A6NK39 (S72L1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Putative RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like protein 1 Short name=CTD phosphatase SSU72-like protein 1 EC=3.1.3.16
Organism	Homo sapiens (Human) [Reference proteome]
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May be involved in the C-terminal domain of RNA polymerase II dephosphorylation, RNA processing and termination By similarity.
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Subcellular location	Nucleus By similarity. Cytoplasm By similarity.
Sequence similarities	Belongs to the SSU72 phosphatase family.

Ontologies

Keywords
Biological process	mRNA processing
Cellular component	Cytoplasm Nucleus
Domain	Coiled coil
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 194	194	Putative RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like protein 1		PRO_0000341198
Regions
	Coiled coil	160 – 186	27	Potential

Sequences

	Sequence		Length	Mass (Da)
	A6NK39 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 9ED74C972D410421	FASTA	194	22,413
	10 20 30 40 50 60 MLSSPLRVAV VCVSNVNRSM EAHSILRRKG LSVRSFGTES HVRLPGPRPN RPVVYDFATT 70 80 90 100 110 120 YKQMYNDLLR KDRERYTRNG ILHILGRNER IKPGPERFQE CTDSFDVIFT CEESVYDTVV 130 140 150 160 170 180 EDLCSREQQT FQPVHVINMD IQDTLEDATL GAFLICEICQ CLQQSDDIED NLEELLLQME 190 EKAGKSFLHT VCFY

References

[1]

"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC018793 Genomic DNA. No translation available.
IPI	IPI00179849.
3D structure databases
ProteinModelPortal	A6NK39.
ModBase	Search...
Proteomic databases
PaxDb	A6NK39.
PRIDE	A6NK39.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
neXtProt	NX_A6NK39.
Phylogenomic databases
eggNOG	COG5211.
HOGENOM	HOG000183445.
HOVERGEN	HBG059831.
InParanoid	A6NK39.
OrthoDB	EOG4D26R1.
PhylomeDB	A6NK39.
Gene expression databases
Genevestigator	A6NK39.
Family and domain databases
InterPro	IPR006811. RNA_pol_II_suA. [Graphical view]
PANTHER	PTHR20383. PTHR20383. 1 hit.
Pfam	PF04722. Ssu72. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

S72L1_HUMAN

Accession

Primary (citable) accession number: A6NK39

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	July 24, 2007
Last modified:	May 1, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.