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A6NJL1

- ZSA5B_HUMAN

UniProt

A6NJL1 - ZSA5B_HUMAN

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Protein
Zinc finger and SCAN domain-containing protein 5B
Gene
ZSCAN5B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri355 – 37723C2H2-type 1
Add
BLAST
Zinc fingeri383 – 40523C2H2-type 2
Add
BLAST
Zinc fingeri411 – 43323C2H2-type 3
Add
BLAST
Zinc fingeri439 – 46123C2H2-type 4
Add
BLAST
Zinc fingeri467 – 48923C2H2-type 5
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

GO - Biological processi

  1. regulation of transcription from RNA polymerase II promoter Source: GOC
  2. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 5B
Gene namesi
Name:ZSCAN5B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:34246. ZSCAN5B.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162411031.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 495495Zinc finger and SCAN domain-containing protein 5B
PRO_0000332169Add
BLAST

Proteomic databases

PaxDbiA6NJL1.
PRIDEiA6NJL1.

PTM databases

PhosphoSiteiA6NJL1.

Expressioni

Gene expression databases

BgeeiA6NJL1.
CleanExiHS_ZSCAN5B.
GenevestigatoriA6NJL1.

Structurei

3D structure databases

ProteinModelPortaliA6NJL1.
SMRiA6NJL1. Positions 40-108, 324-490.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 12683SCAN box
Add
BLAST

Sequence similaritiesi

Contains 1 SCAN box domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000060216.
HOVERGENiHBG072183.
InParanoidiA6NJL1.
KOiK09230.
OMAiCELCHLW.
OrthoDBiEOG78PV8X.
PhylomeDBiA6NJL1.
TreeFamiTF341155.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PfamiPF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NJL1-1 [UniParc]FASTAAdd to Basket

« Hide

MAANWTLSWG QGGPCNSPGS DTPRSVASPE TQLGNHDRNP ETWHMNFRMF    50
SCPEESDPIQ ALRKLTELCH LWLRPDLHTK EQILDMLVME QFMISMPQEL 100
QVLVKVNGVQ SCKDLEDLLR NNRRPKKWSI VNLLGKEYLM LNSDVEMAEA 150
PASVRDDPRD VSSQWASSVN QMHPGTGQAR REQQILPRVA ALSRRQGEDF 200
LLHKSIDVTG DPNSPRPKQT LEKDLKENRE ENPGLSSPEP QLPKSPNLVR 250
AKEGKEPQKR ASVENVDADT PSACVVEREA LTHSGNRGDA LNLSSPKRSK 300
PDASSISQEE PQGEATPVGN RESPGQAEIN PVHSPGPAGP VSHPDGQEAK 350
ALPPFACDVC NKSFKYFSQL SIHRRSHTGD RPFQCDLCRK RFLQPSDLRV 400
HQRVHTGERP YMCDVCQKRF AHESTLQGHK RIHTGERPFK CKYCSKVFSH 450
KGNLNVHQRT HSGEKPYKCP TCQKAFRQLG TFKRHLKTHR ETTSQ 495
Length:495
Mass (Da):55,826
Last modified:July 24, 2007 - v1
Checksum:i1CC269AA13F1367D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti187 – 1871P → S.
Corresponds to variant rs527025 [ dbSNP | Ensembl ].
VAR_042965
Natural varianti208 – 2081V → I.
Corresponds to variant rs4801296 [ dbSNP | Ensembl ].
VAR_042966
Natural varianti236 – 2361S → T.
Corresponds to variant rs10425951 [ dbSNP | Ensembl ].
VAR_042967
Natural varianti304 – 3041S → T.
Corresponds to variant rs892183 [ dbSNP | Ensembl ].
VAR_042968
Natural varianti412 – 4121M → L.
Corresponds to variant rs16987048 [ dbSNP | Ensembl ].
VAR_042969

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC024580 Genomic DNA. No translation available.
CCDSiCCDS46203.1.
RefSeqiNP_001073925.2. NM_001080456.2.
XP_005258921.1. XM_005258864.1.
XP_006723252.1. XM_006723189.1.
UniGeneiHs.132130.

Genome annotation databases

EnsembliENST00000358992; ENSP00000351883; ENSG00000197213.
ENST00000586855; ENSP00000466072; ENSG00000197213.
GeneIDi342933.
KEGGihsa:342933.
UCSCiuc010ygh.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC024580 Genomic DNA. No translation available.
CCDSi CCDS46203.1.
RefSeqi NP_001073925.2. NM_001080456.2.
XP_005258921.1. XM_005258864.1.
XP_006723252.1. XM_006723189.1.
UniGenei Hs.132130.

3D structure databases

ProteinModelPortali A6NJL1.
SMRi A6NJL1. Positions 40-108, 324-490.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei A6NJL1.

Proteomic databases

PaxDbi A6NJL1.
PRIDEi A6NJL1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000358992 ; ENSP00000351883 ; ENSG00000197213 .
ENST00000586855 ; ENSP00000466072 ; ENSG00000197213 .
GeneIDi 342933.
KEGGi hsa:342933.
UCSCi uc010ygh.2. human.

Organism-specific databases

CTDi 342933.
GeneCardsi GC19M056701.
HGNCi HGNC:34246. ZSCAN5B.
neXtProti NX_A6NJL1.
PharmGKBi PA162411031.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000060216.
HOVERGENi HBG072183.
InParanoidi A6NJL1.
KOi K09230.
OMAi CELCHLW.
OrthoDBi EOG78PV8X.
PhylomeDBi A6NJL1.
TreeFami TF341155.

Miscellaneous databases

GenomeRNAii 342933.
NextBioi 98409.
PROi A6NJL1.

Gene expression databases

Bgeei A6NJL1.
CleanExi HS_ZSCAN5B.
Genevestigatori A6NJL1.

Family and domain databases

Gene3Di 3.30.160.60. 5 hits.
InterProi IPR027775. C2H2_Znf_fam.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
PANTHERi PTHR10032. PTHR10032. 1 hit.
Pfami PF02023. SCAN. 1 hit.
[Graphical view ]
SMARTi SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
SUPFAMi SSF47353. SSF47353. 1 hit.
PROSITEi PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiZSA5B_HUMAN
AccessioniPrimary (citable) accession number: A6NJL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 24, 2007
Last modified: July 9, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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