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Protein

Cis-aconitate decarboxylase

Gene

ACOD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.2 Publications

Catalytic activityi

Cis-aconitate = itaconate + CO2.1 Publication

GO - Molecular functioni

  • aconitate decarboxylase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Lyase

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000102794-MONOMER.
BRENDAi4.1.1.6. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Cis-aconitate decarboxylase (EC:4.1.1.61 Publication)
Short name:
CAD
Alternative name(s):
Aconitate decarboxylase
Aconitate decarboxylase 1Imported
Cis-aconitic acid decarboxylase
Immune-responsive gene 1 protein
Gene namesi
Name:ACOD1Imported
Synonyms:IRG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:33904. ACOD1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiIRG1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481Cis-aconitate decarboxylasePRO_0000318692Add
BLAST

Proteomic databases

PaxDbiA6NK06.
PRIDEiA6NK06.

PTM databases

iPTMnetiA6NK06.
PhosphoSiteiA6NK06.

Expressioni

Tissue specificityi

Expressed in LPS-tolerized macrophages (at protein level). Expressed in peripheral blood mononuclear cells (PBMCs), microglia and macrophage cells.2 Publications

Inductioni

Up-regulated after lipopolysaccharide (LPS) stimulation. Up-regulated in LPS-tolerized macrophage by LPS. Up-regulated in peripheral blood mononuclear cells (PBMC) of patient after acute sepsis.2 Publications

Gene expression databases

BgeeiA6NK06.
CleanExiHS_IRG1.
ExpressionAtlasiA6NK06. baseline and differential.
GenevisibleiA6NK06. HS.

Organism-specific databases

HPAiHPA040143.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366682.

Structurei

3D structure databases

ProteinModelPortaliA6NK06.
SMRiA6NK06. Positions 34-453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PrpD family.Curated

Phylogenomic databases

eggNOGiENOG410IEAF. Eukaryota.
COG2079. LUCA.
GeneTreeiENSGT00390000015700.
HOGENOMiHOG000233811.
HOVERGENiHBG059447.
InParanoidiA6NK06.
KOiK17724.
OMAiRIPDVQY.
OrthoDBiEOG7HF1J4.
PhylomeDBiA6NK06.
TreeFamiTF332296.

Family and domain databases

InterProiIPR005656. MmgE_PrpD.
[Graphical view]
PANTHERiPTHR16943. PTHR16943. 1 hit.
PfamiPF03972. MmgE_PrpD. 1 hit.
[Graphical view]
SUPFAMiSSF103378. SSF103378. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NK06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLKSITESF ATAIHGLKVG HLTDRVIQRS KRMILDTLGA GFLGTTTEVF
60 70 80 90 100
HIASQYSKIY SSNISSTVWG QPDIRLPPTY AAFVNGVAIH SMDFDDTWHP
110 120 130 140 150
ATHPSGAVLP VLTALAEALP RSPKFSGLDL LLAFNVGIEV QGRLLHFAKE
160 170 180 190 200
ANDMPKRFHP PSVVGTLGSA AAASKFLGLS STKCREALAI AVSHAGAPMA
210 220 230 240 250
NAATQTKPLH IGNAAKHGIE AAFLAMLGLQ GNKQVLDLEA GFGAFYANYS
260 270 280 290 300
PKVLPSIASY SWLLDQQDVA FKRFPAHLST HWVADAAASV RKHLVAERAL
310 320 330 340 350
LPTDYIKRIV LRIPNVQYVN RPFPVSEHEA RHSFQYVACA MLLDGGITVP
360 370 380 390 400
SFHECQINRP QVRELLSKVE LEYPPDNLPS FNILYCEISV TLKDGATFTD
410 420 430 440 450
RSDTFYGHWR KPLSQEDLEE KFRANASKML SWDTVESLIK IVKNLEDLED
460 470 480
CSVLTTLLKG PSPPEVASNS PACNNSITNL S
Length:481
Mass (Da):52,628
Last modified:July 24, 2007 - v1
Checksum:i4F612CD6410166F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC000403 Genomic DNA. No translation available.
CCDSiCCDS58299.1.
RefSeqiNP_001245335.1. NM_001258406.1.
UniGeneiHs.160789.

Genome annotation databases

EnsembliENST00000377462; ENSP00000366682; ENSG00000102794.
GeneIDi730249.
KEGGihsa:730249.
UCSCiuc031qmi.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC000403 Genomic DNA. No translation available.
CCDSiCCDS58299.1.
RefSeqiNP_001245335.1. NM_001258406.1.
UniGeneiHs.160789.

3D structure databases

ProteinModelPortaliA6NK06.
SMRiA6NK06. Positions 34-453.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000366682.

PTM databases

iPTMnetiA6NK06.
PhosphoSiteiA6NK06.

Polymorphism and mutation databases

BioMutaiIRG1.

Proteomic databases

PaxDbiA6NK06.
PRIDEiA6NK06.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377462; ENSP00000366682; ENSG00000102794.
GeneIDi730249.
KEGGihsa:730249.
UCSCiuc031qmi.3. human.

Organism-specific databases

CTDi730249.
GeneCardsiIRG1.
HGNCiHGNC:33904. ACOD1.
HPAiHPA040143.
MIMi615275. gene.
neXtProtiNX_A6NK06.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEAF. Eukaryota.
COG2079. LUCA.
GeneTreeiENSGT00390000015700.
HOGENOMiHOG000233811.
HOVERGENiHBG059447.
InParanoidiA6NK06.
KOiK17724.
OMAiRIPDVQY.
OrthoDBiEOG7HF1J4.
PhylomeDBiA6NK06.
TreeFamiTF332296.

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000102794-MONOMER.
BRENDAi4.1.1.6. 2681.

Miscellaneous databases

GenomeRNAii730249.
PROiA6NK06.
SOURCEiSearch...

Gene expression databases

BgeeiA6NK06.
CleanExiHS_IRG1.
ExpressionAtlasiA6NK06. baseline and differential.
GenevisibleiA6NK06. HS.

Family and domain databases

InterProiIPR005656. MmgE_PrpD.
[Graphical view]
PANTHERiPTHR16943. PTHR16943. 1 hit.
PfamiPF03972. MmgE_PrpD. 1 hit.
[Graphical view]
SUPFAMiSSF103378. SSF103378. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through ROS."
    Li Y., Zhang P., Wang C., Han C., Meng J., Liu X., Xu S., Li N., Wang Q., Shi X., Cao X.
    J. Biol. Chem. 288:16225-16234(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION BY LPS, TISSUE SPECIFICITY.
  3. Cited for: FUNCTION, CATALYTIC ACTIVITY, INDUCTION BY LPS, TISSUE SPECIFICITY.

Entry informationi

Entry nameiIRG1_HUMAN
AccessioniPrimary (citable) accession number: A6NK06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 24, 2007
Last modified: July 6, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.