A6NI61 (TMM8C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein 8C

Alternative name(s):
Transmembrane protein 226

Gene names

Name:	TMEM8C
Synonyms:	TMEM226

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the TMEM8 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 221	221	Transmembrane protein 8C		PRO_0000319062
Regions
	Transmembrane	4 – 24	21	Helical; Potential
	Transmembrane	35 – 55	21	Helical; Potential
	Transmembrane	65 – 85	21	Helical; Potential
	Transmembrane	114 – 134	21	Helical; Potential
	Transmembrane	154 – 174	21	Helical; Potential
	Transmembrane	176 – 196	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	A6NI61 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 8A163CD15CC25290	FASTA	221	24,699
	10 20 30 40 50 60 MGTLVAKLLL PTLSSLAFLP TVSIAAKRRF HMEAMVYLFT LFFVALHHAC NGPGLSVLCF 70 80 90 100 110 120 MRHDILEYFS VYGTALSMWV SLMALADFDE PKRSTFVMFG VLTIAVRIYH DRWGYGVYSG 130 140 150 160 170 180 PIGTAILIIA AKWLQKMKEK KGLYPDKSVY TQQIGPGLCF GALALMLRFF FEDWDYTYVH 190 200 210 220 SFYHCALAMS FVLLLPKVNK KAGSPGTPAK LDCSTLCCAC V

References

[1]

"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX324209 Genomic DNA. No translation available.
IPI	IPI00374559.
RefSeq	NP_001073952.1. NM_001080483.2.
UniGene	Hs.512467.
3D structure databases
ProteinModelPortal	A6NI61.
ModBase	Search...
PTM databases
PhosphoSite	A6NI61.
Proteomic databases
PRIDE	A6NI61.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000339996; ENSP00000419712; ENSG00000187616.
GeneID	389827.
KEGG	hsa:389827.
UCSC	uc011mdk.2. human.
Organism-specific databases
CTD	389827.
GeneCards	GC09M136379.
HGNC	HGNC:33778. TMEM8C.
neXtProt	NX_A6NI61.
PharmGKB	PA165586306.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG85682.
HOGENOM	HOG000155572.
InParanoid	A6NI61.
OMA	MVYLFTM.
OrthoDB	EOG41NTMX.
PhylomeDB	A6NI61.
Gene expression databases
Bgee	A6NI61.
Genevestigator	A6NI61.
Family and domain databases
InterPro	IPR021910. DUF3522. [Graphical view]
Pfam	PF12036. DUF3522. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	389827.
NextBio	103118.

Entry information

Entry name

TMM8C_HUMAN

Accession

Primary (citable) accession number: A6NI61

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	July 24, 2007
Last modified:	March 6, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.