Reviewed, UniProtKB/Swiss-Prot A6NIR3 (AGAP5_HUMAN)

Names and origin

Protein names

Recommended name:
    Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5
      Short name=AGAP-5
Alternative name(s):
    Centaurin-gamma-like family member 2

Gene names

Name:	AGAP5
Synonyms:	CTGLF2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	663 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Putative GTPase-activating protein Potential.
Miscellaneous	Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.
Sequence similarities	Belongs to the centaurin gamma-like family. Contains 2 ANK repeats. Contains 1 Arf-GAP domain. Contains 1 PH domain.

Ontologies

Keywords
Domain	ANK repeat Repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	GTPase activation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of ARF GTPase activity Inferred from electronic annotation. Source: InterPro
Molecular function	ARF GTPase activator activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 663	663	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5		PRO_0000349205
Regions
	Domain	259 – 420	162	PH
	Domain	441 – 561	121	Arf-GAP
	Repeat	600 – 629	30	ANK 1
	Repeat	633 – 662	30	ANK 2
	Zinc finger	456 – 479	24	C4-type; degenerate

Sequences

	Sequence		Length	Mass (Da)
	A6NIR3-1 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 5B5EB41903613F87	FASTA	663	72,983
	10 20 30 40 50 60 MGNILTCCVH PSVSLEFDQQ QGSVCPSESE IYEAGAGDRM AGAPMAAAVQ PAEVTVEVGE 70 80 90 100 110 120 DLHMHHIRDQ EMPEALEFNP SANPEASTIF QRNSQTDVVE IRRSNCTNHV STERFSQQYS 130 140 150 160 170 180 SCSTIFLDDS TASQHYLTMT IISVTLEIPH HITQRDADRS LSIPDEQLHS FAVSTVHITK 190 200 210 220 230 240 NRNGGGSLNN YSSSIPSTPS TSQEDPQFSV PPTANTPTPV CKRSMRWSNL FTSEKGSHPD 250 260 270 280 290 300 KERKAPENHA DTIGSGRAIP IKQGMLLKRS GKWLKTWKKK YVTLCSNGVL TYYSSLGDYM 310 320 330 340 350 360 KNIHKKEIDL RTSTIKVPGK WPSLATSACA PISSSKSNGL SKDMDTGLGD SICFSPSISS 370 380 390 400 410 420 TTSPKLNPPP SPHANKKKHL KKKSTNNFMI VSATGQTWHF EATTYEERDA WVQAIQSQIL 430 440 450 460 470 480 ASLQSCESSK SKSQLTSQSE AMALQSIQNM RGNAHCVDYE TQNPKWASLN LGVLMCIECS 490 500 510 520 530 540 GIHRSLGTRL SRVRSLELDD WPVELRKVMS SIGNDLANSI WEGSSQGQTK PSVKSTREEK 550 560 570 580 590 600 ERWIRSKYEE KLFLAPLPCT ELSLGQHLLR ATADEDLQTA ILLLAHGSRE EVNETCGEGD 610 620 630 640 650 660 GCTALHLACR KGNVVLAQLL IWYGVDVMAR DAHGNTALTY ARQASSQECI NVLLQYGCPD ECV

References

[1]

"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC073389 Genomic DNA. No translation available.
IPI	IPI00413998.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	A6NIR3.
Genome annotation databases
Ensembl	ENST00000443782; ENSP00000402792; ENSG00000172650; Homo sapiens. [Genome view]
NMPDR	fig|9606.3.peg.4171.
Organism-specific databases
GeneCards	GC10M075107.
HGNC	HGNC:23467. AGAP5.
GenAtlas	Search...
Gene expression databases
Bgee	A6NIR3.
CleanEx	HS_AGAP5.
Genevestigator	A6NIR3.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR001164. ArfGAP. IPR001849. Pleckstrin_homology. [Graphical view]
Pfam	PF00023. Ank. 2 hits. PF01412. ArfGap. 1 hit. PF00169. PH. 1 hit. [Graphical view]
PRINTS	PR00405. REVINTRACTNG.
SMART	SM00248. ANK. 2 hits. SM00105. ArfGap. 1 hit. SM00233. PH. 1 hit. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 1 hit. PS50115. ARFGAP. 1 hit. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AGAP5_HUMAN

Accession

Primary (citable) accession number: A6NIR3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	July 24, 2007
Last modified:	November 24, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.