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Protein

Ras association domain-containing protein 10

Gene

RASSF10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ras association domain-containing protein 10
Gene namesi
Name:RASSF10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:33984. RASSF10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiRASSF10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507Ras association domain-containing protein 10PRO_0000332284Add
BLAST

Proteomic databases

PRIDEiA6NK89.

PTM databases

iPTMnetiA6NK89.
PhosphoSiteiA6NK89.

Expressioni

Tissue specificityi

Expressed in brain. Tends to be down-regulated in astrocytic gliomas due to promoter methylation. Methylation occurs early in gliomagenesis and the extent of methylation parallels with higher glioma grades, so that methylation is observed in close to 70% WHO grade IV primary glioblastomas, but not in grade I astrocytomas.1 Publication

Gene expression databases

CleanExiHS_RASSF10.
GenevisibleiA6NK89. HS.

Interactioni

Protein-protein interaction databases

BioGridi570026. 38 interactions.
IntActiA6NK89. 38 interactions.

Structurei

3D structure databases

ProteinModelPortaliA6NK89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 133130Ras-associatingPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili237 – 26428Sequence analysisAdd
BLAST
Coiled coili319 – 35840Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi197 – 22125Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 Ras-associating domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00510000047164.
HOGENOMiHOG000065674.
HOVERGENiHBG053178.
InParanoidiA6NK89.
KOiK09856.
OMAiCAEVWVD.
PhylomeDBiA6NK89.

Family and domain databases

InterProiIPR000159. RA_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 2 hits.
PROSITEiPS50200. RA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NK89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPSEKKISV WICQEEKLVS GLSRRTTCSD VVRVLLEDGC RRRRRQRRSR
60 70 80 90 100
RLGSAGDPHG PGELPEPPNE DDEDDDEALP QGMLCGPPQC YCIVEKWRGF
110 120 130 140 150
ERILPNKTRI LRLWAAWGEE QENVRFVLVR SEASLPNAGP RSAEARVVLS
160 170 180 190 200
RERPCPARGA PARPSLAMTQ EKQRRVVRKA FRKLAKLNRR RQQQTPSSCS
210 220 230 240 250
STSSSTASSC SSSPRTHESA SVERMETLVH LVLSQDHTIR QQVQRLHELD
260 270 280 290 300
REIDHYEAKV HLDRMRRHGV NYVQDTYLVG AGIELDGSRP GEEPEEVAAE
310 320 330 340 350
AEEAAAAPPL AGEAQAAALE ELARRCDDLL RLQEQRVQQE ELLERLSAEI
360 370 380 390 400
QEELNQRWMR RRQEELAARE EPLEPDGGPD GELLLEQERV RTQLSTSLYI
410 420 430 440 450
GLRLNTDLEA VKSDLDYSQQ QWDSKKRELQ GLLQTLHTLE LTVAPDGAPG
460 470 480 490 500
SGSPSREPGP QACADMWVDQ ARGLAKSGPG NDEDSDTGLS SMHSQDSDSL

PMCESLV
Length:507
Mass (Da):56,900
Last modified:April 29, 2008 - v3
Checksum:iA9A5D0A546F61518
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti194 – 1941Q → H.
Corresponds to variant rs4323847 [ dbSNP | Ensembl ].
VAR_042999

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084859 Genomic DNA. No translation available.
RefSeqiNP_001073990.2. NM_001080521.2.
UniGeneiHs.134650.

Genome annotation databases

EnsembliENST00000529419; ENSP00000485526; ENSG00000189431.
GeneIDi644943.
KEGGihsa:644943.
UCSCiuc021qdz.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084859 Genomic DNA. No translation available.
RefSeqiNP_001073990.2. NM_001080521.2.
UniGeneiHs.134650.

3D structure databases

ProteinModelPortaliA6NK89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi570026. 38 interactions.
IntActiA6NK89. 38 interactions.

PTM databases

iPTMnetiA6NK89.
PhosphoSiteiA6NK89.

Polymorphism and mutation databases

BioMutaiRASSF10.

Proteomic databases

PRIDEiA6NK89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000529419; ENSP00000485526; ENSG00000189431.
GeneIDi644943.
KEGGihsa:644943.
UCSCiuc021qdz.2. human.

Organism-specific databases

CTDi644943.
GeneCardsiRASSF10.
HGNCiHGNC:33984. RASSF10.
MIMi614713. gene.
neXtProtiNX_A6NK89.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00510000047164.
HOGENOMiHOG000065674.
HOVERGENiHBG053178.
InParanoidiA6NK89.
KOiK09856.
OMAiCAEVWVD.
PhylomeDBiA6NK89.

Miscellaneous databases

GenomeRNAii644943.
PROiA6NK89.
SOURCEiSearch...

Gene expression databases

CleanExiHS_RASSF10.
GenevisibleiA6NK89. HS.

Family and domain databases

InterProiIPR000159. RA_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 2 hits.
PROSITEiPS50200. RA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "RASSF7 is a member of a new family of RAS association domain-containing proteins and is required for completing mitosis."
    Sherwood V., Manbodh R., Sheppard C., Chalmers A.D.
    Mol. Biol. Cell 19:1772-1782(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  3. "Epigenetic inactivation of the RASSF10 candidate tumor suppressor gene is a frequent and an early event in gliomagenesis."
    Hill V.K., Underhill-Day N., Krex D., Robel K., Sangan C.B., Summersgill H.R., Morris M., Gentle D., Chalmers A.D., Maher E.R., Latif F.
    Oncogene 30:978-989(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DOWN-REGULATION IN ASTROCYTIC GLIOMAS.

Entry informationi

Entry nameiRASFA_HUMAN
AccessioniPrimary (citable) accession number: A6NK89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: June 8, 2016
This is version 63 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.