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Protein

Solute carrier family 15 member 5

Gene

SLC15A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Proton oligopeptide cotransporter.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

BioCyciZFISH:G66-32045-MONOMER.

Protein family/group databases

TCDBi2.A.17.3.10. the proton-dependent oligopeptide transporter (pot/ptr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 15 member 5
Gene namesi
Name:SLC15A5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:33455. SLC15A5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Transmembranei386 – 406HelicalSequence analysisAdd BLAST21
Transmembranei422 – 442HelicalSequence analysisAdd BLAST21
Transmembranei472 – 492HelicalSequence analysisAdd BLAST21
Transmembranei509 – 529HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188991.
PharmGKBiPA164725785.

Polymorphism and mutation databases

BioMutaiSLC15A5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003322331 – 579Solute carrier family 15 member 5Add BLAST579

Proteomic databases

PaxDbiA6NIM6.
PRIDEiA6NIM6.

PTM databases

PhosphoSitePlusiA6NIM6.

Expressioni

Organism-specific databases

HPAiHPA041638.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000340402.

Structurei

3D structure databases

ProteinModelPortaliA6NIM6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1237. Eukaryota.
COG3104. LUCA.
GeneTreeiENSGT00530000062961.
HOGENOMiHOG000060235.
InParanoidiA6NIM6.
KOiK14639.
OMAiFYLVLQY.
OrthoDBiEOG091G0GF9.
PhylomeDBiA6NIM6.
TreeFamiTF332925.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR000109. POT_fam.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 1 hit.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.

Sequencei

Sequence statusi: Complete.

A6NIM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVTGFTITD EKVHLYHSIE KEKTVRHIGD LCSSHSVKKI QVGICLLLVE
60 70 80 90 100
LCERFTFFEV VCNMIPFCTI KLGYHNCQAA ILNLCFIGTS ILTPVFVRWL
110 120 130 140 150
TDVYLGRNKL VYICLFLHFL GTALLSVVAF PLEDFYLGTY HAVNNIPKTE
160 170 180 190 200
QHRLFYVALL TICLGIGGVR AIVCPLGAFG LQEYGSQKTM SFFNWFYWLM
210 220 230 240 250
NLNATIVFLG ISYIQHSQAW ALVLLIPFMS MLMAVITLHM IYYNLIYQSE
260 270 280 290 300
KRCSLLTGVG VLVSALKTCH PQYCHLGRDV TSQLDHAKEK NGGCYSELHV
310 320 330 340 350
EDTTFFLTLL PLFIFQLLYR MCIMQIPSGY YLQTMNSNLN LDGFLLPIAV
360 370 380 390 400
MNAISSLPLL ILAPFLEYFS TCLFPSKRVG SFLSTCIIAG NLFAALSVMI
410 420 430 440 450
AGFFEIHRKH FPAVEQPLSG KVLTVSSMPC FYLILQYVLL GVAETLVNPA
460 470 480 490 500
LSVISYRFVP SNVRGTSMNF LTLFNGFGCF TGALLVKLVY LISDGNWFPN
510 520 530 540 550
TLNKGNLESF FFFLASLTLL NVLGFCSVSQ RYCNLNHFNA QNIRGSNLEE
560 570
TLLLHEKSLK FYGSIQEFSS SIDLWETAL
Length:579
Mass (Da):65,263
Last modified:April 29, 2008 - v2
Checksum:i836D5266978C9977
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042979141H → Q.Corresponds to variant rs1799516dbSNPEnsembl.1
Natural variantiVAR_042980271P → L.Corresponds to variant rs1527014dbSNPEnsembl.1
Natural variantiVAR_042981494D → E.Corresponds to variant rs1671511dbSNPEnsembl.1
Natural variantiVAR_042982508E → K.Corresponds to variant rs3946358dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073574 Genomic DNA. No translation available.
RefSeqiNP_001164269.1. NM_001170798.1.
UniGeneiHs.692712.

Genome annotation databases

EnsembliENST00000344941; ENSP00000340402; ENSG00000188991.
GeneIDi729025.
KEGGihsa:729025.
UCSCiuc021qvs.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073574 Genomic DNA. No translation available.
RefSeqiNP_001164269.1. NM_001170798.1.
UniGeneiHs.692712.

3D structure databases

ProteinModelPortaliA6NIM6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000340402.

Protein family/group databases

TCDBi2.A.17.3.10. the proton-dependent oligopeptide transporter (pot/ptr) family.

PTM databases

PhosphoSitePlusiA6NIM6.

Polymorphism and mutation databases

BioMutaiSLC15A5.

Proteomic databases

PaxDbiA6NIM6.
PRIDEiA6NIM6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344941; ENSP00000340402; ENSG00000188991.
GeneIDi729025.
KEGGihsa:729025.
UCSCiuc021qvs.1. human.

Organism-specific databases

CTDi729025.
GeneCardsiSLC15A5.
HGNCiHGNC:33455. SLC15A5.
HPAiHPA041638.
neXtProtiNX_A6NIM6.
OpenTargetsiENSG00000188991.
PharmGKBiPA164725785.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1237. Eukaryota.
COG3104. LUCA.
GeneTreeiENSGT00530000062961.
HOGENOMiHOG000060235.
InParanoidiA6NIM6.
KOiK14639.
OMAiFYLVLQY.
OrthoDBiEOG091G0GF9.
PhylomeDBiA6NIM6.
TreeFamiTF332925.

Enzyme and pathway databases

BioCyciZFISH:G66-32045-MONOMER.

Miscellaneous databases

GenomeRNAii729025.
PROiA6NIM6.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR000109. POT_fam.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 1 hit.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiS15A5_HUMAN
AccessioniPrimary (citable) accession number: A6NIM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: November 2, 2016
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.