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Protein

Leucine-rich repeat and IQ domain-containing protein 4

Gene

LRRIQ4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-32554-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat and IQ domain-containing protein 4
Alternative name(s):
Leucine-rich repeat-containing protein 64
Gene namesi
Name:LRRIQ4
Synonyms:LRRC64
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:34298. LRRIQ4.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188306.
PharmGKBiPA162394647.

Polymorphism and mutation databases

BioMutaiLRRIQ4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003321381 – 560Leucine-rich repeat and IQ domain-containing protein 4Add BLAST560

Proteomic databases

PaxDbiA6NIV6.
PRIDEiA6NIV6.

PTM databases

iPTMnetiA6NIV6.
PhosphoSitePlusiA6NIV6.

Expressioni

Gene expression databases

BgeeiENSG00000188306.
CleanExiHS_LRRIQ4.

Organism-specific databases

HPAiHPA036706.

Interactioni

Protein-protein interaction databases

BioGridi131313. 1 interactor.
IntActiA6NIV6. 1 interactor.
STRINGi9606.ENSP00000342188.

Structurei

3D structure databases

ProteinModelPortaliA6NIV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 47LRR 1Add BLAST25
Repeati48 – 70LRR 2Add BLAST23
Repeati72 – 95LRR 3Add BLAST24
Repeati97 – 116LRR 4Add BLAST20
Repeati117 – 140LRR 5Add BLAST24
Repeati141 – 164LRR 6Add BLAST24
Repeati166 – 187LRR 7Add BLAST22
Repeati188 – 210LRR 8Add BLAST23
Repeati212 – 233LRR 9Add BLAST22
Repeati234 – 256LRR 10Add BLAST23
Repeati258 – 281LRR 11Add BLAST24
Repeati283 – 301LRR 12Add BLAST19
Repeati302 – 325LRR 13Add BLAST24
Repeati326 – 348LRR 14Add BLAST23
Repeati350 – 371LRR 15Add BLAST22
Repeati374 – 397LRR 16Add BLAST24
Repeati398 – 422LRR 17Add BLAST25
Repeati424 – 443LRR 18Add BLAST20
Repeati444 – 466LRR 19Add BLAST23
Repeati468 – 489LRR 20Add BLAST22
Domaini504 – 533IQPROSITE-ProRule annotationAdd BLAST30

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 20 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129686.
HOGENOMiHOG000113384.
HOVERGENiHBG076273.
InParanoidiA6NIV6.
OMAiWRGTMVQ.
OrthoDBiEOG091G0BBX.
PhylomeDBiA6NIV6.
TreeFamiTF351429.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF12799. LRR_4. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 15 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS50096. IQ. 1 hit.
PS51450. LRR. 17 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NIV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKDIKSVEH SPKIHQRNDP QHVNDRTFFI DASNQSLTAI PLEIFTFTEL
60 70 80 90 100
EEVHLENNQI EEIPQEIQRL KNIRVLYLDK NNLRSLCPAL GLLSSLESLD
110 120 130 140 150
LSYNPIFSSS LVVVSFLHAL RELRLYQTDL KEIPVVIFKN LHHLELLGLT
160 170 180 190 200
GNHLKCLPKE IVNQTKLREI YLKRNQFEVF PQELCVLYTL EIIDLDENKI
210 220 230 240 250
GAIPEEIGHL TGLQKFYMAS NNLPVLPASL CQCSQLSVLD LSHNLLHSIP
260 270 280 290 300
KSFAELRKMT EIGLSGNRLE KVPRLICRWT SLHLLYLGNT GLHRLRGSFR
310 320 330 340 350
CLVNLRFLDL SQNHLHHCPL QICALKNLEV LGLDDNKIGQ LPSELGSLSK
360 370 380 390 400
LKILGLTGNE FLSFPEEVLS LASLEKLYIG QDQGFKLTYV PEHIRKLQSL
410 420 430 440 450
KELYIENNHL EYLPVSLGSM PNLEVLDCRH NLLKQLPDAI CQAQALKELR
460 470 480 490 500
LEDNLLTHLP ENLDSLVNLK VLTLMDNPME EPPKEVCAEG NEAIWKYLKE
510 520 530 540 550
NRNRNIMATK IQAWWRGTMV QRGFGKFGEL LKPQKKGKTS PKDKKGKKDV
560
KGKPGKGKKK
Length:560
Mass (Da):63,977
Last modified:April 29, 2008 - v2
Checksum:iB5D04894F014040A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042953159K → E.Corresponds to variant rs16854411dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC078795 Genomic DNA. No translation available.
CCDSiCCDS46951.1.
RefSeqiNP_001073929.1. NM_001080460.1.
XP_005247478.1. XM_005247421.2.
XP_006713676.1. XM_006713613.3.
XP_011511050.1. XM_011512748.1.
UniGeneiHs.319484.

Genome annotation databases

EnsembliENST00000340806; ENSP00000342188; ENSG00000188306.
GeneIDi344657.
KEGGihsa:344657.
UCSCiuc003fgb.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC078795 Genomic DNA. No translation available.
CCDSiCCDS46951.1.
RefSeqiNP_001073929.1. NM_001080460.1.
XP_005247478.1. XM_005247421.2.
XP_006713676.1. XM_006713613.3.
XP_011511050.1. XM_011512748.1.
UniGeneiHs.319484.

3D structure databases

ProteinModelPortaliA6NIV6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131313. 1 interactor.
IntActiA6NIV6. 1 interactor.
STRINGi9606.ENSP00000342188.

PTM databases

iPTMnetiA6NIV6.
PhosphoSitePlusiA6NIV6.

Polymorphism and mutation databases

BioMutaiLRRIQ4.

Proteomic databases

PaxDbiA6NIV6.
PRIDEiA6NIV6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340806; ENSP00000342188; ENSG00000188306.
GeneIDi344657.
KEGGihsa:344657.
UCSCiuc003fgb.4. human.

Organism-specific databases

CTDi344657.
GeneCardsiLRRIQ4.
HGNCiHGNC:34298. LRRIQ4.
HPAiHPA036706.
neXtProtiNX_A6NIV6.
OpenTargetsiENSG00000188306.
PharmGKBiPA162394647.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129686.
HOGENOMiHOG000113384.
HOVERGENiHBG076273.
InParanoidiA6NIV6.
OMAiWRGTMVQ.
OrthoDBiEOG091G0BBX.
PhylomeDBiA6NIV6.
TreeFamiTF351429.

Enzyme and pathway databases

BioCyciZFISH:G66-32554-MONOMER.

Miscellaneous databases

GenomeRNAii344657.
PROiA6NIV6.

Gene expression databases

BgeeiENSG00000188306.
CleanExiHS_LRRIQ4.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF12799. LRR_4. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 15 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS50096. IQ. 1 hit.
PS51450. LRR. 17 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRIQ4_HUMAN
AccessioniPrimary (citable) accession number: A6NIV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: November 2, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.