A6NJT0 (UNC4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein unc-4 homolog

Alternative name(s):
Homeobox protein Uncx4.1

Gene names

Name:	UNCX
Synonyms:	UNCX4.1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	531 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the paired homeobox family. Unc-4 subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cartilage condensation Inferred from electronic annotation. Source: Compara common myeloid progenitor cell proliferation Inferred from electronic annotation. Source: Compara dorsal spinal cord development Inferred from electronic annotation. Source: Compara olfactory bulb interneuron differentiation Inferred from electronic annotation. Source: Compara pattern specification process Inferred from electronic annotation. Source: Compara regulation of cell differentiation Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 531	531	Homeobox protein unc-4 homolog		PRO_0000334624
Regions
	DNA binding	105 – 164	60	Homeobox
	Compositional bias	244 – 523	280	Ala/Pro-rich

Sequences

	Sequence		Length	Mass (Da)
	A6NJT0 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: F538F74E77D7F32E	FASTA	531	53,690
	10 20 30 40 50 60 MMDGRLLEHP HAQFGGSLGG VVGFPYPLGH HHVYELAGHQ LQSAAAAASV PFSIDGLLGG 70 80 90 100 110 120 SCAAAASVVN PTPLLPAACG VGGDGQPFKL SDSGDPDKES PGCKRRRTRT NFTGWQLEEL 130 140 150 160 170 180 EKAFNESHYP DVFMREALAL RLDLVESRVQ VWFQNRRAKW RKKENTKKGP GRPAHNSHPT 190 200 210 220 230 240 TCSGEPMDPE EIARKELEKM EKKKRKHEKK LLKSQGRHLH SPGGLSLHSA PSSDSDSGGG 250 260 270 280 290 300 GLSPEPPEPP PPAAKGPGAH ASGAAGTAPA PPGEPPAPGT CDPAFYPSQR SGAGPQPRPG 310 320 330 340 350 360 RPADKDAASC GPGAAVAAVE RGAAGLPKAS PFSVESLLSD SPPRRKAASN AAAAAAAGLD 370 380 390 400 410 420 FAPGLPCAPR TLIGKGHFLL YPITQPLGFL VPQAALKGGA GLEPAPKDAP PAPAVPPAPP 430 440 450 460 470 480 AQASFGAFSG PGGAPDSAFA RRSPDAVASP GAPAPAPAPF RDLASAAATE GGGGDCADAG 490 500 510 520 530 TAGPAPPPPA PSPRPGPRPP SPAEEPATCG VPEPGAAAGP SPPEGEELDM D

References

[1]

"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC073094 Genomic DNA. No translation available. CH236953 Genomic DNA. Translation: EAL23940.1. Sequence problems.
IPI	IPI00894170.
RefSeq	NP_001073930.1. NM_001080461.1.
UniGene	Hs.232272.
3D structure databases
ProteinModelPortal	A6NJT0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000314480.
PTM databases
PhosphoSite	A6NJT0.
Proteomic databases
PaxDb	A6NJT0.
PRIDE	A6NJT0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000316333; ENSP00000314480; ENSG00000164853.
GeneID	340260.
KEGG	hsa:340260.
UCSC	uc011jvw.2. human.
Organism-specific databases
CTD	340260.
GeneCards	GC07P001272.
HGNC	HGNC:33194. UNCX.
neXtProt	NX_A6NJT0.
PharmGKB	PA162408642.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG283594.
HOGENOM	HOG000154780.
HOVERGEN	HBG096185.
InParanoid	A6NJT0.
KO	K09328.
OMA	MMDGRLL.
Gene expression databases
Bgee	A6NJT0.
CleanEx	HS_UNCX.
Genevestigator	A6NJT0.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	340260.
NextBio	97758.

Entry information

Entry name

UNC4_HUMAN

Accession

Primary (citable) accession number: A6NJT0
Secondary accession number(s): A4D221

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	July 24, 2007
Last modified:	May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.