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Protein
Submitted name:

Ubiquitin carboxyl-terminal hydrolase 14

Gene

USP14

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Ubiquitin carboxyl-terminal hydrolase 14Imported
Gene namesi
Name:USP14Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:12612. USP14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000101557.
PharmGKBiPA37238.

PTM / Processingi

Proteomic databases

EPDiA6NJA2.
MaxQBiA6NJA2.
PeptideAtlasiA6NJA2.
PRIDEiA6NJA2.

Expressioni

Gene expression databases

BgeeiENSG00000101557.
ExpressionAtlasiA6NJA2. baseline and differential.
GenevisibleiA6NJA2. HS.

Structurei

3D structure databases

ProteinModelPortaliA6NJA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 437USPInterPro annotationAdd BLAST379

Sequence similaritiesi

Belongs to the peptidase C19 family.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00390000009615.
HOGENOMiHOG000202292.
HOVERGENiHBG054185.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR029071. Ubiquitin-rel_dom.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NJA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLYSVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG
60 70 80 90 100
GTLKMELPCG LTNLGNTCYM NATVQCIRSV PELKDALKRY AGALRASGEM
110 120 130 140 150
ASAQYITAAL RDLFDSMDKT SSSIPPIILL QFLHMAFPQF AEKGEQGQYL
160 170 180 190 200
QQDANECWIQ MMRVLQQKLE AIEDDSVKET DSSSASAATP SKKKSLIDQF
210 220 230 240 250
FGVEFETTMK CTESEEEEVT KGKENQLQLS CFINQEVKYL FTGLKLRLQE
260 270 280 290 300
EITKQSPTLQ RNALYIKSSK ISRLPAYLTI QMVRFFYKEK ESVNAKVLKD
310 320 330 340 350
VKFPLMLDMY ELCTPELQEK MVSFRSKFKD LEDKKVNQQP NTSDKKSSPQ
360 370 380 390 400
KEVKYEPFSF ADDIGSNNCG YYDLQAVLTH QGRSSSSGHY VSWVKRKQDE
410 420 430 440
WIKFDDDKVS IVTPEDILRL SGGGDWHIAY VLLYGPRRVE IMEEESEQ
Length:448
Mass (Da):51,086
Last modified:October 3, 2012 - v2
Checksum:i31759DCBECB8EEE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000845 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000383589; ENSP00000373083; ENSG00000101557.
UCSCiuc060mro.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000845 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliA6NJA2.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiA6NJA2.
MaxQBiA6NJA2.
PeptideAtlasiA6NJA2.
PRIDEiA6NJA2.

Protocols and materials databases

DNASUi9097.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383589; ENSP00000373083; ENSG00000101557.
UCSCiuc060mro.1. human.

Organism-specific databases

HGNCiHGNC:12612. USP14.
OpenTargetsiENSG00000101557.
PharmGKBiPA37238.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000009615.
HOGENOMiHOG000202292.
HOVERGENiHBG054185.

Miscellaneous databases

ChiTaRSiUSP14. human.

Gene expression databases

BgeeiENSG00000101557.
ExpressionAtlasiA6NJA2. baseline and differential.
GenevisibleiA6NJA2. HS.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR029071. Ubiquitin-rel_dom.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA6NJA2_HUMAN
AccessioniPrimary (citable) accession number: A6NJA2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: October 3, 2012
Last modified: November 30, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.