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A6NJG6 (ARGFX_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine-fifty homeobox
Gene names
Name:ARGFX
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative transcription factor By similarity.

Subcellular location

Nucleus By similarity.

Tissue specificity

Expressed at low level in testis and undifferentiated embryonic stem cells. Ref.2

Sequence similarities

Belongs to the paired homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainHomeobox
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Arginine-fifty homeobox
PRO_0000311325

Regions

DNA binding78 – 13760Homeobox

Natural variations

Natural variant1451R → Q.
Corresponds to variant rs9813391 [ dbSNP | Ensembl ].
VAR_037226

Sequences

Sequence LengthMass (Da)Tools
A6NJG6 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: D3EDBA45BAB43352

FASTA31535,617
        10         20         30         40         50         60 
MRNRMAPENP QPDPFINRNY SNMKVIPPQD PASPSFTLLS KLECSGTVSA YCSLNLPGST 

        70         80         90        100        110        120 
DPPTSASRVA ATTAIRRRHK ERTSFTHQQY EELEALFSQT MFPDRNLQEK LALRLDLPES 

       130        140        150        160        170        180 
TVKVWFRNRR FKLKKQQQQQ SAKQRNQILP SKKNVPTSPR TSPSPYAFSP VISDFYSSLP 

       190        200        210        220        230        240 
SQPLDPSNWA WNSTFTESST SDFQMQDTQW ERLVASVPAL YSDAYDIFQI IELYNLPDEN 

       250        260        270        280        290        300 
EISSSSFHCL YQYLSPTKYQ VGGQGSSLSI FAGPAVGLSP AQTWPNMTSQ AFEAYSLTDS 

       310 
LEFQKTSNMV DLGFL 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line."
Booth H.A., Holland P.W.H.
Gene 387:7-14(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC069239 Genomic DNA. No translation available.
RefSeqNP_001012677.1. NM_001012659.1.
XP_005247562.1. XM_005247505.1.
UniGeneHs.224976.

3D structure databases

ProteinModelPortalA6NJG6.
SMRA6NJG6. Positions 80-134.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000335578.

Proteomic databases

PaxDbA6NJG6.
PRIDEA6NJG6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000334384; ENSP00000335578; ENSG00000186103.
GeneID503582.
KEGGhsa:503582.
UCSCuc003eef.3. human.

Organism-specific databases

CTD503582.
GeneCardsGC03P121286.
HGNCHGNC:30146. ARGFX.
HPAHPA043049.
MIM611164. gene.
neXtProtNX_A6NJG6.
PharmGKBPA142672588.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG251024.
HOGENOMHOG000034042.
InParanoidA6NJG6.
OMAMQDTQWE.
OrthoDBEOG7GN2NR.
PhylomeDBA6NJG6.
TreeFamTF351179.

Gene expression databases

BgeeA6NJG6.
CleanExHS_ARGFX.
GenevestigatorA6NJG6.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi503582.
NextBio111963.
PROA6NJG6.
SOURCESearch...

Entry information

Entry nameARGFX_HUMAN
AccessionPrimary (citable) accession number: A6NJG6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM