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Protein

Leukocyte immunoglobulin-like receptor subfamily A member 5

Gene

LILRA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte immunoglobulin-like receptor subfamily A member 5
Alternative name(s):
CD85 antigen-like family member F
Immunoglobulin-like transcript 11
Short name:
ILT-11
Leukocyte immunoglobulin-like receptor 9
Short name:
LIR-9
CD_antigen: CD85f
Gene namesi
Name:LILRA5
Synonyms:ILT11, LILRB7, LIR9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16309. LILRA5.

Subcellular locationi

Isoform 3 :
  • Secreted 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini42 – 268227ExtracellularSequence analysisAdd
BLAST
Transmembranei269 – 28921HelicalSequence analysisAdd
BLAST
Topological domaini290 – 29910CytoplasmicSequence analysis

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671547.

Polymorphism and mutation databases

BioMutaiLILRA5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4141Sequence analysisAdd
BLAST
Chaini42 – 299258Leukocyte immunoglobulin-like receptor subfamily A member 5PRO_0000318708Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence analysis
Disulfide bondi67 ↔ 116Combined sources1 Publication
Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence analysis
Disulfide bondi162 ↔ 214Combined sources1 Publication
Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NI73.
PRIDEiA6NI73.

PTM databases

iPTMnetiA6NI73.

Expressioni

Tissue specificityi

Expressed mostly in tissues of the hematopoietic system, including bone marrow, spleen, lymph node and peripheral leukocytes. Among leukocytes, monocytes and neutrophils express the highest level. Expressed in CD14+ monocytes, but not in T-cells, B-cells or natural killer (NK) cells (at protein level).1 Publication

Gene expression databases

BgeeiA6NI73.
CleanExiHS_LILRA5.
GenevisibleiA6NI73. HS.

Structurei

Secondary structure

1
299
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi48 – 536Combined sources
Beta strandi55 – 584Combined sources
Beta strandi63 – 686Combined sources
Beta strandi75 – 806Combined sources
Beta strandi87 – 904Combined sources
Beta strandi98 – 1058Combined sources
Helixi108 – 1103Combined sources
Beta strandi112 – 1209Combined sources
Beta strandi131 – 1366Combined sources
Beta strandi143 – 1453Combined sources
Beta strandi159 – 1668Combined sources
Beta strandi169 – 1757Combined sources
Beta strandi182 – 1865Combined sources
Beta strandi195 – 2006Combined sources
Beta strandi210 – 2189Combined sources
Beta strandi221 – 2255Combined sources
Beta strandi232 – 2343Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D3VX-ray1.85A42-237[»]
ProteinModelPortaliA6NI73.
SMRiA6NI73. Positions 5-236.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA6NI73.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 13686Ig-like C2-type 1Add
BLAST
Domaini142 – 23089Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JB9F. Eukaryota.
ENOG41114EZ. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiA6NI73.
KOiK06512.
OMAiHYAGQYR.
OrthoDBiEOG7R56S3.
PhylomeDBiA6NI73.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NI73-1) [UniParc]FASTAAdd to basket

Also known as: LIR9m1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPWSHPSAQ LQPVGGDAVS PALMVLLCLG LSLGPRTHVQ AGNLSKATLW
60 70 80 90 100
AEPGSVISRG NSVTIRCQGT LEAQEYRLVK EGSPEPWDTQ NPLEPKNKAR
110 120 130 140 150
FSIPSMTEHH AGRYRCYYYS PAGWSEPSDP LELVVTGFYN KPTLSALPSP
160 170 180 190 200
VVTSGENVTL QCGSRLRFDR FILTEEGDHK LSWTLDSQLT PSGQFQALFP
210 220 230 240 250
VGPVTPSHRW MLRCYGSRRH ILQVWSEPSD LLEIPVSGAA DNLSPSQNKS
260 270 280 290
DSGTASHLQD YAVENLIRMG MAGLILVVLG ILIFQDWHSQ RSPQAAAGR
Length:299
Mass (Da):32,755
Last modified:July 24, 2007 - v1
Checksum:iF5EE25361D4E0F02
GO
Isoform 2 (identifier: A6NI73-2) [UniParc]FASTAAdd to basket

Also known as: LIR9m2

The sequence of this isoform differs from the canonical sequence as follows:
     31-42: Missing.

Show »
Length:287
Mass (Da):31,538
Checksum:iB2CDEEDDD148FF85
GO
Isoform 3 (identifier: A6NI73-3) [UniParc]FASTAAdd to basket

Also known as: LIR9s1

The sequence of this isoform differs from the canonical sequence as follows:
     239-299: AADNLSPSQN...QRSPQAAAGR → EEATVFSSTIQGSQTGCGELYRQGSPC

Show »
Length:265
Mass (Da):29,070
Checksum:i0BAF42BF24CBDA10
GO
Isoform 4 (identifier: A6NI73-4) [UniParc]FASTAAdd to basket

Also known as: LIR9s2

The sequence of this isoform differs from the canonical sequence as follows:
     31-42: Missing.
     239-299: AADNLSPSQN...QRSPQAAAGR → EEATVFSSTIQGSQTGCGELYRQGSPC

Show »
Length:253
Mass (Da):27,852
Checksum:iC34EF35D5C05BCFE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1001R → G in AAF73849 (PubMed:10941842).Curated
Sequence conflicti220 – 2201H → R in AAF73849 (PubMed:10941842).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei31 – 4212Missing in isoform 2 and isoform 4. 1 PublicationVSP_031276Add
BLAST
Alternative sequencei239 – 29961AADNL…AAAGR → EEATVFSSTIQGSQTGCGEL YRQGSPC in isoform 3 and isoform 4. 1 PublicationVSP_031277Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212842 mRNA. Translation: AAF73849.1.
AF324830 mRNA. Translation: AAK52451.1.
AF499916 mRNA. Translation: AAN27925.1.
AF499917 mRNA. Translation: AAN27926.1.
AF499918 mRNA. Translation: AAN27927.1.
AF499919 mRNA. Translation: AAN27928.1.
AC008984 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72226.1.
CH471135 Genomic DNA. Translation: EAW72227.1.
CCDSiCCDS12888.1. [A6NI73-1]
CCDS12889.1. [A6NI73-2]
RefSeqiNP_067073.1. NM_021250.3. [A6NI73-1]
NP_870994.1. NM_181879.2. [A6NI73-3]
NP_871714.1. NM_181985.3. [A6NI73-2]
NP_871715.1. NM_181986.2. [A6NI73-4]
UniGeneiHs.710986.

Genome annotation databases

EnsembliENST00000432233; ENSP00000404236; ENSG00000187116. [A6NI73-1]
ENST00000486742; ENSP00000484372; ENSG00000187116. [A6NI73-2]
ENST00000611164; ENSP00000482658; ENSG00000278355. [A6NI73-2]
ENST00000612266; ENSP00000480436; ENSG00000274914. [A6NI73-4]
ENST00000612621; ENSP00000484785; ENSG00000278355. [A6NI73-1]
ENST00000613559; ENSP00000484775; ENSG00000274914. [A6NI73-3]
ENST00000614299; ENSP00000483992; ENSG00000274914. [A6NI73-2]
ENST00000615820; ENSP00000480204; ENSG00000274113. [A6NI73-2]
ENST00000616133; ENSP00000484062; ENSG00000275404. [A6NI73-4]
ENST00000618711; ENSP00000478354; ENSG00000274914. [A6NI73-1]
ENST00000619516; ENSP00000480382; ENSG00000278355. [A6NI73-4]
ENST00000620091; ENSP00000480458; ENSG00000274113. [A6NI73-1]
ENST00000620692; ENSP00000483958; ENSG00000275404. [A6NI73-3]
ENST00000620898; ENSP00000484869; ENSG00000275404. [A6NI73-2]
ENST00000621042; ENSP00000482882; ENSG00000275404. [A6NI73-1]
ENST00000621482; ENSP00000477785; ENSG00000278355. [A6NI73-3]
GeneIDi353514.
KEGGihsa:353514.
UCSCiuc032idp.1. human. [A6NI73-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212842 mRNA. Translation: AAF73849.1.
AF324830 mRNA. Translation: AAK52451.1.
AF499916 mRNA. Translation: AAN27925.1.
AF499917 mRNA. Translation: AAN27926.1.
AF499918 mRNA. Translation: AAN27927.1.
AF499919 mRNA. Translation: AAN27928.1.
AC008984 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72226.1.
CH471135 Genomic DNA. Translation: EAW72227.1.
CCDSiCCDS12888.1. [A6NI73-1]
CCDS12889.1. [A6NI73-2]
RefSeqiNP_067073.1. NM_021250.3. [A6NI73-1]
NP_870994.1. NM_181879.2. [A6NI73-3]
NP_871714.1. NM_181985.3. [A6NI73-2]
NP_871715.1. NM_181986.2. [A6NI73-4]
UniGeneiHs.710986.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D3VX-ray1.85A42-237[»]
ProteinModelPortaliA6NI73.
SMRiA6NI73. Positions 5-236.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI43.001.

PTM databases

iPTMnetiA6NI73.

Polymorphism and mutation databases

BioMutaiLILRA5.

Proteomic databases

PaxDbiA6NI73.
PRIDEiA6NI73.

Protocols and materials databases

DNASUi353514.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000432233; ENSP00000404236; ENSG00000187116. [A6NI73-1]
ENST00000486742; ENSP00000484372; ENSG00000187116. [A6NI73-2]
ENST00000611164; ENSP00000482658; ENSG00000278355. [A6NI73-2]
ENST00000612266; ENSP00000480436; ENSG00000274914. [A6NI73-4]
ENST00000612621; ENSP00000484785; ENSG00000278355. [A6NI73-1]
ENST00000613559; ENSP00000484775; ENSG00000274914. [A6NI73-3]
ENST00000614299; ENSP00000483992; ENSG00000274914. [A6NI73-2]
ENST00000615820; ENSP00000480204; ENSG00000274113. [A6NI73-2]
ENST00000616133; ENSP00000484062; ENSG00000275404. [A6NI73-4]
ENST00000618711; ENSP00000478354; ENSG00000274914. [A6NI73-1]
ENST00000619516; ENSP00000480382; ENSG00000278355. [A6NI73-4]
ENST00000620091; ENSP00000480458; ENSG00000274113. [A6NI73-1]
ENST00000620692; ENSP00000483958; ENSG00000275404. [A6NI73-3]
ENST00000620898; ENSP00000484869; ENSG00000275404. [A6NI73-2]
ENST00000621042; ENSP00000482882; ENSG00000275404. [A6NI73-1]
ENST00000621482; ENSP00000477785; ENSG00000278355. [A6NI73-3]
GeneIDi353514.
KEGGihsa:353514.
UCSCiuc032idp.1. human. [A6NI73-1]

Organism-specific databases

CTDi353514.
GeneCardsiLILRA5.
HGNCiHGNC:16309. LILRA5.
MIMi606047. gene.
neXtProtiNX_A6NI73.
PharmGKBiPA142671547.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JB9F. Eukaryota.
ENOG41114EZ. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiA6NI73.
KOiK06512.
OMAiHYAGQYR.
OrthoDBiEOG7R56S3.
PhylomeDBiA6NI73.
TreeFamiTF336644.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

EvolutionaryTraceiA6NI73.
GenomeRNAii353514.
PROiA6NI73.
SOURCEiSearch...

Gene expression databases

BgeeiA6NI73.
CleanExiHS_LILRA5.
GenevisibleiA6NI73. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster."
    Wende H., Volz A., Ziegler A.
    Immunogenetics 51:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "LIR9, an immunoglobulin-superfamily-activating receptor, is expressed as a transmembrane and as a secreted molecule."
    Borges L., Kubin M., Kuhlman T.
    Blood 101:1484-1486(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Crystal structure of the human monocyte-activating receptor, 'Group 2' leukocyte Ig-like receptor A5 (LILRA5/LIR9/ILT11)."
    Shiroishi M., Kajikawa M., Kuroki K., Ose T., Kohda D., Maenaka K.
    J. Biol. Chem. 281:19536-19544(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 42-237, FUNCTION, DISULFIDE BOND.

Entry informationi

Entry nameiLIRA5_HUMAN
AccessioniPrimary (citable) accession number: A6NI73
Secondary accession number(s): A6NHI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 24, 2007
Last modified: June 8, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.