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A6NJT0

- UNC4_HUMAN

UniProt

A6NJT0 - UNC4_HUMAN

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Protein

Homeobox protein unc-4 homolog

Gene

UNCX

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi105 – 16460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. cartilage condensation Source: Ensembl
  2. common myeloid progenitor cell proliferation Source: Ensembl
  3. dorsal spinal cord development Source: Ensembl
  4. olfactory bulb interneuron differentiation Source: Ensembl
  5. pattern specification process Source: Ensembl
  6. regulation of cell differentiation Source: Ensembl
  7. regulation of transcription, DNA-templated Source: UniProtKB-KW
  8. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein unc-4 homolog
Alternative name(s):
Homeobox protein Uncx4.1
Gene namesi
Name:UNCX
Synonyms:UNCX4.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:33194. UNCX.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162408642.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 531531Homeobox protein unc-4 homologPRO_0000334624Add
BLAST

Proteomic databases

MaxQBiA6NJT0.
PaxDbiA6NJT0.
PRIDEiA6NJT0.

PTM databases

PhosphoSiteiA6NJT0.

Expressioni

Gene expression databases

BgeeiA6NJT0.
CleanExiHS_UNCX.
GenevestigatoriA6NJT0.

Interactioni

Protein-protein interaction databases

BioGridi131024. 1 interaction.
STRINGi9606.ENSP00000314480.

Structurei

3D structure databases

ProteinModelPortaliA6NJT0.
SMRiA6NJT0. Positions 112-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi244 – 523280Ala/Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the paired homeobox family. Unc-4 subfamily.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG283594.
GeneTreeiENSGT00760000118958.
HOGENOMiHOG000154780.
HOVERGENiHBG096185.
InParanoidiA6NJT0.
KOiK09328.
OMAiCGVAGES.
OrthoDBiEOG7MPRFH.
PhylomeDBiA6NJT0.
TreeFamiTF315554.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NJT0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMDGRLLEHP HAQFGGSLGG VVGFPYPLGH HHVYELAGHQ LQSAAAAASV
60 70 80 90 100
PFSIDGLLGG SCAAAASVVN PTPLLPAACG VGGDGQPFKL SDSGDPDKES
110 120 130 140 150
PGCKRRRTRT NFTGWQLEEL EKAFNESHYP DVFMREALAL RLDLVESRVQ
160 170 180 190 200
VWFQNRRAKW RKKENTKKGP GRPAHNSHPT TCSGEPMDPE EIARKELEKM
210 220 230 240 250
EKKKRKHEKK LLKSQGRHLH SPGGLSLHSA PSSDSDSGGG GLSPEPPEPP
260 270 280 290 300
PPAAKGPGAH ASGAAGTAPA PPGEPPAPGT CDPAFYPSQR SGAGPQPRPG
310 320 330 340 350
RPADKDAASC GPGAAVAAVE RGAAGLPKAS PFSVESLLSD SPPRRKAASN
360 370 380 390 400
AAAAAAAGLD FAPGLPCAPR TLIGKGHFLL YPITQPLGFL VPQAALKGGA
410 420 430 440 450
GLEPAPKDAP PAPAVPPAPP AQASFGAFSG PGGAPDSAFA RRSPDAVASP
460 470 480 490 500
GAPAPAPAPF RDLASAAATE GGGGDCADAG TAGPAPPPPA PSPRPGPRPP
510 520 530
SPAEEPATCG VPEPGAAAGP SPPEGEELDM D
Length:531
Mass (Da):53,690
Last modified:July 24, 2007 - v1
Checksum:iF538F74E77D7F32E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC073094 Genomic DNA. No translation available.
CH236953 Genomic DNA. Translation: EAL23940.1. Sequence problems.
CCDSiCCDS34583.1.
RefSeqiNP_001073930.1. NM_001080461.1.
UniGeneiHs.232272.

Genome annotation databases

EnsembliENST00000316333; ENSP00000314480; ENSG00000164853.
GeneIDi340260.
KEGGihsa:340260.
UCSCiuc011jvw.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC073094 Genomic DNA. No translation available.
CH236953 Genomic DNA. Translation: EAL23940.1 . Sequence problems.
CCDSi CCDS34583.1.
RefSeqi NP_001073930.1. NM_001080461.1.
UniGenei Hs.232272.

3D structure databases

ProteinModelPortali A6NJT0.
SMRi A6NJT0. Positions 112-161.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 131024. 1 interaction.
STRINGi 9606.ENSP00000314480.

PTM databases

PhosphoSitei A6NJT0.

Proteomic databases

MaxQBi A6NJT0.
PaxDbi A6NJT0.
PRIDEi A6NJT0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316333 ; ENSP00000314480 ; ENSG00000164853 .
GeneIDi 340260.
KEGGi hsa:340260.
UCSCi uc011jvw.2. human.

Organism-specific databases

CTDi 340260.
GeneCardsi GC07P001272.
HGNCi HGNC:33194. UNCX.
neXtProti NX_A6NJT0.
PharmGKBi PA162408642.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG283594.
GeneTreei ENSGT00760000118958.
HOGENOMi HOG000154780.
HOVERGENi HBG096185.
InParanoidi A6NJT0.
KOi K09328.
OMAi CGVAGES.
OrthoDBi EOG7MPRFH.
PhylomeDBi A6NJT0.
TreeFami TF315554.

Miscellaneous databases

GenomeRNAii 340260.
NextBioi 97758.
PROi A6NJT0.

Gene expression databases

Bgeei A6NJT0.
CleanExi HS_UNCX.
Genevestigatori A6NJT0.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiUNC4_HUMAN
AccessioniPrimary (citable) accession number: A6NJT0
Secondary accession number(s): A4D221
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3