A6NK06 (IRG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Immune-responsive gene 1 protein homolog

Gene names

Name:

IRG1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	481 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the PrpD family.

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	propionate catabolic process Inferred from electronic annotation. Source: InterPro response to lipopolysaccharide Inferred from electronic annotation. Source: Compara
Molecular_function	2-methylcitrate dehydratase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 481	481	Immune-responsive gene 1 protein homolog		PRO_0000318692

Sequences

	Sequence		Length	Mass (Da)
	A6NK06 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 4F612CD6410166F6	FASTA	481	52,628
	10 20 30 40 50 60 MMLKSITESF ATAIHGLKVG HLTDRVIQRS KRMILDTLGA GFLGTTTEVF HIASQYSKIY 70 80 90 100 110 120 SSNISSTVWG QPDIRLPPTY AAFVNGVAIH SMDFDDTWHP ATHPSGAVLP VLTALAEALP 130 140 150 160 170 180 RSPKFSGLDL LLAFNVGIEV QGRLLHFAKE ANDMPKRFHP PSVVGTLGSA AAASKFLGLS 190 200 210 220 230 240 STKCREALAI AVSHAGAPMA NAATQTKPLH IGNAAKHGIE AAFLAMLGLQ GNKQVLDLEA 250 260 270 280 290 300 GFGAFYANYS PKVLPSIASY SWLLDQQDVA FKRFPAHLST HWVADAAASV RKHLVAERAL 310 320 330 340 350 360 LPTDYIKRIV LRIPNVQYVN RPFPVSEHEA RHSFQYVACA MLLDGGITVP SFHECQINRP 370 380 390 400 410 420 QVRELLSKVE LEYPPDNLPS FNILYCEISV TLKDGATFTD RSDTFYGHWR KPLSQEDLEE 430 440 450 460 470 480 KFRANASKML SWDTVESLIK IVKNLEDLED CSVLTTLLKG PSPPEVASNS PACNNSITNL S

References

[1]

"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC000403 Genomic DNA. No translation available.
IPI	IPI00244043.
RefSeq	NP_001245335.1. NM_001258406.1.
UniGene	Hs.160789.
3D structure databases
ProteinModelPortal	A6NK06.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000366682.
PTM databases
PhosphoSite	A6NK06.
Proteomic databases
PaxDb	A6NK06.
PRIDE	A6NK06.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000377462; ENSP00000366682; ENSG00000102794.
GeneID	730249.
KEGG	hsa:730249.
Organism-specific databases
CTD	730249.
GeneCards	GC13P077511.
HGNC	HGNC:33904. IRG1.
HPA	HPA040143.
neXtProt	NX_A6NK06.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2079.
HOGENOM	HOG000233811.
HOVERGEN	HBG059447.
InParanoid	A6NK06.
OMA	RIPDVQY.
OrthoDB	EOG4MW86C.
Gene expression databases
ArrayExpress	A6NK06.
Bgee	A6NK06.
CleanEx	HS_IRG1.
Genevestigator	A6NK06.
Family and domain databases
InterPro	IPR005656. MmgE_PrpD. [Graphical view]
PANTHER	PTHR16943. PTHR16943. 1 hit.
Pfam	PF03972. MmgE_PrpD. 1 hit. [Graphical view]
SUPFAM	SSF103378. MmgE_PrpD. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	730249.

Entry information

Entry name

IRG1_HUMAN

Accession

Primary (citable) accession number: A6NK06

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	July 24, 2007
Last modified:	May 1, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.