCNVYLE WIQHCARKRQ EPSTTLDSDE DSPLVTLSFA LCTLGRRALG 190 200 210 220 230 240 TAAHNMAISL DSFLYGLHVL FKGDFRITAR DEWVFADMDL LHKVVAPAIR MSLKLHQDQF 250 260 270 280 290 300 TCPDEYEDPA VLYEAIQSFE KKVVICHEGD PAWRGAVLSN KEELLTLRHV VDEGADEYKV 310 320 330 340 350 360 IMLHRSFLSF KVIKVNKECV RGLWAGQQQE LIFLRNRNPE RGSIQNNKQV LRNLINSSCD 370 380 390 400 410 420 QPLGYPMYVS PLTTSYLGTH RQLKNIWGGP ITLDRIRTWF WTKWVRMRKD CNARQHSGGN 430 440 450 460 470 480 IEDVDGGGAP TTGGNNAPSG GSQESSAEQP RKGGAQHGVS SCEGTQRTGR RKGRSQSVQA 490 500 510 520 530 540 HSALSQRPPM LSSSGPILES RQTFLQTSTS VHELAQRLSG SRLSLHASAT SLHSQPPPVT 550 560 570 580 590 600 TTGHLSVRER AEALIRSSLG SSTSSTLSFL FGKRSFSSAL VISGLSAAEG GNTSDTQSSS 610 620 630 640 650 660 SVNIVMGPSA RAASQATRHL SEPCEPPDAT EQGQLHDRCL AEAVADTLGV VCRRASQEDM 670 GLDDTASQQS VSDEQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro." Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ASN-1901. Tissue: Brain.
[2]	Ohara O. Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"The nucleotide sequence of a long cDNA clone isolated from human spleen." Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Spleen.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Embryo.
[5]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Colon.
[7]	"Identification of MARCKS, FLJ11383 and TAF1B as putative novel target genes in colorectal carcinomas with microsatellite instability." Kim N.-G., Rhee H., Li L.S., Kim H., Lee J.-S., Kim J.-H., Kim N.K., Kim H. Oncogene 21:5081-5087(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[8]	"Chromosomal imbalances in the colorectal carcinomas with microsatellite instability." Li L.S., Kim N.-G., Kim S.H., Park C., Kim H., Kang H.J., Koh K.H., Kim S.N., Kim W.H., Kim N.K., Kim H. Am. J. Pathol. 163:1429-1436(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB007895 mRNA. Translation: BAA23708.2. Different initiation. AK074078 mRNA. Translation: BAB84904.1. Different initiation. AK021445 mRNA. Translation: BAB13826.1. AL139342, AL122003, AL133289 Genomic DNA. Translation: CAI18866.1. AL133291 Genomic DNA. No translation available. AL133380 Genomic DNA. No translation available. AL139342 Genomic DNA. Translation: CAI18867.1. AL122003, AL139342, AL133289 Genomic DNA. Translation: CAI22240.1. AL122003, AL133289 Genomic DNA. Translation: CAI22241.1. AL133289, AL139342, AL122003 Genomic DNA. Translation: CAI22872.1. AL133289, AL122003 Genomic DNA. Translation: CAI22873.1. AL359819 Genomic DNA. No translation available. BC008300 mRNA. Translation: AAH08300.2.
IPI	IPI00015501. IPI00186853. IPI00514056. IPI00893561. IPI00902808.
RefSeq	NP_055616.3. NM_014801.3.
UniGene	Hs.370605.
3D structure databases
ProteinModelPortal	A6NKB5.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000258229.
PTM databases
PhosphoSite	A6NKB5.
Proteomic databases
PaxDb	A6NKB5.
PRIDE	A6NKB5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000258229; ENSP00000258229; ENSG00000135749. ENST00000344698; ENSP00000340759; ENSG00000135749. ENST00000430153; ENSP00000394703; ENSG00000135749.
GeneID	80003.
KEGG	hsa:80003.
UCSC	uc001hvk.1. human. uc001hvl.2. human. uc001hvq.1. human.
Organism-specific databases
CTD	80003.
GeneCards	GC01M233119.
H-InvDB	HIX0001704.
HGNC	HGNC:8736. PCNXL2.
HPA	HPA013815. HPA014427.
neXtProt	NX_A6NKB5.
PharmGKB	PA33081.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG297934.
HOVERGEN	HBG108237.
InParanoid	A6NKB5.
OMA	MKDSVKD.
Gene expression databases
ArrayExpress	A6NKB5.
Bgee	A6NKB5.
CleanEx	HS_PCNXL2.
Genevestigator	A6NKB5.
Family and domain databases
InterPro	IPR007735. Pecanex. [Graphical view]
Pfam	PF05041. Pecanex_C. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PCNXL2. human.
GenomeRNAi	80003.
NextBio	70075.

Entry information

Entry name

PCX2_HUMAN

Accession

Primary (citable) accession number: A6NKB5
Secondary accession number(s): O43162 , Q5T9Z8, Q5TDF1, Q8TEP4, Q96HP9, Q9HAL8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	April 3, 2013
This is version 49 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.