A6NJL1 (ZSA5B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger and SCAN domain-containing protein 5B

Gene names

Name:

ZSCAN5B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	495 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Contains 5 C2H2-type zinc fingers. Contains 1 SCAN box domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	viral reproduction Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleus Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding RNA polymerase II transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 495	495	Zinc finger and SCAN domain-containing protein 5B		PRO_0000332169
Regions
	Domain	44 – 126	83	SCAN box
	Zinc finger	355 – 377	23	C2H2-type 1
	Zinc finger	383 – 405	23	C2H2-type 2
	Zinc finger	411 – 433	23	C2H2-type 3
	Zinc finger	439 – 461	23	C2H2-type 4
	Zinc finger	467 – 489	23	C2H2-type 5
Natural variations
	Natural variant	187	1	P → S. Corresponds to variant rs527025 [ dbSNP | Ensembl ].		VAR_042965
	Natural variant	208	1	V → I. Corresponds to variant rs4801296 [ dbSNP | Ensembl ].		VAR_042966
	Natural variant	236	1	S → T. Corresponds to variant rs10425951 [ dbSNP | Ensembl ].		VAR_042967
	Natural variant	304	1	S → T. Corresponds to variant rs892183 [ dbSNP | Ensembl ].		VAR_042968
	Natural variant	412	1	M → L. Corresponds to variant rs16987048 [ dbSNP | Ensembl ].		VAR_042969

Sequences

	Sequence		Length	Mass (Da)
	A6NJL1 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 1CC269AA13F1367D	FASTA	495	55,826
	10 20 30 40 50 60 MAANWTLSWG QGGPCNSPGS DTPRSVASPE TQLGNHDRNP ETWHMNFRMF SCPEESDPIQ 70 80 90 100 110 120 ALRKLTELCH LWLRPDLHTK EQILDMLVME QFMISMPQEL QVLVKVNGVQ SCKDLEDLLR 130 140 150 160 170 180 NNRRPKKWSI VNLLGKEYLM LNSDVEMAEA PASVRDDPRD VSSQWASSVN QMHPGTGQAR 190 200 210 220 230 240 REQQILPRVA ALSRRQGEDF LLHKSIDVTG DPNSPRPKQT LEKDLKENRE ENPGLSSPEP 250 260 270 280 290 300 QLPKSPNLVR AKEGKEPQKR ASVENVDADT PSACVVEREA LTHSGNRGDA LNLSSPKRSK 310 320 330 340 350 360 PDASSISQEE PQGEATPVGN RESPGQAEIN PVHSPGPAGP VSHPDGQEAK ALPPFACDVC 370 380 390 400 410 420 NKSFKYFSQL SIHRRSHTGD RPFQCDLCRK RFLQPSDLRV HQRVHTGERP YMCDVCQKRF 430 440 450 460 470 480 AHESTLQGHK RIHTGERPFK CKYCSKVFSH KGNLNVHQRT HSGEKPYKCP TCQKAFRQLG 490 TFKRHLKTHR ETTSQ

References

[1]

"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC024580 Genomic DNA. No translation available.
IPI	IPI00247123.
RefSeq	NP_001073925.2. NM_001080456.2.
UniGene	Hs.132130.
3D structure databases
ProteinModelPortal	A6NJL1.
ModBase	Search...
PTM databases
PhosphoSite	A6NJL1.
Proteomic databases
PaxDb	A6NJL1.
PRIDE	A6NJL1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000358992; ENSP00000351883; ENSG00000197213. ENST00000586855; ENSP00000466072; ENSG00000197213.
GeneID	342933.
KEGG	hsa:342933.
UCSC	uc010ygh.2. human.
Organism-specific databases
CTD	342933.
GeneCards	GC19M056701.
HGNC	HGNC:34246. ZSCAN5B.
neXtProt	NX_A6NJL1.
PharmGKB	PA162411031.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000060216.
HOVERGEN	HBG072183.
InParanoid	A6NJL1.
KO	K09230.
OMA	WASSVNQ.
OrthoDB	EOG4PVNZC.
Gene expression databases
Bgee	A6NJL1.
CleanEx	HS_ZSCAN5B.
Genevestigator	A6NJL1.
Family and domain databases
Gene3D	3.30.160.60. 5 hits.
InterPro	IPR008916. Retrov_capsid_C. IPR003309. Tscrpt_reg_SCAN. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF02023. SCAN. 1 hit. [Graphical view]
SMART	SM00431. SCAN. 1 hit. SM00355. ZnF_C2H2. 5 hits. [Graphical view]
SUPFAM	SSF47353. Retrov_capsid_C. 1 hit.
PROSITE	PS50804. SCAN_BOX. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 5 hits. PS50157. ZINC_FINGER_C2H2_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	342933.
NextBio	98409.

Entry information

Entry name

ZSA5B_HUMAN

Accession

Primary (citable) accession number: A6NJL1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	July 24, 2007
Last modified:	May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.