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Protein

Solute carrier family 22 member 20

Gene

SLC22A20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Organic anion transporter that mediates the uptake of estrone sulfate. Inhibited by probenecid, propionate, 2-methylbutyrate, 3-methylbutyrate, benzoate, heptanoate and 2-ethylhaxanoate. May act as an odorant transporter (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi2.A.1.19.35. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 20
Alternative name(s):
Organic anion transporter 6
Gene namesi
Name:SLC22A20
Synonyms:OAT6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:29867. SLC22A20.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323CytoplasmicSequence analysisAdd
BLAST
Transmembranei24 – 4421HelicalSequence analysisAdd
BLAST
Topological domaini45 – 13793ExtracellularSequence analysisAdd
BLAST
Transmembranei138 – 15821HelicalSequence analysisAdd
BLAST
Topological domaini159 – 1668CytoplasmicSequence analysis
Transmembranei167 – 18721HelicalSequence analysisAdd
BLAST
Topological domaini188 – 1947ExtracellularSequence analysis
Transmembranei195 – 21521HelicalSequence analysisAdd
BLAST
Topological domaini216 – 22510CytoplasmicSequence analysis
Transmembranei226 – 24621HelicalSequence analysisAdd
BLAST
Topological domaini247 – 2504ExtracellularSequence analysis
Transmembranei251 – 27121HelicalSequence analysisAdd
BLAST
Topological domaini272 – 33968CytoplasmicSequence analysisAdd
BLAST
Transmembranei340 – 36021HelicalSequence analysisAdd
BLAST
Topological domaini361 – 37313ExtracellularSequence analysisAdd
BLAST
Transmembranei374 – 39421HelicalSequence analysisAdd
BLAST
Topological domaini395 – 3973CytoplasmicSequence analysis
Transmembranei398 – 41821HelicalSequence analysisAdd
BLAST
Topological domaini419 – 42911ExtracellularSequence analysisAdd
BLAST
Transmembranei430 – 45021HelicalSequence analysisAdd
BLAST
Topological domaini451 – 48535CytoplasmicSequence analysisAdd
BLAST
Transmembranei486 – 50621HelicalSequence analysisAdd
BLAST
Topological domaini507 – 55549ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162403493.

Polymorphism and mutation databases

BioMutaiSLC22A20.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Solute carrier family 22 member 20PRO_0000326428Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence analysis
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiA6NK97.

PTM databases

PhosphoSiteiA6NK97.

Expressioni

Gene expression databases

CleanExiHS_SLC22A20.

Interactioni

Protein-protein interaction databases

BioGridi136241. 1 interaction.
IntActiA6NK97. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliA6NK97.
SMRiA6NK97. Positions 134-476.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi23 – 264Poly-Leu

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiA6NK97.
KOiK08216.
PhylomeDBiA6NK97.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NK97-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFTDLLDAL GSMGRFQLNH TALLLLPCGL LACHNFLQNF TAAVPPHHCR
60 70 80 90 100
GPANHTEAST NDSGAWLRAT IPLDQLGAPE PCRRFTKPQW ALLSPNSSIP
110 120 130 140 150
GAATEGCKDG WVYNRSVFPS TIVMEWDLVC EARTLRDLAQ SVYMAGVLVG
160 170 180 190 200
AAVFGSLADR LGCKGPLVWS YLQLAASGAA TAYFSSFSAY CVFRFLMGMT
210 220 230 240 250
FSGIILNSVS LVVEWMPTRG RTVAGILLGY SFTLGQLILA GVAYLIRPWR
260 270 280 290 300
CLQFAISAPF LIFFLYSWWL PESSRWLLLH GKSQLAVQNL QKVAAMNGRK
310 320 330 340 350
EEGERLTKEV MSSYIQSEFA SVCTSNSILD LFRTPAIRKV TCCLMVIWFS
360 370 380 390 400
NSVAYYGLAM DLQKFGLSLY LVQALFGIIN TPAMLVATAT MIYVGRRATV
410 420 430 440 450
ASFLILAGLM VIANMFVPEG TQILCTAQAA LGKGCLASSF ICVYLFTGEL
460 470 480 490 500
YPTEIRQMGM GFASVHARLG GLTAPLVTTL GEYSTILPPV SFGATAILAG
510 520 530 540 550
LAVCVLTETR NMPLVETIAA MERRVKEGSS KKHVEEKSEE ISLQQLRASP

LKETI
Note: No experimental confirmation available.
Length:555
Mass (Da):60,459
Last modified:July 24, 2007 - v1
Checksum:i3F3D75A7FFB5E91C
GO
Isoform 2 (identifier: A6NK97-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-347: VEWMPTRGRT...RKVTCCLMVI → ASRVIPLAPP...KQILSSKFQS
     348-555: Missing.

Show »
Length:347
Mass (Da):37,029
Checksum:iD03C6E98DCA8A298
GO

Sequence cautioni

The sequence BAD18487.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti58 – 581A → D.
Corresponds to variant rs11605576 [ dbSNP | Ensembl ].
VAR_040065
Natural varianti139 – 1391A → V.
Corresponds to variant rs12420456 [ dbSNP | Ensembl ].
VAR_040066
Isoform 2 (identifier: A6NK97-2)
Natural varianti244 – 2441G → G.
Corresponds to variant rs514076 [ dbSNP | Ensembl ].

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei213 – 347135VEWMP…CLMVI → ASRVIPLAPPAWQVPVSCTE SAEGGCNEREEGGRGKADQG GDELLHPKRVCKCLHLQLNL GPLPNPGHPQGHMLSHGDLR GRQRSSGSGEQGGSCEPESR NGRLPAVAPAGLGLPFVHLP LSAREKQILSSKFQS in isoform 2. 2 PublicationsVSP_032653Add
BLAST
Alternative sequencei348 – 555208Missing in isoform 2. 2 PublicationsVSP_032654Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131327 mRNA. Translation: BAD18487.1. Different initiation.
AP003068 Genomic DNA. No translation available.
BC146850 mRNA. Translation: AAI46851.1.
RefSeqiNP_001004326.4. NM_001004326.4.
UniGeneiHs.532372.

Genome annotation databases

GeneIDi440044.
KEGGihsa:440044.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131327 mRNA. Translation: BAD18487.1. Different initiation.
AP003068 Genomic DNA. No translation available.
BC146850 mRNA. Translation: AAI46851.1.
RefSeqiNP_001004326.4. NM_001004326.4.
UniGeneiHs.532372.

3D structure databases

ProteinModelPortaliA6NK97.
SMRiA6NK97. Positions 134-476.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136241. 1 interaction.
IntActiA6NK97. 1 interaction.

Protein family/group databases

TCDBi2.A.1.19.35. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteiA6NK97.

Polymorphism and mutation databases

BioMutaiSLC22A20.

Proteomic databases

PRIDEiA6NK97.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi440044.
KEGGihsa:440044.

Organism-specific databases

CTDi440044.
GeneCardsiSLC22A20.
HGNCiHGNC:29867. SLC22A20.
MIMi611696. gene.
neXtProtiNX_A6NK97.
PharmGKBiPA162403493.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiA6NK97.
KOiK08216.
PhylomeDBiA6NK97.

Miscellaneous databases

GenomeRNAii440044.
NextBioi108866.
PROiA6NK97.
SOURCEiSearch...

Gene expression databases

CleanExiHS_SLC22A20.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Synovium.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiS22AK_HUMAN
AccessioniPrimary (citable) accession number: A6NK97
Secondary accession number(s): B9EJB2, Q6ZN88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 24, 2007
Last modified: April 13, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.