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Protein

Homeobox protein Nkx-6.3

Gene

NKX6-3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative transcription factor, which may be involved in patterning of central nervous system and pancreas.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi139 – 19860HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Nkx-6.3
Gene namesi
Name:NKX6-3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:26328. NKX6-3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148400.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Homeobox protein Nkx-6.3PRO_0000311330Add
BLAST

Proteomic databases

PRIDEiA6NJ46.

PTM databases

PhosphoSiteiA6NJ46.

Expressioni

Gene expression databases

BgeeiA6NJ46.
CleanExiHS_NKX6-3.
GenevisibleiA6NJ46. HS.

Organism-specific databases

HPAiHPA042790.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000429553.

Structurei

3D structure databases

ProteinModelPortaliA6NJ46.
SMRiA6NJ46. Positions 143-201.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG258693.
GeneTreeiENSGT00790000122946.
HOGENOMiHOG000060127.
HOVERGENiHBG070987.
InParanoidiA6NJ46.
OMAiTRNCWAD.
OrthoDBiEOG722JC3.
PhylomeDBiA6NJ46.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NJ46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESNLQGTFL LNNTPLAQFP EMKAPVCQYS VQNSFYKLSP PGLGPQLAAG
60 70 80 90 100
TPHGITDILS RPVAAPNNSL LSGYPHVAGF GGLSSQGVYY SPQVGNFSKA
110 120 130 140 150
GNEYPTRTRN CWADTGQDWR GGRQCSNTPD PLSDSIHKKK HTRPTFTGHQ
160 170 180 190 200
IFALEKTFEQ TKYLAGPERA RLAYSLGMTE SQVKVWFQNR RTKWRKKSAL
210 220 230 240 250
EPSSSTPRAP GGAGAGAGGD RAPSENEDDE YNKPLDPDSD DEKIRLLLRK
260
HRAAFSVLSL GAHSV
Length:265
Mass (Da):28,948
Last modified:July 24, 2007 - v1
Checksum:iD8CC4CF5B2201F1C
GO
Isoform 2 (identifier: A6NJ46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-184: MESNLQGTFL...SLGMTESQVK → MQQGQLAPGS...DTPACLSASG

Note: No experimental confirmation available.
Show »
Length:135
Mass (Da):14,322
Checksum:i76B668B5AB913D6F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 184184MESNL…ESQVK → MQQGQLAPGSRLCSGPWGLP ELQPAAPSSSAAQLPWGESW GEEADTPACLSASG in isoform 2. 1 PublicationVSP_029523Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057898 mRNA. Translation: BAB71610.1.
AC113133 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63251.1.
CH471080 Genomic DNA. Translation: EAW63252.1.
CCDSiCCDS6118.1. [A6NJ46-2]
RefSeqiNP_689781.1. NM_152568.2. [A6NJ46-2]
UniGeneiHs.647132.

Genome annotation databases

EnsembliENST00000518699; ENSP00000428361; ENSG00000165066. [A6NJ46-1]
ENST00000524115; ENSP00000429553; ENSG00000165066. [A6NJ46-2]
GeneIDi157848.
KEGGihsa:157848.
UCSCiuc003xoa.2. human. [A6NJ46-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057898 mRNA. Translation: BAB71610.1.
AC113133 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63251.1.
CH471080 Genomic DNA. Translation: EAW63252.1.
CCDSiCCDS6118.1. [A6NJ46-2]
RefSeqiNP_689781.1. NM_152568.2. [A6NJ46-2]
UniGeneiHs.647132.

3D structure databases

ProteinModelPortaliA6NJ46.
SMRiA6NJ46. Positions 143-201.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000429553.

PTM databases

PhosphoSiteiA6NJ46.

Proteomic databases

PRIDEiA6NJ46.

Protocols and materials databases

DNASUi157848.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000518699; ENSP00000428361; ENSG00000165066. [A6NJ46-1]
ENST00000524115; ENSP00000429553; ENSG00000165066. [A6NJ46-2]
GeneIDi157848.
KEGGihsa:157848.
UCSCiuc003xoa.2. human. [A6NJ46-2]

Organism-specific databases

CTDi157848.
GeneCardsiGC08M041503.
HGNCiHGNC:26328. NKX6-3.
HPAiHPA042790.
MIMi610772. gene.
neXtProtiNX_A6NJ46.
PharmGKBiPA145148400.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG258693.
GeneTreeiENSGT00790000122946.
HOGENOMiHOG000060127.
HOVERGENiHBG070987.
InParanoidiA6NJ46.
OMAiTRNCWAD.
OrthoDBiEOG722JC3.
PhylomeDBiA6NJ46.

Miscellaneous databases

ChiTaRSiNKX6-3. human.
GenomeRNAii157848.
NextBioi87562.
PROiA6NJ46.
SOURCEiSearch...

Gene expression databases

BgeeiA6NJ46.
CleanExiHS_NKX6-3.
GenevisibleiA6NJ46. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiNKX63_HUMAN
AccessioniPrimary (citable) accession number: A6NJ46
Secondary accession number(s): Q96LR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: June 24, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.