A6NK53 (ZN233_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 233

Gene names

Name:

ZNF233

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	670 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 12 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from direct assay. Source: HPA
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 670	670	Zinc finger protein 233		PRO_0000304407
Regions
	Domain	8 – 79	72	KRAB
	Zinc finger	258 – 280	23	C2H2-type 1; degenerate
	Zinc finger	311 – 336	26	C2H2-type 2; degenerate
	Zinc finger	342 – 364	23	C2H2-type 3; degenerate
	Zinc finger	370 – 392	23	C2H2-type 4; degenerate
	Zinc finger	398 – 420	23	C2H2-type 5; degenerate
	Zinc finger	452 – 474	23	C2H2-type 6
	Zinc finger	480 – 502	23	C2H2-type 7
	Zinc finger	508 – 530	23	C2H2-type 8
	Zinc finger	536 – 558	23	C2H2-type 9
	Zinc finger	564 – 586	23	C2H2-type 10
	Zinc finger	592 – 614	23	C2H2-type 11
	Zinc finger	620 – 642	23	C2H2-type 12
Natural variations
	Natural variant	247	1	S → P. Corresponds to variant rs16978899 [ dbSNP | Ensembl ].		VAR_035022
	Natural variant	531	1	K → T. Ref.1 Ref.2 Ref.3 Corresponds to variant rs1233428 [ dbSNP | Ensembl ].		VAR_035023
Experimental info
	Sequence conflict	138	1	D → G in AAO45841. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	A6NK53 [UniParc]. Last modified November 30, 2010. Version 3. Checksum: 531D751D1CE4BDA5	FASTA	670	76,861
	10 20 30 40 50 60 MTKFQEMVTF KDVAVVFTRE ELGLLDLAQR KLYQDVMLEN FRNLLSVGYQ PFKLDVILQL 70 80 90 100 110 120 GKEDKLRMME TEIQGDGCSG HKNQNEIDTL QEVRLRFLSY EDLICWQIWE QFTSKLTSNQ 130 140 150 160 170 180 DLIINLQGKR SKLLKQGDSP CQVWTGESSQ VSEDENYVIK LQGESSNSIK NQELPLRTTW 190 200 210 220 230 240 DFWRKMYLRE PQNYQSRCQQ IDVKNKLCKC DHCVRQRIAH QHDDHGVHKR EKAFSHNNCG 250 260 270 280 290 300 KDCVKESSQH SIIQSGEQTS DENGKGLSVG SNLELHQQLH LRDKPHVNVE YGKGIGYSSG 310 320 330 340 350 360 LPRHQCFHIG EKCYRNGDSG EGFSQGSHLQ PHQRVSTGEN LYRCQVYARS SNQNSCLPSH 370 380 390 400 410 420 ELTHPGEKLC TCGRCGKGFH HSLDFDIHCV DSAGERACKC DVYDKGFSQT SQLQAHQRGH 430 440 450 460 470 480 SRDKTYKWEV SDRIFNRNSG LHQRVHTGEK PYKCEVCDKG FSKASNLQAH QRIHTGEKPY 490 500 510 520 530 540 KCDVCDKNFS RNSHLQAHQR VHTGEKPYKC DTCGKDFSQI SHLQAHQRVH KGEKPYKCET 550 560 570 580 590 600 CGKGFSQSSH LQDHQQVHTG ENPYKCDVCG KGFSWSSHLQ AHQRVHTGEK PYKCEECRKG 610 620 630 640 650 660 FIWNSYLHVH QRIHTGEKPY KCGMCGKSFS QTSHLQAHQR VHTGEKPYKC FVCGKGFSKS 670 SLSSDSSESP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-531. Tissue: Tongue.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-531.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-531. Tissue: Brain.
[4]	"Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters." Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L. Genome Res. 13:1097-1110(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 46-153. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK095351 mRNA. Translation: BAG53032.1. AC138470 Genomic DNA. No translation available. AC092477 Genomic DNA. No translation available. BC136734 mRNA. Translation: AAI36735.1. BC136735 mRNA. Translation: AAI36736.1. AY166792 mRNA. Translation: AAO45841.1.
IPI	IPI00479597.
RefSeq	NP_001193934.1. NM_001207005.1. NP_861421.2. NM_181756.2.
UniGene	Hs.466891.
3D structure databases
ProteinModelPortal	A6NK53.
SMR	A6NK53. Positions 8-49, 232-660.
ModBase	Search...
Protein-protein interaction databases
IntAct	A6NK53. 2 interactions.
PTM databases
PhosphoSite	A6NK53.
Proteomic databases
PaxDb	A6NK53.
PRIDE	A6NK53.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000391958; ENSP00000375820; ENSG00000159915.
GeneID	353355.
KEGG	hsa:353355.
UCSC	uc002oyy.2. human.
Organism-specific databases
CTD	353355.
GeneCards	GC19P044754.
HGNC	HGNC:30946. ZNF233.
HPA	HPA020975.
neXtProt	NX_A6NK53.
PharmGKB	PA134917179.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	A6NK53.
KO	K09228.
OMA	SRCQQID.
PhylomeDB	A6NK53.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	A6NK53.
Bgee	A6NK53.
CleanEx	HS_ZNF233.
Genevestigator	A6NK53.
Family and domain databases
Gene3D	3.30.160.60. 11 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 8 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 7 hits. PS50157. ZINC_FINGER_C2H2_2. 8 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	353355.
NextBio	99800.

Entry information

Entry name

ZN233_HUMAN

Accession

Primary (citable) accession number: A6NK53
Secondary accession number(s): B2RN78, B2RN79, Q86WL8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	November 30, 2010
Last modified:	May 1, 2013
This is version 58 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.