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Protein

Ankyrin repeat and SOCS box protein 14

Gene

ASB14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 14
Short name:
ASB-14
Gene namesi
Name:ASB14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:19766. ASB14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134983884.

Polymorphism and mutation databases

BioMutaiASB14.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 587587Ankyrin repeat and SOCS box protein 14PRO_0000066951Add
BLAST

Proteomic databases

PaxDbiA6NK59.
PRIDEiA6NK59.

PTM databases

iPTMnetiA6NK59.
PhosphoSiteiA6NK59.

Expressioni

Gene expression databases

BgeeiENSG00000239388.
GenevisibleiA6NK59. HS.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126775. 21 interactions.
STRINGi9606.ENSP00000419199.

Structurei

3D structure databases

ProteinModelPortaliA6NK59.
SMRiA6NK59. Positions 51-572.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati82 – 11231ANK 1Add
BLAST
Repeati117 – 14630ANK 2Add
BLAST
Repeati150 – 17930ANK 3Add
BLAST
Repeati183 – 21230ANK 4Add
BLAST
Repeati216 – 24530ANK 5Add
BLAST
Repeati248 – 27730ANK 6Add
BLAST
Repeati281 – 31030ANK 7Add
BLAST
Repeati313 – 34230ANK 8Add
BLAST
Repeati355 – 38430ANK 9Add
BLAST
Repeati385 – 41430ANK 10Add
BLAST
Repeati416 – 44934ANK 11Add
BLAST
Domaini521 – 57656SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated
Contains 11 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063050.
HOGENOMiHOG000034086.
InParanoidiA6NK59.
KOiK10336.
OMAiVNLRCAN.
OrthoDBiEOG091G03QP.
PhylomeDBiA6NK59.
TreeFamiTF315127.

Family and domain databases

Gene3Di1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 4 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 11 hits.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 7 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NK59-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDNYTSDEDI DEDFDTQLII QQSLQDIYKP GTAQHAPKDE SLHSFLSADY
60 70 80 90 100
KKIVETIEKV GKEDALSHLT KYHSAFGEAD EIGWIPLHKA AVQLNRKILE
110 120 130 140 150
ITLSASDPSL WEQTTHNGET PLFLAVSSCL LENATFLLLN GCNPNAKNFE
160 170 180 190 200
GNSPLLAAVL RDCYDMAALL INYGADVNLR CANERTALHE AAKLGREDMV
210 220 230 240 250
KLMLVSGAHP DPQSTYGFTP LALAAQSGHT EIMEMLLRKG KIFCLASDSS
260 270 280 290 300
SILLEAASGG NPDAVALLLE YGADANIPKN SGHLPIHVAA DRGHLLALKI
310 320 330 340 350
LIPVTDLAAI KQSGISPVHC AAAGAHPQCL ELLIQAGFDV NFMLDQRINK
360 370 380 390 400
HYDDHRKSAL YFAVSNSDLS SVKLLLSAGA LPNQDPVNCL QIALRMGNYE
410 420 430 440 450
LISLLLRHGA NVNYFCRVNP LHFPSALQYT LKDEVMLRML LNYGYDTERC
460 470 480 490 500
FDCPHGDKVH PSYTVEGWTS TVIKDTKFCE VITLSWLQHL SGKVVRVMLD
510 520 530 540 550
YVDQVRICSK LKAVLQKQGI WSEIHFILTN PRSLKHLCRL KIRKCMGRLH
560 570 580
LRCPVFMSFL PLPNRLKAYV LYKEYDLYGQ GIFTGTW
Length:587
Mass (Da):65,331
Last modified:January 15, 2008 - v2
Checksum:i310E03BF7E618F8C
GO
Isoform 2 (identifier: A6NK59-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-285: Missing.
     286-296: IHVAADRGHLL → MLKCILKFFLR

Note: No experimental confirmation available.
Show »
Length:302
Mass (Da):34,563
Checksum:i0B8C6E7219E9EF7B
GO
Isoform 3 (identifier: A6NK59-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-60: Missing.
     241-245: KIFCL → ANAHGQ

Note: No experimental confirmation available.
Show »
Length:587
Mass (Da):65,206
Checksum:iD4D90FA6C7C69DF4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti410 – 4101A → T in AL832472 (PubMed:17974005).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 285285Missing in isoform 2. 1 PublicationVSP_036925Add
BLAST
Alternative sequencei60 – 601Missing in isoform 3. 1 PublicationVSP_046197
Alternative sequencei241 – 2455KIFCL → ANAHGQ in isoform 3. 1 PublicationVSP_046198
Alternative sequencei286 – 29611IHVAADRGHLL → MLKCILKFFLR in isoform 2. 1 PublicationVSP_036926Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403032 mRNA. Translation: AAL57351.1.
AL832472 mRNA. No translation available.
AC093928 Genomic DNA. No translation available.
CCDSiCCDS46856.2. [A6NK59-3]
RefSeqiNP_001136205.2. NM_001142733.2. [A6NK59-3]
NP_569058.1. NM_130387.5. [A6NK59-2]
UniGeneiHs.665154.

Genome annotation databases

EnsembliENST00000389601; ENSP00000374252; ENSG00000239388. [A6NK59-1]
ENST00000487349; ENSP00000419199; ENSG00000239388. [A6NK59-3]
GeneIDi142686.
KEGGihsa:142686.
UCSCiuc062kwt.1. human. [A6NK59-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403032 mRNA. Translation: AAL57351.1.
AL832472 mRNA. No translation available.
AC093928 Genomic DNA. No translation available.
CCDSiCCDS46856.2. [A6NK59-3]
RefSeqiNP_001136205.2. NM_001142733.2. [A6NK59-3]
NP_569058.1. NM_130387.5. [A6NK59-2]
UniGeneiHs.665154.

3D structure databases

ProteinModelPortaliA6NK59.
SMRiA6NK59. Positions 51-572.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126775. 21 interactions.
STRINGi9606.ENSP00000419199.

PTM databases

iPTMnetiA6NK59.
PhosphoSiteiA6NK59.

Polymorphism and mutation databases

BioMutaiASB14.

Proteomic databases

PaxDbiA6NK59.
PRIDEiA6NK59.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389601; ENSP00000374252; ENSG00000239388. [A6NK59-1]
ENST00000487349; ENSP00000419199; ENSG00000239388. [A6NK59-3]
GeneIDi142686.
KEGGihsa:142686.
UCSCiuc062kwt.1. human. [A6NK59-1]

Organism-specific databases

CTDi142686.
GeneCardsiASB14.
HGNCiHGNC:19766. ASB14.
neXtProtiNX_A6NK59.
PharmGKBiPA134983884.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063050.
HOGENOMiHOG000034086.
InParanoidiA6NK59.
KOiK10336.
OMAiVNLRCAN.
OrthoDBiEOG091G03QP.
PhylomeDBiA6NK59.
TreeFamiTF315127.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GenomeRNAii142686.
PROiA6NK59.

Gene expression databases

BgeeiENSG00000239388.
GenevisibleiA6NK59. HS.

Family and domain databases

Gene3Di1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 4 hits.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 11 hits.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 7 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASB14_HUMAN
AccessioniPrimary (citable) accession number: A6NK59
Secondary accession number(s): C9JX97, Q8WXK2, Q92816
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: September 7, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally derived from a readthrough transcript including ASB14 and DNAH12.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.