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Protein

Leucine-rich repeat-containing protein 10B

Gene

LRRC10B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 10B
Gene namesi
Name:LRRC10B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:37215. LRRC10B.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204950.
PharmGKBiPA165543456.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003461621 – 292Leucine-rich repeat-containing protein 10BAdd BLAST292

Proteomic databases

PaxDbiA6NIK2.
PRIDEiA6NIK2.

PTM databases

iPTMnetiA6NIK2.
PhosphoSitePlusiA6NIK2.

Expressioni

Gene expression databases

BgeeiENSG00000204950.
GenevisibleiA6NIK2. HS.

Organism-specific databases

HPAiHPA047619.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000367315.

Structurei

3D structure databases

ProteinModelPortaliA6NIK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati22 – 43LRR 1Add BLAST22
Repeati45 – 66LRR 2Add BLAST22
Repeati68 – 90LRR 3Add BLAST23
Repeati91 – 112LRR 4Add BLAST22
Repeati114 – 136LRR 5Add BLAST23
Repeati137 – 158LRR 6Add BLAST22
Repeati160 – 181LRR 7Add BLAST22
Repeati183 – 204LRR 8Add BLAST22
Repeati205 – 226LRR 9Add BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi257 – 262Poly-Glu6

Sequence similaritiesi

Contains 9 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129676.
HOGENOMiHOG000113359.
HOVERGENiHBG055066.
InParanoidiA6NIK2.
OMAiQKLYVSG.
OrthoDBiEOG091G0HH2.
PhylomeDBiA6NIK2.
TreeFamiTF332853.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 5 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NIK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIAESTPDE LPSDAEEQLR SGDQQLELSG RRLRRLPSAV CALSRLQKLY
60 70 80 90 100
VSGTGLRELP EEIEELRELR ILALDFNKLE RLPDGLCRLP RLTRLYLGGN
110 120 130 140 150
RLLALPADFA QLQSLRCLWI EGNFLRRFPR PLLRLVALQS LQMGDNRLRA
160 170 180 190 200
LPAELPRMTG LRGLWLYGNR FEEFPPALLR MGRLHILDLD RNRLGGFPDL
210 220 230 240 250
HPLRALRVFS YDHNPVTGPP RVADTVFLVG EGAVERMAER DEPTPRPPPR
260 270 280 290
RPARAFEDEE EEDLLIGGAG SRALGAPGGS FRALEAAPGL GT
Length:292
Mass (Da):32,714
Last modified:September 2, 2008 - v2
Checksum:iC17ECE528B57EE39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003108 Genomic DNA. No translation available.
CCDSiCCDS44621.1.
RefSeqiNP_001138549.1. NM_001145077.1.
UniGeneiHs.441122.

Genome annotation databases

EnsembliENST00000378075; ENSP00000367315; ENSG00000204950.
GeneIDi390205.
KEGGihsa:390205.
UCSCiuc010rlk.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003108 Genomic DNA. No translation available.
CCDSiCCDS44621.1.
RefSeqiNP_001138549.1. NM_001145077.1.
UniGeneiHs.441122.

3D structure databases

ProteinModelPortaliA6NIK2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000367315.

PTM databases

iPTMnetiA6NIK2.
PhosphoSitePlusiA6NIK2.

Proteomic databases

PaxDbiA6NIK2.
PRIDEiA6NIK2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378075; ENSP00000367315; ENSG00000204950.
GeneIDi390205.
KEGGihsa:390205.
UCSCiuc010rlk.2. human.

Organism-specific databases

CTDi390205.
GeneCardsiLRRC10B.
HGNCiHGNC:37215. LRRC10B.
HPAiHPA047619.
neXtProtiNX_A6NIK2.
OpenTargetsiENSG00000204950.
PharmGKBiPA165543456.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129676.
HOGENOMiHOG000113359.
HOVERGENiHBG055066.
InParanoidiA6NIK2.
OMAiQKLYVSG.
OrthoDBiEOG091G0HH2.
PhylomeDBiA6NIK2.
TreeFamiTF332853.

Miscellaneous databases

GenomeRNAii390205.
PROiA6NIK2.

Gene expression databases

BgeeiENSG00000204950.
GenevisibleiA6NIK2. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 5 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLR10B_HUMAN
AccessioniPrimary (citable) accession number: A6NIK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: November 30, 2016
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.