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Protein

Probable methyltransferase-like protein 15

Gene

METTL15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable S-adenosyl-L-methionine-dependent methyltransferase.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei119 – 1191S-adenosyl-L-methionineBy similarity
Binding sitei146 – 1461S-adenosyl-L-methionine; via amide nitrogenBy similarity
Binding sitei169 – 1691S-adenosyl-L-methionineBy similarity
Binding sitei176 – 1761S-adenosyl-L-methionineBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Probable methyltransferase-like protein 15 (EC:2.1.1.-)
Alternative name(s):
Methyltransferase 5 domain-containing protein 1
Gene namesi
Name:METTL15
Synonyms:METT5D1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:26606. METTL15.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671458.

Polymorphism and mutation databases

BioMutaiMETTL15.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Probable methyltransferase-like protein 15PRO_0000308332Add
BLAST

Proteomic databases

EPDiA6NJ78.
MaxQBiA6NJ78.
PaxDbiA6NJ78.
PRIDEiA6NJ78.

PTM databases

iPTMnetiA6NJ78.
PhosphoSiteiA6NJ78.

Expressioni

Gene expression databases

BgeeiA6NJ78.
CleanExiHS_METT5D1.
ExpressionAtlasiA6NJ78. baseline and differential.
GenevisibleiA6NJ78. HS.

Organism-specific databases

HPAiHPA046195.
HPA048994.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIP13Q156453EBI-10174029,EBI-358993

Protein-protein interaction databases

BioGridi128190. 20 interactions.
IntActiA6NJ78. 1 interaction.
STRINGi9606.ENSP00000384369.

Structurei

3D structure databases

ProteinModelPortaliA6NJ78.
SMRiA6NJ78. Positions 72-404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni100 – 1023S-adenosyl-L-methionine bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2782. Eukaryota.
COG0275. LUCA.
GeneTreeiENSGT00390000014756.
HOVERGENiHBG055013.
InParanoidiA6NJ78.
OMAiADGCYLD.
OrthoDBiEOG7PZRX8.
PhylomeDBiA6NJ78.
TreeFamiTF106425.

Family and domain databases

Gene3Di1.10.150.170. 1 hit.
3.40.50.150. 3 hits.
HAMAPiMF_01007. 16SrRNA_methyltr_H.
InterProiIPR002903. RsmH.
IPR023397. SAM-dep_MeTrfase_MraW_recog.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11265. PTHR11265. 1 hit.
PfamiPF01795. Methyltransf_5. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 3 hits.
SSF81799. SSF81799. 1 hit.
TIGRFAMsiTIGR00006. TIGR00006. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NJ78-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRYPYFCRM YKECLSCWLE SGIPNLGVWP NRIHTTAEKY REYEAREQTD
60 70 80 90 100
QTQAQELHRS QDRDFETMAK LHIPVMVDEV VHCLSPQKGQ IFLDMTFGSG
110 120 130 140 150
GHTKAILQKE SDIVLYALDR DPTAYALAEH LSELYPKQIR AMLGQFSQAE
160 170 180 190 200
ALLMKAGVQP GTFDGVLMDL GCSSMQLDTP ERGFSLRKDG PLDMRMDGGR
210 220 230 240 250
YPDMPTAADV VNALDQQALA SILRTYGEEK HAKKIASAIV QARSIYPITR
260 270 280 290 300
TQQLASIVAG AFPPSAIYTR KDLLQRSTHI ATKTFQALRI FVNNELNELY
310 320 330 340 350
TGLKTAQKFL RPGGRLVALS FHSLEDRIVK RFLLGISMTE RFNLSVRQQV
360 370 380 390 400
MKTSQLGSDH ENTEEVSMRR APLMWELIHK KVLSPQDQDV QDNPRGRSAK

LRAAIKL
Length:407
Mass (Da):46,121
Last modified:July 24, 2007 - v1
Checksum:i1DA02B5842483080
GO
Isoform 2 (identifier: A6NJ78-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-273: GAFPPSAIYTRKDL → EYSETYFPVAQTLY
     274-407: Missing.

Show »
Length:273
Mass (Da):30,872
Checksum:i71BBA524769D6066
GO
Isoform 3 (identifier: A6NJ78-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-99: IFLDMTFGS → SLGVRSVGI
     100-407: Missing.

Show »
Length:99
Mass (Da):11,631
Checksum:i0A6B26342AB079D8
GO
Isoform 4 (identifier: A6NJ78-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-320: YPDMPTAADV...RPGGRLVALS → STGTCIYPKN...FPGSSHICEQ
     321-407: Missing.

Show »
Length:279
Mass (Da):31,700
Checksum:iB698284087F05A6E
GO

Sequence cautioni

The sequence AAH30997.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti191 – 1911P → S in AAH30997 (PubMed:15489334).Curated
Sequence conflicti194 – 1941M → V in BAC03631 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311N → K.2 Publications
Corresponds to variant rs2883478 [ dbSNP | Ensembl ].
VAR_036801
Natural varianti149 – 1491A → T.
Corresponds to variant rs11823114 [ dbSNP | Ensembl ].
VAR_036802
Natural varianti267 – 2671I → F.
Corresponds to variant rs11030280 [ dbSNP | Ensembl ].
VAR_059446

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei91 – 999IFLDMTFGS → SLGVRSVGI in isoform 3. 1 PublicationVSP_028970
Alternative sequencei100 – 407308Missing in isoform 3. 1 PublicationVSP_028971Add
BLAST
Alternative sequencei201 – 320120YPDMP…LVALS → STGTCIYPKNIRGGEACQEN RFSNCSGTQHLPHHQNPAAC QHRCRSISSLCYLYTERLTT AIYPYCHQDFPGSSHICEQ in isoform 4. 1 PublicationVSP_028972Add
BLAST
Alternative sequencei260 – 27314GAFPP…TRKDL → EYSETYFPVAQTLY in isoform 2. 1 PublicationVSP_028973Add
BLAST
Alternative sequencei274 – 407134Missing in isoform 2. 1 PublicationVSP_028974Add
BLAST
Alternative sequencei321 – 40787Missing in isoform 4. 1 PublicationVSP_028975Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091298 mRNA. Translation: BAC03631.1.
AC023206 Genomic DNA. No translation available.
AC087376 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68267.1.
CH471064 Genomic DNA. Translation: EAW68266.1.
BC030997 mRNA. Translation: AAH30997.1. Different initiation.
BC105287 mRNA. Translation: AAI05288.1.
CCDSiCCDS31450.1. [A6NJ78-2]
CCDS44559.1. [A6NJ78-1]
CCDS73269.1. [A6NJ78-4]
RefSeqiNP_001107000.1. NM_001113528.1. [A6NJ78-1]
NP_001284704.1. NM_001297775.1. [A6NJ78-4]
NP_689849.2. NM_152636.2. [A6NJ78-2]
UniGeneiHs.243326.
Hs.539002.
Hs.684649.

Genome annotation databases

EnsembliENST00000303459; ENSP00000307251; ENSG00000169519. [A6NJ78-2]
ENST00000406787; ENSP00000385507; ENSG00000169519. [A6NJ78-4]
ENST00000407364; ENSP00000384369; ENSG00000169519. [A6NJ78-1]
ENST00000437814; ENSP00000392806; ENSG00000169519. [A6NJ78-3]
GeneIDi196074.
KEGGihsa:196074.
UCSCiuc001mse.3. human. [A6NJ78-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091298 mRNA. Translation: BAC03631.1.
AC023206 Genomic DNA. No translation available.
AC087376 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68267.1.
CH471064 Genomic DNA. Translation: EAW68266.1.
BC030997 mRNA. Translation: AAH30997.1. Different initiation.
BC105287 mRNA. Translation: AAI05288.1.
CCDSiCCDS31450.1. [A6NJ78-2]
CCDS44559.1. [A6NJ78-1]
CCDS73269.1. [A6NJ78-4]
RefSeqiNP_001107000.1. NM_001113528.1. [A6NJ78-1]
NP_001284704.1. NM_001297775.1. [A6NJ78-4]
NP_689849.2. NM_152636.2. [A6NJ78-2]
UniGeneiHs.243326.
Hs.539002.
Hs.684649.

3D structure databases

ProteinModelPortaliA6NJ78.
SMRiA6NJ78. Positions 72-404.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128190. 20 interactions.
IntActiA6NJ78. 1 interaction.
STRINGi9606.ENSP00000384369.

PTM databases

iPTMnetiA6NJ78.
PhosphoSiteiA6NJ78.

Polymorphism and mutation databases

BioMutaiMETTL15.

Proteomic databases

EPDiA6NJ78.
MaxQBiA6NJ78.
PaxDbiA6NJ78.
PRIDEiA6NJ78.

Protocols and materials databases

DNASUi196074.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303459; ENSP00000307251; ENSG00000169519. [A6NJ78-2]
ENST00000406787; ENSP00000385507; ENSG00000169519. [A6NJ78-4]
ENST00000407364; ENSP00000384369; ENSG00000169519. [A6NJ78-1]
ENST00000437814; ENSP00000392806; ENSG00000169519. [A6NJ78-3]
GeneIDi196074.
KEGGihsa:196074.
UCSCiuc001mse.3. human. [A6NJ78-1]

Organism-specific databases

CTDi196074.
GeneCardsiMETTL15.
HGNCiHGNC:26606. METTL15.
HPAiHPA046195.
HPA048994.
neXtProtiNX_A6NJ78.
PharmGKBiPA142671458.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2782. Eukaryota.
COG0275. LUCA.
GeneTreeiENSGT00390000014756.
HOVERGENiHBG055013.
InParanoidiA6NJ78.
OMAiADGCYLD.
OrthoDBiEOG7PZRX8.
PhylomeDBiA6NJ78.
TreeFamiTF106425.

Miscellaneous databases

GenomeRNAii196074.
NextBioi89414.
PROiA6NJ78.

Gene expression databases

BgeeiA6NJ78.
CleanExiHS_METT5D1.
ExpressionAtlasiA6NJ78. baseline and differential.
GenevisibleiA6NJ78. HS.

Family and domain databases

Gene3Di1.10.150.170. 1 hit.
3.40.50.150. 3 hits.
HAMAPiMF_01007. 16SrRNA_methyltr_H.
InterProiIPR002903. RsmH.
IPR023397. SAM-dep_MeTrfase_MraW_recog.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11265. PTHR11265. 1 hit.
PfamiPF01795. Methyltransf_5. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 3 hits.
SSF81799. SSF81799. 1 hit.
TIGRFAMsiTIGR00006. TIGR00006. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT LYS-31.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), VARIANT LYS-31.
    Tissue: Brain and Testis.

Entry informationi

Entry nameiMET15_HUMAN
AccessioniPrimary (citable) accession number: A6NJ78
Secondary accession number(s): A8MRS5
, B7WNU2, Q3MHD3, Q8N601, Q8NBA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 24, 2007
Last modified: March 16, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.