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A6NJG6

- ARGFX_HUMAN

UniProt

A6NJG6 - ARGFX_HUMAN

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Protein

Arginine-fifty homeobox

Gene

ARGFX

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Putative transcription factor.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi78 – 13760HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine-fifty homeobox
Gene namesi
Name:ARGFX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:30146. ARGFX.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672588.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Arginine-fifty homeoboxPRO_0000311325Add
BLAST

Proteomic databases

PaxDbiA6NJG6.
PRIDEiA6NJG6.

Expressioni

Tissue specificityi

Expressed at low level in testis and undifferentiated embryonic stem cells.1 Publication

Gene expression databases

BgeeiA6NJG6.
CleanExiHS_ARGFX.
GenevestigatoriA6NJG6.

Organism-specific databases

HPAiHPA043049.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000335578.

Structurei

3D structure databases

ProteinModelPortaliA6NJG6.
SMRiA6NJG6. Positions 80-134.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paired homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG251024.
GeneTreeiENSGT00730000111572.
HOGENOMiHOG000034042.
InParanoidiA6NJG6.
OMAiMQDTQWE.
OrthoDBiEOG7GN2NR.
PhylomeDBiA6NJG6.
TreeFamiTF351179.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NJG6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRNRMAPENP QPDPFINRNY SNMKVIPPQD PASPSFTLLS KLECSGTVSA
60 70 80 90 100
YCSLNLPGST DPPTSASRVA ATTAIRRRHK ERTSFTHQQY EELEALFSQT
110 120 130 140 150
MFPDRNLQEK LALRLDLPES TVKVWFRNRR FKLKKQQQQQ SAKQRNQILP
160 170 180 190 200
SKKNVPTSPR TSPSPYAFSP VISDFYSSLP SQPLDPSNWA WNSTFTESST
210 220 230 240 250
SDFQMQDTQW ERLVASVPAL YSDAYDIFQI IELYNLPDEN EISSSSFHCL
260 270 280 290 300
YQYLSPTKYQ VGGQGSSLSI FAGPAVGLSP AQTWPNMTSQ AFEAYSLTDS
310
LEFQKTSNMV DLGFL
Length:315
Mass (Da):35,617
Last modified:July 24, 2007 - v1
Checksum:iD3EDBA45BAB43352
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti145 – 1451R → Q.
Corresponds to variant rs9813391 [ dbSNP | Ensembl ].
VAR_037226

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC069239 Genomic DNA. No translation available.
CCDSiCCDS33834.1.
RefSeqiNP_001012677.1. NM_001012659.1.
XP_005247562.1. XM_005247505.1.
UniGeneiHs.224976.

Genome annotation databases

EnsembliENST00000334384; ENSP00000335578; ENSG00000186103.
GeneIDi503582.
KEGGihsa:503582.
UCSCiuc003eef.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC069239 Genomic DNA. No translation available.
CCDSi CCDS33834.1.
RefSeqi NP_001012677.1. NM_001012659.1.
XP_005247562.1. XM_005247505.1.
UniGenei Hs.224976.

3D structure databases

ProteinModelPortali A6NJG6.
SMRi A6NJG6. Positions 80-134.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000335578.

Proteomic databases

PaxDbi A6NJG6.
PRIDEi A6NJG6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000334384 ; ENSP00000335578 ; ENSG00000186103 .
GeneIDi 503582.
KEGGi hsa:503582.
UCSCi uc003eef.3. human.

Organism-specific databases

CTDi 503582.
GeneCardsi GC03P121286.
HGNCi HGNC:30146. ARGFX.
HPAi HPA043049.
MIMi 611164. gene.
neXtProti NX_A6NJG6.
PharmGKBi PA142672588.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG251024.
GeneTreei ENSGT00730000111572.
HOGENOMi HOG000034042.
InParanoidi A6NJG6.
OMAi MQDTQWE.
OrthoDBi EOG7GN2NR.
PhylomeDBi A6NJG6.
TreeFami TF351179.

Miscellaneous databases

GenomeRNAii 503582.
NextBioi 111963.
PROi A6NJG6.
SOURCEi Search...

Gene expression databases

Bgeei A6NJG6.
CleanExi HS_ARGFX.
Genevestigatori A6NJG6.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line."
    Booth H.A., Holland P.W.H.
    Gene 387:7-14(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiARGFX_HUMAN
AccessioniPrimary (citable) accession number: A6NJG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3