ID   AGAP5_HUMAN             Reviewed;         686 AA.
AC   A6NIR3; A8MSN5;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2011, sequence version 2.
DT   27-MAR-2024, entry version 125.
DE   RecName: Full=Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5;
DE            Short=AGAP-5;
DE   AltName: Full=Centaurin-gamma-like family member 2;
GN   Name=AGAP5; Synonyms=CTGLF2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Putative GTPase-activating protein. {ECO:0000305}.
CC   -!- MISCELLANEOUS: Encoded by one of the numerous copies of centaurin
CC       gamma-like genes clustered in the q11 region of chromosome 10.
CC   -!- SIMILARITY: Belongs to the centaurin gamma-like family. {ECO:0000305}.
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DR   EMBL; AC073389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC022400; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC127746; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS44439.1; -.
DR   RefSeq; NP_001137472.1; NM_001144000.1.
DR   AlphaFoldDB; A6NIR3; -.
DR   SMR; A6NIR3; -.
DR   BioGRID; 609497; 5.
DR   IntAct; A6NIR3; 2.
DR   MINT; A6NIR3; -.
DR   STRING; 9606.ENSP00000363207; -.
DR   iPTMnet; A6NIR3; -.
DR   PhosphoSitePlus; A6NIR3; -.
DR   BioMuta; AGAP5; -.
DR   jPOST; A6NIR3; -.
DR   MassIVE; A6NIR3; -.
DR   MaxQB; A6NIR3; -.
DR   PaxDb; 9606-ENSP00000363207; -.
DR   PeptideAtlas; A6NIR3; -.
DR   ProteomicsDB; 1279; -.
DR   Antibodypedia; 68077; 42 antibodies from 6 providers.
DR   DNASU; 729092; -.
DR   Ensembl; ENST00000374094.9; ENSP00000363207.4; ENSG00000172650.15.
DR   GeneID; 729092; -.
DR   KEGG; hsa:729092; -.
DR   MANE-Select; ENST00000374094.9; ENSP00000363207.4; NM_001144000.4; NP_001137472.1.
DR   UCSC; uc009xri.4; human.
DR   AGR; HGNC:23467; -.
DR   CTD; 729092; -.
DR   GeneCards; AGAP5; -.
DR   HGNC; HGNC:23467; AGAP5.
DR   HPA; ENSG00000172650; Low tissue specificity.
DR   neXtProt; NX_A6NIR3; -.
DR   PharmGKB; PA164715123; -.
DR   VEuPathDB; HostDB:ENSG00000172650; -.
DR   eggNOG; KOG0705; Eukaryota.
DR   GeneTree; ENSGT00940000163475; -.
DR   InParanoid; A6NIR3; -.
DR   OMA; GHDDKSH; -.
DR   OrthoDB; 1449795at2759; -.
DR   PhylomeDB; A6NIR3; -.
DR   TreeFam; TF317762; -.
DR   PathwayCommons; A6NIR3; -.
DR   SignaLink; A6NIR3; -.
DR   BioGRID-ORCS; 729092; 317 hits in 1046 CRISPR screens.
DR   GenomeRNAi; 729092; -.
DR   Pharos; A6NIR3; Tdark.
DR   PRO; PR:A6NIR3; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   RNAct; A6NIR3; Protein.
DR   Bgee; ENSG00000172650; Expressed in body of pancreas and 95 other cell types or tissues.
DR   ExpressionAtlas; A6NIR3; baseline and differential.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd08853; ArfGap_AGAP2; 1.
DR   CDD; cd01250; PH_AGAP; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR45819:SF7; ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 4-RELATED; 1.
DR   PANTHER; PTHR45819; CENTAURIN-GAMMA-1A; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF01412; ArfGap; 1.
DR   PRINTS; PR00405; REVINTRACTNG.
DR   SMART; SM00248; ANK; 2.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS50115; ARFGAP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   Genevisible; A6NIR3; HS.
PE   2: Evidence at transcript level;
KW   ANK repeat; GTPase activation; Metal-binding; Reference proteome; Repeat;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..686
FT                   /note="Arf-GAP with GTPase, ANK repeat and PH domain-
FT                   containing protein 5"
FT                   /id="PRO_0000349205"
FT   DOMAIN          282..443
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   DOMAIN          464..584
FT                   /note="Arf-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00288"
FT   REPEAT          623..652
FT                   /note="ANK 1"
FT   REPEAT          656..685
FT                   /note="ANK 2"
FT   ZN_FING         479..502
FT                   /note="C4-type; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00288"
FT   REGION          205..242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          256..278
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          382..404
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        258..273
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        8
FT                   /note="C -> R (in Ref. 2; BC127746)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        365
FT                   /note="K -> E (in Ref. 2; BC127746)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        482
FT                   /note="Y -> C (in Ref. 2; BC127746)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   686 AA;  75492 MW;  C51D1E96C6179B24 CRC64;
     MGNILTCCVH PSVSLEFDQQ QGSVCPSESE IYEAGAGDRM AGAPMAAAVQ PAEVTVEVGE
     DLHMHHIRDQ EMPEALEFSL SANPEASTIF QRNSQTDALE FNPSANPEAS TIFQRNSQTD
     VVEIRRSNCT NHVSTERFSQ QYSSCSTIFL DDSTASQHYL TMTIISVTLE IPHHITQRDA
     DRSLSIPDEQ LHSFAVSTVH ITKNRNGGGS LNNYSSSIPS TPSTSQEDPQ FSVPPTANTP
     TPVCKRSMRW SNLFTSEKGS HPDKERKAPE NHADTIGSGR AIPIKQGMLL KRSGKWLKTW
     KKKYVTLCSN GVLTYYSSLG DYMKNIHKKE IDLRTSTIKV PGKWPSLATS ACAPISSSKS
     NGLSKDMDTG LGDSICFSPS ISSTTSPKLN PPPSPHANKK KHLKKKSTNN FMIVSATGQT
     WHFEATTYEE RDAWVQAIQS QILASLQSCE SSKSKSQLTS QSEAMALQSI QNMRGNAHCV
     DYETQNPKWA SLNLGVLMCI ECSGIHRSLG TRLSRVRSLE LDDWPVELRK VMSSIGNDLA
     NSIWEGSSQG QTKPSVKSTR EEKERWIRSK YEEKLFLAPL PCTELSLGQH LLRATADEDL
     QTAILLLAHG SREEVNETCG EGDGCTALHL ACRKGNVVLA QLLIWYGVDV MARDAHGNTA
     LTYARQASSQ ECINVLLQYG CPDECV
//