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A6NIM6 (S15A5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 15 member 5
Gene names
Name:SLC15A5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length579 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Proton oligopeptide cotransporter Potential.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the PTR2/POT transporter (TC 2.A.17) family. [View classification]

Ontologies

Keywords
   Biological processPeptide transport
Protein transport
Symport
Transport
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpeptide transport

Inferred from electronic annotation. Source: UniProtKB-KW

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionsymporter activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 579579Solute carrier family 15 member 5
PRO_0000332233

Regions

Transmembrane77 – 9721Helical; Potential
Transmembrane110 – 13021Helical; Potential
Transmembrane154 – 17421Helical; Potential
Transmembrane191 – 21121Helical; Potential
Transmembrane221 – 24121Helical; Potential
Transmembrane304 – 32421Helical; Potential
Transmembrane343 – 36321Helical; Potential
Transmembrane386 – 40621Helical; Potential
Transmembrane422 – 44221Helical; Potential
Transmembrane472 – 49221Helical; Potential
Transmembrane509 – 52921Helical; Potential

Natural variations

Natural variant1411H → Q.
Corresponds to variant rs1799516 [ dbSNP | Ensembl ].
VAR_042979
Natural variant2711P → L.
Corresponds to variant rs1527014 [ dbSNP | Ensembl ].
VAR_042980
Natural variant4941D → E.
Corresponds to variant rs1671511 [ dbSNP | Ensembl ].
VAR_042981
Natural variant5081E → K.
Corresponds to variant rs3946358 [ dbSNP | Ensembl ].
VAR_042982

Sequences

Sequence LengthMass (Da)Tools
A6NIM6 [UniParc].

Last modified April 29, 2008. Version 2.
Checksum: 836D5266978C9977

FASTA57965,263
        10         20         30         40         50         60 
MSVTGFTITD EKVHLYHSIE KEKTVRHIGD LCSSHSVKKI QVGICLLLVE LCERFTFFEV 

        70         80         90        100        110        120 
VCNMIPFCTI KLGYHNCQAA ILNLCFIGTS ILTPVFVRWL TDVYLGRNKL VYICLFLHFL 

       130        140        150        160        170        180 
GTALLSVVAF PLEDFYLGTY HAVNNIPKTE QHRLFYVALL TICLGIGGVR AIVCPLGAFG 

       190        200        210        220        230        240 
LQEYGSQKTM SFFNWFYWLM NLNATIVFLG ISYIQHSQAW ALVLLIPFMS MLMAVITLHM 

       250        260        270        280        290        300 
IYYNLIYQSE KRCSLLTGVG VLVSALKTCH PQYCHLGRDV TSQLDHAKEK NGGCYSELHV 

       310        320        330        340        350        360 
EDTTFFLTLL PLFIFQLLYR MCIMQIPSGY YLQTMNSNLN LDGFLLPIAV MNAISSLPLL 

       370        380        390        400        410        420 
ILAPFLEYFS TCLFPSKRVG SFLSTCIIAG NLFAALSVMI AGFFEIHRKH FPAVEQPLSG 

       430        440        450        460        470        480 
KVLTVSSMPC FYLILQYVLL GVAETLVNPA LSVISYRFVP SNVRGTSMNF LTLFNGFGCF 

       490        500        510        520        530        540 
TGALLVKLVY LISDGNWFPN TLNKGNLESF FFFLASLTLL NVLGFCSVSQ RYCNLNHFNA 

       550        560        570 
QNIRGSNLEE TLLLHEKSLK FYGSIQEFSS SIDLWETAL 

« Hide

References

[1]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC073574 Genomic DNA. No translation available.
RefSeqNP_001164269.1. NM_001170798.1.
UniGeneHs.692712.

3D structure databases

ProteinModelPortalA6NIM6.
SMRA6NIM6. Positions 46-532.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000340402.

Protein family/group databases

TCDB2.A.17.3.10. the proton-dependent oligopeptide transporter (pot) family.

PTM databases

PhosphoSiteA6NIM6.

Proteomic databases

PaxDbA6NIM6.
PRIDEA6NIM6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000344941; ENSP00000340402; ENSG00000188991.
GeneID729025.
KEGGhsa:729025.
UCSCuc021qvs.1. human.

Organism-specific databases

CTD729025.
GeneCardsGC12M016343.
HGNCHGNC:33455. SLC15A5.
HPAHPA041638.
neXtProtNX_A6NIM6.
PharmGKBPA164725785.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG259627.
HOGENOMHOG000060235.
InParanoidA6NIM6.
KOK14639.
OMAGLQEYGS.
OrthoDBEOG74J97R.
PhylomeDBA6NIM6.
TreeFamTF332925.

Gene expression databases

GenevestigatorA6NIM6.

Family and domain databases

InterProIPR016196. MFS_dom_general_subst_transpt.
IPR000109. POT_fam.
[Graphical view]
PANTHERPTHR11654. PTHR11654. 1 hit.
PfamPF00854. PTR2. 2 hits.
[Graphical view]
SUPFAMSSF103473. SSF103473. 3 hits.
ProtoNetSearch...

Other

GenomeRNAi729025.
NextBio129037.
PROA6NIM6.

Entry information

Entry nameS15A5_HUMAN
AccessionPrimary (citable) accession number: A6NIM6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: June 11, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM