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A6NI61

- TMM8C_HUMAN

UniProt

A6NI61 - TMM8C_HUMAN

Protein

Protein myomaker

Gene

TMEM8C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Actively participates in the membrane fusion reaction By similarity.By similarity

    GO - Biological processi

    1. muscle organ development Source: UniProtKB-KW
    2. myoblast fusion Source: UniProtKB
    3. plasma membrane fusion Source: UniProtKB

    Keywords - Biological processi

    Myogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein myomaker
    Alternative name(s):
    Transmembrane protein 226
    Transmembrane protein 8C
    Gene namesi
    Name:TMEM8C
    Synonyms:TMEM226
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:33778. TMEM8C.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity
    Note: Localizes on the cell surface of myoblasts during fusion and is down-regulated thereafter.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165586306.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 221221Protein myomakerPRO_0000319062Add
    BLAST

    Proteomic databases

    PRIDEiA6NI61.

    PTM databases

    PhosphoSiteiA6NI61.

    Expressioni

    Gene expression databases

    BgeeiA6NI61.
    GenevestigatoriA6NI61.

    Organism-specific databases

    HPAiHPA051846.
    HPA055785.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NI61.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei35 – 5521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei65 – 8521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei114 – 13421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei154 – 17421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei176 – 19621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TMEM8 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG85682.
    HOGENOMiHOG000155572.
    InParanoidiA6NI61.
    OMAiMVYLFTM.
    OrthoDBiEOG7S21ZV.
    PhylomeDBiA6NI61.

    Family and domain databases

    InterProiIPR021910. DUF3522.
    [Graphical view]
    PfamiPF12036. DUF3522. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6NI61-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTLVAKLLL PTLSSLAFLP TVSIAAKRRF HMEAMVYLFT LFFVALHHAC    50
    NGPGLSVLCF MRHDILEYFS VYGTALSMWV SLMALADFDE PKRSTFVMFG 100
    VLTIAVRIYH DRWGYGVYSG PIGTAILIIA AKWLQKMKEK KGLYPDKSVY 150
    TQQIGPGLCF GALALMLRFF FEDWDYTYVH SFYHCALAMS FVLLLPKVNK 200
    KAGSPGTPAK LDCSTLCCAC V 221
    Length:221
    Mass (Da):24,699
    Last modified:July 24, 2007 - v1
    Checksum:i8A163CD15CC25290
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX324209 Genomic DNA. No translation available.
    CCDSiCCDS35170.1.
    RefSeqiNP_001073952.1. NM_001080483.2.
    UniGeneiHs.512467.

    Genome annotation databases

    EnsembliENST00000339996; ENSP00000419712; ENSG00000187616.
    GeneIDi389827.
    KEGGihsa:389827.
    UCSCiuc011mdk.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX324209 Genomic DNA. No translation available.
    CCDSi CCDS35170.1.
    RefSeqi NP_001073952.1. NM_001080483.2.
    UniGenei Hs.512467.

    3D structure databases

    ProteinModelPortali A6NI61.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei A6NI61.

    Proteomic databases

    PRIDEi A6NI61.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000339996 ; ENSP00000419712 ; ENSG00000187616 .
    GeneIDi 389827.
    KEGGi hsa:389827.
    UCSCi uc011mdk.2. human.

    Organism-specific databases

    CTDi 389827.
    GeneCardsi GC09M136379.
    HGNCi HGNC:33778. TMEM8C.
    HPAi HPA051846.
    HPA055785.
    MIMi 615345. gene.
    neXtProti NX_A6NI61.
    PharmGKBi PA165586306.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG85682.
    HOGENOMi HOG000155572.
    InParanoidi A6NI61.
    OMAi MVYLFTM.
    OrthoDBi EOG7S21ZV.
    PhylomeDBi A6NI61.

    Miscellaneous databases

    GenomeRNAii 389827.
    NextBioi 103118.
    PROi A6NI61.
    SOURCEi Search...

    Gene expression databases

    Bgeei A6NI61.
    Genevestigatori A6NI61.

    Family and domain databases

    InterProi IPR021910. DUF3522.
    [Graphical view ]
    Pfami PF12036. DUF3522. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiTMM8C_HUMAN
    AccessioniPrimary (citable) accession number: A6NI61
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3