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Protein

Coiled-coil domain-containing protein 69

Gene

CCDC69

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 69
Gene namesi
Name:CCDC69
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:24487. CCDC69.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394640.

Polymorphism and mutation databases

BioMutaiCCDC69.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedSequence analysis
Chaini2 – 296295Coiled-coil domain-containing protein 69PRO_0000328962Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineSequence analysis
Modified residuei154 – 1541PhosphoserineBy similarity
Modified residuei241 – 2411PhosphoserineCombined sources

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

MaxQBiA6NI79.
PaxDbiA6NI79.
PRIDEiA6NI79.
TopDownProteomicsiA6NI79.

PTM databases

iPTMnetiA6NI79.
PhosphoSiteiA6NI79.
SwissPalmiA6NI79.

Expressioni

Gene expression databases

BgeeiA6NI79.
CleanExiHS_CCDC69.
ExpressionAtlasiA6NI79. baseline and differential.
GenevisibleiA6NI79. HS.

Organism-specific databases

HPAiHPA043648.
HPA052896.

Interactioni

Protein-protein interaction databases

BioGridi117558. 20 interactions.
IntActiA6NI79. 6 interactions.
MINTiMINT-8247629.

Structurei

3D structure databases

ProteinModelPortaliA6NI79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili48 – 272225Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IYDA. Eukaryota.
ENOG4111TAG. LUCA.
GeneTreeiENSGT00390000006245.
HOGENOMiHOG000111431.
HOVERGENiHBG107610.
InParanoidiA6NI79.
OMAiLTHSFQE.
OrthoDBiEOG76X5Z9.
PhylomeDBiA6NI79.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6NI79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCRHSRLSS CKPPKKKRQE PEPEQPPRPE PHELGPLNGD TAITVQLCAS
60 70 80 90 100
EEAERHQKDI TRILQQHEEE KKKWAQQVEK ERELELRDRL DEQQRVLEGK
110 120 130 140 150
NEEALQVLRA SYEQEKEALT HSFREASSTQ QETIDRLTSQ LEAFQAKMKR
160 170 180 190 200
VEESILSRNY KKHIQDYGSP SQFWEQELES LHFVIEMKNE RIHELDRRLI
210 220 230 240 250
LMETVKEKNL ILEEKITTLQ QENEDLHVRS RNQVVLSRQL SEDLLLTREA
260 270 280 290
LEKEVQLRRQ LQQEKEELLY RVLGANASPA FPLAPVTPTE VSFLAT
Length:296
Mass (Da):34,796
Last modified:July 24, 2007 - v1
Checksum:i083A804AFAE45C8E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti197 – 1971R → K.1 Publication
Corresponds to variant rs248427 [ dbSNP | Ensembl ].
VAR_042584

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292841 mRNA. Translation: BAF85530.1.
AC011342 Genomic DNA. No translation available.
CCDSiCCDS4312.1.
RefSeqiNP_056436.2. NM_015621.2.
UniGeneiHs.655336.

Genome annotation databases

EnsembliENST00000355417; ENSP00000347586; ENSG00000198624.
GeneIDi26112.
KEGGihsa:26112.
UCSCiuc003ltq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292841 mRNA. Translation: BAF85530.1.
AC011342 Genomic DNA. No translation available.
CCDSiCCDS4312.1.
RefSeqiNP_056436.2. NM_015621.2.
UniGeneiHs.655336.

3D structure databases

ProteinModelPortaliA6NI79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117558. 20 interactions.
IntActiA6NI79. 6 interactions.
MINTiMINT-8247629.

PTM databases

iPTMnetiA6NI79.
PhosphoSiteiA6NI79.
SwissPalmiA6NI79.

Polymorphism and mutation databases

BioMutaiCCDC69.

Proteomic databases

MaxQBiA6NI79.
PaxDbiA6NI79.
PRIDEiA6NI79.
TopDownProteomicsiA6NI79.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355417; ENSP00000347586; ENSG00000198624.
GeneIDi26112.
KEGGihsa:26112.
UCSCiuc003ltq.4. human.

Organism-specific databases

CTDi26112.
GeneCardsiCCDC69.
HGNCiHGNC:24487. CCDC69.
HPAiHPA043648.
HPA052896.
neXtProtiNX_A6NI79.
PharmGKBiPA128394640.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYDA. Eukaryota.
ENOG4111TAG. LUCA.
GeneTreeiENSGT00390000006245.
HOGENOMiHOG000111431.
HOVERGENiHBG107610.
InParanoidiA6NI79.
OMAiLTHSFQE.
OrthoDBiEOG76X5Z9.
PhylomeDBiA6NI79.

Miscellaneous databases

ChiTaRSiCCDC69. human.
GenomeRNAii26112.
NextBioi48110.
PROiA6NI79.

Gene expression databases

BgeeiA6NI79.
CleanExiHS_CCDC69.
ExpressionAtlasiA6NI79. baseline and differential.
GenevisibleiA6NI79. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-197.
    Tissue: Trachea.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCCD69_HUMAN
AccessioniPrimary (citable) accession number: A6NI79
Secondary accession number(s): A8K9X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 24, 2007
Last modified: March 16, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.