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Protein

Coiled-coil domain-containing protein 69

Gene

CCDC69

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone.1 Publication

GO - Biological processi

  • spindle midzone assembly Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 69Curated
Gene namesi
Name:CCDC69Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000198624.12.
HGNCiHGNC:24487. CCDC69.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198624.
PharmGKBiPA128394640.

Polymorphism and mutation databases

BioMutaiCCDC69.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00003289622 – 296Coiled-coil domain-containing protein 69Add BLAST295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1
Modified residuei154PhosphoserineBy similarity1
Modified residuei241PhosphoserineCombined sources1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiA6NI79.
MaxQBiA6NI79.
PaxDbiA6NI79.
PRIDEiA6NI79.
TopDownProteomicsiA6NI79.

PTM databases

iPTMnetiA6NI79.
PhosphoSitePlusiA6NI79.
SwissPalmiA6NI79.

Expressioni

Tissue specificityi

Highly expressed in duodenum, esophagus, pancreas, prostate, salivary gland, thymus and urinary bladder.1 Publication

Gene expression databases

BgeeiENSG00000198624.
CleanExiHS_CCDC69.
ExpressionAtlasiA6NI79. baseline and differential.
GenevisibleiA6NI79. HS.

Organism-specific databases

HPAiHPA043648.
HPA052896.

Interactioni

Protein-protein interaction databases

BioGridi117558. 23 interactors.
IntActiA6NI79. 6 interactors.
MINTiMINT-8247629.
STRINGi9606.ENSP00000347586.

Structurei

3D structure databases

ProteinModelPortaliA6NI79.
SMRiA6NI79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili48 – 272Sequence analysisAdd BLAST225

Sequence similaritiesi

Belongs to the CCDC69 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IYDA. Eukaryota.
ENOG4111TAG. LUCA.
GeneTreeiENSGT00390000006245.
HOGENOMiHOG000111431.
HOVERGENiHBG107610.
InParanoidiA6NI79.
OMAiQAKMKRV.
OrthoDBiEOG091G0DE4.
PhylomeDBiA6NI79.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6NI79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCRHSRLSS CKPPKKKRQE PEPEQPPRPE PHELGPLNGD TAITVQLCAS
60 70 80 90 100
EEAERHQKDI TRILQQHEEE KKKWAQQVEK ERELELRDRL DEQQRVLEGK
110 120 130 140 150
NEEALQVLRA SYEQEKEALT HSFREASSTQ QETIDRLTSQ LEAFQAKMKR
160 170 180 190 200
VEESILSRNY KKHIQDYGSP SQFWEQELES LHFVIEMKNE RIHELDRRLI
210 220 230 240 250
LMETVKEKNL ILEEKITTLQ QENEDLHVRS RNQVVLSRQL SEDLLLTREA
260 270 280 290
LEKEVQLRRQ LQQEKEELLY RVLGANASPA FPLAPVTPTE VSFLAT
Length:296
Mass (Da):34,796
Last modified:July 24, 2007 - v1
Checksum:i083A804AFAE45C8E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042584197R → K1 PublicationCorresponds to variant dbSNP:rs248427Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292841 mRNA. Translation: BAF85530.1.
AC011342 Genomic DNA. No translation available.
CCDSiCCDS4312.1.
RefSeqiNP_056436.2. NM_015621.2.
UniGeneiHs.655336.

Genome annotation databases

EnsembliENST00000355417; ENSP00000347586; ENSG00000198624.
GeneIDi26112.
KEGGihsa:26112.
UCSCiuc003ltq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCCD69_HUMAN
AccessioniPrimary (citable) accession number: A6NI79
Secondary accession number(s): A8K9X6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 24, 2007
Last modified: September 27, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families