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A6NJL1

- ZSA5B_HUMAN

UniProt

A6NJL1 - ZSA5B_HUMAN

Protein

Zinc finger and SCAN domain-containing protein 5B

Gene

ZSCAN5B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri355 – 37723C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri383 – 40523C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri411 – 43323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri439 – 46123C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri467 – 48923C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

    GO - Biological processi

    1. regulation of transcription from RNA polymerase II promoter Source: GOC
    2. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger and SCAN domain-containing protein 5B
    Gene namesi
    Name:ZSCAN5B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:34246. ZSCAN5B.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: RefGenome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162411031.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 495495Zinc finger and SCAN domain-containing protein 5BPRO_0000332169Add
    BLAST

    Proteomic databases

    PaxDbiA6NJL1.
    PRIDEiA6NJL1.

    PTM databases

    PhosphoSiteiA6NJL1.

    Expressioni

    Gene expression databases

    BgeeiA6NJL1.
    CleanExiHS_ZSCAN5B.
    GenevestigatoriA6NJL1.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NJL1.
    SMRiA6NJL1. Positions 40-108, 324-490.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini44 – 12683SCAN boxPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 SCAN box domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri355 – 37723C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri383 – 40523C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri411 – 43323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri439 – 46123C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri467 – 48923C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000060216.
    HOVERGENiHBG072183.
    InParanoidiA6NJL1.
    KOiK09230.
    OMAiCELCHLW.
    OrthoDBiEOG78PV8X.
    PhylomeDBiA6NJL1.
    TreeFamiTF341155.

    Family and domain databases

    Gene3Di3.30.160.60. 5 hits.
    InterProiIPR027775. C2H2_Znf_fam.
    IPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PANTHERiPTHR10032. PTHR10032. 1 hit.
    PfamiPF02023. SCAN. 1 hit.
    [Graphical view]
    SMARTiSM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    SUPFAMiSSF47353. SSF47353. 1 hit.
    PROSITEiPS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6NJL1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAANWTLSWG QGGPCNSPGS DTPRSVASPE TQLGNHDRNP ETWHMNFRMF    50
    SCPEESDPIQ ALRKLTELCH LWLRPDLHTK EQILDMLVME QFMISMPQEL 100
    QVLVKVNGVQ SCKDLEDLLR NNRRPKKWSI VNLLGKEYLM LNSDVEMAEA 150
    PASVRDDPRD VSSQWASSVN QMHPGTGQAR REQQILPRVA ALSRRQGEDF 200
    LLHKSIDVTG DPNSPRPKQT LEKDLKENRE ENPGLSSPEP QLPKSPNLVR 250
    AKEGKEPQKR ASVENVDADT PSACVVEREA LTHSGNRGDA LNLSSPKRSK 300
    PDASSISQEE PQGEATPVGN RESPGQAEIN PVHSPGPAGP VSHPDGQEAK 350
    ALPPFACDVC NKSFKYFSQL SIHRRSHTGD RPFQCDLCRK RFLQPSDLRV 400
    HQRVHTGERP YMCDVCQKRF AHESTLQGHK RIHTGERPFK CKYCSKVFSH 450
    KGNLNVHQRT HSGEKPYKCP TCQKAFRQLG TFKRHLKTHR ETTSQ 495
    Length:495
    Mass (Da):55,826
    Last modified:July 24, 2007 - v1
    Checksum:i1CC269AA13F1367D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti187 – 1871P → S.
    Corresponds to variant rs527025 [ dbSNP | Ensembl ].
    VAR_042965
    Natural varianti208 – 2081V → I.
    Corresponds to variant rs4801296 [ dbSNP | Ensembl ].
    VAR_042966
    Natural varianti236 – 2361S → T.
    Corresponds to variant rs10425951 [ dbSNP | Ensembl ].
    VAR_042967
    Natural varianti304 – 3041S → T.
    Corresponds to variant rs892183 [ dbSNP | Ensembl ].
    VAR_042968
    Natural varianti412 – 4121M → L.
    Corresponds to variant rs16987048 [ dbSNP | Ensembl ].
    VAR_042969

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC024580 Genomic DNA. No translation available.
    CCDSiCCDS46203.1.
    RefSeqiNP_001073925.2. NM_001080456.2.
    XP_005258921.1. XM_005258864.1.
    XP_006723252.1. XM_006723189.1.
    UniGeneiHs.132130.

    Genome annotation databases

    EnsembliENST00000358992; ENSP00000351883; ENSG00000197213.
    ENST00000586855; ENSP00000466072; ENSG00000197213.
    GeneIDi342933.
    KEGGihsa:342933.
    UCSCiuc010ygh.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC024580 Genomic DNA. No translation available.
    CCDSi CCDS46203.1.
    RefSeqi NP_001073925.2. NM_001080456.2.
    XP_005258921.1. XM_005258864.1.
    XP_006723252.1. XM_006723189.1.
    UniGenei Hs.132130.

    3D structure databases

    ProteinModelPortali A6NJL1.
    SMRi A6NJL1. Positions 40-108, 324-490.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei A6NJL1.

    Proteomic databases

    PaxDbi A6NJL1.
    PRIDEi A6NJL1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358992 ; ENSP00000351883 ; ENSG00000197213 .
    ENST00000586855 ; ENSP00000466072 ; ENSG00000197213 .
    GeneIDi 342933.
    KEGGi hsa:342933.
    UCSCi uc010ygh.2. human.

    Organism-specific databases

    CTDi 342933.
    GeneCardsi GC19M056701.
    HGNCi HGNC:34246. ZSCAN5B.
    neXtProti NX_A6NJL1.
    PharmGKBi PA162411031.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000060216.
    HOVERGENi HBG072183.
    InParanoidi A6NJL1.
    KOi K09230.
    OMAi CELCHLW.
    OrthoDBi EOG78PV8X.
    PhylomeDBi A6NJL1.
    TreeFami TF341155.

    Miscellaneous databases

    GenomeRNAii 342933.
    NextBioi 98409.
    PROi A6NJL1.

    Gene expression databases

    Bgeei A6NJL1.
    CleanExi HS_ZSCAN5B.
    Genevestigatori A6NJL1.

    Family and domain databases

    Gene3Di 3.30.160.60. 5 hits.
    InterProi IPR027775. C2H2_Znf_fam.
    IPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    PANTHERi PTHR10032. PTHR10032. 1 hit.
    Pfami PF02023. SCAN. 1 hit.
    [Graphical view ]
    SMARTi SM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    SUPFAMi SSF47353. SSF47353. 1 hit.
    PROSITEi PS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiZSA5B_HUMAN
    AccessioniPrimary (citable) accession number: A6NJL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3