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A6NK53

- ZN233_HUMAN

UniProt

A6NK53 - ZN233_HUMAN

Protein

Zinc finger protein 233

Gene

ZNF233

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 3 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri258 – 28023C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri311 – 33626C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri342 – 36423C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri370 – 39223C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri398 – 42023C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri452 – 47423C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri480 – 50223C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri508 – 53023C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri536 – 55823C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri564 – 58623C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri592 – 61423C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri620 – 64223C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 233
    Gene namesi
    Name:ZNF233
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:30946. ZNF233.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134917179.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 670670Zinc finger protein 233PRO_0000304407Add
    BLAST

    Proteomic databases

    PaxDbiA6NK53.
    PRIDEiA6NK53.

    PTM databases

    PhosphoSiteiA6NK53.

    Expressioni

    Gene expression databases

    ArrayExpressiA6NK53.
    BgeeiA6NK53.
    CleanExiHS_ZNF233.
    GenevestigatoriA6NK53.

    Organism-specific databases

    HPAiHPA020975.

    Interactioni

    Protein-protein interaction databases

    BioGridi131691. 2 interactions.
    IntActiA6NK53. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NK53.
    SMRiA6NK53. Positions 8-49, 232-660.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 7972KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri258 – 28023C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri311 – 33626C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri342 – 36423C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri370 – 39223C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri398 – 42023C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri452 – 47423C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri480 – 50223C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri508 – 53023C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri536 – 55823C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri564 – 58623C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri592 – 61423C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri620 – 64223C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiA6NK53.
    KOiK09228.
    OMAiFWRKMYL.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiA6NK53.
    TreeFamiTF350845.

    Family and domain databases

    Gene3Di3.30.160.60. 11 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 8 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 8 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6NK53-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKFQEMVTF KDVAVVFTRE ELGLLDLAQR KLYQDVMLEN FRNLLSVGYQ    50
    PFKLDVILQL GKEDKLRMME TEIQGDGCSG HKNQNEIDTL QEVRLRFLSY 100
    EDLICWQIWE QFTSKLTSNQ DLIINLQGKR SKLLKQGDSP CQVWTGESSQ 150
    VSEDENYVIK LQGESSNSIK NQELPLRTTW DFWRKMYLRE PQNYQSRCQQ 200
    IDVKNKLCKC DHCVRQRIAH QHDDHGVHKR EKAFSHNNCG KDCVKESSQH 250
    SIIQSGEQTS DENGKGLSVG SNLELHQQLH LRDKPHVNVE YGKGIGYSSG 300
    LPRHQCFHIG EKCYRNGDSG EGFSQGSHLQ PHQRVSTGEN LYRCQVYARS 350
    SNQNSCLPSH ELTHPGEKLC TCGRCGKGFH HSLDFDIHCV DSAGERACKC 400
    DVYDKGFSQT SQLQAHQRGH SRDKTYKWEV SDRIFNRNSG LHQRVHTGEK 450
    PYKCEVCDKG FSKASNLQAH QRIHTGEKPY KCDVCDKNFS RNSHLQAHQR 500
    VHTGEKPYKC DTCGKDFSQI SHLQAHQRVH KGEKPYKCET CGKGFSQSSH 550
    LQDHQQVHTG ENPYKCDVCG KGFSWSSHLQ AHQRVHTGEK PYKCEECRKG 600
    FIWNSYLHVH QRIHTGEKPY KCGMCGKSFS QTSHLQAHQR VHTGEKPYKC 650
    FVCGKGFSKS SLSSDSSESP 670
    Length:670
    Mass (Da):76,861
    Last modified:November 30, 2010 - v3
    Checksum:i531D751D1CE4BDA5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti138 – 1381D → G in AAO45841. (PubMed:12743021)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti247 – 2471S → P.
    Corresponds to variant rs16978899 [ dbSNP | Ensembl ].
    VAR_035022
    Natural varianti531 – 5311K → T.3 Publications
    Corresponds to variant rs1233428 [ dbSNP | Ensembl ].
    VAR_035023

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK095351 mRNA. Translation: BAG53032.1.
    AC138470 Genomic DNA. No translation available.
    AC092477 Genomic DNA. No translation available.
    BC136734 mRNA. Translation: AAI36735.1.
    BC136735 mRNA. Translation: AAI36736.1.
    AY166792 mRNA. Translation: AAO45841.1.
    CCDSiCCDS33047.1.
    RefSeqiNP_001193934.1. NM_001207005.1.
    NP_861421.2. NM_181756.2.
    UniGeneiHs.466891.

    Genome annotation databases

    EnsembliENST00000391958; ENSP00000375820; ENSG00000159915.
    GeneIDi353355.
    KEGGihsa:353355.
    UCSCiuc002oyy.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK095351 mRNA. Translation: BAG53032.1 .
    AC138470 Genomic DNA. No translation available.
    AC092477 Genomic DNA. No translation available.
    BC136734 mRNA. Translation: AAI36735.1 .
    BC136735 mRNA. Translation: AAI36736.1 .
    AY166792 mRNA. Translation: AAO45841.1 .
    CCDSi CCDS33047.1.
    RefSeqi NP_001193934.1. NM_001207005.1.
    NP_861421.2. NM_181756.2.
    UniGenei Hs.466891.

    3D structure databases

    ProteinModelPortali A6NK53.
    SMRi A6NK53. Positions 8-49, 232-660.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 131691. 2 interactions.
    IntActi A6NK53. 2 interactions.

    PTM databases

    PhosphoSitei A6NK53.

    Proteomic databases

    PaxDbi A6NK53.
    PRIDEi A6NK53.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000391958 ; ENSP00000375820 ; ENSG00000159915 .
    GeneIDi 353355.
    KEGGi hsa:353355.
    UCSCi uc002oyy.2. human.

    Organism-specific databases

    CTDi 353355.
    GeneCardsi GC19P044754.
    HGNCi HGNC:30946. ZNF233.
    HPAi HPA020975.
    neXtProti NX_A6NK53.
    PharmGKBi PA134917179.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi A6NK53.
    KOi K09228.
    OMAi FWRKMYL.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi A6NK53.
    TreeFami TF350845.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 353355.
    NextBioi 99800.
    PROi A6NK53.

    Gene expression databases

    ArrayExpressi A6NK53.
    Bgeei A6NK53.
    CleanExi HS_ZNF233.
    Genevestigatori A6NK53.

    Family and domain databases

    Gene3Di 3.30.160.60. 11 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 8 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-531.
      Tissue: Tongue.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-531.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-531.
      Tissue: Brain.
    4. "Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters."
      Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.
      Genome Res. 13:1097-1110(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 46-153.
      Tissue: Testis.

    Entry informationi

    Entry nameiZN233_HUMAN
    AccessioniPrimary (citable) accession number: A6NK53
    Secondary accession number(s): B2RN78, B2RN79, Q86WL8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 71 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3