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A6NI61 (TMM8C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein myomaker
Alternative name(s):
Transmembrane protein 226
Transmembrane protein 8C
Gene names
Name:TMEM8C
Synonyms:TMEM226
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length221 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Actively participates in the membrane fusion reaction By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Note: Localizes on the cell surface of myoblasts during fusion and is down-regulated thereafter By similarity.

Sequence similarities

Belongs to the TMEM8 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 221221Protein myomaker
PRO_0000319062

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane35 – 5521Helical; Potential
Transmembrane65 – 8521Helical; Potential
Transmembrane114 – 13421Helical; Potential
Transmembrane154 – 17421Helical; Potential
Transmembrane176 – 19621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A6NI61 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 8A163CD15CC25290

FASTA22124,699
        10         20         30         40         50         60 
MGTLVAKLLL PTLSSLAFLP TVSIAAKRRF HMEAMVYLFT LFFVALHHAC NGPGLSVLCF 

        70         80         90        100        110        120 
MRHDILEYFS VYGTALSMWV SLMALADFDE PKRSTFVMFG VLTIAVRIYH DRWGYGVYSG 

       130        140        150        160        170        180 
PIGTAILIIA AKWLQKMKEK KGLYPDKSVY TQQIGPGLCF GALALMLRFF FEDWDYTYVH 

       190        200        210        220 
SFYHCALAMS FVLLLPKVNK KAGSPGTPAK LDCSTLCCAC V 

« Hide

References

[1]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX324209 Genomic DNA. No translation available.
RefSeqNP_001073952.1. NM_001080483.2.
UniGeneHs.512467.

3D structure databases

ProteinModelPortalA6NI61.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteA6NI61.

Proteomic databases

PRIDEA6NI61.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000339996; ENSP00000419712; ENSG00000187616.
GeneID389827.
KEGGhsa:389827.
UCSCuc011mdk.2. human.

Organism-specific databases

CTD389827.
GeneCardsGC09M136379.
HGNCHGNC:33778. TMEM8C.
HPAHPA051846.
HPA055785.
MIM615345. gene.
neXtProtNX_A6NI61.
PharmGKBPA165586306.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG85682.
HOGENOMHOG000155572.
InParanoidA6NI61.
OMAMVYLFTM.
OrthoDBEOG7S21ZV.
PhylomeDBA6NI61.

Gene expression databases

BgeeA6NI61.
GenevestigatorA6NI61.

Family and domain databases

InterProIPR021910. DUF3522.
[Graphical view]
PfamPF12036. DUF3522. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi389827.
NextBio103118.
PROA6NI61.
SOURCESearch...

Entry information

Entry nameTMM8C_HUMAN
AccessionPrimary (citable) accession number: A6NI61
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 24, 2007
Last modified: February 19, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM