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A6NIM6

- S15A5_HUMAN

UniProt

A6NIM6 - S15A5_HUMAN

Protein

Solute carrier family 15 member 5

Gene

SLC15A5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 2 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Proton oligopeptide cotransporter.Curated

    GO - Molecular functioni

    1. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. peptide transport Source: UniProtKB-KW
    2. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Peptide transport, Protein transport, Symport, Transport

    Protein family/group databases

    TCDBi2.A.17.3.10. the proton-dependent oligopeptide transporter (pot/ptr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 15 member 5
    Gene namesi
    Name:SLC15A5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:33455. SLC15A5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164725785.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 579579Solute carrier family 15 member 5PRO_0000332233Add
    BLAST

    Proteomic databases

    PaxDbiA6NIM6.
    PRIDEiA6NIM6.

    PTM databases

    PhosphoSiteiA6NIM6.

    Expressioni

    Gene expression databases

    GenevestigatoriA6NIM6.

    Organism-specific databases

    HPAiHPA041638.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000340402.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NIM6.
    SMRiA6NIM6. Positions 46-532.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei77 – 9721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei110 – 13021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei154 – 17421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei191 – 21121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei221 – 24121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei304 – 32421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei343 – 36321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei386 – 40621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei422 – 44221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei472 – 49221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei509 – 52921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG259627.
    HOGENOMiHOG000060235.
    InParanoidiA6NIM6.
    KOiK14639.
    OMAiGLQEYGS.
    OrthoDBiEOG74J97R.
    PhylomeDBiA6NIM6.
    TreeFamiTF332925.

    Family and domain databases

    InterProiIPR016196. MFS_dom_general_subst_transpt.
    IPR000109. POT_fam.
    [Graphical view]
    PANTHERiPTHR11654. PTHR11654. 1 hit.
    PfamiPF00854. PTR2. 2 hits.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    A6NIM6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVTGFTITD EKVHLYHSIE KEKTVRHIGD LCSSHSVKKI QVGICLLLVE    50
    LCERFTFFEV VCNMIPFCTI KLGYHNCQAA ILNLCFIGTS ILTPVFVRWL 100
    TDVYLGRNKL VYICLFLHFL GTALLSVVAF PLEDFYLGTY HAVNNIPKTE 150
    QHRLFYVALL TICLGIGGVR AIVCPLGAFG LQEYGSQKTM SFFNWFYWLM 200
    NLNATIVFLG ISYIQHSQAW ALVLLIPFMS MLMAVITLHM IYYNLIYQSE 250
    KRCSLLTGVG VLVSALKTCH PQYCHLGRDV TSQLDHAKEK NGGCYSELHV 300
    EDTTFFLTLL PLFIFQLLYR MCIMQIPSGY YLQTMNSNLN LDGFLLPIAV 350
    MNAISSLPLL ILAPFLEYFS TCLFPSKRVG SFLSTCIIAG NLFAALSVMI 400
    AGFFEIHRKH FPAVEQPLSG KVLTVSSMPC FYLILQYVLL GVAETLVNPA 450
    LSVISYRFVP SNVRGTSMNF LTLFNGFGCF TGALLVKLVY LISDGNWFPN 500
    TLNKGNLESF FFFLASLTLL NVLGFCSVSQ RYCNLNHFNA QNIRGSNLEE 550
    TLLLHEKSLK FYGSIQEFSS SIDLWETAL 579
    Length:579
    Mass (Da):65,263
    Last modified:April 29, 2008 - v2
    Checksum:i836D5266978C9977
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti141 – 1411H → Q.
    Corresponds to variant rs1799516 [ dbSNP | Ensembl ].
    VAR_042979
    Natural varianti271 – 2711P → L.
    Corresponds to variant rs1527014 [ dbSNP | Ensembl ].
    VAR_042980
    Natural varianti494 – 4941D → E.
    Corresponds to variant rs1671511 [ dbSNP | Ensembl ].
    VAR_042981
    Natural varianti508 – 5081E → K.
    Corresponds to variant rs3946358 [ dbSNP | Ensembl ].
    VAR_042982

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC073574 Genomic DNA. No translation available.
    RefSeqiNP_001164269.1. NM_001170798.1.
    UniGeneiHs.692712.

    Genome annotation databases

    EnsembliENST00000344941; ENSP00000340402; ENSG00000188991.
    GeneIDi729025.
    KEGGihsa:729025.
    UCSCiuc021qvs.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC073574 Genomic DNA. No translation available.
    RefSeqi NP_001164269.1. NM_001170798.1.
    UniGenei Hs.692712.

    3D structure databases

    ProteinModelPortali A6NIM6.
    SMRi A6NIM6. Positions 46-532.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000340402.

    Protein family/group databases

    TCDBi 2.A.17.3.10. the proton-dependent oligopeptide transporter (pot/ptr) family.

    PTM databases

    PhosphoSitei A6NIM6.

    Proteomic databases

    PaxDbi A6NIM6.
    PRIDEi A6NIM6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000344941 ; ENSP00000340402 ; ENSG00000188991 .
    GeneIDi 729025.
    KEGGi hsa:729025.
    UCSCi uc021qvs.1. human.

    Organism-specific databases

    CTDi 729025.
    GeneCardsi GC12M016343.
    HGNCi HGNC:33455. SLC15A5.
    HPAi HPA041638.
    neXtProti NX_A6NIM6.
    PharmGKBi PA164725785.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG259627.
    HOGENOMi HOG000060235.
    InParanoidi A6NIM6.
    KOi K14639.
    OMAi GLQEYGS.
    OrthoDBi EOG74J97R.
    PhylomeDBi A6NIM6.
    TreeFami TF332925.

    Miscellaneous databases

    GenomeRNAii 729025.
    NextBioi 129037.
    PROi A6NIM6.

    Gene expression databases

    Genevestigatori A6NIM6.

    Family and domain databases

    InterProi IPR016196. MFS_dom_general_subst_transpt.
    IPR000109. POT_fam.
    [Graphical view ]
    PANTHERi PTHR11654. PTHR11654. 1 hit.
    Pfami PF00854. PTR2. 2 hits.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiS15A5_HUMAN
    AccessioniPrimary (citable) accession number: A6NIM6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 62 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3