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Protein

Probable methyltransferase-like protein 15

Gene

METTL15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable S-adenosyl-L-methionine-dependent methyltransferase.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei119S-adenosyl-L-methionineBy similarity1
Binding sitei146S-adenosyl-L-methionine; via amide nitrogenBy similarity1
Binding sitei169S-adenosyl-L-methionineBy similarity1
Binding sitei176S-adenosyl-L-methionineBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Probable methyltransferase-like protein 15 (EC:2.1.1.-)
Alternative name(s):
Methyltransferase 5 domain-containing protein 1
Gene namesi
Name:METTL15
Synonyms:METT5D1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000169519.20.
HGNCiHGNC:26606. METTL15.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169519.
PharmGKBiPA142671458.

Polymorphism and mutation databases

BioMutaiMETTL15.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003083321 – 407Probable methyltransferase-like protein 15Add BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei358PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA6NJ78.
MaxQBiA6NJ78.
PaxDbiA6NJ78.
PRIDEiA6NJ78.

PTM databases

iPTMnetiA6NJ78.
PhosphoSitePlusiA6NJ78.

Expressioni

Gene expression databases

BgeeiENSG00000169519.
CleanExiHS_METT5D1.
ExpressionAtlasiA6NJ78. baseline and differential.
GenevisibleiA6NJ78. HS.

Organism-specific databases

HPAiHPA039885.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi128190. 20 interactors.
IntActiA6NJ78. 15 interactors.
STRINGi9606.ENSP00000384369.

Structurei

3D structure databases

ProteinModelPortaliA6NJ78.
SMRiA6NJ78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni100 – 102S-adenosyl-L-methionine bindingBy similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2782. Eukaryota.
COG0275. LUCA.
GeneTreeiENSGT00390000014756.
HOVERGENiHBG055013.
InParanoidiA6NJ78.
OMAiKKIHPAT.
OrthoDBiEOG091G0BQA.
PhylomeDBiA6NJ78.
TreeFamiTF106425.

Family and domain databases

Gene3Di1.10.150.170. 1 hit.
HAMAPiMF_01007. 16SrRNA_methyltr_H. 1 hit.
InterProiView protein in InterPro
IPR002903. RsmH.
IPR023397. SAM-dep_MeTrfase_MraW_recog.
IPR029063. SAM-dependent_MTases.
PANTHERiPTHR11265. PTHR11265. 1 hit.
PfamiView protein in Pfam
PF01795. Methyltransf_5. 1 hit.
SUPFAMiSSF53335. SSF53335. 3 hits.
SSF81799. SSF81799. 1 hit.
TIGRFAMsiTIGR00006. TIGR00006. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NJ78-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRYPYFCRM YKECLSCWLE SGIPNLGVWP NRIHTTAEKY REYEAREQTD
60 70 80 90 100
QTQAQELHRS QDRDFETMAK LHIPVMVDEV VHCLSPQKGQ IFLDMTFGSG
110 120 130 140 150
GHTKAILQKE SDIVLYALDR DPTAYALAEH LSELYPKQIR AMLGQFSQAE
160 170 180 190 200
ALLMKAGVQP GTFDGVLMDL GCSSMQLDTP ERGFSLRKDG PLDMRMDGGR
210 220 230 240 250
YPDMPTAADV VNALDQQALA SILRTYGEEK HAKKIASAIV QARSIYPITR
260 270 280 290 300
TQQLASIVAG AFPPSAIYTR KDLLQRSTHI ATKTFQALRI FVNNELNELY
310 320 330 340 350
TGLKTAQKFL RPGGRLVALS FHSLEDRIVK RFLLGISMTE RFNLSVRQQV
360 370 380 390 400
MKTSQLGSDH ENTEEVSMRR APLMWELIHK KVLSPQDQDV QDNPRGRSAK

LRAAIKL
Length:407
Mass (Da):46,121
Last modified:July 24, 2007 - v1
Checksum:i1DA02B5842483080
GO
Isoform 2 (identifier: A6NJ78-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-273: GAFPPSAIYTRKDL → EYSETYFPVAQTLY
     274-407: Missing.

Show »
Length:273
Mass (Da):30,872
Checksum:i71BBA524769D6066
GO
Isoform 3 (identifier: A6NJ78-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-99: IFLDMTFGS → SLGVRSVGI
     100-407: Missing.

Show »
Length:99
Mass (Da):11,631
Checksum:i0A6B26342AB079D8
GO
Isoform 4 (identifier: A6NJ78-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-320: YPDMPTAADV...RPGGRLVALS → STGTCIYPKN...FPGSSHICEQ
     321-407: Missing.

Show »
Length:279
Mass (Da):31,700
Checksum:iB698284087F05A6E
GO

Sequence cautioni

A6NJ78: The sequence AAH30997 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191P → S in AAH30997 (PubMed:15489334).Curated1
Sequence conflicti194M → V in BAC03631 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03680131N → K2 PublicationsCorresponds to variant dbSNP:rs2883478Ensembl.1
Natural variantiVAR_036802149A → T. Corresponds to variant dbSNP:rs11823114Ensembl.1
Natural variantiVAR_059446267I → F. Corresponds to variant dbSNP:rs11030280Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02897091 – 99IFLDMTFGS → SLGVRSVGI in isoform 3. 1 Publication9
Alternative sequenceiVSP_028971100 – 407Missing in isoform 3. 1 PublicationAdd BLAST308
Alternative sequenceiVSP_028972201 – 320YPDMP…LVALS → STGTCIYPKNIRGGEACQEN RFSNCSGTQHLPHHQNPAAC QHRCRSISSLCYLYTERLTT AIYPYCHQDFPGSSHICEQ in isoform 4. 1 PublicationAdd BLAST120
Alternative sequenceiVSP_028973260 – 273GAFPP…TRKDL → EYSETYFPVAQTLY in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_028974274 – 407Missing in isoform 2. 1 PublicationAdd BLAST134
Alternative sequenceiVSP_028975321 – 407Missing in isoform 4. 1 PublicationAdd BLAST87

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091298 mRNA. Translation: BAC03631.1.
AC023206 Genomic DNA. No translation available.
AC087376 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68267.1.
CH471064 Genomic DNA. Translation: EAW68266.1.
BC030997 mRNA. Translation: AAH30997.1. Different initiation.
BC105287 mRNA. Translation: AAI05288.1.
CCDSiCCDS31450.1. [A6NJ78-2]
CCDS44559.1. [A6NJ78-1]
CCDS73269.1. [A6NJ78-4]
RefSeqiNP_001107000.1. NM_001113528.1. [A6NJ78-1]
NP_001284704.1. NM_001297775.1. [A6NJ78-4]
NP_689849.2. NM_152636.2. [A6NJ78-2]
XP_016872786.1. XM_017017297.1. [A6NJ78-1]
UniGeneiHs.243326.
Hs.539002.
Hs.684649.

Genome annotation databases

EnsembliENST00000303459; ENSP00000307251; ENSG00000169519. [A6NJ78-2]
ENST00000406787; ENSP00000385507; ENSG00000169519. [A6NJ78-4]
ENST00000407364; ENSP00000384369; ENSG00000169519. [A6NJ78-1]
ENST00000437814; ENSP00000392806; ENSG00000169519. [A6NJ78-3]
GeneIDi196074.
KEGGihsa:196074.
UCSCiuc001mse.3. human. [A6NJ78-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMET15_HUMAN
AccessioniPrimary (citable) accession number: A6NJ78
Secondary accession number(s): A8MRS5
, B7WNU2, Q3MHD3, Q8N601, Q8NBA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 24, 2007
Last modified: September 27, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families