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Protein

Leucine-rich repeat-containing protein 10B

Gene

LRRC10B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 10B
Gene namesi
Name:LRRC10B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:37215. LRRC10B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165543456.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Leucine-rich repeat-containing protein 10BPRO_0000346162Add
BLAST

Proteomic databases

PaxDbiA6NIK2.
PRIDEiA6NIK2.

PTM databases

PhosphoSiteiA6NIK2.

Expressioni

Gene expression databases

BgeeiA6NIK2.
GenevisibleiA6NIK2. HS.

Organism-specific databases

HPAiHPA047619.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000367315.

Structurei

3D structure databases

ProteinModelPortaliA6NIK2.
SMRiA6NIK2. Positions 6-270.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati22 – 4322LRR 1Add
BLAST
Repeati45 – 6622LRR 2Add
BLAST
Repeati68 – 9023LRR 3Add
BLAST
Repeati91 – 11222LRR 4Add
BLAST
Repeati114 – 13623LRR 5Add
BLAST
Repeati137 – 15822LRR 6Add
BLAST
Repeati160 – 18122LRR 7Add
BLAST
Repeati183 – 20422LRR 8Add
BLAST
Repeati205 – 22622LRR 9Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi257 – 2626Poly-Glu

Sequence similaritiesi

Contains 9 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00780000121846.
HOGENOMiHOG000113359.
HOVERGENiHBG055066.
InParanoidiA6NIK2.
OMAiQKLYVSG.
OrthoDBiEOG7BW0KV.
PhylomeDBiA6NIK2.
TreeFamiTF332853.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF13504. LRR_7. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NIK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIAESTPDE LPSDAEEQLR SGDQQLELSG RRLRRLPSAV CALSRLQKLY
60 70 80 90 100
VSGTGLRELP EEIEELRELR ILALDFNKLE RLPDGLCRLP RLTRLYLGGN
110 120 130 140 150
RLLALPADFA QLQSLRCLWI EGNFLRRFPR PLLRLVALQS LQMGDNRLRA
160 170 180 190 200
LPAELPRMTG LRGLWLYGNR FEEFPPALLR MGRLHILDLD RNRLGGFPDL
210 220 230 240 250
HPLRALRVFS YDHNPVTGPP RVADTVFLVG EGAVERMAER DEPTPRPPPR
260 270 280 290
RPARAFEDEE EEDLLIGGAG SRALGAPGGS FRALEAAPGL GT
Length:292
Mass (Da):32,714
Last modified:September 2, 2008 - v2
Checksum:iC17ECE528B57EE39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003108 Genomic DNA. No translation available.
CCDSiCCDS44621.1.
RefSeqiNP_001138549.1. NM_001145077.1.
UniGeneiHs.441122.

Genome annotation databases

EnsembliENST00000378075; ENSP00000367315; ENSG00000204950.
GeneIDi390205.
KEGGihsa:390205.
UCSCiuc010rlk.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003108 Genomic DNA. No translation available.
CCDSiCCDS44621.1.
RefSeqiNP_001138549.1. NM_001145077.1.
UniGeneiHs.441122.

3D structure databases

ProteinModelPortaliA6NIK2.
SMRiA6NIK2. Positions 6-270.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000367315.

PTM databases

PhosphoSiteiA6NIK2.

Proteomic databases

PaxDbiA6NIK2.
PRIDEiA6NIK2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378075; ENSP00000367315; ENSG00000204950.
GeneIDi390205.
KEGGihsa:390205.
UCSCiuc010rlk.2. human.

Organism-specific databases

CTDi390205.
GeneCardsiGC11P061277.
HGNCiHGNC:37215. LRRC10B.
HPAiHPA047619.
neXtProtiNX_A6NIK2.
PharmGKBiPA165543456.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00780000121846.
HOGENOMiHOG000113359.
HOVERGENiHBG055066.
InParanoidiA6NIK2.
OMAiQKLYVSG.
OrthoDBiEOG7BW0KV.
PhylomeDBiA6NIK2.
TreeFamiTF332853.

Miscellaneous databases

GenomeRNAii390205.
NextBioi103522.
PROiA6NIK2.

Gene expression databases

BgeeiA6NIK2.
GenevisibleiA6NIK2. HS.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF13504. LRR_7. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiLR10B_HUMAN
AccessioniPrimary (citable) accession number: A6NIK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: June 24, 2015
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.