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A6NJZ7 (RIM3C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RIMS-binding protein 3C

Short name=RIM-BP3.C
Alternative name(s):
RIMS-binding protein 3.3
Short name=RIM-BP3.3
Gene names
Name:RIMBP3C
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1639 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with FASLG. Ref.2

Sequence similarities

Belongs to the RIMBP family.

Contains 2 fibronectin type-III domains.

Contains 3 SH3 domains.

Caution

It is uncertain whether Met-1 or Met-95 is the initiator.

Ontologies

Keywords
   DomainCoiled coil
Repeat
SH3 domain
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 16391639RIMS-binding protein 3C
PRO_0000332275

Regions

Domain832 – 89968SH3 1
Domain995 – 108389Fibronectin type-III 1
Domain1088 – 118497Fibronectin type-III 2
Domain1452 – 152069SH3 2
Domain1569 – 163668SH3 3
Coiled coil21 – 143123 Potential
Coiled coil409 – 44234 Potential
Coiled coil480 – 619140 Potential
Compositional bias30 – 137108Arg-rich
Compositional bias312 – 36655Pro-rich

Sequences

Sequence LengthMass (Da)Tools
A6NJZ7 [UniParc].

Last modified March 21, 2012. Version 3.
Checksum: A91AA22674EA0F26

FASTA1,639180,950
        10         20         30         40         50         60 
MAKDSPSPLG ASPKKPGCSS PAAAVLENQR RELEKLRAEL EAERAGWRAE RRRFAARERQ 

        70         80         90        100        110        120 
LREEAERERR QLADRLRSKW EAQRSRELRQ LQEEMQRERE AEIRQLLRWK EAEQRQLQQL 

       130        140        150        160        170        180 
LHRERDGVVR QARELQRQLA EELVNRGHCS RPGASEVSAA QCRCRLQEVL AQLRWQTDGE 

       190        200        210        220        230        240 
QAARIRYLQA ALEVERQLFL KYILAHFRGH PALSGSPDPQ AVHSLEEPLP QTSSGSCHAP 

       250        260        270        280        290        300 
KPACQLGSLD SLSAEVGVRS RSLGLVSSAC SSSPDGLLST HASSLDCFAP ACSRSLDSTR 

       310        320        330        340        350        360 
SLPKASKSEE RPSSPDTSTP GSRRLSPPPS PLPPPPPPSA HRKLSNPRGG EGSESQPCEV 

       370        380        390        400        410        420 
LTPSPPGLGH HELIKLNWLL AKALWVLARR CYTLQEENKQ LRRAGCPYQA DEKVKRLKVK 

       430        440        450        460        470        480 
RAELTGLARR LADRARELQE TNLRAVSAPI PGESCAGLEL CQVFARQRAR DLSEQASAPL 

       490        500        510        520        530        540 
AKDKQIEELR QECHLLQARV ASGPCSDLHT GRGGPCTQWL NVRDLDRLQR ESQREVLRLQ 

       550        560        570        580        590        600 
RQLMLQQGNG GAWPEAGGQS ATCEEVRRQM LALERELDQR RRECQELGTQ AAPARRRGEE 

       610        620        630        640        650        660 
AETQLQAALL KNAWLAEENG RLQAKTDWVR KVEAENSEVR GHLGRACQER DASGLIAEQL 

       670        680        690        700        710        720 
LQQAARGQDR QQQLQRDPQK ALCDLHPSWK EIQALQCRPG HPPEQPWETS QMPESQVKGS 

       730        740        750        760        770        780 
RRPKFHARPE DYAVSQPNRD IQEKREASLE ESPVALGESA SVPQVSETVP ASQPLSKKTS 

       790        800        810        820        830        840 
SQSNSSSEGS MWATVPSSPT LDRDTASEVD DLEPDSVSLA LEMGGSAAPA APKLKIFMAQ 

       850        860        870        880        890        900 
YNYNPFEGPN DHPEGELPLT AGDYIYIFGD MDEDGFYEGE LDDGRRGLVP SNFVEQIPDS 

       910        920        930        940        950        960 
YIPGCLPAKS PDLGPSQLPA GQDEALEEDS LLSGKAQGMV DRGLCQMVRV GSKTEVATEI 

       970        980        990       1000       1010       1020 
LDTKTEACQL GLLQSMGKQG LSRPLLGTKG VLRMAPMQLH LQNVTATSAN ITWVYSSHRH 

      1030       1040       1050       1060       1070       1080 
PHVVYLDDRE HALTPAGVSC YTFQGLCPGT HYRVRVEVRL PWDLLQVYWG TMSSTVTFDT 

      1090       1100       1110       1120       1130       1140 
LLAGPPYPPL DVLVERHASP GVLVVSWLPV TIDSAGSSNG VQVTGYAVYA DGLKVCEVAD 

      1150       1160       1170       1180       1190       1200 
ATAGSTVLEF SQLQVPLTWQ KVSVRTMSLC GESLDSVPAQ IPEDFFMCHR WPETPPFSYT 

      1210       1220       1230       1240       1250       1260 
CGDPSTYRVT FPVCPQKLSL APPSAKASPH NPGSCGEPQA KFLEAFFEEP PRRQSPVSNL 

      1270       1280       1290       1300       1310       1320 
GSEGECPSSG AGSQAQELAE AWEGCRKDLL FQKSPQNHRP PSVSDQPGEK ENCYQHMGTS 

      1330       1340       1350       1360       1370       1380 
KSPAPGFIHL RTECGPRKEP CQEKAALERV LRQKQDAQGF TPPQLGASQQ YASDFHNVLK 

      1390       1400       1410       1420       1430       1440 
EEQEALCLDL RGTERREERR EPEPHSRQGQ ALGVKRGCQL HEPSSALCPA PSAKVIKMPR 

      1450       1460       1470       1480       1490       1500 
GGPQQLGTGA NTPARVFVAL SDYNPLVMSA NLKAAEEELV FQKRQLLRVW GSQDTHDFYL 

      1510       1520       1530       1540       1550       1560 
SECNRQVGNI PGRLVAEMEV GTEQTDRRWR SPAQGHLPSV AHLEDFQGLI IPQGSSLVLQ 

      1570       1580       1590       1600       1610       1620 
GNSKRLPLWT PKIMIAALDY DPGDGQMGGQ GKGRLALRAG DVVMVYGPMD DQGFYYGELG 

      1630 
GHRGLVPAHL LDHMSLHGH 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
Voss M., Lettau M., Janssen O.
BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FASLG.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP000557 Genomic DNA. No translation available.
CCDSCCDS46669.1.
RefSeqNP_001122105.1. NM_001128633.1.
UniGeneHs.447643.

3D structure databases

ProteinModelPortalA6NJZ7.
SMRA6NJZ7. Positions 833-900, 1572-1639.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActA6NJZ7. 1 interaction.
STRING9606.ENSP00000390630.

PTM databases

PhosphoSiteA6NJZ7.

Proteomic databases

PaxDbA6NJZ7.
PRIDEA6NJZ7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000433039; ENSP00000390630; ENSG00000183246.
GeneID150221.
KEGGhsa:150221.
UCSCuc002zuy.4. human.

Organism-specific databases

CTD150221.
GeneCardsGC22M021900.
HGNCHGNC:33892. RIMBP3C.
HPAHPA001183.
MIM612701. gene.
neXtProtNX_A6NJZ7.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG327664.
HOGENOMHOG000090231.
HOVERGENHBG096074.
InParanoidA6NJZ7.
OMAFREKENC.
PhylomeDBA6NJZ7.
TreeFamTF316230.

Gene expression databases

BgeeA6NJZ7.
CleanExHS_RIMBP3C.
GenevestigatorA6NJZ7.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamPF07653. SH3_2. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 2 hits.
SM00326. SH3. 3 hits.
[Graphical view]
SUPFAMSSF49265. SSF49265. 1 hit.
SSF50044. SSF50044. 3 hits.
PROSITEPS50853. FN3. 2 hits.
PS50002. SH3. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi150221.
PROA6NJZ7.
SOURCESearch...

Entry information

Entry nameRIM3C_HUMAN
AccessionPrimary (citable) accession number: A6NJZ7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 21, 2012
Last modified: July 9, 2014
This is version 57 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM