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Protein

Glyoxalase domain-containing protein 5

Gene

GLOD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Glyoxalase domain-containing protein 5
Gene namesi
Name:GLOD5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:33358. GLOD5.

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiGLOD5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 160160Glyoxalase domain-containing protein 5PRO_0000305326Add
BLAST

Proteomic databases

PaxDbiA6NK44.
PRIDEiA6NK44.

PTM databases

iPTMnetiA6NK44.

Expressioni

Gene expression databases

BgeeiA6NK44.
CleanExiHS_GLOD5.
ExpressionAtlasiA6NK44. baseline and differential.
GenevisibleiA6NK44. HS.

Organism-specific databases

HPAiHPA010667.

Interactioni

Protein-protein interaction databases

BioGridi134231. 1 interaction.
IntActiA6NK44. 1 interaction.
STRINGi9606.ENSP00000302552.

Structurei

Secondary structure

1
160
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi36 – 4611Combined sources
Helixi48 – 5912Combined sources
Beta strandi62 – 665Combined sources
Turni67 – 693Combined sources
Beta strandi70 – 756Combined sources
Beta strandi78 – 847Combined sources
Beta strandi102 – 1065Combined sources
Helixi111 – 12010Combined sources
Beta strandi127 – 1348Combined sources
Beta strandi137 – 1459Combined sources
Beta strandi151 – 1566Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZW5X-ray1.60A/B34-157[»]
ProteinModelPortaliA6NK44.
SMRiA6NK44. Positions 34-157.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA6NK44.

Family & Domainsi

Sequence similaritiesi

Belongs to the glyoxalase I family.Curated

Phylogenomic databases

eggNOGiENOG410IYGI. Eukaryota.
ENOG4111Q4U. LUCA.
GeneTreeiENSGT00390000014115.
HOGENOMiHOG000232026.
HOVERGENiHBG107951.
InParanoidiA6NK44.
OMAiATIDFYT.
PhylomeDBiA6NK44.
TreeFamiTF300075.

Family and domain databases

Gene3Di3.10.180.10. 1 hit.
InterProiIPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR004360. Glyas_Fos-R_dOase_dom.
[Graphical view]
PfamiPF00903. Glyoxalase. 1 hit.
[Graphical view]
SUPFAMiSSF54593. SSF54593. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NK44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRHLPSRLP VKMWGRTLEK QSWRDSSQTP PPCLIRRLDH IVMTVKSIKD
60 70 80 90 100
TTMFYSKILG MEVMTFKEDR KALCFGDQKF NLHEVGKEFE PKAAHPVPGS
110 120 130 140 150
LDICLITEVP LEEMIQHLKA CDVPIEEGPV PRTGAKGPIM SIYFRDPDRN
160
LIEVSNYISS
Length:160
Mass (Da):18,322
Last modified:October 31, 2012 - v3
Checksum:iCB59F7A2814C0E96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115617 Genomic DNA. No translation available.
AF196970 Genomic DNA. No translation available.
CCDSiCCDS55410.1.
RefSeqiNP_001073958.2. NM_001080489.2.
UniGeneiHs.437539.

Genome annotation databases

EnsembliENST00000303227; ENSP00000302552; ENSG00000171433.
GeneIDi392465.
KEGGihsa:392465.
UCSCiuc011mmh.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115617 Genomic DNA. No translation available.
AF196970 Genomic DNA. No translation available.
CCDSiCCDS55410.1.
RefSeqiNP_001073958.2. NM_001080489.2.
UniGeneiHs.437539.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZW5X-ray1.60A/B34-157[»]
ProteinModelPortaliA6NK44.
SMRiA6NK44. Positions 34-157.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134231. 1 interaction.
IntActiA6NK44. 1 interaction.
STRINGi9606.ENSP00000302552.

PTM databases

iPTMnetiA6NK44.

Polymorphism and mutation databases

BioMutaiGLOD5.

Proteomic databases

PaxDbiA6NK44.
PRIDEiA6NK44.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303227; ENSP00000302552; ENSG00000171433.
GeneIDi392465.
KEGGihsa:392465.
UCSCiuc011mmh.3. human.

Organism-specific databases

CTDi392465.
GeneCardsiGLOD5.
HGNCiHGNC:33358. GLOD5.
HPAiHPA010667.
neXtProtiNX_A6NK44.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYGI. Eukaryota.
ENOG4111Q4U. LUCA.
GeneTreeiENSGT00390000014115.
HOGENOMiHOG000232026.
HOVERGENiHBG107951.
InParanoidiA6NK44.
OMAiATIDFYT.
PhylomeDBiA6NK44.
TreeFamiTF300075.

Miscellaneous databases

EvolutionaryTraceiA6NK44.
GenomeRNAii392465.
PROiA6NK44.

Gene expression databases

BgeeiA6NK44.
CleanExiHS_GLOD5.
ExpressionAtlasiA6NK44. baseline and differential.
GenevisibleiA6NK44. HS.

Family and domain databases

Gene3Di3.10.180.10. 1 hit.
InterProiIPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR004360. Glyas_Fos-R_dOase_dom.
[Graphical view]
PfamiPF00903. Glyoxalase. 1 hit.
[Graphical view]
SUPFAMiSSF54593. SSF54593. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Crystal structure of the human glyoxalase domain-containing protein 5."
    Structural genomics consortium (SGC)
    Submitted (AUG-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 34-157.

Entry informationi

Entry nameiGLOD5_HUMAN
AccessioniPrimary (citable) accession number: A6NK44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 31, 2012
Last modified: June 8, 2016
This is version 65 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-13 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.