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A6NJG6

- ARGFX_HUMAN

UniProt

A6NJG6 - ARGFX_HUMAN

Protein

Arginine-fifty homeobox

Gene

ARGFX

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Putative transcription factor.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi78 – 13760HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginine-fifty homeobox
    Gene namesi
    Name:ARGFX
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:30146. ARGFX.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672588.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Arginine-fifty homeoboxPRO_0000311325Add
    BLAST

    Proteomic databases

    PaxDbiA6NJG6.
    PRIDEiA6NJG6.

    Expressioni

    Tissue specificityi

    Expressed at low level in testis and undifferentiated embryonic stem cells.1 Publication

    Gene expression databases

    BgeeiA6NJG6.
    CleanExiHS_ARGFX.
    GenevestigatoriA6NJG6.

    Organism-specific databases

    HPAiHPA043049.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000335578.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NJG6.
    SMRiA6NJG6. Positions 80-134.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the paired homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG251024.
    HOGENOMiHOG000034042.
    InParanoidiA6NJG6.
    OMAiMQDTQWE.
    OrthoDBiEOG7GN2NR.
    PhylomeDBiA6NJG6.
    TreeFamiTF351179.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6NJG6-1 [UniParc]FASTAAdd to Basket

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    MRNRMAPENP QPDPFINRNY SNMKVIPPQD PASPSFTLLS KLECSGTVSA    50
    YCSLNLPGST DPPTSASRVA ATTAIRRRHK ERTSFTHQQY EELEALFSQT 100
    MFPDRNLQEK LALRLDLPES TVKVWFRNRR FKLKKQQQQQ SAKQRNQILP 150
    SKKNVPTSPR TSPSPYAFSP VISDFYSSLP SQPLDPSNWA WNSTFTESST 200
    SDFQMQDTQW ERLVASVPAL YSDAYDIFQI IELYNLPDEN EISSSSFHCL 250
    YQYLSPTKYQ VGGQGSSLSI FAGPAVGLSP AQTWPNMTSQ AFEAYSLTDS 300
    LEFQKTSNMV DLGFL 315
    Length:315
    Mass (Da):35,617
    Last modified:July 24, 2007 - v1
    Checksum:iD3EDBA45BAB43352
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti145 – 1451R → Q.
    Corresponds to variant rs9813391 [ dbSNP | Ensembl ].
    VAR_037226

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC069239 Genomic DNA. No translation available.
    CCDSiCCDS33834.1.
    RefSeqiNP_001012677.1. NM_001012659.1.
    XP_005247562.1. XM_005247505.1.
    UniGeneiHs.224976.

    Genome annotation databases

    EnsembliENST00000334384; ENSP00000335578; ENSG00000186103.
    GeneIDi503582.
    KEGGihsa:503582.
    UCSCiuc003eef.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC069239 Genomic DNA. No translation available.
    CCDSi CCDS33834.1.
    RefSeqi NP_001012677.1. NM_001012659.1.
    XP_005247562.1. XM_005247505.1.
    UniGenei Hs.224976.

    3D structure databases

    ProteinModelPortali A6NJG6.
    SMRi A6NJG6. Positions 80-134.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000335578.

    Proteomic databases

    PaxDbi A6NJG6.
    PRIDEi A6NJG6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334384 ; ENSP00000335578 ; ENSG00000186103 .
    GeneIDi 503582.
    KEGGi hsa:503582.
    UCSCi uc003eef.3. human.

    Organism-specific databases

    CTDi 503582.
    GeneCardsi GC03P121286.
    HGNCi HGNC:30146. ARGFX.
    HPAi HPA043049.
    MIMi 611164. gene.
    neXtProti NX_A6NJG6.
    PharmGKBi PA142672588.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG251024.
    HOGENOMi HOG000034042.
    InParanoidi A6NJG6.
    OMAi MQDTQWE.
    OrthoDBi EOG7GN2NR.
    PhylomeDBi A6NJG6.
    TreeFami TF351179.

    Miscellaneous databases

    GenomeRNAii 503582.
    NextBioi 111963.
    PROi A6NJG6.
    SOURCEi Search...

    Gene expression databases

    Bgeei A6NJG6.
    CleanExi HS_ARGFX.
    Genevestigatori A6NJG6.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line."
      Booth H.A., Holland P.W.H.
      Gene 387:7-14(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiARGFX_HUMAN
    AccessioniPrimary (citable) accession number: A6NJG6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3