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Protein

Zinc finger protein 98

Gene

ZNF98

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri182 – 204C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri210 – 232C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri238 – 260C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri266 – 288C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri294 – 316C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri322 – 344C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri378 – 400C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri406 – 428C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri462 – 484C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 512C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri518 – 540C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-31954-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 98
Alternative name(s):
Zinc finger protein 739
Zinc finger protein F7175
Gene namesi
Name:ZNF98
Synonyms:ZNF739
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13174. ZNF98.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi148198.
OpenTargetsiENSG00000197360.

Polymorphism and mutation databases

BioMutaiZNF98.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003169481 – 572Zinc finger protein 98Add BLAST572

Proteomic databases

MaxQBiA6NK75.
PaxDbiA6NK75.
PRIDEiA6NK75.

PTM databases

iPTMnetiA6NK75.
PhosphoSitePlusiA6NK75.

Expressioni

Gene expression databases

BgeeiENSG00000197360.
CleanExiHS_ZNF98.
ExpressionAtlasiA6NK75. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiA6NK75. 1 interactor.
STRINGi9606.ENSP00000350418.

Structurei

3D structure databases

ProteinModelPortaliA6NK75.
SMRiA6NK75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 84KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri182 – 204C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri210 – 232C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri238 – 260C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri266 – 288C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri294 – 316C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri322 – 344C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri378 – 400C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri406 – 428C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri462 – 484C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 512C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri518 – 540C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiA6NK75.
KOiK09228.
OMAiYKKCGRE.
OrthoDBiEOG091G02KC.
PhylomeDBiA6NK75.
TreeFamiTF342117.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NK75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGPLGSLEM GVLTFRDVAL EFSLEEWQCL DTAQQNLYRN VMLENYRNLV
60 70 80 90 100
FVGIAASKPD LITCLEQGKE PWNVKRHEMV TEPPVVYSYF AQDLWPKQGK
110 120 130 140 150
KNYFQKVILR TYKKCGRENL QLRKYCKSMD ECKVHKECYN GLNQCLTTTQ
160 170 180 190 200
NKIFQYDKYV KVFHKFSNSN RHKIGHTGKK SFKCKECEKS FCMLSHLAQH
210 220 230 240 250
KRIHSGEKPY KCKECGKAYN EASNLSTHKR IHTGKKPYKC EECGKAFNRL
260 270 280 290 300
SHLTTHKIIH TGKKPYKCEE CGKAFNQSAN LTTHKRIHTG EKPYKCEECG
310 320 330 340 350
RAFSQSSTLT AHKIIHAGEK PYKCEECGKA FSQSSTLTTH KIIHTGEKFY
360 370 380 390 400
KCEECGKAFS RLSHLTTHKR IHSGEKPYKC EECGKAFKQS STLTTHKRIH
410 420 430 440 450
AGEKFYKCEV CSKAFSRFSH LTTHKRIHTG EKPYKCEECG KAFNLSSQLT
460 470 480 490 500
THKIIHTGEK PYKCEECGKA FNQSSTLSKH KVIHTGEKPY KCEECGKAFN
510 520 530 540 550
QSSHLTTHKM IHTGEKPYKC EECGKAFNNS SILNRHKMIH TGEKLYKPES
560 570
CNNACDNIAK ISKYKRNCAG EK
Length:572
Mass (Da):65,799
Last modified:March 8, 2011 - v4
Checksum:iC65F15683A8876CA
GO

Sequence cautioni

The sequence AAI10577 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI29811 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti407K → E in AAI10577 (PubMed:15489334).Curated1
Sequence conflicti407K → E in AAI29811 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011516 Genomic DNA. No translation available.
BX955247 mRNA. No translation available.
BC110576 mRNA. Translation: AAI10577.1. Different initiation.
BC129810 mRNA. Translation: AAI29811.1. Different initiation.
CCDSiCCDS46031.1.
RefSeqiNP_001092096.1. NM_001098626.1.
UniGeneiHs.667355.

Genome annotation databases

EnsembliENST00000357774; ENSP00000350418; ENSG00000197360.
GeneIDi148198.
KEGGihsa:148198.
UCSCiuc002nqt.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011516 Genomic DNA. No translation available.
BX955247 mRNA. No translation available.
BC110576 mRNA. Translation: AAI10577.1. Different initiation.
BC129810 mRNA. Translation: AAI29811.1. Different initiation.
CCDSiCCDS46031.1.
RefSeqiNP_001092096.1. NM_001098626.1.
UniGeneiHs.667355.

3D structure databases

ProteinModelPortaliA6NK75.
SMRiA6NK75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA6NK75. 1 interactor.
STRINGi9606.ENSP00000350418.

PTM databases

iPTMnetiA6NK75.
PhosphoSitePlusiA6NK75.

Polymorphism and mutation databases

BioMutaiZNF98.

Proteomic databases

MaxQBiA6NK75.
PaxDbiA6NK75.
PRIDEiA6NK75.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357774; ENSP00000350418; ENSG00000197360.
GeneIDi148198.
KEGGihsa:148198.
UCSCiuc002nqt.3. human.

Organism-specific databases

CTDi148198.
DisGeNETi148198.
GeneCardsiZNF98.
HGNCiHGNC:13174. ZNF98.
MIMi603980. gene.
neXtProtiNX_A6NK75.
OpenTargetsiENSG00000197360.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiA6NK75.
KOiK09228.
OMAiYKKCGRE.
OrthoDBiEOG091G02KC.
PhylomeDBiA6NK75.
TreeFamiTF342117.

Enzyme and pathway databases

BioCyciZFISH:G66-31954-MONOMER.

Miscellaneous databases

GenomeRNAii148198.
PROiA6NK75.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197360.
CleanExiHS_ZNF98.
ExpressionAtlasiA6NK75. baseline and differential.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNF98_HUMAN
AccessioniPrimary (citable) accession number: A6NK75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 8, 2011
Last modified: November 30, 2016
This is version 85 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.