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Protein

Zinc finger protein 233

Gene

ZNF233

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri258 – 280C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 336C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri342 – 364C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri370 – 392C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri508 – 530C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri536 – 558C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri564 – 586C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri592 – 614C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri620 – 642C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 233
Gene namesi
Name:ZNF233
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30946. ZNF233.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000159915.
PharmGKBiPA134917179.

Polymorphism and mutation databases

BioMutaiZNF233.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003044071 – 670Zinc finger protein 233Add BLAST670

Proteomic databases

PaxDbiA6NK53.
PRIDEiA6NK53.

PTM databases

iPTMnetiA6NK53.
PhosphoSitePlusiA6NK53.

Expressioni

Gene expression databases

BgeeiENSG00000159915.
CleanExiHS_ZNF233.
ExpressionAtlasiA6NK53. baseline and differential.
GenevisibleiA6NK53. HS.

Organism-specific databases

HPAiHPA020975.

Interactioni

Protein-protein interaction databases

BioGridi131691. 1 interactor.
IntActiA6NK53. 2 interactors.
STRINGi9606.ENSP00000375820.

Structurei

3D structure databases

ProteinModelPortaliA6NK53.
SMRiA6NK53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri258 – 280C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 336C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri342 – 364C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri370 – 392C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri508 – 530C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri536 – 558C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri564 – 586C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri592 – 614C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri620 – 642C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiA6NK53.
KOiK09228.
OMAiYKCGMCG.
OrthoDBiEOG091G02KC.
PhylomeDBiA6NK53.
TreeFamiTF350845.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NK53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKFQEMVTF KDVAVVFTRE ELGLLDLAQR KLYQDVMLEN FRNLLSVGYQ
60 70 80 90 100
PFKLDVILQL GKEDKLRMME TEIQGDGCSG HKNQNEIDTL QEVRLRFLSY
110 120 130 140 150
EDLICWQIWE QFTSKLTSNQ DLIINLQGKR SKLLKQGDSP CQVWTGESSQ
160 170 180 190 200
VSEDENYVIK LQGESSNSIK NQELPLRTTW DFWRKMYLRE PQNYQSRCQQ
210 220 230 240 250
IDVKNKLCKC DHCVRQRIAH QHDDHGVHKR EKAFSHNNCG KDCVKESSQH
260 270 280 290 300
SIIQSGEQTS DENGKGLSVG SNLELHQQLH LRDKPHVNVE YGKGIGYSSG
310 320 330 340 350
LPRHQCFHIG EKCYRNGDSG EGFSQGSHLQ PHQRVSTGEN LYRCQVYARS
360 370 380 390 400
SNQNSCLPSH ELTHPGEKLC TCGRCGKGFH HSLDFDIHCV DSAGERACKC
410 420 430 440 450
DVYDKGFSQT SQLQAHQRGH SRDKTYKWEV SDRIFNRNSG LHQRVHTGEK
460 470 480 490 500
PYKCEVCDKG FSKASNLQAH QRIHTGEKPY KCDVCDKNFS RNSHLQAHQR
510 520 530 540 550
VHTGEKPYKC DTCGKDFSQI SHLQAHQRVH KGEKPYKCET CGKGFSQSSH
560 570 580 590 600
LQDHQQVHTG ENPYKCDVCG KGFSWSSHLQ AHQRVHTGEK PYKCEECRKG
610 620 630 640 650
FIWNSYLHVH QRIHTGEKPY KCGMCGKSFS QTSHLQAHQR VHTGEKPYKC
660 670
FVCGKGFSKS SLSSDSSESP
Length:670
Mass (Da):76,861
Last modified:November 30, 2010 - v3
Checksum:i531D751D1CE4BDA5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti138D → G in AAO45841 (PubMed:12743021).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035022247S → P.Corresponds to variant rs16978899dbSNPEnsembl.1
Natural variantiVAR_035023531K → T.3 PublicationsCorresponds to variant rs1233428dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095351 mRNA. Translation: BAG53032.1.
AC138470 Genomic DNA. No translation available.
AC092477 Genomic DNA. No translation available.
BC136734 mRNA. Translation: AAI36735.1.
BC136735 mRNA. Translation: AAI36736.1.
AY166792 mRNA. Translation: AAO45841.1.
CCDSiCCDS33047.1.
RefSeqiNP_001193934.1. NM_001207005.1.
NP_861421.2. NM_181756.2.
UniGeneiHs.466891.

Genome annotation databases

EnsembliENST00000391958; ENSP00000375820; ENSG00000159915.
GeneIDi353355.
KEGGihsa:353355.
UCSCiuc002oyz.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095351 mRNA. Translation: BAG53032.1.
AC138470 Genomic DNA. No translation available.
AC092477 Genomic DNA. No translation available.
BC136734 mRNA. Translation: AAI36735.1.
BC136735 mRNA. Translation: AAI36736.1.
AY166792 mRNA. Translation: AAO45841.1.
CCDSiCCDS33047.1.
RefSeqiNP_001193934.1. NM_001207005.1.
NP_861421.2. NM_181756.2.
UniGeneiHs.466891.

3D structure databases

ProteinModelPortaliA6NK53.
SMRiA6NK53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131691. 1 interactor.
IntActiA6NK53. 2 interactors.
STRINGi9606.ENSP00000375820.

PTM databases

iPTMnetiA6NK53.
PhosphoSitePlusiA6NK53.

Polymorphism and mutation databases

BioMutaiZNF233.

Proteomic databases

PaxDbiA6NK53.
PRIDEiA6NK53.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391958; ENSP00000375820; ENSG00000159915.
GeneIDi353355.
KEGGihsa:353355.
UCSCiuc002oyz.3. human.

Organism-specific databases

CTDi353355.
GeneCardsiZNF233.
HGNCiHGNC:30946. ZNF233.
HPAiHPA020975.
neXtProtiNX_A6NK53.
OpenTargetsiENSG00000159915.
PharmGKBiPA134917179.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiA6NK53.
KOiK09228.
OMAiYKCGMCG.
OrthoDBiEOG091G02KC.
PhylomeDBiA6NK53.
TreeFamiTF350845.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii353355.
PROiA6NK53.

Gene expression databases

BgeeiENSG00000159915.
CleanExiHS_ZNF233.
ExpressionAtlasiA6NK53. baseline and differential.
GenevisibleiA6NK53. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN233_HUMAN
AccessioniPrimary (citable) accession number: A6NK53
Secondary accession number(s): B2RN78, B2RN79, Q86WL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 30, 2010
Last modified: November 30, 2016
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.