A6NJA2 (A6NJA2_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Ubiquitin carboxyl-terminal hydrolase RuleBase RU004435
EC=3.4.19.12 RuleBase RU004435

Gene names

Name:

USP14 Ensembl ENSP00000373083

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000373083

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). RuleBase RU004435
Sequence similarities	Belongs to the peptidase C19 family. RuleBase RU004434
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000373083

Ontologies

Keywords
Biological process	Ubl conjugation pathway RuleBase RU004434
Molecular function	Hydrolase Protease Thiol protease RuleBase RU004434
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA
Molecular_function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin thiolesterase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A6NJA2 [UniParc]. Last modified October 3, 2012. Version 2. Checksum: 31759DCBECB8EEE1	FASTA	448	51,086
	10 20 30 40 50 60 MPLYSVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG GTLKMELPCG 70 80 90 100 110 120 LTNLGNTCYM NATVQCIRSV PELKDALKRY AGALRASGEM ASAQYITAAL RDLFDSMDKT 130 140 150 160 170 180 SSSIPPIILL QFLHMAFPQF AEKGEQGQYL QQDANECWIQ MMRVLQQKLE AIEDDSVKET 190 200 210 220 230 240 DSSSASAATP SKKKSLIDQF FGVEFETTMK CTESEEEEVT KGKENQLQLS CFINQEVKYL 250 260 270 280 290 300 FTGLKLRLQE EITKQSPTLQ RNALYIKSSK ISRLPAYLTI QMVRFFYKEK ESVNAKVLKD 310 320 330 340 350 360 VKFPLMLDMY ELCTPELQEK MVSFRSKFKD LEDKKVNQQP NTSDKKSSPQ KEVKYEPFSF 370 380 390 400 410 420 ADDIGSNNCG YYDLQAVLTH QGRSSSSGHY VSWVKRKQDE WIKFDDDKVS IVTPEDILRL 430 440 SGGGDWHIAY VLLYGPRRVE IMEEESEQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., O'Neill K., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP000845 Genomic DNA. No translation available.
IPI	IPI00640357.
3D structure databases
ProteinModelPortal	A6NJA2.
SMR	A6NJA2. Positions 6-437.
ModBase	Search...
Proteomic databases
PRIDE	A6NJA2.
Protocols and materials databases
DNASU	9097.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000383589; ENSP00000373083; ENSG00000101557.
UCSC	uc002kkg.1. human.
Organism-specific databases
HGNC	HGNC:12612. USP14.
PharmGKB	PA37238.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000202292.
HOVERGEN	HBG054185.
OrthoDB	EOG4JT05C.
Gene expression databases
ArrayExpress	A6NJA2.
Bgee	A6NJA2.
Family and domain databases
InterPro	IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. IPR000626. Ubiquitin. [Graphical view]
Pfam	PF00443. UCH. 1 hit. [Graphical view]
SMART	SM00213. UBQ. 1 hit. [Graphical view]
PROSITE	PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	34093.

Entry information

Entry name

A6NJA2_HUMAN

Accession

Primary (citable) accession number: A6NJA2

Entry history

Integrated into UniProtKB/TrEMBL:	July 24, 2007
Last sequence update:	October 3, 2012
Last modified:	May 29, 2013
This is version 48 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.