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Protein

Zinc finger and SCAN domain-containing protein 5B

Gene

ZSCAN5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri355 – 37723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri383 – 40523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri439 – 46123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri467 – 48923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: GO_Central

GO - Biological processi

  1. regulation of transcription from RNA polymerase II promoter Source: GOC
  2. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 5B
Gene namesi
Name:ZSCAN5B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:34246. ZSCAN5B.

Subcellular locationi

  1. Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162411031.

Polymorphism and mutation databases

BioMutaiZSCAN5B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 495495Zinc finger and SCAN domain-containing protein 5BPRO_0000332169Add
BLAST

Proteomic databases

PaxDbiA6NJL1.
PRIDEiA6NJL1.

PTM databases

PhosphoSiteiA6NJL1.

Expressioni

Gene expression databases

BgeeiA6NJL1.
CleanExiHS_ZSCAN5B.
ExpressionAtlasiA6NJL1. baseline.
GenevestigatoriA6NJL1.

Organism-specific databases

HPAiHPA043123.
HPA046836.
HPA059494.

Structurei

3D structure databases

ProteinModelPortaliA6NJL1.
SMRiA6NJL1. Positions 40-108, 354-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 12683SCAN boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri355 – 37723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri383 – 40523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri439 – 46123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri467 – 48923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00710000106788.
HOGENOMiHOG000060216.
HOVERGENiHBG072183.
InParanoidiA6NJL1.
KOiK09230.
OMAiCELCHLW.
OrthoDBiEOG78PV8X.
PhylomeDBiA6NJL1.
TreeFamiTF341155.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PfamiPF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NJL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANWTLSWG QGGPCNSPGS DTPRSVASPE TQLGNHDRNP ETWHMNFRMF
60 70 80 90 100
SCPEESDPIQ ALRKLTELCH LWLRPDLHTK EQILDMLVME QFMISMPQEL
110 120 130 140 150
QVLVKVNGVQ SCKDLEDLLR NNRRPKKWSI VNLLGKEYLM LNSDVEMAEA
160 170 180 190 200
PASVRDDPRD VSSQWASSVN QMHPGTGQAR REQQILPRVA ALSRRQGEDF
210 220 230 240 250
LLHKSIDVTG DPNSPRPKQT LEKDLKENRE ENPGLSSPEP QLPKSPNLVR
260 270 280 290 300
AKEGKEPQKR ASVENVDADT PSACVVEREA LTHSGNRGDA LNLSSPKRSK
310 320 330 340 350
PDASSISQEE PQGEATPVGN RESPGQAEIN PVHSPGPAGP VSHPDGQEAK
360 370 380 390 400
ALPPFACDVC NKSFKYFSQL SIHRRSHTGD RPFQCDLCRK RFLQPSDLRV
410 420 430 440 450
HQRVHTGERP YMCDVCQKRF AHESTLQGHK RIHTGERPFK CKYCSKVFSH
460 470 480 490
KGNLNVHQRT HSGEKPYKCP TCQKAFRQLG TFKRHLKTHR ETTSQ
Length:495
Mass (Da):55,826
Last modified:July 24, 2007 - v1
Checksum:i1CC269AA13F1367D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti187 – 1871P → S.
Corresponds to variant rs527025 [ dbSNP | Ensembl ].
VAR_042965
Natural varianti208 – 2081V → I.
Corresponds to variant rs4801296 [ dbSNP | Ensembl ].
VAR_042966
Natural varianti236 – 2361S → T.
Corresponds to variant rs10425951 [ dbSNP | Ensembl ].
VAR_042967
Natural varianti304 – 3041S → T.
Corresponds to variant rs892183 [ dbSNP | Ensembl ].
VAR_042968
Natural varianti412 – 4121M → L.
Corresponds to variant rs16987048 [ dbSNP | Ensembl ].
VAR_042969

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024580 Genomic DNA. No translation available.
CCDSiCCDS46203.1.
RefSeqiNP_001073925.2. NM_001080456.2.
XP_005258921.1. XM_005258864.2.
XP_006723252.1. XM_006723189.2.
UniGeneiHs.132130.

Genome annotation databases

EnsembliENST00000358992; ENSP00000351883; ENSG00000197213.
ENST00000586855; ENSP00000466072; ENSG00000197213.
GeneIDi342933.
KEGGihsa:342933.
UCSCiuc010ygh.2. human.

Polymorphism and mutation databases

BioMutaiZSCAN5B.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024580 Genomic DNA. No translation available.
CCDSiCCDS46203.1.
RefSeqiNP_001073925.2. NM_001080456.2.
XP_005258921.1. XM_005258864.2.
XP_006723252.1. XM_006723189.2.
UniGeneiHs.132130.

3D structure databases

ProteinModelPortaliA6NJL1.
SMRiA6NJL1. Positions 40-108, 354-489.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiA6NJL1.

Polymorphism and mutation databases

BioMutaiZSCAN5B.

Proteomic databases

PaxDbiA6NJL1.
PRIDEiA6NJL1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358992; ENSP00000351883; ENSG00000197213.
ENST00000586855; ENSP00000466072; ENSG00000197213.
GeneIDi342933.
KEGGihsa:342933.
UCSCiuc010ygh.2. human.

Organism-specific databases

CTDi342933.
GeneCardsiGC19M056701.
HGNCiHGNC:34246. ZSCAN5B.
HPAiHPA043123.
HPA046836.
HPA059494.
neXtProtiNX_A6NJL1.
PharmGKBiPA162411031.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00710000106788.
HOGENOMiHOG000060216.
HOVERGENiHBG072183.
InParanoidiA6NJL1.
KOiK09230.
OMAiCELCHLW.
OrthoDBiEOG78PV8X.
PhylomeDBiA6NJL1.
TreeFamiTF341155.

Miscellaneous databases

GenomeRNAii342933.
NextBioi98409.
PROiA6NJL1.

Gene expression databases

BgeeiA6NJL1.
CleanExiHS_ZSCAN5B.
ExpressionAtlasiA6NJL1. baseline.
GenevestigatoriA6NJL1.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PfamiPF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiZSA5B_HUMAN
AccessioniPrimary (citable) accession number: A6NJL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 24, 2007
Last modified: April 29, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.