ID   UNC4_HUMAN              Reviewed;         531 AA.
AC   A6NJT0; A4D221;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   24-JAN-2024, entry version 131.
DE   RecName: Full=Homeobox protein unc-4 homolog;
DE   AltName: Full=Homeobox protein Uncx4.1;
GN   Name=UNCX; Synonyms=UNCX4.1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12690205; DOI=10.1126/science.1083423;
RA   Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA   Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA   Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA   Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA   Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA   Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA   Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA   Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA   Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA   Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA   Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA   Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA   Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA   Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA   Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA   Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA   Adams M.D., Tsui L.-C.;
RT   "Human chromosome 7: DNA sequence and biology.";
RL   Science 300:767-772(2003).
CC   -!- FUNCTION: Transcription factor involved in somitogenesis and
CC       neurogenesis. Required for the maintenance and differentiation of
CC       particular elements of the axial skeleton. May act upstream of PAX9.
CC       Plays a role in controlling the development of connections of
CC       hypothalamic neurons to pituitary elements, allowing central neurons to
CC       reach the peripheral blood circulation and to deliver hormones for
CC       control of peripheral functions (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Unc-4 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AC073094; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH236953; EAL23940.1; ALT_SEQ; Genomic_DNA.
DR   CCDS; CCDS34583.1; -.
DR   RefSeq; NP_001073930.1; NM_001080461.1.
DR   AlphaFoldDB; A6NJT0; -.
DR   BioGRID; 131024; 1.
DR   STRING; 9606.ENSP00000314480; -.
DR   iPTMnet; A6NJT0; -.
DR   PhosphoSitePlus; A6NJT0; -.
DR   BioMuta; UNCX; -.
DR   EPD; A6NJT0; -.
DR   MassIVE; A6NJT0; -.
DR   MaxQB; A6NJT0; -.
DR   PaxDb; 9606-ENSP00000314480; -.
DR   PeptideAtlas; A6NJT0; -.
DR   ProteomicsDB; 1352; -.
DR   Antibodypedia; 24186; 156 antibodies from 22 providers.
DR   DNASU; 340260; -.
DR   Ensembl; ENST00000316333.9; ENSP00000314480.8; ENSG00000164853.9.
DR   GeneID; 340260; -.
DR   KEGG; hsa:340260; -.
DR   MANE-Select; ENST00000316333.9; ENSP00000314480.8; NM_001080461.3; NP_001073930.1.
DR   UCSC; uc011jvw.3; human.
DR   AGR; HGNC:33194; -.
DR   CTD; 340260; -.
DR   DisGeNET; 340260; -.
DR   GeneCards; UNCX; -.
DR   HGNC; HGNC:33194; UNCX.
DR   HPA; ENSG00000164853; Tissue enriched (brain).
DR   neXtProt; NX_A6NJT0; -.
DR   OpenTargets; ENSG00000164853; -.
DR   PharmGKB; PA162408642; -.
DR   VEuPathDB; HostDB:ENSG00000164853; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   GeneTree; ENSGT00940000161420; -.
DR   HOGENOM; CLU_041996_0_0_1; -.
DR   InParanoid; A6NJT0; -.
DR   OMA; DKDAAPC; -.
DR   OrthoDB; 2902937at2759; -.
DR   PhylomeDB; A6NJT0; -.
DR   TreeFam; TF315554; -.
DR   PathwayCommons; A6NJT0; -.
DR   BioGRID-ORCS; 340260; 24 hits in 1163 CRISPR screens.
DR   GenomeRNAi; 340260; -.
DR   Pharos; A6NJT0; Tbio.
DR   PRO; PR:A6NJT0; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; A6NJT0; Protein.
DR   Bgee; ENSG00000164853; Expressed in cerebellum and 19 other cell types or tissues.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0001502; P:cartilage condensation; IEA:Ensembl.
DR   GO; GO:0035726; P:common myeloid progenitor cell proliferation; IEA:Ensembl.
DR   GO; GO:0021516; P:dorsal spinal cord development; IEA:Ensembl.
DR   GO; GO:0021889; P:olfactory bulb interneuron differentiation; IEA:Ensembl.
DR   GO; GO:0007389; P:pattern specification process; IEA:Ensembl.
DR   GO; GO:0045595; P:regulation of cell differentiation; IEA:Ensembl.
DR   GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   PANTHER; PTHR46799; HOMEOBOX PROTEIN UNC-4 HOMOLOG; 1.
DR   PANTHER; PTHR46799:SF1; HOMEOBOX PROTEIN UNC-4 HOMOLOG; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; Differentiation; DNA-binding; Homeobox;
KW   Neurogenesis; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..531
FT                   /note="Homeobox protein unc-4 homolog"
FT                   /id="PRO_0000334624"
FT   DNA_BIND        105..164
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          87..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          161..312
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          324..344
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          401..531
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..106
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        188..203
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        406..420
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        482..507
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   531 AA;  53690 MW;  F538F74E77D7F32E CRC64;
     MMDGRLLEHP HAQFGGSLGG VVGFPYPLGH HHVYELAGHQ LQSAAAAASV PFSIDGLLGG
     SCAAAASVVN PTPLLPAACG VGGDGQPFKL SDSGDPDKES PGCKRRRTRT NFTGWQLEEL
     EKAFNESHYP DVFMREALAL RLDLVESRVQ VWFQNRRAKW RKKENTKKGP GRPAHNSHPT
     TCSGEPMDPE EIARKELEKM EKKKRKHEKK LLKSQGRHLH SPGGLSLHSA PSSDSDSGGG
     GLSPEPPEPP PPAAKGPGAH ASGAAGTAPA PPGEPPAPGT CDPAFYPSQR SGAGPQPRPG
     RPADKDAASC GPGAAVAAVE RGAAGLPKAS PFSVESLLSD SPPRRKAASN AAAAAAAGLD
     FAPGLPCAPR TLIGKGHFLL YPITQPLGFL VPQAALKGGA GLEPAPKDAP PAPAVPPAPP
     AQASFGAFSG PGGAPDSAFA RRSPDAVASP GAPAPAPAPF RDLASAAATE GGGGDCADAG
     TAGPAPPPPA PSPRPGPRPP SPAEEPATCG VPEPGAAAGP SPPEGEELDM D
//