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A6NJ46

- NKX63_HUMAN

UniProt

A6NJ46 - NKX63_HUMAN

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Protein
Homeobox protein Nkx-6.3
Gene
NKX6-3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Putative transcription factor, which may be involved in patterning of central nervous system and pancreas By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi139 – 19860Homeobox
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: InterPro
  2. transcription regulatory region sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. cell fate determination Source: Ensembl
  2. glandular epithelial cell differentiation Source: Ensembl
  3. negative regulation of epithelial cell differentiation Source: Ensembl
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Nkx-6.3
Gene namesi
Name:NKX6-3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:26328. NKX6-3.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148400.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Homeobox protein Nkx-6.3
PRO_0000311330Add
BLAST

Proteomic databases

PRIDEiA6NJ46.

PTM databases

PhosphoSiteiA6NJ46.

Expressioni

Gene expression databases

BgeeiA6NJ46.
CleanExiHS_NKX6-3.
GenevestigatoriA6NJ46.

Organism-specific databases

HPAiHPA042790.

Structurei

3D structure databases

ProteinModelPortaliA6NJ46.
SMRiA6NJ46. Positions 143-201.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG258693.
HOGENOMiHOG000060127.
HOVERGENiHBG070987.
OMAiTRNCWAD.
OrthoDBiEOG722JC3.
PhylomeDBiA6NJ46.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A6NJ46-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MESNLQGTFL LNNTPLAQFP EMKAPVCQYS VQNSFYKLSP PGLGPQLAAG    50
TPHGITDILS RPVAAPNNSL LSGYPHVAGF GGLSSQGVYY SPQVGNFSKA 100
GNEYPTRTRN CWADTGQDWR GGRQCSNTPD PLSDSIHKKK HTRPTFTGHQ 150
IFALEKTFEQ TKYLAGPERA RLAYSLGMTE SQVKVWFQNR RTKWRKKSAL 200
EPSSSTPRAP GGAGAGAGGD RAPSENEDDE YNKPLDPDSD DEKIRLLLRK 250
HRAAFSVLSL GAHSV 265
Length:265
Mass (Da):28,948
Last modified:July 24, 2007 - v1
Checksum:iD8CC4CF5B2201F1C
GO
Isoform 2 (identifier: A6NJ46-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-184: MESNLQGTFL...SLGMTESQVK → MQQGQLAPGS...DTPACLSASG

Note: No experimental confirmation available.

Show »
Length:135
Mass (Da):14,322
Checksum:i76B668B5AB913D6F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 184184MESNL…ESQVK → MQQGQLAPGSRLCSGPWGLP ELQPAAPSSSAAQLPWGESW GEEADTPACLSASG in isoform 2.
VSP_029523Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057898 mRNA. Translation: BAB71610.1.
AC113133 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63251.1.
CH471080 Genomic DNA. Translation: EAW63252.1.
CCDSiCCDS6118.1. [A6NJ46-2]
RefSeqiNP_689781.1. NM_152568.2. [A6NJ46-2]
XP_005273479.1. XM_005273422.1. [A6NJ46-1]
UniGeneiHs.647132.

Genome annotation databases

EnsembliENST00000518699; ENSP00000428361; ENSG00000165066. [A6NJ46-1]
ENST00000524115; ENSP00000429553; ENSG00000165066. [A6NJ46-2]
GeneIDi157848.
KEGGihsa:157848.
UCSCiuc003xoa.2. human. [A6NJ46-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057898 mRNA. Translation: BAB71610.1 .
AC113133 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63251.1 .
CH471080 Genomic DNA. Translation: EAW63252.1 .
CCDSi CCDS6118.1. [A6NJ46-2 ]
RefSeqi NP_689781.1. NM_152568.2. [A6NJ46-2 ]
XP_005273479.1. XM_005273422.1. [A6NJ46-1 ]
UniGenei Hs.647132.

3D structure databases

ProteinModelPortali A6NJ46.
SMRi A6NJ46. Positions 143-201.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei A6NJ46.

Proteomic databases

PRIDEi A6NJ46.

Protocols and materials databases

DNASUi 157848.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000518699 ; ENSP00000428361 ; ENSG00000165066 . [A6NJ46-1 ]
ENST00000524115 ; ENSP00000429553 ; ENSG00000165066 . [A6NJ46-2 ]
GeneIDi 157848.
KEGGi hsa:157848.
UCSCi uc003xoa.2. human. [A6NJ46-2 ]

Organism-specific databases

CTDi 157848.
GeneCardsi GC08M041503.
HGNCi HGNC:26328. NKX6-3.
HPAi HPA042790.
MIMi 610772. gene.
neXtProti NX_A6NJ46.
PharmGKBi PA145148400.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG258693.
HOGENOMi HOG000060127.
HOVERGENi HBG070987.
OMAi TRNCWAD.
OrthoDBi EOG722JC3.
PhylomeDBi A6NJ46.

Miscellaneous databases

ChiTaRSi NKX6-3. human.
GenomeRNAii 157848.
NextBioi 87562.
PROi A6NJ46.
SOURCEi Search...

Gene expression databases

Bgeei A6NJ46.
CleanExi HS_NKX6-3.
Genevestigatori A6NJ46.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiNKX63_HUMAN
AccessioniPrimary (citable) accession number: A6NJ46
Secondary accession number(s): Q96LR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: July 9, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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