Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A6NJT0

- UNC4_HUMAN

UniProt

A6NJT0 - UNC4_HUMAN

Protein

Homeobox protein unc-4 homolog

Gene

UNCX

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi105 – 16460HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. cartilage condensation Source: Ensembl
    2. common myeloid progenitor cell proliferation Source: Ensembl
    3. dorsal spinal cord development Source: Ensembl
    4. olfactory bulb interneuron differentiation Source: Ensembl
    5. pattern specification process Source: Ensembl
    6. regulation of cell differentiation Source: Ensembl
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein unc-4 homolog
    Alternative name(s):
    Homeobox protein Uncx4.1
    Gene namesi
    Name:UNCX
    Synonyms:UNCX4.1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:33194. UNCX.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162408642.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 531531Homeobox protein unc-4 homologPRO_0000334624Add
    BLAST

    Proteomic databases

    PaxDbiA6NJT0.
    PRIDEiA6NJT0.

    PTM databases

    PhosphoSiteiA6NJT0.

    Expressioni

    Gene expression databases

    BgeeiA6NJT0.
    CleanExiHS_UNCX.
    GenevestigatoriA6NJT0.

    Interactioni

    Protein-protein interaction databases

    BioGridi131024. 1 interaction.
    STRINGi9606.ENSP00000314480.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NJT0.
    SMRiA6NJT0. Positions 112-161.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi244 – 523280Ala/Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the paired homeobox family. Unc-4 subfamily.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG283594.
    HOGENOMiHOG000154780.
    HOVERGENiHBG096185.
    InParanoidiA6NJT0.
    KOiK09328.
    OMAiCGVAGES.
    OrthoDBiEOG7MPRFH.
    PhylomeDBiA6NJT0.
    TreeFamiTF315554.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6NJT0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMDGRLLEHP HAQFGGSLGG VVGFPYPLGH HHVYELAGHQ LQSAAAAASV    50
    PFSIDGLLGG SCAAAASVVN PTPLLPAACG VGGDGQPFKL SDSGDPDKES 100
    PGCKRRRTRT NFTGWQLEEL EKAFNESHYP DVFMREALAL RLDLVESRVQ 150
    VWFQNRRAKW RKKENTKKGP GRPAHNSHPT TCSGEPMDPE EIARKELEKM 200
    EKKKRKHEKK LLKSQGRHLH SPGGLSLHSA PSSDSDSGGG GLSPEPPEPP 250
    PPAAKGPGAH ASGAAGTAPA PPGEPPAPGT CDPAFYPSQR SGAGPQPRPG 300
    RPADKDAASC GPGAAVAAVE RGAAGLPKAS PFSVESLLSD SPPRRKAASN 350
    AAAAAAAGLD FAPGLPCAPR TLIGKGHFLL YPITQPLGFL VPQAALKGGA 400
    GLEPAPKDAP PAPAVPPAPP AQASFGAFSG PGGAPDSAFA RRSPDAVASP 450
    GAPAPAPAPF RDLASAAATE GGGGDCADAG TAGPAPPPPA PSPRPGPRPP 500
    SPAEEPATCG VPEPGAAAGP SPPEGEELDM D 531
    Length:531
    Mass (Da):53,690
    Last modified:July 24, 2007 - v1
    Checksum:iF538F74E77D7F32E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC073094 Genomic DNA. No translation available.
    CH236953 Genomic DNA. Translation: EAL23940.1. Sequence problems.
    CCDSiCCDS34583.1.
    RefSeqiNP_001073930.1. NM_001080461.1.
    UniGeneiHs.232272.

    Genome annotation databases

    EnsembliENST00000316333; ENSP00000314480; ENSG00000164853.
    GeneIDi340260.
    KEGGihsa:340260.
    UCSCiuc011jvw.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC073094 Genomic DNA. No translation available.
    CH236953 Genomic DNA. Translation: EAL23940.1 . Sequence problems.
    CCDSi CCDS34583.1.
    RefSeqi NP_001073930.1. NM_001080461.1.
    UniGenei Hs.232272.

    3D structure databases

    ProteinModelPortali A6NJT0.
    SMRi A6NJT0. Positions 112-161.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 131024. 1 interaction.
    STRINGi 9606.ENSP00000314480.

    PTM databases

    PhosphoSitei A6NJT0.

    Proteomic databases

    PaxDbi A6NJT0.
    PRIDEi A6NJT0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000316333 ; ENSP00000314480 ; ENSG00000164853 .
    GeneIDi 340260.
    KEGGi hsa:340260.
    UCSCi uc011jvw.2. human.

    Organism-specific databases

    CTDi 340260.
    GeneCardsi GC07P001272.
    HGNCi HGNC:33194. UNCX.
    neXtProti NX_A6NJT0.
    PharmGKBi PA162408642.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG283594.
    HOGENOMi HOG000154780.
    HOVERGENi HBG096185.
    InParanoidi A6NJT0.
    KOi K09328.
    OMAi CGVAGES.
    OrthoDBi EOG7MPRFH.
    PhylomeDBi A6NJT0.
    TreeFami TF315554.

    Miscellaneous databases

    GenomeRNAii 340260.
    NextBioi 97758.
    PROi A6NJT0.

    Gene expression databases

    Bgeei A6NJT0.
    CleanExi HS_UNCX.
    Genevestigatori A6NJT0.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiUNC4_HUMAN
    AccessioniPrimary (citable) accession number: A6NJT0
    Secondary accession number(s): A4D221
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3