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A6NJL1 (ZSA5B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger and SCAN domain-containing protein 5B
Gene names
Name:ZSCAN5B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length495 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Contains 5 C2H2-type zinc fingers.

Contains 1 SCAN box domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 495495Zinc finger and SCAN domain-containing protein 5B
PRO_0000332169

Regions

Domain44 – 12683SCAN box
Zinc finger355 – 37723C2H2-type 1
Zinc finger383 – 40523C2H2-type 2
Zinc finger411 – 43323C2H2-type 3
Zinc finger439 – 46123C2H2-type 4
Zinc finger467 – 48923C2H2-type 5

Natural variations

Natural variant1871P → S.
Corresponds to variant rs527025 [ dbSNP | Ensembl ].
VAR_042965
Natural variant2081V → I.
Corresponds to variant rs4801296 [ dbSNP | Ensembl ].
VAR_042966
Natural variant2361S → T.
Corresponds to variant rs10425951 [ dbSNP | Ensembl ].
VAR_042967
Natural variant3041S → T.
Corresponds to variant rs892183 [ dbSNP | Ensembl ].
VAR_042968
Natural variant4121M → L.
Corresponds to variant rs16987048 [ dbSNP | Ensembl ].
VAR_042969

Sequences

Sequence LengthMass (Da)Tools
A6NJL1 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 1CC269AA13F1367D

FASTA49555,826
        10         20         30         40         50         60 
MAANWTLSWG QGGPCNSPGS DTPRSVASPE TQLGNHDRNP ETWHMNFRMF SCPEESDPIQ 

        70         80         90        100        110        120 
ALRKLTELCH LWLRPDLHTK EQILDMLVME QFMISMPQEL QVLVKVNGVQ SCKDLEDLLR 

       130        140        150        160        170        180 
NNRRPKKWSI VNLLGKEYLM LNSDVEMAEA PASVRDDPRD VSSQWASSVN QMHPGTGQAR 

       190        200        210        220        230        240 
REQQILPRVA ALSRRQGEDF LLHKSIDVTG DPNSPRPKQT LEKDLKENRE ENPGLSSPEP 

       250        260        270        280        290        300 
QLPKSPNLVR AKEGKEPQKR ASVENVDADT PSACVVEREA LTHSGNRGDA LNLSSPKRSK 

       310        320        330        340        350        360 
PDASSISQEE PQGEATPVGN RESPGQAEIN PVHSPGPAGP VSHPDGQEAK ALPPFACDVC 

       370        380        390        400        410        420 
NKSFKYFSQL SIHRRSHTGD RPFQCDLCRK RFLQPSDLRV HQRVHTGERP YMCDVCQKRF 

       430        440        450        460        470        480 
AHESTLQGHK RIHTGERPFK CKYCSKVFSH KGNLNVHQRT HSGEKPYKCP TCQKAFRQLG 

       490 
TFKRHLKTHR ETTSQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC024580 Genomic DNA. No translation available.
RefSeqNP_001073925.2. NM_001080456.2.
XP_005258921.1. XM_005258864.1.
UniGeneHs.132130.

3D structure databases

ProteinModelPortalA6NJL1.
SMRA6NJL1. Positions 40-108, 259-490.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteA6NJL1.

Proteomic databases

PaxDbA6NJL1.
PRIDEA6NJL1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000358992; ENSP00000351883; ENSG00000197213.
ENST00000586855; ENSP00000466072; ENSG00000197213.
GeneID342933.
KEGGhsa:342933.
UCSCuc010ygh.2. human.

Organism-specific databases

CTD342933.
GeneCardsGC19M056701.
HGNCHGNC:34246. ZSCAN5B.
neXtProtNX_A6NJL1.
PharmGKBPA162411031.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000060216.
HOVERGENHBG072183.
InParanoidA6NJL1.
KOK09230.
OMACELCHLW.
OrthoDBEOG78PV8X.
PhylomeDBA6NJL1.
TreeFamTF341155.

Gene expression databases

BgeeA6NJL1.
CleanExHS_ZSCAN5B.
GenevestigatorA6NJL1.

Family and domain databases

Gene3D3.30.160.60. 5 hits.
InterProIPR027775. C2H2_Znf_fam.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERPTHR10032. PTHR10032. 1 hit.
PfamPF02023. SCAN. 1 hit.
[Graphical view]
SMARTSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMSSF47353. SSF47353. 1 hit.
PROSITEPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi342933.
NextBio98409.
PROA6NJL1.

Entry information

Entry nameZSA5B_HUMAN
AccessionPrimary (citable) accession number: A6NJL1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM