A6NJZ7 (RIM3C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RIMS-binding protein 3C
Short name=RIM-BP3.C

Alternative name(s):
RIMS-binding protein 3.3
Short name=RIM-BP3.3

Gene names

Name:

RIMBP3C

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1639 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with FASLG. Ref.2
Sequence similarities	Belongs to the RIMBP family. Contains 2 fibronectin type-III domains. Contains 3 SH3 domains.
Caution	It is uncertain whether Met-1 or Met-95 is the initiator.

Ontologies

Keywords
Domain	Coiled coil Repeat SH3 domain
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1639	1639	RIMS-binding protein 3C		PRO_0000332275
Regions
	Domain	832 – 899	68	SH3 1
	Domain	992 – 1077	86	Fibronectin type-III 1
	Domain	1085 – 1183	99	Fibronectin type-III 2
	Domain	1452 – 1520	69	SH3 2
	Domain	1569 – 1636	68	SH3 3
	Coiled coil	21 – 143	123	Potential
	Coiled coil	409 – 442	34	Potential
	Coiled coil	480 – 619	140	Potential
	Compositional bias	30 – 137	108	Arg-rich
	Compositional bias	312 – 366	55	Pro-rich

Sequences

	Sequence		Length	Mass (Da)
	A6NJZ7 [UniParc]. Last modified March 21, 2012. Version 3. Checksum: A91AA22674EA0F26	FASTA	1,639	180,950
	10 20 30 40 50 60 MAKDSPSPLG ASPKKPGCSS PAAAVLENQR RELEKLRAEL EAERAGWRAE RRRFAARERQ 70 80 90 100 110 120 LREEAERERR QLADRLRSKW EAQRSRELRQ LQEEMQRERE AEIRQLLRWK EAEQRQLQQL 130 140 150 160 170 180 LHRERDGVVR QARELQRQLA EELVNRGHCS RPGASEVSAA QCRCRLQEVL AQLRWQTDGE 190 200 210 220 230 240 QAARIRYLQA ALEVERQLFL KYILAHFRGH PALSGSPDPQ AVHSLEEPLP QTSSGSCHAP 250 260 270 280 290 300 KPACQLGSLD SLSAEVGVRS RSLGLVSSAC SSSPDGLLST HASSLDCFAP ACSRSLDSTR 310 320 330 340 350 360 SLPKASKSEE RPSSPDTSTP GSRRLSPPPS PLPPPPPPSA HRKLSNPRGG EGSESQPCEV 370 380 390 400 410 420 LTPSPPGLGH HELIKLNWLL AKALWVLARR CYTLQEENKQ LRRAGCPYQA DEKVKRLKVK 430 440 450 460 470 480 RAELTGLARR LADRARELQE TNLRAVSAPI PGESCAGLEL CQVFARQRAR DLSEQASAPL 490 500 510 520 530 540 AKDKQIEELR QECHLLQARV ASGPCSDLHT GRGGPCTQWL NVRDLDRLQR ESQREVLRLQ 550 560 570 580 590 600 RQLMLQQGNG GAWPEAGGQS ATCEEVRRQM LALERELDQR RRECQELGTQ AAPARRRGEE 610 620 630 640 650 660 AETQLQAALL KNAWLAEENG RLQAKTDWVR KVEAENSEVR GHLGRACQER DASGLIAEQL 670 680 690 700 710 720 LQQAARGQDR QQQLQRDPQK ALCDLHPSWK EIQALQCRPG HPPEQPWETS QMPESQVKGS 730 740 750 760 770 780 RRPKFHARPE DYAVSQPNRD IQEKREASLE ESPVALGESA SVPQVSETVP ASQPLSKKTS 790 800 810 820 830 840 SQSNSSSEGS MWATVPSSPT LDRDTASEVD DLEPDSVSLA LEMGGSAAPA APKLKIFMAQ 850 860 870 880 890 900 YNYNPFEGPN DHPEGELPLT AGDYIYIFGD MDEDGFYEGE LDDGRRGLVP SNFVEQIPDS 910 920 930 940 950 960 YIPGCLPAKS PDLGPSQLPA GQDEALEEDS LLSGKAQGMV DRGLCQMVRV GSKTEVATEI 970 980 990 1000 1010 1020 LDTKTEACQL GLLQSMGKQG LSRPLLGTKG VLRMAPMQLH LQNVTATSAN ITWVYSSHRH 1030 1040 1050 1060 1070 1080 PHVVYLDDRE HALTPAGVSC YTFQGLCPGT HYRVRVEVRL PWDLLQVYWG TMSSTVTFDT 1090 1100 1110 1120 1130 1140 LLAGPPYPPL DVLVERHASP GVLVVSWLPV TIDSAGSSNG VQVTGYAVYA DGLKVCEVAD 1150 1160 1170 1180 1190 1200 ATAGSTVLEF SQLQVPLTWQ KVSVRTMSLC GESLDSVPAQ IPEDFFMCHR WPETPPFSYT 1210 1220 1230 1240 1250 1260 CGDPSTYRVT FPVCPQKLSL APPSAKASPH NPGSCGEPQA KFLEAFFEEP PRRQSPVSNL 1270 1280 1290 1300 1310 1320 GSEGECPSSG AGSQAQELAE AWEGCRKDLL FQKSPQNHRP PSVSDQPGEK ENCYQHMGTS 1330 1340 1350 1360 1370 1380 KSPAPGFIHL RTECGPRKEP CQEKAALERV LRQKQDAQGF TPPQLGASQQ YASDFHNVLK 1390 1400 1410 1420 1430 1440 EEQEALCLDL RGTERREERR EPEPHSRQGQ ALGVKRGCQL HEPSSALCPA PSAKVIKMPR 1450 1460 1470 1480 1490 1500 GGPQQLGTGA NTPARVFVAL SDYNPLVMSA NLKAAEEELV FQKRQLLRVW GSQDTHDFYL 1510 1520 1530 1540 1550 1560 SECNRQVGNI PGRLVAEMEV GTEQTDRRWR SPAQGHLPSV AHLEDFQGLI IPQGSSLVLQ 1570 1580 1590 1600 1610 1620 GNSKRLPLWT PKIMIAALDY DPGDGQMGGQ GKGRLALRAG DVVMVYGPMD DQGFYYGELG 1630 GHRGLVPAHL LDHMSLHGH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening." Voss M., Lettau M., Janssen O. BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FASLG.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP000557 Genomic DNA. No translation available.
IPI	IPI00719269.
RefSeq	NP_001122105.1. NM_001128633.1.
UniGene	Hs.447643.
3D structure databases
ProteinModelPortal	A6NJZ7.
SMR	A6NJZ7. Positions 833-900, 1572-1639.
ModBase	Search...
Protein-protein interaction databases
IntAct	A6NJZ7. 1 interaction.
STRING	9606.ENSP00000390630.
PTM databases
PhosphoSite	A6NJZ7.
Proteomic databases
PaxDb	A6NJZ7.
PRIDE	A6NJZ7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000433039; ENSP00000390630; ENSG00000183246.
GeneID	150221.
KEGG	hsa:150221.
UCSC	uc002zuy.4. human.
Organism-specific databases
CTD	150221.
GeneCards	GC22M021900.
HGNC	HGNC:33892. RIMBP3C.
HPA	HPA001183.
MIM	612701. gene.
neXtProt	NX_A6NJZ7.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG327664.
HOGENOM	HOG000090231.
HOVERGEN	HBG096074.
InParanoid	A6NJZ7.
OMA	FREKENC.
OrthoDB	EOG4HX506.
Gene expression databases
Bgee	A6NJZ7.
CleanEx	HS_RIMBP3C.
Genevestigator	A6NJZ7.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR003961. Fibronectin_type3. IPR013783. Ig-like_fold. IPR011511. SH3_2. IPR001452. SH3_domain. [Graphical view]
Pfam	PF07653. SH3_2. 2 hits. [Graphical view]
SMART	SM00060. FN3. 2 hits. SM00326. SH3. 3 hits. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 2 hits. SSF50044. SH3. 3 hits.
PROSITE	PS50853. FN3. 2 hits. PS50002. SH3. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	150221.
SOURCE	Search...

Entry information

Entry name

RIM3C_HUMAN

Accession

Primary (citable) accession number: A6NJZ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	March 21, 2012
Last modified:	April 3, 2013
This is version 48 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.