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A6NIR3 (AGAP5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5

Short name=AGAP-5
Alternative name(s):
Centaurin-gamma-like family member 2
Gene names
Name:AGAP5
Synonyms:CTGLF2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length686 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative GTPase-activating protein Potential.

Miscellaneous

Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.

Sequence similarities

Belongs to the centaurin gamma-like family.

Contains 2 ANK repeats.

Contains 1 Arf-GAP domain.

Contains 1 PH domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 686686Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5
PRO_0000349205

Regions

Domain282 – 443162PH
Domain464 – 584121Arf-GAP
Repeat623 – 65230ANK 1
Repeat656 – 68530ANK 2
Zinc finger479 – 50224C4-type; degenerate

Experimental info

Sequence conflict81C → R in BC127746. Ref.2
Sequence conflict3651K → E in BC127746. Ref.2
Sequence conflict4821Y → C in BC127746. Ref.2

Sequences

Sequence LengthMass (Da)Tools
A6NIR3 [UniParc].

Last modified January 11, 2011. Version 2.
Checksum: C51D1E96C6179B24

FASTA68675,492
        10         20         30         40         50         60 
MGNILTCCVH PSVSLEFDQQ QGSVCPSESE IYEAGAGDRM AGAPMAAAVQ PAEVTVEVGE 

        70         80         90        100        110        120 
DLHMHHIRDQ EMPEALEFSL SANPEASTIF QRNSQTDALE FNPSANPEAS TIFQRNSQTD 

       130        140        150        160        170        180 
VVEIRRSNCT NHVSTERFSQ QYSSCSTIFL DDSTASQHYL TMTIISVTLE IPHHITQRDA 

       190        200        210        220        230        240 
DRSLSIPDEQ LHSFAVSTVH ITKNRNGGGS LNNYSSSIPS TPSTSQEDPQ FSVPPTANTP 

       250        260        270        280        290        300 
TPVCKRSMRW SNLFTSEKGS HPDKERKAPE NHADTIGSGR AIPIKQGMLL KRSGKWLKTW 

       310        320        330        340        350        360 
KKKYVTLCSN GVLTYYSSLG DYMKNIHKKE IDLRTSTIKV PGKWPSLATS ACAPISSSKS 

       370        380        390        400        410        420 
NGLSKDMDTG LGDSICFSPS ISSTTSPKLN PPPSPHANKK KHLKKKSTNN FMIVSATGQT 

       430        440        450        460        470        480 
WHFEATTYEE RDAWVQAIQS QILASLQSCE SSKSKSQLTS QSEAMALQSI QNMRGNAHCV 

       490        500        510        520        530        540 
DYETQNPKWA SLNLGVLMCI ECSGIHRSLG TRLSRVRSLE LDDWPVELRK VMSSIGNDLA 

       550        560        570        580        590        600 
NSIWEGSSQG QTKPSVKSTR EEKERWIRSK YEEKLFLAPL PCTELSLGQH LLRATADEDL 

       610        620        630        640        650        660 
QTAILLLAHG SREEVNETCG EGDGCTALHL ACRKGNVVLA QLLIWYGVDV MARDAHGNTA 

       670        680 
LTYARQASSQ ECINVLLQYG CPDECV 

« Hide

References

[1]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC073389 Genomic DNA. No translation available.
AC022400 Genomic DNA. No translation available.
BC127746 mRNA. No translation available.
CCDSCCDS44439.1.
RefSeqNP_001137472.1. NM_001144000.1.
UniGeneHs.651147.

3D structure databases

ProteinModelPortalA6NIR3.
SMRA6NIR3. Positions 280-447, 470-680.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteA6NIR3.

Proteomic databases

PRIDEA6NIR3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000374094; ENSP00000363207; ENSG00000172650.
GeneID729092.
KEGGhsa:729092.
UCSCuc001juu.4. human.

Organism-specific databases

CTD729092.
GeneCardsGC10M075435.
HGNCHGNC:23467. AGAP5.
HPAHPA042490.
neXtProtNX_A6NIR3.
PharmGKBPA164715123.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000007233.
HOVERGENHBG054045.
InParanoidA6NIR3.
OMASQHYLTM.
PhylomeDBA6NIR3.
TreeFamTF317762.

Gene expression databases

BgeeA6NIR3.
CleanExHS_AGAP5.
GenevestigatorA6NIR3.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
2.30.29.30. 2 hits.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
[Graphical view]
PfamPF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSPR00405. REVINTRACTNG.
SMARTSM00248. ANK. 2 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi729092.
NextBio129216.
PROA6NIR3.

Entry information

Entry nameAGAP5_HUMAN
AccessionPrimary (citable) accession number: A6NIR3
Secondary accession number(s): A8MSN5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM