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A6NI61

- TMM8C_HUMAN

UniProt

A6NI61 - TMM8C_HUMAN

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Protein

Protein myomaker

Gene

TMEM8C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Actively participates in the membrane fusion reaction By similarity.By similarity

GO - Biological processi

  1. muscle organ development Source: UniProtKB-KW
  2. myoblast fusion Source: UniProtKB
  3. plasma membrane fusion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein myomaker
Alternative name(s):
Transmembrane protein 226
Transmembrane protein 8C
Gene namesi
Name:TMEM8C
Synonyms:TMEM226
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:33778. TMEM8C.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity
Note: Localizes on the cell surface of myoblasts during fusion and is down-regulated thereafter.By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165586306.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Protein myomakerPRO_0000319062Add
BLAST

Proteomic databases

PRIDEiA6NI61.

PTM databases

PhosphoSiteiA6NI61.

Expressioni

Gene expression databases

BgeeiA6NI61.
GenevestigatoriA6NI61.

Organism-specific databases

HPAiHPA051846.
HPA055785.

Structurei

3D structure databases

ProteinModelPortaliA6NI61.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalSequence AnalysisAdd
BLAST
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST
Transmembranei65 – 8521HelicalSequence AnalysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence AnalysisAdd
BLAST
Transmembranei154 – 17421HelicalSequence AnalysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM8 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG85682.
GeneTreeiENSGT00390000004668.
HOGENOMiHOG000155572.
InParanoidiA6NI61.
OMAiMVYLFTM.
OrthoDBiEOG7S21ZV.
PhylomeDBiA6NI61.

Family and domain databases

InterProiIPR021910. DUF3522.
[Graphical view]
PfamiPF12036. DUF3522. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NI61-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTLVAKLLL PTLSSLAFLP TVSIAAKRRF HMEAMVYLFT LFFVALHHAC
60 70 80 90 100
NGPGLSVLCF MRHDILEYFS VYGTALSMWV SLMALADFDE PKRSTFVMFG
110 120 130 140 150
VLTIAVRIYH DRWGYGVYSG PIGTAILIIA AKWLQKMKEK KGLYPDKSVY
160 170 180 190 200
TQQIGPGLCF GALALMLRFF FEDWDYTYVH SFYHCALAMS FVLLLPKVNK
210 220
KAGSPGTPAK LDCSTLCCAC V
Length:221
Mass (Da):24,699
Last modified:July 24, 2007 - v1
Checksum:i8A163CD15CC25290
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX324209 Genomic DNA. No translation available.
CCDSiCCDS35170.1.
RefSeqiNP_001073952.1. NM_001080483.2.
UniGeneiHs.512467.

Genome annotation databases

EnsembliENST00000339996; ENSP00000419712; ENSG00000187616.
GeneIDi389827.
KEGGihsa:389827.
UCSCiuc011mdk.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX324209 Genomic DNA. No translation available.
CCDSi CCDS35170.1.
RefSeqi NP_001073952.1. NM_001080483.2.
UniGenei Hs.512467.

3D structure databases

ProteinModelPortali A6NI61.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei A6NI61.

Proteomic databases

PRIDEi A6NI61.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000339996 ; ENSP00000419712 ; ENSG00000187616 .
GeneIDi 389827.
KEGGi hsa:389827.
UCSCi uc011mdk.2. human.

Organism-specific databases

CTDi 389827.
GeneCardsi GC09M136379.
HGNCi HGNC:33778. TMEM8C.
HPAi HPA051846.
HPA055785.
MIMi 615345. gene.
neXtProti NX_A6NI61.
PharmGKBi PA165586306.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG85682.
GeneTreei ENSGT00390000004668.
HOGENOMi HOG000155572.
InParanoidi A6NI61.
OMAi MVYLFTM.
OrthoDBi EOG7S21ZV.
PhylomeDBi A6NI61.

Miscellaneous databases

GenomeRNAii 389827.
NextBioi 103118.
PROi A6NI61.
SOURCEi Search...

Gene expression databases

Bgeei A6NI61.
Genevestigatori A6NI61.

Family and domain databases

InterProi IPR021910. DUF3522.
[Graphical view ]
Pfami PF12036. DUF3522. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTMM8C_HUMAN
AccessioniPrimary (citable) accession number: A6NI61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3