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Protein

Solute carrier family 22 member 20

Gene

SLC22A20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Organic anion transporter that mediates the uptake of estrone sulfate. Inhibited by probenecid, propionate, 2-methylbutyrate, 3-methylbutyrate, benzoate, heptanoate and 2-ethylhaxanoate. May act as an odorant transporter (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciZFISH:G66-32933-MONOMER.

Protein family/group databases

TCDBi2.A.1.19.35. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 20
Alternative name(s):
Organic anion transporter 6
Gene namesi
Name:SLC22A20
Synonyms:OAT6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:29867. SLC22A20.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23CytoplasmicSequence analysisAdd BLAST23
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Topological domaini45 – 137ExtracellularSequence analysisAdd BLAST93
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 166CytoplasmicSequence analysis8
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 194ExtracellularSequence analysis7
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 225CytoplasmicSequence analysis10
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Topological domaini247 – 250ExtracellularSequence analysis4
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Topological domaini272 – 339CytoplasmicSequence analysisAdd BLAST68
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21
Topological domaini361 – 373ExtracellularSequence analysisAdd BLAST13
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Topological domaini395 – 397CytoplasmicSequence analysis3
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Topological domaini419 – 429ExtracellularSequence analysisAdd BLAST11
Transmembranei430 – 450HelicalSequence analysisAdd BLAST21
Topological domaini451 – 485CytoplasmicSequence analysisAdd BLAST35
Transmembranei486 – 506HelicalSequence analysisAdd BLAST21
Topological domaini507 – 555ExtracellularSequence analysisAdd BLAST49

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162403493.

Polymorphism and mutation databases

BioMutaiSLC22A20.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003264281 – 555Solute carrier family 22 member 20Add BLAST555

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi54N-linked (GlcNAc...)Sequence analysis1
Glycosylationi114N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiA6NK97.

PTM databases

iPTMnetiA6NK97.
PhosphoSitePlusiA6NK97.

Expressioni

Gene expression databases

CleanExiHS_SLC22A20.

Interactioni

Protein-protein interaction databases

BioGridi136241. 1 interactor.
IntActiA6NK97. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliA6NK97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 26Poly-Leu4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiA6NK97.
KOiK08216.
PhylomeDBiA6NK97.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NK97-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFTDLLDAL GSMGRFQLNH TALLLLPCGL LACHNFLQNF TAAVPPHHCR
60 70 80 90 100
GPANHTEAST NDSGAWLRAT IPLDQLGAPE PCRRFTKPQW ALLSPNSSIP
110 120 130 140 150
GAATEGCKDG WVYNRSVFPS TIVMEWDLVC EARTLRDLAQ SVYMAGVLVG
160 170 180 190 200
AAVFGSLADR LGCKGPLVWS YLQLAASGAA TAYFSSFSAY CVFRFLMGMT
210 220 230 240 250
FSGIILNSVS LVVEWMPTRG RTVAGILLGY SFTLGQLILA GVAYLIRPWR
260 270 280 290 300
CLQFAISAPF LIFFLYSWWL PESSRWLLLH GKSQLAVQNL QKVAAMNGRK
310 320 330 340 350
EEGERLTKEV MSSYIQSEFA SVCTSNSILD LFRTPAIRKV TCCLMVIWFS
360 370 380 390 400
NSVAYYGLAM DLQKFGLSLY LVQALFGIIN TPAMLVATAT MIYVGRRATV
410 420 430 440 450
ASFLILAGLM VIANMFVPEG TQILCTAQAA LGKGCLASSF ICVYLFTGEL
460 470 480 490 500
YPTEIRQMGM GFASVHARLG GLTAPLVTTL GEYSTILPPV SFGATAILAG
510 520 530 540 550
LAVCVLTETR NMPLVETIAA MERRVKEGSS KKHVEEKSEE ISLQQLRASP

LKETI
Note: No experimental confirmation available.
Length:555
Mass (Da):60,459
Last modified:July 24, 2007 - v1
Checksum:i3F3D75A7FFB5E91C
GO
Isoform 2 (identifier: A6NK97-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-347: VEWMPTRGRT...RKVTCCLMVI → ASRVIPLAPP...KQILSSKFQS
     348-555: Missing.

Show »
Length:347
Mass (Da):37,029
Checksum:iD03C6E98DCA8A298
GO

Sequence cautioni

The sequence BAD18487 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04006558A → D.Corresponds to variant rs11605576dbSNPEnsembl.1
Natural variantiVAR_040066139A → V.Corresponds to variant rs12420456dbSNPEnsembl.1
Isoform 2 (identifier: A6NK97-2)
Natural varianti244G → G.Corresponds to variant rs514076dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032653213 – 347VEWMP…CLMVI → ASRVIPLAPPAWQVPVSCTE SAEGGCNEREEGGRGKADQG GDELLHPKRVCKCLHLQLNL GPLPNPGHPQGHMLSHGDLR GRQRSSGSGEQGGSCEPESR NGRLPAVAPAGLGLPFVHLP LSAREKQILSSKFQS in isoform 2. 2 PublicationsAdd BLAST135
Alternative sequenceiVSP_032654348 – 555Missing in isoform 2. 2 PublicationsAdd BLAST208

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131327 mRNA. Translation: BAD18487.1. Different initiation.
AP003068 Genomic DNA. No translation available.
BC146850 mRNA. Translation: AAI46851.1.
RefSeqiNP_001004326.4. NM_001004326.4.
UniGeneiHs.532372.

Genome annotation databases

GeneIDi440044.
KEGGihsa:440044.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131327 mRNA. Translation: BAD18487.1. Different initiation.
AP003068 Genomic DNA. No translation available.
BC146850 mRNA. Translation: AAI46851.1.
RefSeqiNP_001004326.4. NM_001004326.4.
UniGeneiHs.532372.

3D structure databases

ProteinModelPortaliA6NK97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136241. 1 interactor.
IntActiA6NK97. 1 interactor.

Protein family/group databases

TCDBi2.A.1.19.35. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiA6NK97.
PhosphoSitePlusiA6NK97.

Polymorphism and mutation databases

BioMutaiSLC22A20.

Proteomic databases

PRIDEiA6NK97.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi440044.
KEGGihsa:440044.

Organism-specific databases

CTDi440044.
GeneCardsiSLC22A20.
HGNCiHGNC:29867. SLC22A20.
MIMi611696. gene.
neXtProtiNX_A6NK97.
PharmGKBiPA162403493.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiA6NK97.
KOiK08216.
PhylomeDBiA6NK97.

Enzyme and pathway databases

BioCyciZFISH:G66-32933-MONOMER.

Miscellaneous databases

GenomeRNAii440044.
PROiA6NK97.
SOURCEiSearch...

Gene expression databases

CleanExiHS_SLC22A20.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS22AK_HUMAN
AccessioniPrimary (citable) accession number: A6NK97
Secondary accession number(s): B9EJB2, Q6ZN88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 24, 2007
Last modified: November 30, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.