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Protein

Protein myomaker

Gene

TMEM8C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Actively participates in the membrane fusion reaction (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein myomaker
Alternative name(s):
Transmembrane protein 226
Transmembrane protein 8C
Gene namesi
Name:TMEM8C
Synonyms:TMEM226
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:33778. TMEM8C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalSequence AnalysisAdd
BLAST
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST
Transmembranei65 – 8521HelicalSequence AnalysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence AnalysisAdd
BLAST
Transmembranei154 – 17421HelicalSequence AnalysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165586306.

Polymorphism and mutation databases

BioMutaiTMEM8C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Protein myomakerPRO_0000319062Add
BLAST

Proteomic databases

PRIDEiA6NI61.

PTM databases

PhosphoSiteiA6NI61.

Expressioni

Gene expression databases

BgeeiA6NI61.

Organism-specific databases

HPAiHPA051846.
HPA055785.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000419712.

Structurei

3D structure databases

ProteinModelPortaliA6NI61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM8 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG85682.
GeneTreeiENSGT00390000004668.
HOGENOMiHOG000155572.
InParanoidiA6NI61.
OMAiAPAKLDC.
OrthoDBiEOG7S21ZV.
PhylomeDBiA6NI61.

Family and domain databases

InterProiIPR021910. DUF3522.
[Graphical view]
PfamiPF12036. DUF3522. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NI61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTLVAKLLL PTLSSLAFLP TVSIAAKRRF HMEAMVYLFT LFFVALHHAC
60 70 80 90 100
NGPGLSVLCF MRHDILEYFS VYGTALSMWV SLMALADFDE PKRSTFVMFG
110 120 130 140 150
VLTIAVRIYH DRWGYGVYSG PIGTAILIIA AKWLQKMKEK KGLYPDKSVY
160 170 180 190 200
TQQIGPGLCF GALALMLRFF FEDWDYTYVH SFYHCALAMS FVLLLPKVNK
210 220
KAGSPGTPAK LDCSTLCCAC V
Length:221
Mass (Da):24,699
Last modified:July 24, 2007 - v1
Checksum:i8A163CD15CC25290
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX324209 Genomic DNA. No translation available.
CCDSiCCDS35170.1.
RefSeqiNP_001073952.1. NM_001080483.2.
UniGeneiHs.512467.

Genome annotation databases

EnsembliENST00000339996; ENSP00000419712; ENSG00000187616.
GeneIDi389827.
KEGGihsa:389827.
UCSCiuc011mdk.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX324209 Genomic DNA. No translation available.
CCDSiCCDS35170.1.
RefSeqiNP_001073952.1. NM_001080483.2.
UniGeneiHs.512467.

3D structure databases

ProteinModelPortaliA6NI61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000419712.

PTM databases

PhosphoSiteiA6NI61.

Polymorphism and mutation databases

BioMutaiTMEM8C.

Proteomic databases

PRIDEiA6NI61.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339996; ENSP00000419712; ENSG00000187616.
GeneIDi389827.
KEGGihsa:389827.
UCSCiuc011mdk.2. human.

Organism-specific databases

CTDi389827.
GeneCardsiGC09M136379.
HGNCiHGNC:33778. TMEM8C.
HPAiHPA051846.
HPA055785.
MIMi615345. gene.
neXtProtiNX_A6NI61.
PharmGKBiPA165586306.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG85682.
GeneTreeiENSGT00390000004668.
HOGENOMiHOG000155572.
InParanoidiA6NI61.
OMAiAPAKLDC.
OrthoDBiEOG7S21ZV.
PhylomeDBiA6NI61.

Miscellaneous databases

GenomeRNAii389827.
NextBioi103118.
PROiA6NI61.
SOURCEiSearch...

Gene expression databases

BgeeiA6NI61.

Family and domain databases

InterProiIPR021910. DUF3522.
[Graphical view]
PfamiPF12036. DUF3522. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTMM8C_HUMAN
AccessioniPrimary (citable) accession number: A6NI61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 24, 2007
Last modified: July 22, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.