A6NIM6 (S15A5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 15 member 5

Gene names

Name:

SLC15A5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	579 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Proton oligopeptide cotransporter Potential.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the PTR2/POT transporter (TC 2.A.17) family. [View classification]

Ontologies

Keywords
Biological process	Peptide transport Protein transport Symport Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptide transport Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	symporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 579	579	Solute carrier family 15 member 5		PRO_0000332233
Regions
	Transmembrane	77 – 97	21	Helical; Potential
	Transmembrane	110 – 130	21	Helical; Potential
	Transmembrane	154 – 174	21	Helical; Potential
	Transmembrane	191 – 211	21	Helical; Potential
	Transmembrane	221 – 241	21	Helical; Potential
	Transmembrane	304 – 324	21	Helical; Potential
	Transmembrane	343 – 363	21	Helical; Potential
	Transmembrane	386 – 406	21	Helical; Potential
	Transmembrane	422 – 442	21	Helical; Potential
	Transmembrane	472 – 492	21	Helical; Potential
	Transmembrane	509 – 529	21	Helical; Potential
Natural variations
	Natural variant	141	1	H → Q. Corresponds to variant rs1799516 [ dbSNP | Ensembl ].		VAR_042979
	Natural variant	271	1	P → L. Corresponds to variant rs1527014 [ dbSNP | Ensembl ].		VAR_042980
	Natural variant	494	1	D → E. Corresponds to variant rs1671511 [ dbSNP | Ensembl ].		VAR_042981
	Natural variant	508	1	E → K. Corresponds to variant rs3946358 [ dbSNP | Ensembl ].		VAR_042982

Sequences

	Sequence		Length	Mass (Da)
	A6NIM6 [UniParc]. Last modified April 29, 2008. Version 2. Checksum: 836D5266978C9977	FASTA	579	65,263
	10 20 30 40 50 60 MSVTGFTITD EKVHLYHSIE KEKTVRHIGD LCSSHSVKKI QVGICLLLVE LCERFTFFEV 70 80 90 100 110 120 VCNMIPFCTI KLGYHNCQAA ILNLCFIGTS ILTPVFVRWL TDVYLGRNKL VYICLFLHFL 130 140 150 160 170 180 GTALLSVVAF PLEDFYLGTY HAVNNIPKTE QHRLFYVALL TICLGIGGVR AIVCPLGAFG 190 200 210 220 230 240 LQEYGSQKTM SFFNWFYWLM NLNATIVFLG ISYIQHSQAW ALVLLIPFMS MLMAVITLHM 250 260 270 280 290 300 IYYNLIYQSE KRCSLLTGVG VLVSALKTCH PQYCHLGRDV TSQLDHAKEK NGGCYSELHV 310 320 330 340 350 360 EDTTFFLTLL PLFIFQLLYR MCIMQIPSGY YLQTMNSNLN LDGFLLPIAV MNAISSLPLL 370 380 390 400 410 420 ILAPFLEYFS TCLFPSKRVG SFLSTCIIAG NLFAALSVMI AGFFEIHRKH FPAVEQPLSG 430 440 450 460 470 480 KVLTVSSMPC FYLILQYVLL GVAETLVNPA LSVISYRFVP SNVRGTSMNF LTLFNGFGCF 490 500 510 520 530 540 TGALLVKLVY LISDGNWFPN TLNKGNLESF FFFLASLTLL NVLGFCSVSQ RYCNLNHFNA 550 560 570 QNIRGSNLEE TLLLHEKSLK FYGSIQEFSS SIDLWETAL

References

[1]

"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC073574 Genomic DNA. No translation available.
IPI	IPI00413216.
RefSeq	NP_001164269.1. NM_001170798.1.
UniGene	Hs.692712.
3D structure databases
ProteinModelPortal	A6NIM6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000340402.
PTM databases
PhosphoSite	A6NIM6.
Proteomic databases
PaxDb	A6NIM6.
PRIDE	A6NIM6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000344941; ENSP00000340402; ENSG00000188991.
GeneID	729025.
KEGG	hsa:729025.
UCSC	uc021qvs.1. human.
Organism-specific databases
CTD	729025.
GeneCards	GC12M016343.
HGNC	HGNC:33455. SLC15A5.
HPA	HPA041638.
neXtProt	NX_A6NIM6.
PharmGKB	PA164725785.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG259627.
HOGENOM	HOG000060235.
InParanoid	A6NIM6.
KO	K14639.
OMA	WFASTIY.
OrthoDB	EOG4H72BW.
Gene expression databases
Genevestigator	A6NIM6.
Family and domain databases
InterPro	IPR000109. POT_fam. [Graphical view]
PANTHER	PTHR11654. PTHR11654. 1 hit.
Pfam	PF00854. PTR2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	729025.
NextBio	129037.

Entry information

Entry name

S15A5_HUMAN

Accession

Primary (citable) accession number: A6NIM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	April 3, 2013
This is version 52 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.