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Protein

Putative neutrophil cytosol factor 1B

Gene

NCF1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

May be required for activation of the latent NADPH oxidase (necessary for superoxide production).By similarity

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Putative neutrophil cytosol factor 1B
Short name:
NCF-1B
Alternative name(s):
Putative SH3 and PX domain-containing protein 1B
Gene namesi
Name:NCF1B
Synonyms:SH3PXD1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:32522. NCF1B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Putative neutrophil cytosol factor 1BPRO_0000349367Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei304 – 3041PhosphoserineBy similarity
Modified residuei305 – 3051PhosphoserineBy similarity
Modified residuei321 – 3211PhosphoserineBy similarity
Modified residuei329 – 3291PhosphoserineBy similarity
Modified residuei346 – 3461PhosphoserineBy similarity
Modified residuei349 – 3491PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA6NI72.
PaxDbiA6NI72.
PRIDEiA6NI72.

Expressioni

Organism-specific databases

HPAiHPA047836.
HPA052095.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000289473.

Structurei

3D structure databases

ProteinModelPortaliA6NI72.
SMRiA6NI72. Positions 2-142, 157-333, 360-391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 126126PXPROSITE-ProRule annotationAdd
BLAST
Domaini157 – 21660SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini227 – 28660SH3 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation
Contains 2 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiENOG410IRR3. Eukaryota.
ENOG410YYZE. LUCA.
HOGENOMiHOG000232124.
HOVERGENiHBG002055.
InParanoidiA6NI72.
PhylomeDBiA6NI72.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR015039. NADPH_oxidase_p47Phox_C.
IPR032136. NECFESHC.
IPR001655. P47PHOX.
IPR001683. Phox.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF16621. NECFESHC. 1 hit.
PF08944. p47_phox_C. 1 hit.
PF00787. PX. 1 hit.
PF00018. SH3_1. 2 hits.
[Graphical view]
PRINTSiPR00498. P47PHOX.
SMARTiSM00312. PX. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NI72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDTFIRHIA LLGFEKRFVP SQHYVRYMFL VKWQDLSEKV VYRRFTEIYE
60 70 80 90 100
FHKTLKEMFP IEAGAINPEN RIIPHLPAPK WFDGQRAAEN HQGTLTEYCG
110 120 130 140 150
TLMSLPTKIS RCPHLLDFFK VRPDDLKLPT DNQTKKPETY LMPKDGKSTA
160 170 180 190 200
TDITGPIILQ TYRAIANYEK TSGSEMALST GDVVEVVEKS ESGWWFCQMK
210 220 230 240 250
AKRGWIPASF LEPLDSPDET EDPEPNYAGE PYVAIKAYTA VEGDEVSLLE
260 270 280 290 300
GEAVEVIHKL LDGWWVIRKD DVTGYFPSMY LQKSGQDVSQ AQRQIKRGAP
310 320 330 340 350
PRRSSIRNVH SIHQRSRKRL SQDAYRRNSV RFLQQRRRQA RPGPQSPGSP
360 370 380 390
LEEERQTQRS KPQPAVPPRP SADLILNRCS ESTKRKLASA V
Length:391
Mass (Da):44,817
Last modified:January 15, 2008 - v2
Checksum:iDD386BF36C25DF9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006995 Genomic DNA. No translation available.
UniGeneiHs.655201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006995 Genomic DNA. No translation available.
UniGeneiHs.655201.

3D structure databases

ProteinModelPortaliA6NI72.
SMRiA6NI72. Positions 2-142, 157-333, 360-391.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000289473.

Proteomic databases

EPDiA6NI72.
PaxDbiA6NI72.
PRIDEiA6NI72.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiNCF1B.
HGNCiHGNC:32522. NCF1B.
HPAiHPA047836.
HPA052095.
neXtProtiNX_A6NI72.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRR3. Eukaryota.
ENOG410YYZE. LUCA.
HOGENOMiHOG000232124.
HOVERGENiHBG002055.
InParanoidiA6NI72.
PhylomeDBiA6NI72.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR015039. NADPH_oxidase_p47Phox_C.
IPR032136. NECFESHC.
IPR001655. P47PHOX.
IPR001683. Phox.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF16621. NECFESHC. 1 hit.
PF08944. p47_phox_C. 1 hit.
PF00787. PX. 1 hit.
PF00018. SH3_1. 2 hits.
[Graphical view]
PRINTSiPR00498. P47PHOX.
SMARTiSM00312. PX. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiNCF1B_HUMAN
AccessioniPrimary (citable) accession number: A6NI72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: January 15, 2008
Last modified: March 16, 2016
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.