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A6NIR3

- AGAP5_HUMAN

UniProt

A6NIR3 - AGAP5_HUMAN

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Protein
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5
Gene
AGAP5, CTGLF2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Putative GTPase-activating protein Reviewed prediction.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri479 – 50224C4-type; degenerate
Add
BLAST

GO - Molecular functioni

  1. ARF GTPase activator activity Source: InterPro
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. regulation of ARF GTPase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5
Short name:
AGAP-5
Alternative name(s):
Centaurin-gamma-like family member 2
Gene namesi
Name:AGAP5
Synonyms:CTGLF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23467. AGAP5.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164715123.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 686686Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5
PRO_0000349205Add
BLAST

Proteomic databases

PRIDEiA6NIR3.

PTM databases

PhosphoSiteiA6NIR3.

Expressioni

Gene expression databases

BgeeiA6NIR3.
CleanExiHS_AGAP5.
GenevestigatoriA6NIR3.

Organism-specific databases

HPAiHPA042490.

Structurei

3D structure databases

ProteinModelPortaliA6NIR3.
SMRiA6NIR3. Positions 280-447, 470-680.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini282 – 443162PH
Add
BLAST
Domaini464 – 584121Arf-GAP
Add
BLAST
Repeati623 – 65230ANK 1
Add
BLAST
Repeati656 – 68530ANK 2
Add
BLAST

Sequence similaritiesi

Contains 2 ANK repeats.
Contains 1 Arf-GAP domain.
Contains 1 PH domain.

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

HOGENOMiHOG000007233.
HOVERGENiHBG054045.
InParanoidiA6NIR3.
OMAiSQHYLTM.
PhylomeDBiA6NIR3.
TreeFamiTF317762.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.30.29.30. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00248. ANK. 2 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NIR3-1 [UniParc]FASTAAdd to Basket

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MGNILTCCVH PSVSLEFDQQ QGSVCPSESE IYEAGAGDRM AGAPMAAAVQ    50
PAEVTVEVGE DLHMHHIRDQ EMPEALEFSL SANPEASTIF QRNSQTDALE 100
FNPSANPEAS TIFQRNSQTD VVEIRRSNCT NHVSTERFSQ QYSSCSTIFL 150
DDSTASQHYL TMTIISVTLE IPHHITQRDA DRSLSIPDEQ LHSFAVSTVH 200
ITKNRNGGGS LNNYSSSIPS TPSTSQEDPQ FSVPPTANTP TPVCKRSMRW 250
SNLFTSEKGS HPDKERKAPE NHADTIGSGR AIPIKQGMLL KRSGKWLKTW 300
KKKYVTLCSN GVLTYYSSLG DYMKNIHKKE IDLRTSTIKV PGKWPSLATS 350
ACAPISSSKS NGLSKDMDTG LGDSICFSPS ISSTTSPKLN PPPSPHANKK 400
KHLKKKSTNN FMIVSATGQT WHFEATTYEE RDAWVQAIQS QILASLQSCE 450
SSKSKSQLTS QSEAMALQSI QNMRGNAHCV DYETQNPKWA SLNLGVLMCI 500
ECSGIHRSLG TRLSRVRSLE LDDWPVELRK VMSSIGNDLA NSIWEGSSQG 550
QTKPSVKSTR EEKERWIRSK YEEKLFLAPL PCTELSLGQH LLRATADEDL 600
QTAILLLAHG SREEVNETCG EGDGCTALHL ACRKGNVVLA QLLIWYGVDV 650
MARDAHGNTA LTYARQASSQ ECINVLLQYG CPDECV 686
Length:686
Mass (Da):75,492
Last modified:January 11, 2011 - v2
Checksum:iC51D1E96C6179B24
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81C → R in BC127746. 1 Publication
Sequence conflicti365 – 3651K → E in BC127746. 1 Publication
Sequence conflicti482 – 4821Y → C in BC127746. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC073389 Genomic DNA. No translation available.
AC022400 Genomic DNA. No translation available.
BC127746 mRNA. No translation available.
CCDSiCCDS44439.1.
RefSeqiNP_001137472.1. NM_001144000.1.
UniGeneiHs.651147.

Genome annotation databases

EnsembliENST00000374094; ENSP00000363207; ENSG00000172650.
GeneIDi729092.
KEGGihsa:729092.
UCSCiuc001juu.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC073389 Genomic DNA. No translation available.
AC022400 Genomic DNA. No translation available.
BC127746 mRNA. No translation available.
CCDSi CCDS44439.1.
RefSeqi NP_001137472.1. NM_001144000.1.
UniGenei Hs.651147.

3D structure databases

ProteinModelPortali A6NIR3.
SMRi A6NIR3. Positions 280-447, 470-680.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei A6NIR3.

Proteomic databases

PRIDEi A6NIR3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374094 ; ENSP00000363207 ; ENSG00000172650 .
GeneIDi 729092.
KEGGi hsa:729092.
UCSCi uc001juu.4. human.

Organism-specific databases

CTDi 729092.
GeneCardsi GC10M075435.
HGNCi HGNC:23467. AGAP5.
HPAi HPA042490.
neXtProti NX_A6NIR3.
PharmGKBi PA164715123.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000007233.
HOVERGENi HBG054045.
InParanoidi A6NIR3.
OMAi SQHYLTM.
PhylomeDBi A6NIR3.
TreeFami TF317762.

Miscellaneous databases

GenomeRNAii 729092.
NextBioi 129216.
PROi A6NIR3.

Gene expression databases

Bgeei A6NIR3.
CleanExi HS_AGAP5.
Genevestigatori A6NIR3.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
2.30.29.30. 2 hits.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
Pfami PF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
PF00169. PH. 1 hit.
[Graphical view ]
PRINTSi PR00405. REVINTRACTNG.
SMARTi SM00248. ANK. 2 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiAGAP5_HUMAN
AccessioniPrimary (citable) accession number: A6NIR3
Secondary accession number(s): A8MSN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: January 11, 2011
Last modified: September 3, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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