ID   CCD69_HUMAN             Reviewed;         296 AA.
AC   A6NI79; A8K9X6;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   11-NOV-2015, entry version 65.
DE   RecName: Full=Coiled-coil domain-containing protein 69;
GN   Name=CCDC69;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LYS-197.
RC   TISSUE=Trachea;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241, AND IDENTIFICATION
RP   BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
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DR   EMBL; AK292841; BAF85530.1; -; mRNA.
DR   EMBL; AC011342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS4312.1; -.
DR   RefSeq; NP_056436.2; NM_015621.2.
DR   UniGene; Hs.655336; -.
DR   ProteinModelPortal; A6NI79; -.
DR   BioGrid; 117558; 20.
DR   IntAct; A6NI79; 6.
DR   MINT; MINT-8247629; -.
DR   PhosphoSite; A6NI79; -.
DR   BioMuta; CCDC69; -.
DR   MaxQB; A6NI79; -.
DR   PaxDb; A6NI79; -.
DR   PRIDE; A6NI79; -.
DR   Ensembl; ENST00000355417; ENSP00000347586; ENSG00000198624.
DR   GeneID; 26112; -.
DR   KEGG; hsa:26112; -.
DR   UCSC; uc003ltq.3; human.
DR   CTD; 26112; -.
DR   GeneCards; CCDC69; -.
DR   HGNC; HGNC:24487; CCDC69.
DR   HPA; HPA043648; -.
DR   HPA; HPA052896; -.
DR   neXtProt; NX_A6NI79; -.
DR   PharmGKB; PA128394640; -.
DR   eggNOG; ENOG410IYDA; Eukaryota.
DR   eggNOG; ENOG4111TAG; LUCA.
DR   GeneTree; ENSGT00390000006245; -.
DR   HOGENOM; HOG000111431; -.
DR   HOVERGEN; HBG107610; -.
DR   InParanoid; A6NI79; -.
DR   OMA; LTHSFQE; -.
DR   OrthoDB; EOG76X5Z9; -.
DR   PhylomeDB; A6NI79; -.
DR   ChiTaRS; CCDC69; human.
DR   GenomeRNAi; 26112; -.
DR   NextBio; 48110; -.
DR   PRO; PR:A6NI79; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; A6NI79; -.
DR   CleanEx; HS_CCDC69; -.
DR   ExpressionAtlas; A6NI79; baseline and differential.
DR   Genevisible; A6NI79; HS.
PE   1: Evidence at protein level;
KW   Coiled coil; Complete proteome; Lipoprotein; Myristate;
KW   Phosphoprotein; Polymorphism; Reference proteome.
FT   INIT_MET      1      1       Removed. {ECO:0000255}.
FT   CHAIN         2    296       Coiled-coil domain-containing protein 69.
FT                                /FTId=PRO_0000328962.
FT   COILED       48    272       {ECO:0000255}.
FT   MOD_RES     154    154       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:Q3TCJ8}.
FT   MOD_RES     241    241       Phosphoserine.
FT                                {ECO:0000244|PubMed:24275569}.
FT   LIPID         2      2       N-myristoyl glycine. {ECO:0000255}.
FT   VARIANT     197    197       R -> K (in dbSNP:rs248427).
FT                                {ECO:0000269|PubMed:14702039}.
FT                                /FTId=VAR_042584.
SQ   SEQUENCE   296 AA;  34796 MW;  083A804AFAE45C8E CRC64;
     MGCRHSRLSS CKPPKKKRQE PEPEQPPRPE PHELGPLNGD TAITVQLCAS EEAERHQKDI
     TRILQQHEEE KKKWAQQVEK ERELELRDRL DEQQRVLEGK NEEALQVLRA SYEQEKEALT
     HSFREASSTQ QETIDRLTSQ LEAFQAKMKR VEESILSRNY KKHIQDYGSP SQFWEQELES
     LHFVIEMKNE RIHELDRRLI LMETVKEKNL ILEEKITTLQ QENEDLHVRS RNQVVLSRQL
     SEDLLLTREA LEKEVQLRRQ LQQEKEELLY RVLGANASPA FPLAPVTPTE VSFLAT
//