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A6NK53 (ZN233_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 233
Gene names
Name:ZNF233
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length670 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 12 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 670670Zinc finger protein 233
PRO_0000304407

Regions

Domain8 – 7972KRAB
Zinc finger258 – 28023C2H2-type 1; degenerate
Zinc finger311 – 33626C2H2-type 2; degenerate
Zinc finger342 – 36423C2H2-type 3; degenerate
Zinc finger370 – 39223C2H2-type 4; degenerate
Zinc finger398 – 42023C2H2-type 5; degenerate
Zinc finger452 – 47423C2H2-type 6
Zinc finger480 – 50223C2H2-type 7
Zinc finger508 – 53023C2H2-type 8
Zinc finger536 – 55823C2H2-type 9
Zinc finger564 – 58623C2H2-type 10
Zinc finger592 – 61423C2H2-type 11
Zinc finger620 – 64223C2H2-type 12

Natural variations

Natural variant2471S → P.
Corresponds to variant rs16978899 [ dbSNP | Ensembl ].
VAR_035022
Natural variant5311K → T. Ref.1 Ref.2 Ref.3
Corresponds to variant rs1233428 [ dbSNP | Ensembl ].
VAR_035023

Experimental info

Sequence conflict1381D → G in AAO45841. Ref.4

Sequences

Sequence LengthMass (Da)Tools
A6NK53 [UniParc].

Last modified November 30, 2010. Version 3.
Checksum: 531D751D1CE4BDA5

FASTA67076,861
        10         20         30         40         50         60 
MTKFQEMVTF KDVAVVFTRE ELGLLDLAQR KLYQDVMLEN FRNLLSVGYQ PFKLDVILQL 

        70         80         90        100        110        120 
GKEDKLRMME TEIQGDGCSG HKNQNEIDTL QEVRLRFLSY EDLICWQIWE QFTSKLTSNQ 

       130        140        150        160        170        180 
DLIINLQGKR SKLLKQGDSP CQVWTGESSQ VSEDENYVIK LQGESSNSIK NQELPLRTTW 

       190        200        210        220        230        240 
DFWRKMYLRE PQNYQSRCQQ IDVKNKLCKC DHCVRQRIAH QHDDHGVHKR EKAFSHNNCG 

       250        260        270        280        290        300 
KDCVKESSQH SIIQSGEQTS DENGKGLSVG SNLELHQQLH LRDKPHVNVE YGKGIGYSSG 

       310        320        330        340        350        360 
LPRHQCFHIG EKCYRNGDSG EGFSQGSHLQ PHQRVSTGEN LYRCQVYARS SNQNSCLPSH 

       370        380        390        400        410        420 
ELTHPGEKLC TCGRCGKGFH HSLDFDIHCV DSAGERACKC DVYDKGFSQT SQLQAHQRGH 

       430        440        450        460        470        480 
SRDKTYKWEV SDRIFNRNSG LHQRVHTGEK PYKCEVCDKG FSKASNLQAH QRIHTGEKPY 

       490        500        510        520        530        540 
KCDVCDKNFS RNSHLQAHQR VHTGEKPYKC DTCGKDFSQI SHLQAHQRVH KGEKPYKCET 

       550        560        570        580        590        600 
CGKGFSQSSH LQDHQQVHTG ENPYKCDVCG KGFSWSSHLQ AHQRVHTGEK PYKCEECRKG 

       610        620        630        640        650        660 
FIWNSYLHVH QRIHTGEKPY KCGMCGKSFS QTSHLQAHQR VHTGEKPYKC FVCGKGFSKS 

       670 
SLSSDSSESP 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-531.
Tissue: Tongue.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-531.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-531.
Tissue: Brain.
[4]"Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters."
Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.
Genome Res. 13:1097-1110(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 46-153.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK095351 mRNA. Translation: BAG53032.1.
AC138470 Genomic DNA. No translation available.
AC092477 Genomic DNA. No translation available.
BC136734 mRNA. Translation: AAI36735.1.
BC136735 mRNA. Translation: AAI36736.1.
AY166792 mRNA. Translation: AAO45841.1.
CCDSCCDS33047.1.
RefSeqNP_001193934.1. NM_001207005.1.
NP_861421.2. NM_181756.2.
UniGeneHs.466891.

3D structure databases

ProteinModelPortalA6NK53.
SMRA6NK53. Positions 8-49, 232-660.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid131691. 2 interactions.
IntActA6NK53. 2 interactions.

PTM databases

PhosphoSiteA6NK53.

Proteomic databases

PaxDbA6NK53.
PRIDEA6NK53.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000391958; ENSP00000375820; ENSG00000159915.
GeneID353355.
KEGGhsa:353355.
UCSCuc002oyy.2. human.

Organism-specific databases

CTD353355.
GeneCardsGC19P044754.
HGNCHGNC:30946. ZNF233.
HPAHPA020975.
neXtProtNX_A6NK53.
PharmGKBPA134917179.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidA6NK53.
KOK09228.
OMAFWRKMYL.
OrthoDBEOG7KSX7Q.
PhylomeDBA6NK53.
TreeFamTF350845.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressA6NK53.
BgeeA6NK53.
CleanExHS_ZNF233.
GenevestigatorA6NK53.

Family and domain databases

Gene3D3.30.160.60. 11 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi353355.
NextBio99800.
PROA6NK53.

Entry information

Entry nameZN233_HUMAN
AccessionPrimary (citable) accession number: A6NK53
Secondary accession number(s): B2RN78, B2RN79, Q86WL8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 69 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM