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A6NJ46

- NKX63_HUMAN

UniProt

A6NJ46 - NKX63_HUMAN

Protein

Homeobox protein Nkx-6.3

Gene

NKX6-3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Putative transcription factor, which may be involved in patterning of central nervous system and pancreas.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi139 – 19860HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: InterPro
    2. transcription regulatory region sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. cell fate determination Source: Ensembl
    2. glandular epithelial cell differentiation Source: Ensembl
    3. negative regulation of epithelial cell differentiation Source: Ensembl
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Nkx-6.3
    Gene namesi
    Name:NKX6-3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:26328. NKX6-3.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145148400.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 265265Homeobox protein Nkx-6.3PRO_0000311330Add
    BLAST

    Proteomic databases

    PRIDEiA6NJ46.

    PTM databases

    PhosphoSiteiA6NJ46.

    Expressioni

    Gene expression databases

    BgeeiA6NJ46.
    CleanExiHS_NKX6-3.
    GenevestigatoriA6NJ46.

    Organism-specific databases

    HPAiHPA042790.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NJ46.
    SMRiA6NJ46. Positions 143-201.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG258693.
    HOGENOMiHOG000060127.
    HOVERGENiHBG070987.
    OMAiTRNCWAD.
    OrthoDBiEOG722JC3.
    PhylomeDBiA6NJ46.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A6NJ46-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MESNLQGTFL LNNTPLAQFP EMKAPVCQYS VQNSFYKLSP PGLGPQLAAG    50
    TPHGITDILS RPVAAPNNSL LSGYPHVAGF GGLSSQGVYY SPQVGNFSKA 100
    GNEYPTRTRN CWADTGQDWR GGRQCSNTPD PLSDSIHKKK HTRPTFTGHQ 150
    IFALEKTFEQ TKYLAGPERA RLAYSLGMTE SQVKVWFQNR RTKWRKKSAL 200
    EPSSSTPRAP GGAGAGAGGD RAPSENEDDE YNKPLDPDSD DEKIRLLLRK 250
    HRAAFSVLSL GAHSV 265
    Length:265
    Mass (Da):28,948
    Last modified:July 24, 2007 - v1
    Checksum:iD8CC4CF5B2201F1C
    GO
    Isoform 2 (identifier: A6NJ46-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-184: MESNLQGTFL...SLGMTESQVK → MQQGQLAPGS...DTPACLSASG

    Note: No experimental confirmation available.

    Show »
    Length:135
    Mass (Da):14,322
    Checksum:i76B668B5AB913D6F
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 184184MESNL…ESQVK → MQQGQLAPGSRLCSGPWGLP ELQPAAPSSSAAQLPWGESW GEEADTPACLSASG in isoform 2. 1 PublicationVSP_029523Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057898 mRNA. Translation: BAB71610.1.
    AC113133 Genomic DNA. No translation available.
    CH471080 Genomic DNA. Translation: EAW63251.1.
    CH471080 Genomic DNA. Translation: EAW63252.1.
    CCDSiCCDS6118.1. [A6NJ46-2]
    RefSeqiNP_689781.1. NM_152568.2. [A6NJ46-2]
    XP_005273479.1. XM_005273422.1. [A6NJ46-1]
    UniGeneiHs.647132.

    Genome annotation databases

    EnsembliENST00000518699; ENSP00000428361; ENSG00000165066. [A6NJ46-1]
    ENST00000524115; ENSP00000429553; ENSG00000165066. [A6NJ46-2]
    GeneIDi157848.
    KEGGihsa:157848.
    UCSCiuc003xoa.2. human. [A6NJ46-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057898 mRNA. Translation: BAB71610.1 .
    AC113133 Genomic DNA. No translation available.
    CH471080 Genomic DNA. Translation: EAW63251.1 .
    CH471080 Genomic DNA. Translation: EAW63252.1 .
    CCDSi CCDS6118.1. [A6NJ46-2 ]
    RefSeqi NP_689781.1. NM_152568.2. [A6NJ46-2 ]
    XP_005273479.1. XM_005273422.1. [A6NJ46-1 ]
    UniGenei Hs.647132.

    3D structure databases

    ProteinModelPortali A6NJ46.
    SMRi A6NJ46. Positions 143-201.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei A6NJ46.

    Proteomic databases

    PRIDEi A6NJ46.

    Protocols and materials databases

    DNASUi 157848.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000518699 ; ENSP00000428361 ; ENSG00000165066 . [A6NJ46-1 ]
    ENST00000524115 ; ENSP00000429553 ; ENSG00000165066 . [A6NJ46-2 ]
    GeneIDi 157848.
    KEGGi hsa:157848.
    UCSCi uc003xoa.2. human. [A6NJ46-2 ]

    Organism-specific databases

    CTDi 157848.
    GeneCardsi GC08M041503.
    HGNCi HGNC:26328. NKX6-3.
    HPAi HPA042790.
    MIMi 610772. gene.
    neXtProti NX_A6NJ46.
    PharmGKBi PA145148400.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG258693.
    HOGENOMi HOG000060127.
    HOVERGENi HBG070987.
    OMAi TRNCWAD.
    OrthoDBi EOG722JC3.
    PhylomeDBi A6NJ46.

    Miscellaneous databases

    ChiTaRSi NKX6-3. human.
    GenomeRNAii 157848.
    NextBioi 87562.
    PROi A6NJ46.
    SOURCEi Search...

    Gene expression databases

    Bgeei A6NJ46.
    CleanExi HS_NKX6-3.
    Genevestigatori A6NJ46.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    2. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiNKX63_HUMAN
    AccessioniPrimary (citable) accession number: A6NJ46
    Secondary accession number(s): Q96LR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3