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Protein

Glyoxalase domain-containing protein 5

Gene

GLOD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

It is uncertain whether Met-1 or Met-13 is the initiator.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Glyoxalase domain-containing protein 5
Gene namesi
Name:GLOD5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000171433.11
HGNCiHGNC:33358 GLOD5
neXtProtiNX_A6NK44

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171433

Polymorphism and mutation databases

BioMutaiGLOD5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003053261 – 160Glyoxalase domain-containing protein 5Add BLAST160

Proteomic databases

PaxDbiA6NK44
PRIDEiA6NK44

PTM databases

iPTMnetiA6NK44
PhosphoSitePlusiA6NK44

Expressioni

Gene expression databases

BgeeiENSG00000171433
CleanExiHS_GLOD5
ExpressionAtlasiA6NK44 baseline and differential
GenevisibleiA6NK44 HS

Organism-specific databases

HPAiHPA010667

Interactioni

Protein-protein interaction databases

BioGridi134231, 1 interactor
IntActiA6NK44, 1 interactor
STRINGi9606.ENSP00000302552

Structurei

Secondary structure

1160
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi36 – 46Combined sources11
Helixi48 – 59Combined sources12
Beta strandi62 – 66Combined sources5
Turni67 – 69Combined sources3
Beta strandi70 – 75Combined sources6
Beta strandi78 – 84Combined sources7
Beta strandi102 – 106Combined sources5
Helixi111 – 120Combined sources10
Beta strandi127 – 134Combined sources8
Beta strandi137 – 145Combined sources9
Beta strandi151 – 156Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZW5X-ray1.60A/B34-157[»]
ProteinModelPortaliA6NK44
SMRiA6NK44
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA6NK44

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 157VOCPROSITE-ProRule annotationAdd BLAST121

Sequence similaritiesi

Belongs to the glyoxalase I family.Curated

Phylogenomic databases

eggNOGiENOG410IYGI Eukaryota
ENOG4111Q4U LUCA
GeneTreeiENSGT00390000014115
HOGENOMiHOG000232026
HOVERGENiHBG107951
InParanoidiA6NK44
OMAiITFKGDR
OrthoDBiEOG091G0T0J
PhylomeDBiA6NK44
TreeFamiTF300075

Family and domain databases

Gene3Di3.10.180.10, 1 hit
InterProiView protein in InterPro
IPR029068 Glyas_Bleomycin-R_OHBP_Dase
IPR004360 Glyas_Fos-R_dOase_dom
IPR037523 VOC
PfamiView protein in Pfam
PF00903 Glyoxalase, 1 hit
SUPFAMiSSF54593 SSF54593, 1 hit
PROSITEiView protein in PROSITE
PS51819 VOC, 1 hit

Sequencei

Sequence statusi: Complete.

A6NK44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRHLPSRLP VKMWGRTLEK QSWRDSSQTP PPCLIRRLDH IVMTVKSIKD
60 70 80 90 100
TTMFYSKILG MEVMTFKEDR KALCFGDQKF NLHEVGKEFE PKAAHPVPGS
110 120 130 140 150
LDICLITEVP LEEMIQHLKA CDVPIEEGPV PRTGAKGPIM SIYFRDPDRN
160
LIEVSNYISS
Length:160
Mass (Da):18,322
Last modified:October 31, 2012 - v3
Checksum:iCB59F7A2814C0E96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115617 Genomic DNA No translation available.
AF196970 Genomic DNA No translation available.
CCDSiCCDS55410.1
RefSeqiNP_001073958.2, NM_001080489.2
UniGeneiHs.437539

Genome annotation databases

EnsembliENST00000303227; ENSP00000302552; ENSG00000171433
GeneIDi392465
KEGGihsa:392465
UCSCiuc011mmh.3 human

Similar proteinsi

Entry informationi

Entry nameiGLOD5_HUMAN
AccessioniPrimary (citable) accession number: A6NK44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 31, 2012
Last modified: January 31, 2018
This is version 77 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health