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Protein

Zinc finger and SCAN domain-containing protein 5B

Gene

ZSCAN5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri355 – 377C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-33172-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 5B
Gene namesi
Name:ZSCAN5B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:34246. ZSCAN5B.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197213.
PharmGKBiPA162411031.

Polymorphism and mutation databases

BioMutaiZSCAN5B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003321691 – 495Zinc finger and SCAN domain-containing protein 5BAdd BLAST495

Proteomic databases

MaxQBiA6NJL1.
PaxDbiA6NJL1.
PRIDEiA6NJL1.

PTM databases

iPTMnetiA6NJL1.
PhosphoSitePlusiA6NJL1.

Expressioni

Gene expression databases

BgeeiENSG00000197213.
CleanExiHS_ZSCAN5B.
ExpressionAtlasiA6NJL1. baseline and differential.

Organism-specific databases

HPAiHPA043123.
HPA046836.
HPA059494.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000351883.

Structurei

3D structure databases

ProteinModelPortaliA6NJL1.
SMRiA6NJL1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 126SCAN boxPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri355 – 377C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00710000106788.
HOGENOMiHOG000060216.
HOVERGENiHBG072183.
InParanoidiA6NJL1.
KOiK09230.
OMAiCELCHLW.
OrthoDBiEOG091G0B1S.
PhylomeDBiA6NJL1.
TreeFamiTF341155.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NJL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANWTLSWG QGGPCNSPGS DTPRSVASPE TQLGNHDRNP ETWHMNFRMF
60 70 80 90 100
SCPEESDPIQ ALRKLTELCH LWLRPDLHTK EQILDMLVME QFMISMPQEL
110 120 130 140 150
QVLVKVNGVQ SCKDLEDLLR NNRRPKKWSI VNLLGKEYLM LNSDVEMAEA
160 170 180 190 200
PASVRDDPRD VSSQWASSVN QMHPGTGQAR REQQILPRVA ALSRRQGEDF
210 220 230 240 250
LLHKSIDVTG DPNSPRPKQT LEKDLKENRE ENPGLSSPEP QLPKSPNLVR
260 270 280 290 300
AKEGKEPQKR ASVENVDADT PSACVVEREA LTHSGNRGDA LNLSSPKRSK
310 320 330 340 350
PDASSISQEE PQGEATPVGN RESPGQAEIN PVHSPGPAGP VSHPDGQEAK
360 370 380 390 400
ALPPFACDVC NKSFKYFSQL SIHRRSHTGD RPFQCDLCRK RFLQPSDLRV
410 420 430 440 450
HQRVHTGERP YMCDVCQKRF AHESTLQGHK RIHTGERPFK CKYCSKVFSH
460 470 480 490
KGNLNVHQRT HSGEKPYKCP TCQKAFRQLG TFKRHLKTHR ETTSQ
Length:495
Mass (Da):55,826
Last modified:July 24, 2007 - v1
Checksum:i1CC269AA13F1367D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042965187P → S.Corresponds to variant rs527025dbSNPEnsembl.1
Natural variantiVAR_042966208V → I.Corresponds to variant rs4801296dbSNPEnsembl.1
Natural variantiVAR_042967236S → T.Corresponds to variant rs10425951dbSNPEnsembl.1
Natural variantiVAR_042968304S → T.Corresponds to variant rs892183dbSNPEnsembl.1
Natural variantiVAR_042969412M → L.Corresponds to variant rs16987048dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024580 Genomic DNA. No translation available.
CCDSiCCDS46203.1.
RefSeqiNP_001073925.2. NM_001080456.2.
XP_006723252.1. XM_006723189.3.
UniGeneiHs.132130.

Genome annotation databases

EnsembliENST00000358992; ENSP00000351883; ENSG00000197213.
ENST00000586855; ENSP00000466072; ENSG00000197213.
GeneIDi342933.
KEGGihsa:342933.
UCSCiuc010ygh.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024580 Genomic DNA. No translation available.
CCDSiCCDS46203.1.
RefSeqiNP_001073925.2. NM_001080456.2.
XP_006723252.1. XM_006723189.3.
UniGeneiHs.132130.

3D structure databases

ProteinModelPortaliA6NJL1.
SMRiA6NJL1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000351883.

PTM databases

iPTMnetiA6NJL1.
PhosphoSitePlusiA6NJL1.

Polymorphism and mutation databases

BioMutaiZSCAN5B.

Proteomic databases

MaxQBiA6NJL1.
PaxDbiA6NJL1.
PRIDEiA6NJL1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358992; ENSP00000351883; ENSG00000197213.
ENST00000586855; ENSP00000466072; ENSG00000197213.
GeneIDi342933.
KEGGihsa:342933.
UCSCiuc010ygh.2. human.

Organism-specific databases

CTDi342933.
GeneCardsiZSCAN5B.
HGNCiHGNC:34246. ZSCAN5B.
HPAiHPA043123.
HPA046836.
HPA059494.
neXtProtiNX_A6NJL1.
OpenTargetsiENSG00000197213.
PharmGKBiPA162411031.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00710000106788.
HOGENOMiHOG000060216.
HOVERGENiHBG072183.
InParanoidiA6NJL1.
KOiK09230.
OMAiCELCHLW.
OrthoDBiEOG091G0B1S.
PhylomeDBiA6NJL1.
TreeFamiTF341155.

Enzyme and pathway databases

BioCyciZFISH:G66-33172-MONOMER.

Miscellaneous databases

GenomeRNAii342933.
PROiA6NJL1.

Gene expression databases

BgeeiENSG00000197213.
CleanExiHS_ZSCAN5B.
ExpressionAtlasiA6NJL1. baseline and differential.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZSA5B_HUMAN
AccessioniPrimary (citable) accession number: A6NJL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 24, 2007
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.