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Protein

Zinc finger protein 98

Gene

ZNF98

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri182 – 204C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri210 – 232C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri238 – 260C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri266 – 288C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri294 – 316C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri322 – 344C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri378 – 400C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri406 – 428C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri462 – 484C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 512C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri518 – 540C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 98
Alternative name(s):
Zinc finger protein 739
Zinc finger protein F7175
Gene namesi
Name:ZNF98
Synonyms:ZNF739
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000197360.9
HGNCiHGNC:13174 ZNF98
MIMi603980 gene
neXtProtiNX_A6NK75

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197360

Polymorphism and mutation databases

BioMutaiZNF98

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003169481 – 572Zinc finger protein 98Add BLAST572

Proteomic databases

EPDiA6NK75
MaxQBiA6NK75
PaxDbiA6NK75
PRIDEiA6NK75

PTM databases

iPTMnetiA6NK75
PhosphoSitePlusiA6NK75

Expressioni

Gene expression databases

BgeeiENSG00000197360
CleanExiHS_ZNF98
ExpressionAtlasiA6NK75 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiA6NK75, 1 interactor
STRINGi9606.ENSP00000350418

Structurei

3D structure databases

ProteinModelPortaliA6NK75
SMRiA6NK75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 84KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri182 – 204C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri210 – 232C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri238 – 260C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri266 – 288C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri294 – 316C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri322 – 344C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri378 – 400C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri406 – 428C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri462 – 484C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 512C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri518 – 540C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiA6NK75
KOiK09228
OMAiFTEMSKL
OrthoDBiEOG091G02KC
PhylomeDBiA6NK75
TreeFamiTF342117

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequencei

Sequence statusi: Complete.

A6NK75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGPLGSLEM GVLTFRDVAL EFSLEEWQCL DTAQQNLYRN VMLENYRNLV
60 70 80 90 100
FVGIAASKPD LITCLEQGKE PWNVKRHEMV TEPPVVYSYF AQDLWPKQGK
110 120 130 140 150
KNYFQKVILR TYKKCGRENL QLRKYCKSMD ECKVHKECYN GLNQCLTTTQ
160 170 180 190 200
NKIFQYDKYV KVFHKFSNSN RHKIGHTGKK SFKCKECEKS FCMLSHLAQH
210 220 230 240 250
KRIHSGEKPY KCKECGKAYN EASNLSTHKR IHTGKKPYKC EECGKAFNRL
260 270 280 290 300
SHLTTHKIIH TGKKPYKCEE CGKAFNQSAN LTTHKRIHTG EKPYKCEECG
310 320 330 340 350
RAFSQSSTLT AHKIIHAGEK PYKCEECGKA FSQSSTLTTH KIIHTGEKFY
360 370 380 390 400
KCEECGKAFS RLSHLTTHKR IHSGEKPYKC EECGKAFKQS STLTTHKRIH
410 420 430 440 450
AGEKFYKCEV CSKAFSRFSH LTTHKRIHTG EKPYKCEECG KAFNLSSQLT
460 470 480 490 500
THKIIHTGEK PYKCEECGKA FNQSSTLSKH KVIHTGEKPY KCEECGKAFN
510 520 530 540 550
QSSHLTTHKM IHTGEKPYKC EECGKAFNNS SILNRHKMIH TGEKLYKPES
560 570
CNNACDNIAK ISKYKRNCAG EK
Length:572
Mass (Da):65,799
Last modified:March 8, 2011 - v4
Checksum:iC65F15683A8876CA
GO

Sequence cautioni

The sequence AAI10577 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI29811 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti407K → E in AAI10577 (PubMed:15489334).Curated1
Sequence conflicti407K → E in AAI29811 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011516 Genomic DNA No translation available.
BX955247 mRNA No translation available.
BC110576 mRNA Translation: AAI10577.1 Different initiation.
BC129810 mRNA Translation: AAI29811.1 Different initiation.
CCDSiCCDS46031.1
RefSeqiNP_001092096.1, NM_001098626.1
UniGeneiHs.667355

Genome annotation databases

EnsembliENST00000357774; ENSP00000350418; ENSG00000197360
GeneIDi148198
KEGGihsa:148198
UCSCiuc002nqt.3 human

Similar proteinsi

Entry informationi

Entry nameiZNF98_HUMAN
AccessioniPrimary (citable) accession number: A6NK75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 8, 2011
Last modified: March 28, 2018
This is version 96 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health