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A6NJZ7

- RIM3C_HUMAN

UniProt

A6NJZ7 - RIM3C_HUMAN

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Protein
RIMS-binding protein 3C
Gene
RIMBP3C
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
RIMS-binding protein 3C
Short name:
RIM-BP3.C
Alternative name(s):
RIMS-binding protein 3.3
Short name:
RIM-BP3.3
Gene namesi
Name:RIMBP3C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:33892. RIMBP3C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16391639RIMS-binding protein 3C
PRO_0000332275Add
BLAST

Proteomic databases

PaxDbiA6NJZ7.
PRIDEiA6NJZ7.

PTM databases

PhosphoSiteiA6NJZ7.

Expressioni

Gene expression databases

BgeeiA6NJZ7.
CleanExiHS_RIMBP3C.
GenevestigatoriA6NJZ7.

Organism-specific databases

HPAiHPA001183.

Interactioni

Subunit structurei

Interacts with FASLG.1 Publication

Protein-protein interaction databases

IntActiA6NJZ7. 1 interaction.
STRINGi9606.ENSP00000390630.

Structurei

3D structure databases

ProteinModelPortaliA6NJZ7.
SMRiA6NJZ7. Positions 833-900, 1572-1639.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini832 – 89968SH3 1
Add
BLAST
Domaini995 – 108389Fibronectin type-III 1
Add
BLAST
Domaini1088 – 118497Fibronectin type-III 2
Add
BLAST
Domaini1452 – 152069SH3 2
Add
BLAST
Domaini1569 – 163668SH3 3
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili21 – 143123 Reviewed prediction
Add
BLAST
Coiled coili409 – 44234 Reviewed prediction
Add
BLAST
Coiled coili480 – 619140 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi30 – 137108Arg-rich
Add
BLAST
Compositional biasi312 – 36655Pro-rich
Add
BLAST

Sequence similaritiesi

Belongs to the RIMBP family.
Contains 3 SH3 domains.

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiNOG327664.
HOGENOMiHOG000090231.
HOVERGENiHBG096074.
InParanoidiA6NJZ7.
OMAiFREKENC.
PhylomeDBiA6NJZ7.
TreeFamiTF316230.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF07653. SH3_2. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00326. SH3. 3 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF50044. SSF50044. 3 hits.
PROSITEiPS50853. FN3. 2 hits.
PS50002. SH3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NJZ7-1 [UniParc]FASTAAdd to Basket

« Hide

MAKDSPSPLG ASPKKPGCSS PAAAVLENQR RELEKLRAEL EAERAGWRAE     50
RRRFAARERQ LREEAERERR QLADRLRSKW EAQRSRELRQ LQEEMQRERE 100
AEIRQLLRWK EAEQRQLQQL LHRERDGVVR QARELQRQLA EELVNRGHCS 150
RPGASEVSAA QCRCRLQEVL AQLRWQTDGE QAARIRYLQA ALEVERQLFL 200
KYILAHFRGH PALSGSPDPQ AVHSLEEPLP QTSSGSCHAP KPACQLGSLD 250
SLSAEVGVRS RSLGLVSSAC SSSPDGLLST HASSLDCFAP ACSRSLDSTR 300
SLPKASKSEE RPSSPDTSTP GSRRLSPPPS PLPPPPPPSA HRKLSNPRGG 350
EGSESQPCEV LTPSPPGLGH HELIKLNWLL AKALWVLARR CYTLQEENKQ 400
LRRAGCPYQA DEKVKRLKVK RAELTGLARR LADRARELQE TNLRAVSAPI 450
PGESCAGLEL CQVFARQRAR DLSEQASAPL AKDKQIEELR QECHLLQARV 500
ASGPCSDLHT GRGGPCTQWL NVRDLDRLQR ESQREVLRLQ RQLMLQQGNG 550
GAWPEAGGQS ATCEEVRRQM LALERELDQR RRECQELGTQ AAPARRRGEE 600
AETQLQAALL KNAWLAEENG RLQAKTDWVR KVEAENSEVR GHLGRACQER 650
DASGLIAEQL LQQAARGQDR QQQLQRDPQK ALCDLHPSWK EIQALQCRPG 700
HPPEQPWETS QMPESQVKGS RRPKFHARPE DYAVSQPNRD IQEKREASLE 750
ESPVALGESA SVPQVSETVP ASQPLSKKTS SQSNSSSEGS MWATVPSSPT 800
LDRDTASEVD DLEPDSVSLA LEMGGSAAPA APKLKIFMAQ YNYNPFEGPN 850
DHPEGELPLT AGDYIYIFGD MDEDGFYEGE LDDGRRGLVP SNFVEQIPDS 900
YIPGCLPAKS PDLGPSQLPA GQDEALEEDS LLSGKAQGMV DRGLCQMVRV 950
GSKTEVATEI LDTKTEACQL GLLQSMGKQG LSRPLLGTKG VLRMAPMQLH 1000
LQNVTATSAN ITWVYSSHRH PHVVYLDDRE HALTPAGVSC YTFQGLCPGT 1050
HYRVRVEVRL PWDLLQVYWG TMSSTVTFDT LLAGPPYPPL DVLVERHASP 1100
GVLVVSWLPV TIDSAGSSNG VQVTGYAVYA DGLKVCEVAD ATAGSTVLEF 1150
SQLQVPLTWQ KVSVRTMSLC GESLDSVPAQ IPEDFFMCHR WPETPPFSYT 1200
CGDPSTYRVT FPVCPQKLSL APPSAKASPH NPGSCGEPQA KFLEAFFEEP 1250
PRRQSPVSNL GSEGECPSSG AGSQAQELAE AWEGCRKDLL FQKSPQNHRP 1300
PSVSDQPGEK ENCYQHMGTS KSPAPGFIHL RTECGPRKEP CQEKAALERV 1350
LRQKQDAQGF TPPQLGASQQ YASDFHNVLK EEQEALCLDL RGTERREERR 1400
EPEPHSRQGQ ALGVKRGCQL HEPSSALCPA PSAKVIKMPR GGPQQLGTGA 1450
NTPARVFVAL SDYNPLVMSA NLKAAEEELV FQKRQLLRVW GSQDTHDFYL 1500
SECNRQVGNI PGRLVAEMEV GTEQTDRRWR SPAQGHLPSV AHLEDFQGLI 1550
IPQGSSLVLQ GNSKRLPLWT PKIMIAALDY DPGDGQMGGQ GKGRLALRAG 1600
DVVMVYGPMD DQGFYYGELG GHRGLVPAHL LDHMSLHGH 1639
Length:1,639
Mass (Da):180,950
Last modified:March 21, 2012 - v3
Checksum:iA91AA22674EA0F26
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP000557 Genomic DNA. No translation available.
CCDSiCCDS46669.1.
RefSeqiNP_001122105.1. NM_001128633.1.
UniGeneiHs.447643.

Genome annotation databases

EnsembliENST00000433039; ENSP00000390630; ENSG00000183246.
GeneIDi150221.
KEGGihsa:150221.
UCSCiuc002zuy.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP000557 Genomic DNA. No translation available.
CCDSi CCDS46669.1.
RefSeqi NP_001122105.1. NM_001128633.1.
UniGenei Hs.447643.

3D structure databases

ProteinModelPortali A6NJZ7.
SMRi A6NJZ7. Positions 833-900, 1572-1639.
ModBasei Search...

Protein-protein interaction databases

IntActi A6NJZ7. 1 interaction.
STRINGi 9606.ENSP00000390630.

PTM databases

PhosphoSitei A6NJZ7.

Proteomic databases

PaxDbi A6NJZ7.
PRIDEi A6NJZ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000433039 ; ENSP00000390630 ; ENSG00000183246 .
GeneIDi 150221.
KEGGi hsa:150221.
UCSCi uc002zuy.4. human.

Organism-specific databases

CTDi 150221.
GeneCardsi GC22M021900.
HGNCi HGNC:33892. RIMBP3C.
HPAi HPA001183.
MIMi 612701. gene.
neXtProti NX_A6NJZ7.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG327664.
HOGENOMi HOG000090231.
HOVERGENi HBG096074.
InParanoidi A6NJZ7.
OMAi FREKENC.
PhylomeDBi A6NJZ7.
TreeFami TF316230.

Miscellaneous databases

GenomeRNAii 150221.
PROi A6NJZ7.
SOURCEi Search...

Gene expression databases

Bgeei A6NJZ7.
CleanExi HS_RIMBP3C.
Genevestigatori A6NJZ7.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 2 hits.
SM00326. SH3. 3 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
SSF50044. SSF50044. 3 hits.
PROSITEi PS50853. FN3. 2 hits.
PS50002. SH3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
    Voss M., Lettau M., Janssen O.
    BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FASLG.

Entry informationi

Entry nameiRIM3C_HUMAN
AccessioniPrimary (citable) accession number: A6NJZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 21, 2012
Last modified: July 9, 2014
This is version 57 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-95 is the initiator.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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