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Protein

Olfactory receptor 6C65

Gene

OR6C65

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6C65
Gene namesi
Name:OR6C65
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000205328.2.
HGNCiHGNC:31295. OR6C65.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 63CytoplasmicSequence analysisAdd BLAST19
Transmembranei64 – 84Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini85 – 95ExtracellularSequence analysisAdd BLAST11
Transmembranei96 – 116Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini117 – 141CytoplasmicSequence analysisAdd BLAST25
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 194ExtracellularSequence analysisAdd BLAST32
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 237CytoplasmicSequence analysisAdd BLAST22
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 272ExtracellularSequence analysisAdd BLAST14
Transmembranei273 – 290Helical; Name=7Sequence analysisAdd BLAST18
Topological domaini291 – 312CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134924624.

Polymorphism and mutation databases

BioMutaiOR6C65.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003104661 – 312Olfactory receptor 6C65Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA6NJZ3.
PRIDEiA6NJZ3.

PTM databases

iPTMnetiA6NJZ3.
PhosphoSitePlusiA6NJZ3.

Expressioni

Gene expression databases

CleanExiHS_OR6C65.
ExpressionAtlasiA6NJZ3. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000368986.

Structurei

3D structure databases

ProteinModelPortaliA6NJZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFJ6. Eukaryota.
ENOG41120HT. LUCA.
GeneTreeiENSGT00900000140821.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6NJZ3.
KOiK04257.
OMAiMPNKTSI.
OrthoDBiEOG091G0F9F.
PhylomeDBiA6NJZ3.
TreeFamiTF336833.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NJZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNMTSIREF ILLGFTDNPE LQVVIFFFML ITYLLSVSGN MIIIMLTLSN
60 70 80 90 100
IHLKTPMYFF LRNFSFLEIS FTTVFIPRFL INIATGDTTI SYNASMAQVF
110 120 130 140 150
FLILLGSTEF FLLAVMSYDR YVAICKPLHY TTIMSNKVCN WLVISSWLAG
160 170 180 190 200
FLIIFPPVIM GLQLDFCDSS TIDHFICDSS PMLLIACTDT QFLELMAFLL
210 220 230 240 250
AVFTLMVTLA LVVLSYTLIL KTILKIPSAQ QRKKAFSTCS SHMIVVSVSY
260 270 280 290 300
GSCIFMCVKT SAKEGMALSK GVAVLNTSVA PMLNPFIYTL RNQQVKQALR
310
EFTKKILSLN KQ
Length:312
Mass (Da):35,198
Last modified:July 24, 2007 - v1
Checksum:i104C00A0A6051314
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03704913L → Q. Corresponds to variant dbSNP:rs12424958Ensembl.1
Natural variantiVAR_037050222T → A2 PublicationsCorresponds to variant dbSNP:rs7971073Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125816 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW96810.1.
BC136897 mRNA. Translation: AAI36898.1.
BC136899 mRNA. Translation: AAI36900.1.
CCDSiCCDS31821.1.
RefSeqiNP_001005518.1. NM_001005518.1.
UniGeneiHs.554553.

Genome annotation databases

EnsembliENST00000379665; ENSP00000368986; ENSG00000205328.
GeneIDi403282.
KEGGihsa:403282.
UCSCiuc010spl.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO6C65_HUMAN
AccessioniPrimary (citable) accession number: A6NJZ3
Secondary accession number(s): B2RNH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: October 25, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families