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Protein

Zinc finger protein 233

Gene

ZNF233

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri258 – 280C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 336C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri342 – 364C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri370 – 392C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri508 – 530C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri536 – 558C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri564 – 586C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri592 – 614C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri620 – 642C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 233
Gene namesi
Name:ZNF233
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000159915.12
HGNCiHGNC:30946 ZNF233
neXtProtiNX_A6NK53

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000159915
PharmGKBiPA134917179

Polymorphism and mutation databases

BioMutaiZNF233

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003044071 – 670Zinc finger protein 233Add BLAST670

Proteomic databases

PaxDbiA6NK53
PRIDEiA6NK53

PTM databases

iPTMnetiA6NK53
PhosphoSitePlusiA6NK53

Expressioni

Gene expression databases

BgeeiENSG00000159915
CleanExiHS_ZNF233
ExpressionAtlasiA6NK53 baseline and differential
GenevisibleiA6NK53 HS

Organism-specific databases

HPAiHPA020975

Interactioni

Protein-protein interaction databases

BioGridi131691, 1 interactor
IntActiA6NK53, 3 interactors
STRINGi9606.ENSP00000375820

Structurei

3D structure databases

ProteinModelPortaliA6NK53
SMRiA6NK53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri258 – 280C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 336C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri342 – 364C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri370 – 392C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri508 – 530C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri536 – 558C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri564 – 586C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri592 – 614C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri620 – 642C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00870000136402
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiA6NK53
KOiK09228
OMAiIWNSYLH
OrthoDBiEOG091G02KC
PhylomeDBiA6NK53
TreeFamiTF350845

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequencei

Sequence statusi: Complete.

A6NK53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKFQEMVTF KDVAVVFTRE ELGLLDLAQR KLYQDVMLEN FRNLLSVGYQ
60 70 80 90 100
PFKLDVILQL GKEDKLRMME TEIQGDGCSG HKNQNEIDTL QEVRLRFLSY
110 120 130 140 150
EDLICWQIWE QFTSKLTSNQ DLIINLQGKR SKLLKQGDSP CQVWTGESSQ
160 170 180 190 200
VSEDENYVIK LQGESSNSIK NQELPLRTTW DFWRKMYLRE PQNYQSRCQQ
210 220 230 240 250
IDVKNKLCKC DHCVRQRIAH QHDDHGVHKR EKAFSHNNCG KDCVKESSQH
260 270 280 290 300
SIIQSGEQTS DENGKGLSVG SNLELHQQLH LRDKPHVNVE YGKGIGYSSG
310 320 330 340 350
LPRHQCFHIG EKCYRNGDSG EGFSQGSHLQ PHQRVSTGEN LYRCQVYARS
360 370 380 390 400
SNQNSCLPSH ELTHPGEKLC TCGRCGKGFH HSLDFDIHCV DSAGERACKC
410 420 430 440 450
DVYDKGFSQT SQLQAHQRGH SRDKTYKWEV SDRIFNRNSG LHQRVHTGEK
460 470 480 490 500
PYKCEVCDKG FSKASNLQAH QRIHTGEKPY KCDVCDKNFS RNSHLQAHQR
510 520 530 540 550
VHTGEKPYKC DTCGKDFSQI SHLQAHQRVH KGEKPYKCET CGKGFSQSSH
560 570 580 590 600
LQDHQQVHTG ENPYKCDVCG KGFSWSSHLQ AHQRVHTGEK PYKCEECRKG
610 620 630 640 650
FIWNSYLHVH QRIHTGEKPY KCGMCGKSFS QTSHLQAHQR VHTGEKPYKC
660 670
FVCGKGFSKS SLSSDSSESP
Length:670
Mass (Da):76,861
Last modified:November 30, 2010 - v3
Checksum:i531D751D1CE4BDA5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti138D → G in AAO45841 (PubMed:12743021).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035022247S → P. Corresponds to variant dbSNP:rs16978899Ensembl.1
Natural variantiVAR_035023531K → T3 PublicationsCorresponds to variant dbSNP:rs1233428Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095351 mRNA Translation: BAG53032.1
AC138470 Genomic DNA No translation available.
AC092477 Genomic DNA No translation available.
BC136734 mRNA Translation: AAI36735.1
BC136735 mRNA Translation: AAI36736.1
AY166792 mRNA Translation: AAO45841.1
CCDSiCCDS33047.1
RefSeqiNP_001193934.1, NM_001207005.1
NP_861421.2, NM_181756.2
UniGeneiHs.466891

Genome annotation databases

EnsembliENST00000391958; ENSP00000375820; ENSG00000159915
GeneIDi353355
KEGGihsa:353355
UCSCiuc002oyz.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN233_HUMAN
AccessioniPrimary (citable) accession number: A6NK53
Secondary accession number(s): B2RN78, B2RN79, Q86WL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 30, 2010
Last modified: May 23, 2018
This is version 102 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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