A6NK02 (TRI75_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative tripartite motif-containing protein 75

Gene names

Name:

TRIM75

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Sequence similarities	Belongs to the TRIM/RBCC family. Contains 1 B box-type zinc finger. Contains 1 B30.2/SPRY domain. Contains 1 RING-type zinc finger.
Caution	Could be the product of a pseudogene.

Ontologies

Keywords
Domain	Coiled coil Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 468	468	Putative tripartite motif-containing protein 75		PRO_0000331192
Regions
	Domain	276 – 468	193	B30.2/SPRY
	Zinc finger	16 – 57	42	RING-type
	Zinc finger	92 – 133	42	B box-type
	Coiled coil	170 – 222	53	Potential

Sequences

	Sequence		Length	Mass (Da)
	A6NK02 [UniParc]. Last modified April 29, 2008. Version 2. Checksum: 793C2F1E8EEB2BF9	FASTA	468	53,678
	10 20 30 40 50 60 MAVAAALTGL QAEAKCSICL DYLSDPVTIE CGHNFCRSCI QQSWLDLQEL FPCPVCRHQC 70 80 90 100 110 120 QEGHFRSNTQ LGRMIEIAKL LQSTKSNKRK QEETTLCEKH NQPLSVFCKE DLMVLCPLCT 130 140 150 160 170 180 QPPDHQGHHV RPIEKAAIHY RKRFCSYIQP LKKQLADLQK LISTQSKKPL ELREMVENQR 190 200 210 220 230 240 QELSSEFEHL NQFLDREQQA VLSRLAEEEK DNQQKLSANI TAFSNYSATL KSQLSKVVEL 250 260 270 280 290 300 SELSELELLS QIKIFYESEN ESSPSIFSIH LKRDGCSFPP QYSALQRIIK KFKVEIILDP 310 320 330 340 350 360 ETAHPNLIVS EDKKRVRFTK RKQKVPGFPK RFTVKPVVLG FPYFHSGRHF WEIEVGDKSE 370 380 390 400 410 420 WAIGICKDSL PTKARRPSSA QQECWRIELQ DDGYHAPGAF PTPLLLEVKA RAIGIFLDYE 430 440 450 460 MGEISFYNMA EKSHICTFTD TFTGPLRPYF YVGPDSQPLR ICTGTVCE

References

[1]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC108465 Genomic DNA. No translation available.
IPI	IPI00398090.
3D structure databases
ProteinModelPortal	A6NK02.
ModBase	Search...
Proteomic databases
PaxDb	A6NK02.
PRIDE	A6NK02.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC04P165980.
HGNC	HGNC:32686. TRIM75.
neXtProt	NX_A6NK02.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG254111.
HOVERGEN	HBG001357.
InParanoid	A6NK02.
OrthoDB	EOG4NP73C.
Gene expression databases
CleanEx	HS_TRIM75.
Genevestigator	A6NK02.
Family and domain databases
Gene3D	3.30.40.10. 1 hit.
InterPro	IPR001870. B30.2/SPRY. IPR003879. Butyrophylin. IPR008985. ConA-like_lec_gl_sf. IPR006574. PRY. IPR018355. SPla/RYanodine_receptor_subgr. IPR003877. SPRY_rcpt. IPR000315. Znf_B-box. IPR018957. Znf_C3HC4_RING-type. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. IPR017907. Znf_RING_CS. [Graphical view]
Pfam	PF00622. SPRY. 1 hit. PF00643. zf-B_box. 1 hit. PF00097. zf-C3HC4. 1 hit. [Graphical view]
PRINTS	PR01407. BUTYPHLNCDUF.
SMART	SM00336. BBOX. 1 hit. SM00589. PRY. 1 hit. SM00184. RING. 1 hit. SM00449. SPRY. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS50188. B302_SPRY. 1 hit. PS50119. ZF_BBOX. 1 hit. PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	21545455.

Entry information

Entry name

TRI75_HUMAN

Accession

Primary (citable) accession number: A6NK02

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	May 1, 2013
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.