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Protein

RIMS-binding protein 3C

Gene

RIMBP3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
RIMS-binding protein 3C
Short name:
RIM-BP3.C
Alternative name(s):
RIMS-binding protein 3.3
Short name:
RIM-BP3.3
Gene namesi
Name:RIMBP3C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:33892. RIMBP3C.

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiRIMBP3C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16391639RIMS-binding protein 3CPRO_0000332275Add
BLAST

Proteomic databases

PaxDbiA6NJZ7.
PRIDEiA6NJZ7.

PTM databases

PhosphoSiteiA6NJZ7.

Expressioni

Gene expression databases

BgeeiA6NJZ7.
CleanExiHS_RIMBP3C.
ExpressionAtlasiA6NJZ7. baseline.

Organism-specific databases

HPAiHPA001183.

Interactioni

Subunit structurei

Interacts with FASLG.1 Publication

Protein-protein interaction databases

BioGridi127271. 1 interaction.
IntActiA6NJZ7. 1 interaction.
STRINGi9606.ENSP00000390630.

Structurei

3D structure databases

ProteinModelPortaliA6NJZ7.
SMRiA6NJZ7. Positions 833-900, 1572-1639.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini832 – 89968SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini995 – 108389Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini1088 – 118497Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini1452 – 152069SH3 2PROSITE-ProRule annotationAdd
BLAST
Domaini1569 – 163668SH3 3PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili21 – 143123Sequence AnalysisAdd
BLAST
Coiled coili409 – 44234Sequence AnalysisAdd
BLAST
Coiled coili480 – 619140Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi30 – 137108Arg-richAdd
BLAST
Compositional biasi312 – 36655Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the RIMBP family.Curated
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 3 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiNOG327664.
GeneTreeiENSGT00390000017228.
HOGENOMiHOG000090231.
HOVERGENiHBG096074.
InParanoidiA6NJZ7.
OMAiFREKENC.
PhylomeDBiA6NJZ7.
TreeFamiTF316230.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF07653. SH3_2. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00326. SH3. 3 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF50044. SSF50044. 3 hits.
PROSITEiPS50853. FN3. 2 hits.
PS50002. SH3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NJZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKDSPSPLG ASPKKPGCSS PAAAVLENQR RELEKLRAEL EAERAGWRAE
60 70 80 90 100
RRRFAARERQ LREEAERERR QLADRLRSKW EAQRSRELRQ LQEEMQRERE
110 120 130 140 150
AEIRQLLRWK EAEQRQLQQL LHRERDGVVR QARELQRQLA EELVNRGHCS
160 170 180 190 200
RPGASEVSAA QCRCRLQEVL AQLRWQTDGE QAARIRYLQA ALEVERQLFL
210 220 230 240 250
KYILAHFRGH PALSGSPDPQ AVHSLEEPLP QTSSGSCHAP KPACQLGSLD
260 270 280 290 300
SLSAEVGVRS RSLGLVSSAC SSSPDGLLST HASSLDCFAP ACSRSLDSTR
310 320 330 340 350
SLPKASKSEE RPSSPDTSTP GSRRLSPPPS PLPPPPPPSA HRKLSNPRGG
360 370 380 390 400
EGSESQPCEV LTPSPPGLGH HELIKLNWLL AKALWVLARR CYTLQEENKQ
410 420 430 440 450
LRRAGCPYQA DEKVKRLKVK RAELTGLARR LADRARELQE TNLRAVSAPI
460 470 480 490 500
PGESCAGLEL CQVFARQRAR DLSEQASAPL AKDKQIEELR QECHLLQARV
510 520 530 540 550
ASGPCSDLHT GRGGPCTQWL NVRDLDRLQR ESQREVLRLQ RQLMLQQGNG
560 570 580 590 600
GAWPEAGGQS ATCEEVRRQM LALERELDQR RRECQELGTQ AAPARRRGEE
610 620 630 640 650
AETQLQAALL KNAWLAEENG RLQAKTDWVR KVEAENSEVR GHLGRACQER
660 670 680 690 700
DASGLIAEQL LQQAARGQDR QQQLQRDPQK ALCDLHPSWK EIQALQCRPG
710 720 730 740 750
HPPEQPWETS QMPESQVKGS RRPKFHARPE DYAVSQPNRD IQEKREASLE
760 770 780 790 800
ESPVALGESA SVPQVSETVP ASQPLSKKTS SQSNSSSEGS MWATVPSSPT
810 820 830 840 850
LDRDTASEVD DLEPDSVSLA LEMGGSAAPA APKLKIFMAQ YNYNPFEGPN
860 870 880 890 900
DHPEGELPLT AGDYIYIFGD MDEDGFYEGE LDDGRRGLVP SNFVEQIPDS
910 920 930 940 950
YIPGCLPAKS PDLGPSQLPA GQDEALEEDS LLSGKAQGMV DRGLCQMVRV
960 970 980 990 1000
GSKTEVATEI LDTKTEACQL GLLQSMGKQG LSRPLLGTKG VLRMAPMQLH
1010 1020 1030 1040 1050
LQNVTATSAN ITWVYSSHRH PHVVYLDDRE HALTPAGVSC YTFQGLCPGT
1060 1070 1080 1090 1100
HYRVRVEVRL PWDLLQVYWG TMSSTVTFDT LLAGPPYPPL DVLVERHASP
1110 1120 1130 1140 1150
GVLVVSWLPV TIDSAGSSNG VQVTGYAVYA DGLKVCEVAD ATAGSTVLEF
1160 1170 1180 1190 1200
SQLQVPLTWQ KVSVRTMSLC GESLDSVPAQ IPEDFFMCHR WPETPPFSYT
1210 1220 1230 1240 1250
CGDPSTYRVT FPVCPQKLSL APPSAKASPH NPGSCGEPQA KFLEAFFEEP
1260 1270 1280 1290 1300
PRRQSPVSNL GSEGECPSSG AGSQAQELAE AWEGCRKDLL FQKSPQNHRP
1310 1320 1330 1340 1350
PSVSDQPGEK ENCYQHMGTS KSPAPGFIHL RTECGPRKEP CQEKAALERV
1360 1370 1380 1390 1400
LRQKQDAQGF TPPQLGASQQ YASDFHNVLK EEQEALCLDL RGTERREERR
1410 1420 1430 1440 1450
EPEPHSRQGQ ALGVKRGCQL HEPSSALCPA PSAKVIKMPR GGPQQLGTGA
1460 1470 1480 1490 1500
NTPARVFVAL SDYNPLVMSA NLKAAEEELV FQKRQLLRVW GSQDTHDFYL
1510 1520 1530 1540 1550
SECNRQVGNI PGRLVAEMEV GTEQTDRRWR SPAQGHLPSV AHLEDFQGLI
1560 1570 1580 1590 1600
IPQGSSLVLQ GNSKRLPLWT PKIMIAALDY DPGDGQMGGQ GKGRLALRAG
1610 1620 1630
DVVMVYGPMD DQGFYYGELG GHRGLVPAHL LDHMSLHGH
Length:1,639
Mass (Da):180,950
Last modified:March 21, 2012 - v3
Checksum:iA91AA22674EA0F26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000557 Genomic DNA. No translation available.
CCDSiCCDS46669.1.
RefSeqiNP_001122105.1. NM_001128633.1.
UniGeneiHs.447643.

Genome annotation databases

EnsembliENST00000433039; ENSP00000390630; ENSG00000183246.
GeneIDi150221.
KEGGihsa:150221.
UCSCiuc002zuy.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000557 Genomic DNA. No translation available.
CCDSiCCDS46669.1.
RefSeqiNP_001122105.1. NM_001128633.1.
UniGeneiHs.447643.

3D structure databases

ProteinModelPortaliA6NJZ7.
SMRiA6NJZ7. Positions 833-900, 1572-1639.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127271. 1 interaction.
IntActiA6NJZ7. 1 interaction.
STRINGi9606.ENSP00000390630.

PTM databases

PhosphoSiteiA6NJZ7.

Polymorphism and mutation databases

BioMutaiRIMBP3C.

Proteomic databases

PaxDbiA6NJZ7.
PRIDEiA6NJZ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000433039; ENSP00000390630; ENSG00000183246.
GeneIDi150221.
KEGGihsa:150221.
UCSCiuc002zuy.4. human.

Organism-specific databases

CTDi150221.
GeneCardsiGC22M021900.
HGNCiHGNC:33892. RIMBP3C.
HPAiHPA001183.
MIMi612701. gene.
neXtProtiNX_A6NJZ7.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG327664.
GeneTreeiENSGT00390000017228.
HOGENOMiHOG000090231.
HOVERGENiHBG096074.
InParanoidiA6NJZ7.
OMAiFREKENC.
PhylomeDBiA6NJZ7.
TreeFamiTF316230.

Miscellaneous databases

GenomeRNAii150221.
PROiA6NJZ7.
SOURCEiSearch...

Gene expression databases

BgeeiA6NJZ7.
CleanExiHS_RIMBP3C.
ExpressionAtlasiA6NJZ7. baseline.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF07653. SH3_2. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00326. SH3. 3 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF50044. SSF50044. 3 hits.
PROSITEiPS50853. FN3. 2 hits.
PS50002. SH3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
    Voss M., Lettau M., Janssen O.
    BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FASLG.

Entry informationi

Entry nameiRIM3C_HUMAN
AccessioniPrimary (citable) accession number: A6NJZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 21, 2012
Last modified: June 24, 2015
This is version 62 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-95 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.