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Protein

Leucine-rich repeat and IQ domain-containing protein 4

Gene

LRRIQ4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat and IQ domain-containing protein 4
Alternative name(s):
Leucine-rich repeat-containing protein 64
Gene namesi
Name:LRRIQ4
Synonyms:LRRC64
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:34298. LRRIQ4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162394647.

Polymorphism and mutation databases

BioMutaiLRRIQ4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Leucine-rich repeat and IQ domain-containing protein 4PRO_0000332138Add
BLAST

Proteomic databases

PaxDbiA6NIV6.
PRIDEiA6NIV6.

PTM databases

iPTMnetiA6NIV6.
PhosphoSiteiA6NIV6.

Expressioni

Gene expression databases

BgeeiA6NIV6.
CleanExiHS_LRRIQ4.

Organism-specific databases

HPAiHPA036706.

Interactioni

Protein-protein interaction databases

BioGridi131313. 1 interaction.
IntActiA6NIV6. 1 interaction.
STRINGi9606.ENSP00000342188.

Structurei

3D structure databases

ProteinModelPortaliA6NIV6.
SMRiA6NIV6. Positions 30-479.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati23 – 4725LRR 1Add
BLAST
Repeati48 – 7023LRR 2Add
BLAST
Repeati72 – 9524LRR 3Add
BLAST
Repeati97 – 11620LRR 4Add
BLAST
Repeati117 – 14024LRR 5Add
BLAST
Repeati141 – 16424LRR 6Add
BLAST
Repeati166 – 18722LRR 7Add
BLAST
Repeati188 – 21023LRR 8Add
BLAST
Repeati212 – 23322LRR 9Add
BLAST
Repeati234 – 25623LRR 10Add
BLAST
Repeati258 – 28124LRR 11Add
BLAST
Repeati283 – 30119LRR 12Add
BLAST
Repeati302 – 32524LRR 13Add
BLAST
Repeati326 – 34823LRR 14Add
BLAST
Repeati350 – 37122LRR 15Add
BLAST
Repeati374 – 39724LRR 16Add
BLAST
Repeati398 – 42225LRR 17Add
BLAST
Repeati424 – 44320LRR 18Add
BLAST
Repeati444 – 46623LRR 19Add
BLAST
Repeati468 – 48922LRR 20Add
BLAST
Domaini504 – 53330IQPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 20 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129686.
HOGENOMiHOG000113384.
HOVERGENiHBG076273.
InParanoidiA6NIV6.
OMAiWRGTMVQ.
OrthoDBiEOG7HF1HZ.
PhylomeDBiA6NIV6.
TreeFamiTF351429.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF12799. LRR_4. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 15 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS50096. IQ. 1 hit.
PS51450. LRR. 17 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NIV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKDIKSVEH SPKIHQRNDP QHVNDRTFFI DASNQSLTAI PLEIFTFTEL
60 70 80 90 100
EEVHLENNQI EEIPQEIQRL KNIRVLYLDK NNLRSLCPAL GLLSSLESLD
110 120 130 140 150
LSYNPIFSSS LVVVSFLHAL RELRLYQTDL KEIPVVIFKN LHHLELLGLT
160 170 180 190 200
GNHLKCLPKE IVNQTKLREI YLKRNQFEVF PQELCVLYTL EIIDLDENKI
210 220 230 240 250
GAIPEEIGHL TGLQKFYMAS NNLPVLPASL CQCSQLSVLD LSHNLLHSIP
260 270 280 290 300
KSFAELRKMT EIGLSGNRLE KVPRLICRWT SLHLLYLGNT GLHRLRGSFR
310 320 330 340 350
CLVNLRFLDL SQNHLHHCPL QICALKNLEV LGLDDNKIGQ LPSELGSLSK
360 370 380 390 400
LKILGLTGNE FLSFPEEVLS LASLEKLYIG QDQGFKLTYV PEHIRKLQSL
410 420 430 440 450
KELYIENNHL EYLPVSLGSM PNLEVLDCRH NLLKQLPDAI CQAQALKELR
460 470 480 490 500
LEDNLLTHLP ENLDSLVNLK VLTLMDNPME EPPKEVCAEG NEAIWKYLKE
510 520 530 540 550
NRNRNIMATK IQAWWRGTMV QRGFGKFGEL LKPQKKGKTS PKDKKGKKDV
560
KGKPGKGKKK
Length:560
Mass (Da):63,977
Last modified:April 29, 2008 - v2
Checksum:iB5D04894F014040A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti159 – 1591K → E.
Corresponds to variant rs16854411 [ dbSNP | Ensembl ].
VAR_042953

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC078795 Genomic DNA. No translation available.
CCDSiCCDS46951.1.
RefSeqiNP_001073929.1. NM_001080460.1.
XP_005247478.1. XM_005247421.2.
XP_006713676.1. XM_006713613.2.
XP_011511050.1. XM_011512748.1.
UniGeneiHs.319484.

Genome annotation databases

EnsembliENST00000340806; ENSP00000342188; ENSG00000188306.
GeneIDi344657.
KEGGihsa:344657.
UCSCiuc003fgb.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC078795 Genomic DNA. No translation available.
CCDSiCCDS46951.1.
RefSeqiNP_001073929.1. NM_001080460.1.
XP_005247478.1. XM_005247421.2.
XP_006713676.1. XM_006713613.2.
XP_011511050.1. XM_011512748.1.
UniGeneiHs.319484.

3D structure databases

ProteinModelPortaliA6NIV6.
SMRiA6NIV6. Positions 30-479.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131313. 1 interaction.
IntActiA6NIV6. 1 interaction.
STRINGi9606.ENSP00000342188.

PTM databases

iPTMnetiA6NIV6.
PhosphoSiteiA6NIV6.

Polymorphism and mutation databases

BioMutaiLRRIQ4.

Proteomic databases

PaxDbiA6NIV6.
PRIDEiA6NIV6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340806; ENSP00000342188; ENSG00000188306.
GeneIDi344657.
KEGGihsa:344657.
UCSCiuc003fgb.4. human.

Organism-specific databases

CTDi344657.
GeneCardsiLRRIQ4.
HGNCiHGNC:34298. LRRIQ4.
HPAiHPA036706.
neXtProtiNX_A6NIV6.
PharmGKBiPA162394647.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129686.
HOGENOMiHOG000113384.
HOVERGENiHBG076273.
InParanoidiA6NIV6.
OMAiWRGTMVQ.
OrthoDBiEOG7HF1HZ.
PhylomeDBiA6NIV6.
TreeFamiTF351429.

Miscellaneous databases

GenomeRNAii344657.
PROiA6NIV6.

Gene expression databases

BgeeiA6NIV6.
CleanExiHS_LRRIQ4.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF12799. LRR_4. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 15 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS50096. IQ. 1 hit.
PS51450. LRR. 17 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiLRIQ4_HUMAN
AccessioniPrimary (citable) accession number: A6NIV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: June 8, 2016
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.