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A6NJA2

- A6NJA2_HUMAN

UniProt

A6NJA2 - A6NJA2_HUMAN

Protein

Ubiquitin carboxyl-terminal hydrolase

Gene

USP14

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitinyl hydrolase activity Source: InterPro

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol proteaseUniRule annotation

    Keywords - Biological processi

    Ubl conjugation pathwayUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolaseUniRule annotation (EC:3.4.19.12UniRule annotation)
    Gene namesi
    Name:USP14Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:12612. USP14.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37238.

    Expressioni

    Gene expression databases

    ArrayExpressiA6NJA2.
    BgeeiA6NJA2.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NJA2.
    SMRiA6NJA2. Positions 6-437.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C19 family.UniRule annotation
    Contains USP domain.SAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000202292.
    HOVERGENiHBG054185.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    SMARTiSM00213. UBQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    PROSITEiPS00972. UCH_2_1. 1 hit.
    PS00973. UCH_2_2. 1 hit.
    PS50235. UCH_2_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6NJA2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLYSVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG    50
    GTLKMELPCG LTNLGNTCYM NATVQCIRSV PELKDALKRY AGALRASGEM 100
    ASAQYITAAL RDLFDSMDKT SSSIPPIILL QFLHMAFPQF AEKGEQGQYL 150
    QQDANECWIQ MMRVLQQKLE AIEDDSVKET DSSSASAATP SKKKSLIDQF 200
    FGVEFETTMK CTESEEEEVT KGKENQLQLS CFINQEVKYL FTGLKLRLQE 250
    EITKQSPTLQ RNALYIKSSK ISRLPAYLTI QMVRFFYKEK ESVNAKVLKD 300
    VKFPLMLDMY ELCTPELQEK MVSFRSKFKD LEDKKVNQQP NTSDKKSSPQ 350
    KEVKYEPFSF ADDIGSNNCG YYDLQAVLTH QGRSSSSGHY VSWVKRKQDE 400
    WIKFDDDKVS IVTPEDILRL SGGGDWHIAY VLLYGPRRVE IMEEESEQ 448
    Length:448
    Mass (Da):51,086
    Last modified:October 3, 2012 - v2
    Checksum:i31759DCBECB8EEE1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP000845 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000383589; ENSP00000373083; ENSG00000101557.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP000845 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali A6NJA2.
    SMRi A6NJA2. Positions 6-437.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 9097.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000383589 ; ENSP00000373083 ; ENSG00000101557 .

    Organism-specific databases

    HGNCi HGNC:12612. USP14.
    PharmGKBi PA37238.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000202292.
    HOVERGENi HBG054185.

    Miscellaneous databases

    NextBioi 34093.

    Gene expression databases

    ArrayExpressi A6NJA2.
    Bgeei A6NJA2.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    SMARTi SM00213. UBQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    PROSITEi PS00972. UCH_2_1. 1 hit.
    PS00973. UCH_2_2. 1 hit.
    PS50235. UCH_2_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
      Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
      J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiA6NJA2_HUMAN
    AccessioniPrimary (citable) accession number: A6NJA2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 24, 2007
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 59 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3