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Protein

Zinc finger and SCAN domain-containing protein 5B

Gene

ZSCAN5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri355 – 377C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 5B
Gene namesi
Name:ZSCAN5B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000197213.9
HGNCiHGNC:34246 ZSCAN5B
neXtProtiNX_A6NJL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197213
PharmGKBiPA162411031

Polymorphism and mutation databases

BioMutaiZSCAN5B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003321691 – 495Zinc finger and SCAN domain-containing protein 5BAdd BLAST495

Proteomic databases

MaxQBiA6NJL1
PaxDbiA6NJL1
PRIDEiA6NJL1

PTM databases

iPTMnetiA6NJL1
PhosphoSitePlusiA6NJL1

Expressioni

Gene expression databases

BgeeiENSG00000197213
CleanExiHS_ZSCAN5B
ExpressionAtlasiA6NJL1 baseline and differential

Organism-specific databases

HPAiHPA043123
HPA046836
HPA059494
HPA060667

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000351883

Structurei

3D structure databases

ProteinModelPortaliA6NJL1
SMRiA6NJL1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 126SCAN boxPROSITE-ProRule annotationAdd BLAST83

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri355 – 377C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00710000106788
HOGENOMiHOG000060216
HOVERGENiHBG072183
InParanoidiA6NJL1
KOiK09230
OMAiWASSVNQ
OrthoDBiEOG091G0B1S
PhylomeDBiA6NJL1
TreeFamiTF341155

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.101 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequencei

Sequence statusi: Complete.

A6NJL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANWTLSWG QGGPCNSPGS DTPRSVASPE TQLGNHDRNP ETWHMNFRMF
60 70 80 90 100
SCPEESDPIQ ALRKLTELCH LWLRPDLHTK EQILDMLVME QFMISMPQEL
110 120 130 140 150
QVLVKVNGVQ SCKDLEDLLR NNRRPKKWSI VNLLGKEYLM LNSDVEMAEA
160 170 180 190 200
PASVRDDPRD VSSQWASSVN QMHPGTGQAR REQQILPRVA ALSRRQGEDF
210 220 230 240 250
LLHKSIDVTG DPNSPRPKQT LEKDLKENRE ENPGLSSPEP QLPKSPNLVR
260 270 280 290 300
AKEGKEPQKR ASVENVDADT PSACVVEREA LTHSGNRGDA LNLSSPKRSK
310 320 330 340 350
PDASSISQEE PQGEATPVGN RESPGQAEIN PVHSPGPAGP VSHPDGQEAK
360 370 380 390 400
ALPPFACDVC NKSFKYFSQL SIHRRSHTGD RPFQCDLCRK RFLQPSDLRV
410 420 430 440 450
HQRVHTGERP YMCDVCQKRF AHESTLQGHK RIHTGERPFK CKYCSKVFSH
460 470 480 490
KGNLNVHQRT HSGEKPYKCP TCQKAFRQLG TFKRHLKTHR ETTSQ
Length:495
Mass (Da):55,826
Last modified:July 24, 2007 - v1
Checksum:i1CC269AA13F1367D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042965187P → S. Corresponds to variant dbSNP:rs527025Ensembl.1
Natural variantiVAR_042966208V → I. Corresponds to variant dbSNP:rs4801296Ensembl.1
Natural variantiVAR_042967236S → T. Corresponds to variant dbSNP:rs10425951Ensembl.1
Natural variantiVAR_042968304S → T. Corresponds to variant dbSNP:rs892183Ensembl.1
Natural variantiVAR_042969412M → L. Corresponds to variant dbSNP:rs16987048Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024580 Genomic DNA No translation available.
CCDSiCCDS46203.1
RefSeqiNP_001073925.2, NM_001080456.2
XP_006723252.1, XM_006723189.3
UniGeneiHs.132130

Genome annotation databases

EnsembliENST00000358992; ENSP00000351883; ENSG00000197213
ENST00000586855; ENSP00000466072; ENSG00000197213
GeneIDi342933
KEGGihsa:342933
UCSCiuc010ygh.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZSA5B_HUMAN
AccessioniPrimary (citable) accession number: A6NJL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 24, 2007
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome