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A6NIR3

- AGAP5_HUMAN

UniProt

A6NIR3 - AGAP5_HUMAN

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Protein

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5

Gene

AGAP5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Putative GTPase-activating protein.Curated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri479 – 50224C4-type; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ARF GTPase activator activity Source: InterPro
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. regulation of ARF GTPase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5
Short name:
AGAP-5
Alternative name(s):
Centaurin-gamma-like family member 2
Gene namesi
Name:AGAP5
Synonyms:CTGLF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23467. AGAP5.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164715123.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 686686Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5PRO_0000349205Add
BLAST

Proteomic databases

PRIDEiA6NIR3.

PTM databases

PhosphoSiteiA6NIR3.

Expressioni

Gene expression databases

BgeeiA6NIR3.
CleanExiHS_AGAP5.
ExpressionAtlasiA6NIR3. baseline.
GenevestigatoriA6NIR3.

Organism-specific databases

HPAiHPA042490.

Structurei

3D structure databases

ProteinModelPortaliA6NIR3.
SMRiA6NIR3. Positions 280-447, 470-680.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini282 – 443162PHPROSITE-ProRule annotationAdd
BLAST
Domaini464 – 584121Arf-GAPPROSITE-ProRule annotationAdd
BLAST
Repeati623 – 65230ANK 1Add
BLAST
Repeati656 – 68530ANK 2Add
BLAST

Sequence similaritiesi

Belongs to the centaurin gamma-like family.Curated
Contains 2 ANK repeats.PROSITE-ProRule annotation
Contains 1 Arf-GAP domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri479 – 50224C4-type; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00760000118874.
HOGENOMiHOG000007233.
HOVERGENiHBG054045.
InParanoidiA6NIR3.
OMAiSQHYLTM.
PhylomeDBiA6NIR3.
TreeFamiTF317762.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00248. ANK. 2 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NIR3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNILTCCVH PSVSLEFDQQ QGSVCPSESE IYEAGAGDRM AGAPMAAAVQ
60 70 80 90 100
PAEVTVEVGE DLHMHHIRDQ EMPEALEFSL SANPEASTIF QRNSQTDALE
110 120 130 140 150
FNPSANPEAS TIFQRNSQTD VVEIRRSNCT NHVSTERFSQ QYSSCSTIFL
160 170 180 190 200
DDSTASQHYL TMTIISVTLE IPHHITQRDA DRSLSIPDEQ LHSFAVSTVH
210 220 230 240 250
ITKNRNGGGS LNNYSSSIPS TPSTSQEDPQ FSVPPTANTP TPVCKRSMRW
260 270 280 290 300
SNLFTSEKGS HPDKERKAPE NHADTIGSGR AIPIKQGMLL KRSGKWLKTW
310 320 330 340 350
KKKYVTLCSN GVLTYYSSLG DYMKNIHKKE IDLRTSTIKV PGKWPSLATS
360 370 380 390 400
ACAPISSSKS NGLSKDMDTG LGDSICFSPS ISSTTSPKLN PPPSPHANKK
410 420 430 440 450
KHLKKKSTNN FMIVSATGQT WHFEATTYEE RDAWVQAIQS QILASLQSCE
460 470 480 490 500
SSKSKSQLTS QSEAMALQSI QNMRGNAHCV DYETQNPKWA SLNLGVLMCI
510 520 530 540 550
ECSGIHRSLG TRLSRVRSLE LDDWPVELRK VMSSIGNDLA NSIWEGSSQG
560 570 580 590 600
QTKPSVKSTR EEKERWIRSK YEEKLFLAPL PCTELSLGQH LLRATADEDL
610 620 630 640 650
QTAILLLAHG SREEVNETCG EGDGCTALHL ACRKGNVVLA QLLIWYGVDV
660 670 680
MARDAHGNTA LTYARQASSQ ECINVLLQYG CPDECV
Length:686
Mass (Da):75,492
Last modified:January 11, 2011 - v2
Checksum:iC51D1E96C6179B24
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81C → R in BC127746. (PubMed:15489334)Curated
Sequence conflicti365 – 3651K → E in BC127746. (PubMed:15489334)Curated
Sequence conflicti482 – 4821Y → C in BC127746. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC073389 Genomic DNA. No translation available.
AC022400 Genomic DNA. No translation available.
BC127746 mRNA. No translation available.
CCDSiCCDS44439.1.
RefSeqiNP_001137472.1. NM_001144000.1.
UniGeneiHs.651147.

Genome annotation databases

EnsembliENST00000374094; ENSP00000363207; ENSG00000172650.
GeneIDi729092.
KEGGihsa:729092.
UCSCiuc001juu.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC073389 Genomic DNA. No translation available.
AC022400 Genomic DNA. No translation available.
BC127746 mRNA. No translation available.
CCDSi CCDS44439.1.
RefSeqi NP_001137472.1. NM_001144000.1.
UniGenei Hs.651147.

3D structure databases

ProteinModelPortali A6NIR3.
SMRi A6NIR3. Positions 280-447, 470-680.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei A6NIR3.

Proteomic databases

PRIDEi A6NIR3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374094 ; ENSP00000363207 ; ENSG00000172650 .
GeneIDi 729092.
KEGGi hsa:729092.
UCSCi uc001juu.4. human.

Organism-specific databases

CTDi 729092.
GeneCardsi GC10M075435.
HGNCi HGNC:23467. AGAP5.
HPAi HPA042490.
neXtProti NX_A6NIR3.
PharmGKBi PA164715123.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000118874.
HOGENOMi HOG000007233.
HOVERGENi HBG054045.
InParanoidi A6NIR3.
OMAi SQHYLTM.
PhylomeDBi A6NIR3.
TreeFami TF317762.

Miscellaneous databases

GenomeRNAii 729092.
NextBioi 129216.
PROi A6NIR3.

Gene expression databases

Bgeei A6NIR3.
CleanExi HS_AGAP5.
ExpressionAtlasi A6NIR3. baseline.
Genevestigatori A6NIR3.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
2.30.29.30. 2 hits.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
Pfami PF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
PF00169. PH. 1 hit.
[Graphical view ]
PRINTSi PR00405. REVINTRACTNG.
SMARTi SM00248. ANK. 2 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiAGAP5_HUMAN
AccessioniPrimary (citable) accession number: A6NIR3
Secondary accession number(s): A8MSN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3