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Protein

UPF0573 protein C2orf70

Gene

C2orf70

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0573 protein C2orf70
Gene namesi
Name:C2orf70
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:27938. C2orf70.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173557.
PharmGKBiPA162379496.

Polymorphism and mutation databases

BioMutaiC2orf70.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003322771 – 201UPF0573 protein C2orf70Add BLAST201

Proteomic databases

PaxDbiA6NJV1.
PRIDEiA6NJV1.

PTM databases

PhosphoSitePlusiA6NJV1.

Expressioni

Gene expression databases

BgeeiENSG00000173557.
CleanExiHS_C2orf70.
ExpressionAtlasiA6NJV1. baseline and differential.
GenevisibleiA6NJV1. HS.

Organism-specific databases

HPAiHPA062453.
HPA069279.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000332875.

Structurei

3D structure databases

ProteinModelPortaliA6NJV1.
SMRiA6NJV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0573 family.Curated

Phylogenomic databases

eggNOGiENOG410IWU2. Eukaryota.
ENOG4111R30. LUCA.
GeneTreeiENSGT00390000018634.
HOGENOMiHOG000007112.
HOVERGENiHBG107581.
InParanoidiA6NJV1.
OMAiPGLMPGY.
OrthoDBiEOG091G0UVK.
PhylomeDBiA6NJV1.
TreeFamiTF329317.

Family and domain databases

InterProiIPR018902. UPF0573/UPF0605.
[Graphical view]
PfamiPF10629. DUF2475. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NJV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRSAGTLL TEFNAAYVPP GLMPGYQGHV PTVAFSFGAP YGTTTLKYFQ
60 70 80 90 100
DHRNRAMEKS HTPFSQGGHF PTIFSTNPNL LLMERASTRD RWLHKPSYTR
110 120 130 140 150
FNLDSHRSTE LTNFYQMVQQ HRKYYQDKTG TVPRVPYFAM PVREPERYPL
160 170 180 190 200
PTVLPPLCPK KKWHLLRLAP ENLKTYQTFP SGKRVSPQER KKRDCYFEFR

A
Length:201
Mass (Da):23,421
Last modified:July 24, 2007 - v1
Checksum:iDE69E9AFC9B7A4D4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04299866Q → H.Corresponds to variant rs13002673dbSNPEnsembl.1
Natural variantiVAR_054056177Q → L.Corresponds to variant rs2272466dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015977 Genomic DNA. No translation available.
AC108070 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00681.1.
CCDSiCCDS42661.1.
RefSeqiNP_001098989.1. NM_001105519.2.
UniGeneiHs.407083.

Genome annotation databases

EnsembliENST00000329615; ENSP00000332875; ENSG00000173557.
GeneIDi339778.
KEGGihsa:339778.
UCSCiuc010eyn.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015977 Genomic DNA. No translation available.
AC108070 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00681.1.
CCDSiCCDS42661.1.
RefSeqiNP_001098989.1. NM_001105519.2.
UniGeneiHs.407083.

3D structure databases

ProteinModelPortaliA6NJV1.
SMRiA6NJV1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000332875.

PTM databases

PhosphoSitePlusiA6NJV1.

Polymorphism and mutation databases

BioMutaiC2orf70.

Proteomic databases

PaxDbiA6NJV1.
PRIDEiA6NJV1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329615; ENSP00000332875; ENSG00000173557.
GeneIDi339778.
KEGGihsa:339778.
UCSCiuc010eyn.4. human.

Organism-specific databases

CTDi339778.
GeneCardsiC2orf70.
HGNCiHGNC:27938. C2orf70.
HPAiHPA062453.
HPA069279.
neXtProtiNX_A6NJV1.
OpenTargetsiENSG00000173557.
PharmGKBiPA162379496.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWU2. Eukaryota.
ENOG4111R30. LUCA.
GeneTreeiENSGT00390000018634.
HOGENOMiHOG000007112.
HOVERGENiHBG107581.
InParanoidiA6NJV1.
OMAiPGLMPGY.
OrthoDBiEOG091G0UVK.
PhylomeDBiA6NJV1.
TreeFamiTF329317.

Miscellaneous databases

GenomeRNAii339778.
PROiA6NJV1.

Gene expression databases

BgeeiENSG00000173557.
CleanExiHS_C2orf70.
ExpressionAtlasiA6NJV1. baseline and differential.
GenevisibleiA6NJV1. HS.

Family and domain databases

InterProiIPR018902. UPF0573/UPF0605.
[Graphical view]
PfamiPF10629. DUF2475. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCB070_HUMAN
AccessioniPrimary (citable) accession number: A6NJV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 24, 2007
Last modified: November 2, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.