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Protein

Putative lipoyltransferase 2, mitochondrial

Gene

LIPT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity).By similarity

Catalytic activityi

Octanoyl-[acyl-carrier-protein] + protein = protein N(6)-(octanoyl)lysine + [acyl-carrier-protein].

Pathwayi: protein lipoylation via endogenous pathway

This protein is involved in step 1 of the subpathway that synthesizes protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein].
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Putative lipoyltransferase 2, mitochondrial (LIPT2)
  2. Lipoyl synthase, mitochondrial (LIAS), Lipoyl synthase, mitochondrial (LIAS)
This subpathway is part of the pathway protein lipoylation via endogenous pathway, which is itself part of Protein modification.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein], the pathway protein lipoylation via endogenous pathway and in Protein modification.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei151 – 1511Lowers pKa of active site CysBy similarity
Active sitei185 – 1851Acyl-thioester intermediateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Ligase, Transferase

Enzyme and pathway databases

ReactomeiR-HSA-389661. Glyoxylate metabolism and glycine degradation.
UniPathwayiUPA00538; UER00592.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative lipoyltransferase 2, mitochondrial (EC:2.3.1.181)
Alternative name(s):
Lipoate-protein ligase B
Lipoyl/octanoyl transferase
Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase
Gene namesi
Name:LIPT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:37216. LIPT2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165543447.

Polymorphism and mutation databases

BioMutaiLIPT2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3131MitochondrionSequence analysisAdd
BLAST
Chaini32 – 231200Putative lipoyltransferase 2, mitochondrialPRO_0000332305Add
BLAST

Proteomic databases

MaxQBiA6NK58.
PaxDbiA6NK58.
PRIDEiA6NK58.

Expressioni

Gene expression databases

BgeeiA6NK58.
ExpressionAtlasiA6NK58. baseline and differential.

Organism-specific databases

HPAiHPA040249.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000309463.

Structurei

3D structure databases

ProteinModelPortaliA6NK58.
SMRiA6NK58. Positions 5-207.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 224184BPL/LPL catalyticPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni85 – 928Substrate bindingBy similarity
Regioni154 – 1563Substrate bindingBy similarity
Regioni167 – 1693Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the LipB family.Curated
Contains 1 BPL/LPL catalytic domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0325. Eukaryota.
COG0321. LUCA.
GeneTreeiENSGT00390000006450.
HOGENOMiHOG000194322.
HOVERGENiHBG076127.
InParanoidiA6NK58.
KOiK03801.
OMAiSIRWYVA.
PhylomeDBiA6NK58.
TreeFamiTF314262.

Family and domain databases

InterProiIPR004143. BPL_LPL_catalytic.
IPR000544. Octanoyltransferase.
[Graphical view]
PfamiPF03099. BPL_LplA_LipB. 1 hit.
[Graphical view]
PIRSFiPIRSF016262. LPLase. 1 hit.
TIGRFAMsiTIGR00214. lipB. 1 hit.
PROSITEiPS51733. BPL_LPL_CATALYTIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6NK58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQPAVRLVR LGRVPYAELL GLQDRWLRRL QAEPGIEAPS GTEAGALLLC
60 70 80 90 100
EPAGPVYTAG LRGGLTPEET ARLRALGAEV RVTGRGGLAT FHGPGQLLCH
110 120 130 140 150
PVLDLRRLGL RLRMHVASLE ACAVRLCELQ GLQDARARPP PYTGVWLDDR
160 170 180 190 200
KICAIGVRCG RHITSHGLAL NCSTDLTWFE HIVPCGLVGT GVTSLSKELQ
210 220 230
RHVTVEEVMP PFLVAFKEIY KCTLISEDSP N
Length:231
Mass (Da):25,195
Last modified:July 24, 2007 - v1
Checksum:iD6713EF69C49FF44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001372 Genomic DNA. No translation available.
CCDSiCCDS44679.1.
RefSeqiNP_001138341.1. NM_001144869.1.
UniGeneiHs.591971.

Genome annotation databases

EnsembliENST00000310109; ENSP00000309463; ENSG00000175536.
GeneIDi387787.
KEGGihsa:387787.
UCSCiuc010rrk.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001372 Genomic DNA. No translation available.
CCDSiCCDS44679.1.
RefSeqiNP_001138341.1. NM_001144869.1.
UniGeneiHs.591971.

3D structure databases

ProteinModelPortaliA6NK58.
SMRiA6NK58. Positions 5-207.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000309463.

Polymorphism and mutation databases

BioMutaiLIPT2.

Proteomic databases

MaxQBiA6NK58.
PaxDbiA6NK58.
PRIDEiA6NK58.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310109; ENSP00000309463; ENSG00000175536.
GeneIDi387787.
KEGGihsa:387787.
UCSCiuc010rrk.3. human.

Organism-specific databases

CTDi387787.
GeneCardsiLIPT2.
HGNCiHGNC:37216. LIPT2.
HPAiHPA040249.
neXtProtiNX_A6NK58.
PharmGKBiPA165543447.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0325. Eukaryota.
COG0321. LUCA.
GeneTreeiENSGT00390000006450.
HOGENOMiHOG000194322.
HOVERGENiHBG076127.
InParanoidiA6NK58.
KOiK03801.
OMAiSIRWYVA.
PhylomeDBiA6NK58.
TreeFamiTF314262.

Enzyme and pathway databases

UniPathwayiUPA00538; UER00592.
ReactomeiR-HSA-389661. Glyoxylate metabolism and glycine degradation.

Miscellaneous databases

GenomeRNAii387787.
PROiA6NK58.

Gene expression databases

BgeeiA6NK58.
ExpressionAtlasiA6NK58. baseline and differential.

Family and domain databases

InterProiIPR004143. BPL_LPL_catalytic.
IPR000544. Octanoyltransferase.
[Graphical view]
PfamiPF03099. BPL_LplA_LipB. 1 hit.
[Graphical view]
PIRSFiPIRSF016262. LPLase. 1 hit.
TIGRFAMsiTIGR00214. lipB. 1 hit.
PROSITEiPS51733. BPL_LPL_CATALYTIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiLIPT2_HUMAN
AccessioniPrimary (citable) accession number: A6NK58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 24, 2007
Last modified: June 8, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.