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A6NJZ7

- RIM3C_HUMAN

UniProt

A6NJZ7 - RIM3C_HUMAN

Protein

RIMS-binding protein 3C

Gene

RIMBP3C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 3 (21 Mar 2012)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RIMS-binding protein 3C
    Short name:
    RIM-BP3.C
    Alternative name(s):
    RIMS-binding protein 3.3
    Short name:
    RIM-BP3.3
    Gene namesi
    Name:RIMBP3C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:33892. RIMBP3C.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16391639RIMS-binding protein 3CPRO_0000332275Add
    BLAST

    Proteomic databases

    PaxDbiA6NJZ7.
    PRIDEiA6NJZ7.

    PTM databases

    PhosphoSiteiA6NJZ7.

    Expressioni

    Gene expression databases

    BgeeiA6NJZ7.
    CleanExiHS_RIMBP3C.
    GenevestigatoriA6NJZ7.

    Organism-specific databases

    HPAiHPA001183.

    Interactioni

    Subunit structurei

    Interacts with FASLG.1 Publication

    Protein-protein interaction databases

    IntActiA6NJZ7. 1 interaction.
    STRINGi9606.ENSP00000390630.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NJZ7.
    SMRiA6NJZ7. Positions 833-900, 1572-1639.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini832 – 89968SH3 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini995 – 108389Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1088 – 118497Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1452 – 152069SH3 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1569 – 163668SH3 3PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili21 – 143123Sequence AnalysisAdd
    BLAST
    Coiled coili409 – 44234Sequence AnalysisAdd
    BLAST
    Coiled coili480 – 619140Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi30 – 137108Arg-richAdd
    BLAST
    Compositional biasi312 – 36655Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RIMBP family.Curated
    Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 3 SH3 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiNOG327664.
    HOGENOMiHOG000090231.
    HOVERGENiHBG096074.
    InParanoidiA6NJZ7.
    OMAiFREKENC.
    PhylomeDBiA6NJZ7.
    TreeFamiTF316230.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF07653. SH3_2. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 2 hits.
    SM00326. SH3. 3 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    SSF50044. SSF50044. 3 hits.
    PROSITEiPS50853. FN3. 2 hits.
    PS50002. SH3. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6NJZ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKDSPSPLG ASPKKPGCSS PAAAVLENQR RELEKLRAEL EAERAGWRAE     50
    RRRFAARERQ LREEAERERR QLADRLRSKW EAQRSRELRQ LQEEMQRERE 100
    AEIRQLLRWK EAEQRQLQQL LHRERDGVVR QARELQRQLA EELVNRGHCS 150
    RPGASEVSAA QCRCRLQEVL AQLRWQTDGE QAARIRYLQA ALEVERQLFL 200
    KYILAHFRGH PALSGSPDPQ AVHSLEEPLP QTSSGSCHAP KPACQLGSLD 250
    SLSAEVGVRS RSLGLVSSAC SSSPDGLLST HASSLDCFAP ACSRSLDSTR 300
    SLPKASKSEE RPSSPDTSTP GSRRLSPPPS PLPPPPPPSA HRKLSNPRGG 350
    EGSESQPCEV LTPSPPGLGH HELIKLNWLL AKALWVLARR CYTLQEENKQ 400
    LRRAGCPYQA DEKVKRLKVK RAELTGLARR LADRARELQE TNLRAVSAPI 450
    PGESCAGLEL CQVFARQRAR DLSEQASAPL AKDKQIEELR QECHLLQARV 500
    ASGPCSDLHT GRGGPCTQWL NVRDLDRLQR ESQREVLRLQ RQLMLQQGNG 550
    GAWPEAGGQS ATCEEVRRQM LALERELDQR RRECQELGTQ AAPARRRGEE 600
    AETQLQAALL KNAWLAEENG RLQAKTDWVR KVEAENSEVR GHLGRACQER 650
    DASGLIAEQL LQQAARGQDR QQQLQRDPQK ALCDLHPSWK EIQALQCRPG 700
    HPPEQPWETS QMPESQVKGS RRPKFHARPE DYAVSQPNRD IQEKREASLE 750
    ESPVALGESA SVPQVSETVP ASQPLSKKTS SQSNSSSEGS MWATVPSSPT 800
    LDRDTASEVD DLEPDSVSLA LEMGGSAAPA APKLKIFMAQ YNYNPFEGPN 850
    DHPEGELPLT AGDYIYIFGD MDEDGFYEGE LDDGRRGLVP SNFVEQIPDS 900
    YIPGCLPAKS PDLGPSQLPA GQDEALEEDS LLSGKAQGMV DRGLCQMVRV 950
    GSKTEVATEI LDTKTEACQL GLLQSMGKQG LSRPLLGTKG VLRMAPMQLH 1000
    LQNVTATSAN ITWVYSSHRH PHVVYLDDRE HALTPAGVSC YTFQGLCPGT 1050
    HYRVRVEVRL PWDLLQVYWG TMSSTVTFDT LLAGPPYPPL DVLVERHASP 1100
    GVLVVSWLPV TIDSAGSSNG VQVTGYAVYA DGLKVCEVAD ATAGSTVLEF 1150
    SQLQVPLTWQ KVSVRTMSLC GESLDSVPAQ IPEDFFMCHR WPETPPFSYT 1200
    CGDPSTYRVT FPVCPQKLSL APPSAKASPH NPGSCGEPQA KFLEAFFEEP 1250
    PRRQSPVSNL GSEGECPSSG AGSQAQELAE AWEGCRKDLL FQKSPQNHRP 1300
    PSVSDQPGEK ENCYQHMGTS KSPAPGFIHL RTECGPRKEP CQEKAALERV 1350
    LRQKQDAQGF TPPQLGASQQ YASDFHNVLK EEQEALCLDL RGTERREERR 1400
    EPEPHSRQGQ ALGVKRGCQL HEPSSALCPA PSAKVIKMPR GGPQQLGTGA 1450
    NTPARVFVAL SDYNPLVMSA NLKAAEEELV FQKRQLLRVW GSQDTHDFYL 1500
    SECNRQVGNI PGRLVAEMEV GTEQTDRRWR SPAQGHLPSV AHLEDFQGLI 1550
    IPQGSSLVLQ GNSKRLPLWT PKIMIAALDY DPGDGQMGGQ GKGRLALRAG 1600
    DVVMVYGPMD DQGFYYGELG GHRGLVPAHL LDHMSLHGH 1639
    Length:1,639
    Mass (Da):180,950
    Last modified:March 21, 2012 - v3
    Checksum:iA91AA22674EA0F26
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP000557 Genomic DNA. No translation available.
    CCDSiCCDS46669.1.
    RefSeqiNP_001122105.1. NM_001128633.1.
    UniGeneiHs.447643.

    Genome annotation databases

    EnsembliENST00000433039; ENSP00000390630; ENSG00000183246.
    GeneIDi150221.
    KEGGihsa:150221.
    UCSCiuc002zuy.4. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP000557 Genomic DNA. No translation available.
    CCDSi CCDS46669.1.
    RefSeqi NP_001122105.1. NM_001128633.1.
    UniGenei Hs.447643.

    3D structure databases

    ProteinModelPortali A6NJZ7.
    SMRi A6NJZ7. Positions 833-900, 1572-1639.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi A6NJZ7. 1 interaction.
    STRINGi 9606.ENSP00000390630.

    PTM databases

    PhosphoSitei A6NJZ7.

    Proteomic databases

    PaxDbi A6NJZ7.
    PRIDEi A6NJZ7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000433039 ; ENSP00000390630 ; ENSG00000183246 .
    GeneIDi 150221.
    KEGGi hsa:150221.
    UCSCi uc002zuy.4. human.

    Organism-specific databases

    CTDi 150221.
    GeneCardsi GC22M021900.
    HGNCi HGNC:33892. RIMBP3C.
    HPAi HPA001183.
    MIMi 612701. gene.
    neXtProti NX_A6NJZ7.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG327664.
    HOGENOMi HOG000090231.
    HOVERGENi HBG096074.
    InParanoidi A6NJZ7.
    OMAi FREKENC.
    PhylomeDBi A6NJZ7.
    TreeFami TF316230.

    Miscellaneous databases

    GenomeRNAii 150221.
    PROi A6NJZ7.
    SOURCEi Search...

    Gene expression databases

    Bgeei A6NJZ7.
    CleanExi HS_RIMBP3C.
    Genevestigatori A6NJZ7.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF07653. SH3_2. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 2 hits.
    SM00326. SH3. 3 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    SSF50044. SSF50044. 3 hits.
    PROSITEi PS50853. FN3. 2 hits.
    PS50002. SH3. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
      Voss M., Lettau M., Janssen O.
      BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FASLG.

    Entry informationi

    Entry nameiRIM3C_HUMAN
    AccessioniPrimary (citable) accession number: A6NJZ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 58 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-95 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3