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Protein

Arginine-fifty homeobox

Gene

ARGFX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Putative transcription factor.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi78 – 13760HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine-fifty homeobox
Gene namesi
Name:ARGFX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30146. ARGFX.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672588.

Polymorphism and mutation databases

BioMutaiARGFX.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Arginine-fifty homeoboxPRO_0000311325Add
BLAST

Proteomic databases

PaxDbiA6NJG6.
PRIDEiA6NJG6.

Expressioni

Tissue specificityi

Expressed at low level in testis and undifferentiated embryonic stem cells.1 Publication

Gene expression databases

BgeeiA6NJG6.
CleanExiHS_ARGFX.

Organism-specific databases

HPAiHPA043049.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000335578.

Structurei

3D structure databases

ProteinModelPortaliA6NJG6.
SMRiA6NJG6. Positions 80-134.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paired homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG251024.
GeneTreeiENSGT00730000111572.
HOGENOMiHOG000034042.
InParanoidiA6NJG6.
OMAiMQDTQWE.
OrthoDBiEOG7GN2NR.
PhylomeDBiA6NJG6.
TreeFamiTF351179.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NJG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNRMAPENP QPDPFINRNY SNMKVIPPQD PASPSFTLLS KLECSGTVSA
60 70 80 90 100
YCSLNLPGST DPPTSASRVA ATTAIRRRHK ERTSFTHQQY EELEALFSQT
110 120 130 140 150
MFPDRNLQEK LALRLDLPES TVKVWFRNRR FKLKKQQQQQ SAKQRNQILP
160 170 180 190 200
SKKNVPTSPR TSPSPYAFSP VISDFYSSLP SQPLDPSNWA WNSTFTESST
210 220 230 240 250
SDFQMQDTQW ERLVASVPAL YSDAYDIFQI IELYNLPDEN EISSSSFHCL
260 270 280 290 300
YQYLSPTKYQ VGGQGSSLSI FAGPAVGLSP AQTWPNMTSQ AFEAYSLTDS
310
LEFQKTSNMV DLGFL
Length:315
Mass (Da):35,617
Last modified:July 24, 2007 - v1
Checksum:iD3EDBA45BAB43352
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti145 – 1451R → Q.
Corresponds to variant rs9813391 [ dbSNP | Ensembl ].
VAR_037226

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC069239 Genomic DNA. No translation available.
CCDSiCCDS33834.1.
RefSeqiNP_001012677.1. NM_001012659.1.
XP_005247562.1. XM_005247505.2.
UniGeneiHs.224976.

Genome annotation databases

EnsembliENST00000334384; ENSP00000335578; ENSG00000186103.
GeneIDi503582.
KEGGihsa:503582.
UCSCiuc003eef.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC069239 Genomic DNA. No translation available.
CCDSiCCDS33834.1.
RefSeqiNP_001012677.1. NM_001012659.1.
XP_005247562.1. XM_005247505.2.
UniGeneiHs.224976.

3D structure databases

ProteinModelPortaliA6NJG6.
SMRiA6NJG6. Positions 80-134.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000335578.

Polymorphism and mutation databases

BioMutaiARGFX.

Proteomic databases

PaxDbiA6NJG6.
PRIDEiA6NJG6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334384; ENSP00000335578; ENSG00000186103.
GeneIDi503582.
KEGGihsa:503582.
UCSCiuc003eef.3. human.

Organism-specific databases

CTDi503582.
GeneCardsiGC03P121286.
HGNCiHGNC:30146. ARGFX.
HPAiHPA043049.
MIMi611164. gene.
neXtProtiNX_A6NJG6.
PharmGKBiPA142672588.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG251024.
GeneTreeiENSGT00730000111572.
HOGENOMiHOG000034042.
InParanoidiA6NJG6.
OMAiMQDTQWE.
OrthoDBiEOG7GN2NR.
PhylomeDBiA6NJG6.
TreeFamiTF351179.

Miscellaneous databases

GenomeRNAii503582.
NextBioi111963.
PROiA6NJG6.
SOURCEiSearch...

Gene expression databases

BgeeiA6NJG6.
CleanExiHS_ARGFX.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line."
    Booth H.A., Holland P.W.H.
    Gene 387:7-14(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiARGFX_HUMAN
AccessioniPrimary (citable) accession number: A6NJG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: June 24, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.