Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A6NK53

- ZN233_HUMAN

UniProt

A6NK53 - ZN233_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Zinc finger protein 233

Gene

ZNF233

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri258 – 28023C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri311 – 33626C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri342 – 36423C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri370 – 39223C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri398 – 42023C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri452 – 47423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri480 – 50223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri508 – 53023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri536 – 55823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri564 – 58623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri592 – 61423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri620 – 64223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 233
Gene namesi
Name:ZNF233
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:30946. ZNF233.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134917179.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 670670Zinc finger protein 233PRO_0000304407Add
BLAST

Proteomic databases

PaxDbiA6NK53.
PRIDEiA6NK53.

PTM databases

PhosphoSiteiA6NK53.

Expressioni

Gene expression databases

BgeeiA6NK53.
CleanExiHS_ZNF233.
ExpressionAtlasiA6NK53. baseline and differential.
GenevestigatoriA6NK53.

Organism-specific databases

HPAiHPA020975.

Interactioni

Protein-protein interaction databases

BioGridi131691. 2 interactions.
IntActiA6NK53. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliA6NK53.
SMRiA6NK53. Positions 8-49, 232-660.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7972KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri258 – 28023C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri311 – 33626C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri342 – 36423C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri370 – 39223C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri398 – 42023C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri452 – 47423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri480 – 50223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri508 – 53023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri536 – 55823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri564 – 58623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri592 – 61423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri620 – 64223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119262.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiA6NK53.
KOiK09228.
OMAiFWRKMYL.
OrthoDBiEOG7KSX7Q.
PhylomeDBiA6NK53.
TreeFamiTF350845.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NK53-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKFQEMVTF KDVAVVFTRE ELGLLDLAQR KLYQDVMLEN FRNLLSVGYQ
60 70 80 90 100
PFKLDVILQL GKEDKLRMME TEIQGDGCSG HKNQNEIDTL QEVRLRFLSY
110 120 130 140 150
EDLICWQIWE QFTSKLTSNQ DLIINLQGKR SKLLKQGDSP CQVWTGESSQ
160 170 180 190 200
VSEDENYVIK LQGESSNSIK NQELPLRTTW DFWRKMYLRE PQNYQSRCQQ
210 220 230 240 250
IDVKNKLCKC DHCVRQRIAH QHDDHGVHKR EKAFSHNNCG KDCVKESSQH
260 270 280 290 300
SIIQSGEQTS DENGKGLSVG SNLELHQQLH LRDKPHVNVE YGKGIGYSSG
310 320 330 340 350
LPRHQCFHIG EKCYRNGDSG EGFSQGSHLQ PHQRVSTGEN LYRCQVYARS
360 370 380 390 400
SNQNSCLPSH ELTHPGEKLC TCGRCGKGFH HSLDFDIHCV DSAGERACKC
410 420 430 440 450
DVYDKGFSQT SQLQAHQRGH SRDKTYKWEV SDRIFNRNSG LHQRVHTGEK
460 470 480 490 500
PYKCEVCDKG FSKASNLQAH QRIHTGEKPY KCDVCDKNFS RNSHLQAHQR
510 520 530 540 550
VHTGEKPYKC DTCGKDFSQI SHLQAHQRVH KGEKPYKCET CGKGFSQSSH
560 570 580 590 600
LQDHQQVHTG ENPYKCDVCG KGFSWSSHLQ AHQRVHTGEK PYKCEECRKG
610 620 630 640 650
FIWNSYLHVH QRIHTGEKPY KCGMCGKSFS QTSHLQAHQR VHTGEKPYKC
660 670
FVCGKGFSKS SLSSDSSESP
Length:670
Mass (Da):76,861
Last modified:November 30, 2010 - v3
Checksum:i531D751D1CE4BDA5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti138 – 1381D → G in AAO45841. (PubMed:12743021)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti247 – 2471S → P.
Corresponds to variant rs16978899 [ dbSNP | Ensembl ].
VAR_035022
Natural varianti531 – 5311K → T.3 Publications
Corresponds to variant rs1233428 [ dbSNP | Ensembl ].
VAR_035023

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK095351 mRNA. Translation: BAG53032.1.
AC138470 Genomic DNA. No translation available.
AC092477 Genomic DNA. No translation available.
BC136734 mRNA. Translation: AAI36735.1.
BC136735 mRNA. Translation: AAI36736.1.
AY166792 mRNA. Translation: AAO45841.1.
CCDSiCCDS33047.1.
RefSeqiNP_001193934.1. NM_001207005.1.
NP_861421.2. NM_181756.2.
UniGeneiHs.466891.

Genome annotation databases

EnsembliENST00000391958; ENSP00000375820; ENSG00000159915.
GeneIDi353355.
KEGGihsa:353355.
UCSCiuc002oyy.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK095351 mRNA. Translation: BAG53032.1 .
AC138470 Genomic DNA. No translation available.
AC092477 Genomic DNA. No translation available.
BC136734 mRNA. Translation: AAI36735.1 .
BC136735 mRNA. Translation: AAI36736.1 .
AY166792 mRNA. Translation: AAO45841.1 .
CCDSi CCDS33047.1.
RefSeqi NP_001193934.1. NM_001207005.1.
NP_861421.2. NM_181756.2.
UniGenei Hs.466891.

3D structure databases

ProteinModelPortali A6NK53.
SMRi A6NK53. Positions 8-49, 232-660.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 131691. 2 interactions.
IntActi A6NK53. 2 interactions.

PTM databases

PhosphoSitei A6NK53.

Proteomic databases

PaxDbi A6NK53.
PRIDEi A6NK53.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000391958 ; ENSP00000375820 ; ENSG00000159915 .
GeneIDi 353355.
KEGGi hsa:353355.
UCSCi uc002oyy.2. human.

Organism-specific databases

CTDi 353355.
GeneCardsi GC19P044754.
HGNCi HGNC:30946. ZNF233.
HPAi HPA020975.
neXtProti NX_A6NK53.
PharmGKBi PA134917179.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000119262.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi A6NK53.
KOi K09228.
OMAi FWRKMYL.
OrthoDBi EOG7KSX7Q.
PhylomeDBi A6NK53.
TreeFami TF350845.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 353355.
NextBioi 99800.
PROi A6NK53.

Gene expression databases

Bgeei A6NK53.
CleanExi HS_ZNF233.
ExpressionAtlasi A6NK53. baseline and differential.
Genevestigatori A6NK53.

Family and domain databases

Gene3Di 3.30.160.60. 11 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-531.
    Tissue: Tongue.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-531.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-531.
    Tissue: Brain.
  4. "Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters."
    Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.
    Genome Res. 13:1097-1110(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 46-153.
    Tissue: Testis.

Entry informationi

Entry nameiZN233_HUMAN
AccessioniPrimary (citable) accession number: A6NK53
Secondary accession number(s): B2RN78, B2RN79, Q86WL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 30, 2010
Last modified: October 29, 2014
This is version 72 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3