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A6NIR3

- AGAP5_HUMAN

UniProt

A6NIR3 - AGAP5_HUMAN

Protein

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5

Gene

AGAP5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 2 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Putative GTPase-activating protein.Curated

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri479 – 50224C4-type; degeneratePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ARF GTPase activator activity Source: InterPro
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. regulation of ARF GTPase activity Source: InterPro

    Keywords - Molecular functioni

    GTPase activation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5
    Short name:
    AGAP-5
    Alternative name(s):
    Centaurin-gamma-like family member 2
    Gene namesi
    Name:AGAP5
    Synonyms:CTGLF2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:23467. AGAP5.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164715123.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 686686Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5PRO_0000349205Add
    BLAST

    Proteomic databases

    PRIDEiA6NIR3.

    PTM databases

    PhosphoSiteiA6NIR3.

    Expressioni

    Gene expression databases

    BgeeiA6NIR3.
    CleanExiHS_AGAP5.
    GenevestigatoriA6NIR3.

    Organism-specific databases

    HPAiHPA042490.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NIR3.
    SMRiA6NIR3. Positions 280-447, 470-680.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini282 – 443162PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini464 – 584121Arf-GAPPROSITE-ProRule annotationAdd
    BLAST
    Repeati623 – 65230ANK 1Add
    BLAST
    Repeati656 – 68530ANK 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the centaurin gamma-like family.Curated
    Contains 2 ANK repeats.PROSITE-ProRule annotation
    Contains 1 Arf-GAP domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri479 – 50224C4-type; degeneratePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    ANK repeat, Repeat, Zinc-finger

    Phylogenomic databases

    HOGENOMiHOG000007233.
    HOVERGENiHBG054045.
    InParanoidiA6NIR3.
    OMAiSQHYLTM.
    PhylomeDBiA6NIR3.
    TreeFamiTF317762.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    2.30.29.30. 2 hits.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001164. ArfGAP.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PfamiPF12796. Ank_2. 1 hit.
    PF01412. ArfGap. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view]
    PRINTSiPR00405. REVINTRACTNG.
    SMARTiSM00248. ANK. 2 hits.
    SM00105. ArfGap. 1 hit.
    SM00233. PH. 1 hit.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    PS50115. ARFGAP. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6NIR3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNILTCCVH PSVSLEFDQQ QGSVCPSESE IYEAGAGDRM AGAPMAAAVQ    50
    PAEVTVEVGE DLHMHHIRDQ EMPEALEFSL SANPEASTIF QRNSQTDALE 100
    FNPSANPEAS TIFQRNSQTD VVEIRRSNCT NHVSTERFSQ QYSSCSTIFL 150
    DDSTASQHYL TMTIISVTLE IPHHITQRDA DRSLSIPDEQ LHSFAVSTVH 200
    ITKNRNGGGS LNNYSSSIPS TPSTSQEDPQ FSVPPTANTP TPVCKRSMRW 250
    SNLFTSEKGS HPDKERKAPE NHADTIGSGR AIPIKQGMLL KRSGKWLKTW 300
    KKKYVTLCSN GVLTYYSSLG DYMKNIHKKE IDLRTSTIKV PGKWPSLATS 350
    ACAPISSSKS NGLSKDMDTG LGDSICFSPS ISSTTSPKLN PPPSPHANKK 400
    KHLKKKSTNN FMIVSATGQT WHFEATTYEE RDAWVQAIQS QILASLQSCE 450
    SSKSKSQLTS QSEAMALQSI QNMRGNAHCV DYETQNPKWA SLNLGVLMCI 500
    ECSGIHRSLG TRLSRVRSLE LDDWPVELRK VMSSIGNDLA NSIWEGSSQG 550
    QTKPSVKSTR EEKERWIRSK YEEKLFLAPL PCTELSLGQH LLRATADEDL 600
    QTAILLLAHG SREEVNETCG EGDGCTALHL ACRKGNVVLA QLLIWYGVDV 650
    MARDAHGNTA LTYARQASSQ ECINVLLQYG CPDECV 686
    Length:686
    Mass (Da):75,492
    Last modified:January 11, 2011 - v2
    Checksum:iC51D1E96C6179B24
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 81C → R in BC127746. (PubMed:15489334)Curated
    Sequence conflicti365 – 3651K → E in BC127746. (PubMed:15489334)Curated
    Sequence conflicti482 – 4821Y → C in BC127746. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC073389 Genomic DNA. No translation available.
    AC022400 Genomic DNA. No translation available.
    BC127746 mRNA. No translation available.
    CCDSiCCDS44439.1.
    RefSeqiNP_001137472.1. NM_001144000.1.
    UniGeneiHs.651147.

    Genome annotation databases

    EnsembliENST00000374094; ENSP00000363207; ENSG00000172650.
    GeneIDi729092.
    KEGGihsa:729092.
    UCSCiuc001juu.4. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC073389 Genomic DNA. No translation available.
    AC022400 Genomic DNA. No translation available.
    BC127746 mRNA. No translation available.
    CCDSi CCDS44439.1.
    RefSeqi NP_001137472.1. NM_001144000.1.
    UniGenei Hs.651147.

    3D structure databases

    ProteinModelPortali A6NIR3.
    SMRi A6NIR3. Positions 280-447, 470-680.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei A6NIR3.

    Proteomic databases

    PRIDEi A6NIR3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374094 ; ENSP00000363207 ; ENSG00000172650 .
    GeneIDi 729092.
    KEGGi hsa:729092.
    UCSCi uc001juu.4. human.

    Organism-specific databases

    CTDi 729092.
    GeneCardsi GC10M075435.
    HGNCi HGNC:23467. AGAP5.
    HPAi HPA042490.
    neXtProti NX_A6NIR3.
    PharmGKBi PA164715123.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000007233.
    HOVERGENi HBG054045.
    InParanoidi A6NIR3.
    OMAi SQHYLTM.
    PhylomeDBi A6NIR3.
    TreeFami TF317762.

    Miscellaneous databases

    GenomeRNAii 729092.
    NextBioi 129216.
    PROi A6NIR3.

    Gene expression databases

    Bgeei A6NIR3.
    CleanExi HS_AGAP5.
    Genevestigatori A6NIR3.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    2.30.29.30. 2 hits.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001164. ArfGAP.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    Pfami PF12796. Ank_2. 1 hit.
    PF01412. ArfGap. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view ]
    PRINTSi PR00405. REVINTRACTNG.
    SMARTi SM00248. ANK. 2 hits.
    SM00105. ArfGap. 1 hit.
    SM00233. PH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    PS50115. ARFGAP. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiAGAP5_HUMAN
    AccessioniPrimary (citable) accession number: A6NIR3
    Secondary accession number(s): A8MSN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 66 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3