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Protein

Homeobox protein Nkx-6.3

Gene

NKX6-3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative transcription factor, which may be involved in patterning of central nervous system and pancreas.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi139 – 198HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Nkx-6.3
Gene namesi
Name:NKX6-3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000165066.12.
HGNCiHGNC:26328. NKX6-3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165066.
PharmGKBiPA145148400.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003113301 – 265Homeobox protein Nkx-6.3Add BLAST265

Proteomic databases

PRIDEiA6NJ46.

PTM databases

iPTMnetiA6NJ46.
PhosphoSitePlusiA6NJ46.

Expressioni

Gene expression databases

BgeeiENSG00000165066.
CleanExiHS_NKX6-3.
GenevisibleiA6NJ46. HS.

Organism-specific databases

HPAiHPA042790.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000429553.

Structurei

3D structure databases

ProteinModelPortaliA6NJ46.
SMRiA6NJ46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Homeobox

Phylogenomic databases

GeneTreeiENSGT00870000136367.
HOGENOMiHOG000060127.
HOVERGENiHBG070987.
InParanoidiA6NJ46.
OMAiTRNCWAD.
OrthoDBiEOG091G142D.
PhylomeDBiA6NJ46.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR000047. HTH_motif.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NJ46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESNLQGTFL LNNTPLAQFP EMKAPVCQYS VQNSFYKLSP PGLGPQLAAG
60 70 80 90 100
TPHGITDILS RPVAAPNNSL LSGYPHVAGF GGLSSQGVYY SPQVGNFSKA
110 120 130 140 150
GNEYPTRTRN CWADTGQDWR GGRQCSNTPD PLSDSIHKKK HTRPTFTGHQ
160 170 180 190 200
IFALEKTFEQ TKYLAGPERA RLAYSLGMTE SQVKVWFQNR RTKWRKKSAL
210 220 230 240 250
EPSSSTPRAP GGAGAGAGGD RAPSENEDDE YNKPLDPDSD DEKIRLLLRK
260
HRAAFSVLSL GAHSV
Length:265
Mass (Da):28,948
Last modified:July 24, 2007 - v1
Checksum:iD8CC4CF5B2201F1C
GO
Isoform 2 (identifier: A6NJ46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-184: MESNLQGTFL...SLGMTESQVK → MQQGQLAPGS...DTPACLSASG

Note: No experimental confirmation available.
Show »
Length:135
Mass (Da):14,322
Checksum:i76B668B5AB913D6F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0295231 – 184MESNL…ESQVK → MQQGQLAPGSRLCSGPWGLP ELQPAAPSSSAAQLPWGESW GEEADTPACLSASG in isoform 2. 1 PublicationAdd BLAST184

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057898 mRNA. Translation: BAB71610.1.
AC113133 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63251.1.
CH471080 Genomic DNA. Translation: EAW63252.1.
CCDSiCCDS6118.1. [A6NJ46-2]
RefSeqiNP_689781.1. NM_152568.3. [A6NJ46-2]
XP_016868632.1. XM_017013143.1. [A6NJ46-1]

Genome annotation databases

EnsembliENST00000518699; ENSP00000428361; ENSG00000165066. [A6NJ46-1]
ENST00000524115; ENSP00000429553; ENSG00000165066. [A6NJ46-2]
GeneIDi157848.
KEGGihsa:157848.
UCSCiuc003xoa.3. human. [A6NJ46-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNKX63_HUMAN
AccessioniPrimary (citable) accession number: A6NJ46
Secondary accession number(s): Q96LR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: September 27, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot